KIMBERLEY TOLIAS

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cheng J, Scala F, Blanco FA, Niu S, Firozi K, Keehan L, Mulherkar S, Froudarakis E, Li L, Duman JG, Jiang X, Tolias KF. The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions. J Neurosci. 2021 Feb 10; 41(6):1191-1206. PMID: 33328293.
      Citations:    Fields:    
    2. Cadwell CR, Scala F, Fahey PG, Kobak D, Mulherkar S, Sinz FH, Papadopoulos S, Tan ZH, Johnsson P, Hartmanis L, Li S, Cotton RJ, Tolias KF, Sandberg R, Berens P, Jiang X, Tolias AS. Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex. Elife. 2020 03 05; 9. PMID: 32134385.
      Citations: 1     Fields:    
    3. Mulherkar S, Tolias KF. RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury. Cells. 2020 01 18; 9(1). PMID: 31963704.
      Citations: 4     Fields:    
    4. Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife. 2019 08 28; 8. PMID: 31461398.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2019 11; 1456(1):5-25. PMID: 31168816.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL, Zoghbi HY. An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function. Mol Psychiatry. 2020 10; 25(10):2534-2555. PMID: 30610205.
      Citations: 9     Fields:    
    7. Tu YK, Duman JG, Tolias KF. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018 09 26; 38(39):8388-8406. PMID: 30120207.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Paveškovic M, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses. Neuro Oncol. 2018 04 09; 20(5):655-665. PMID: 29112734.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    9. Mulherkar S, Firozi K, Huang W, Uddin MD, Grill RJ, Costa-Mattioli M, Robertson C, Tolias KF. RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury. Sci Rep. 2017 09 06; 7(1):10689. PMID: 28878396.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Duman JG, Tolias KF. RhoGTPases Spread the Word for Synaptic Crosstalk. Dev Cell. 2016 10 24; 39(2):136-138. PMID: 27780038.
      Citations: 1     Fields:    Translation:HumansCells
    11. Lai KO, Jordan BA, Ma XM, Srivastava DP, Tolias KF. Molecular Mechanisms of Dendritic Spine Development and Plasticity. Neural Plast. 2016; 2016:2078121. PMID: 27127656.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Duman JG, Tu YK, Tolias KF. Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity. Neural Plast. 2016; 2016:8301737. PMID: 26881134.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R, Tolias AS. Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq. Nat Biotechnol. 2016 Feb; 34(2):199-203. PMID: 26689543.
      Citations: 89     Fields:    Translation:AnimalsCells
    14. Duman JG, Mulherkar S, Tu YK, X Cheng J, Tolias KF. Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses. Neurosci Lett. 2015 Aug 05; 601:4-10. PMID: 26003445.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    15. Mulherkar S, Uddin MD, Couvillon AD, Sillitoe RV, Tolias KF. The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation. Dev Biol. 2014 Oct 01; 394(1):39-53. PMID: 25128586.
      Citations: 12     Fields:    Translation:AnimalsCells
    16. Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15. PMID: 24960694.
      Citations: 27     Fields:    Translation:AnimalsCells
    17. Schwechter B, Tolias KF. Cytoskeletal mechanisms for synaptic potentiation. Commun Integr Biol. 2013 Nov 01; 6(6):e27343. PMID: 24505509.
      Citations:    
    18. Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013 Dec; 24(24):3857-68. PMID: 24152735.
      Citations: 9     Fields:    Translation:AnimalsCells
    19. Schwechter B, Rosenmund C, Tolias KF. RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14462-7. PMID: 23940355.
      Citations: 16     Fields:    Translation:AnimalsCells
    20. Mulherkar S, Liu F, Chen Q, Narayanan A, Couvillon AD, Shine HD, Tolias KF. The small GTPase RhoA is required for proper locomotor circuit assembly. PLoS One. 2013; 8(6):e67015. PMID: 23825607.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013 Apr 17; 33(16):6964-78. PMID: 23595754.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    22. Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH. avß8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell. 2013 Feb; 24(4):474-82. PMID: 23283986.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    23. Tolias KF, Duman JG, Um K. Control of synapse development and plasticity by Rho GTPase regulatory proteins. Prog Neurobiol. 2011 Jul; 94(2):133-48. PMID: 21530608.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    24. Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA. Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron. 2007 Jul 05; 55(1):53-68. PMID: 17610817.
      Citations: 64     Fields:    Translation:AnimalsCells
    25. Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7265-70. PMID: 17440041.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    26. Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron. 2005 Feb 17; 45(4):525-38. PMID: 15721239.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    27. Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL. BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity. 2003 Nov; 19(5):669-78. PMID: 14614854.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    28. Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL. Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000 Feb 10; 10(3):153-6. PMID: 10679324.
      Citations: 74     Fields:    Translation:AnimalsCells
    29. Tolias K, Carpenter CL. In vitro interaction of phosphoinositide-4-phosphate 5-kinases with Rac. Methods Enzymol. 2000; 325:190-200. PMID: 11036604.
      Citations: 3     Fields:    Translation:Cells
    30. Kost B, Lemichez E, Spielhofer P, Hong Y, Tolias K, Carpenter C, Chua NH. Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth. J Cell Biol. 1999 Apr 19; 145(2):317-30. PMID: 10209027.
      Citations: 187     Fields:    Translation:AnimalsCells
    31. Tolias KF, Cantley LC. Pathways for phosphoinositide synthesis. Chem Phys Lipids. 1999 Apr; 98(1-2):69-77. PMID: 10358929.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    32. Carpenter CL, Tolias KF, Van Vugt A, Hartwig J. Lipid kinases are novel effectors of the GTPase Rac1. Adv Enzyme Regul. 1999; 39:299-312. PMID: 10470380.
      Citations: 2     Fields:    Translation:AnimalsCells
    33. Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. J Biol Chem. 1998 Jul 17; 273(29):18040-6. PMID: 9660759.
      Citations: 30     Fields:    Translation:AnimalsCells
    34. Tolias KF, Couvillon AD, Cantley LC, Carpenter CL. Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Mol Cell Biol. 1998 Feb; 18(2):762-70. PMID: 9447972.
      Citations: 49     Fields:    Translation:AnimalsCells
    35. Rameh LE, Tolias KF, Duckworth BC, Cantley LC. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature. 1997 Nov 13; 390(6656):192-6. PMID: 9367159.
      Citations: 127     Fields:    Translation:AnimalsCells
    36. Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997 Jan 31; 272(5):2595-8. PMID: 9006891.
      Citations: 71     Fields:    Translation:HumansCells
    37. Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases. Adv Enzyme Regul. 1997; 37:377-90. PMID: 9381982.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    38. Kolluri R, Tolias KF, Carpenter CL, Rosen FS, Kirchhausen T. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5615-8. PMID: 8643625.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    39. Tolias KF, Cantley LC, Carpenter CL. Rho family GTPases bind to phosphoinositide kinases. J Biol Chem. 1995 Jul 28; 270(30):17656-9. PMID: 7629060.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
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