"Chromosome Fragile Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
| Descriptor ID |
D043283
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| MeSH Number(s) |
G05.360.340.024.189.610
|
| Concept/Terms |
Chromosome Fragile Sites- Chromosome Fragile Sites
- Chromosome Fragile Site
- Fragile Site, Chromosome
- Site, Chromosome Fragile
- Sites, Chromosome Fragile
- Fragile Sites, Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".
This graph shows the total number of publications written about "Chromosome Fragile Sites" by people in this website by year, and whether "Chromosome Fragile Sites" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 1 | 3 |
| 2006 | 2 | 0 | 2 |
| 2007 | 0 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2013 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Chromosome Fragile Sites" by people in Profiles.
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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. Proc Natl Acad Sci U S A. 2021 11 30; 118(48).
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Biology before the SOS Response-DNA Damage Mechanisms at Chromosome Fragile Sites. Cells. 2021 09 01; 10(9).
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WWOX, the FRA16D gene: A target of and a contributor to genomic instability. Genes Chromosomes Cancer. 2019 05; 58(5):324-338.
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MicroRNAs, Regulatory Messengers Inside and Outside Cancer Cells. Adv Exp Med Biol. 2018; 1056:87-108.
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G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia. Mol Cell Biol. 2013 Nov; 33(21):4266-81.
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ZNF365 promotes stability of fragile sites and telomeres. Cancer Discov. 2013 Jul; 3(7):798-811.
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Signatures of mutation and selection in the cancer genome. Nature. 2010 Feb 18; 463(7283):893-8.
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An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene. 2010 May 06; 29(18):2659-71.
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Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias. Oral Oncol. 2008 Aug; 44(8):753-8.
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Association between decreased WWOX protein expression and thyroid cancer development. Thyroid. 2007 Nov; 17(11):1055-9.