"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
| Descriptor ID |
D016875
|
| MeSH Number(s) |
D12.776.220.600.450.510 D12.776.631.560.510
|
| Concept/Terms |
tau Proteins- tau Proteins
- Proteins, tau
- tau Protein
- Protein, tau
|
Below are MeSH descriptors whose meaning is more general than "tau Proteins".
Below are MeSH descriptors whose meaning is more specific than "tau Proteins".
This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 3 | 2 | 5 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 2 | 4 |
| 2004 | 0 | 1 | 1 |
| 2005 | 5 | 1 | 6 |
| 2006 | 3 | 5 | 8 |
| 2007 | 3 | 2 | 5 |
| 2008 | 2 | 3 | 5 |
| 2009 | 4 | 0 | 4 |
| 2010 | 5 | 1 | 6 |
| 2011 | 6 | 2 | 8 |
| 2012 | 3 | 2 | 5 |
| 2013 | 7 | 2 | 9 |
| 2014 | 9 | 3 | 12 |
| 2015 | 2 | 2 | 4 |
| 2016 | 7 | 2 | 9 |
| 2017 | 2 | 1 | 3 |
| 2018 | 9 | 2 | 11 |
| 2019 | 5 | 3 | 8 |
| 2020 | 3 | 0 | 3 |
| 2021 | 3 | 2 | 5 |
| 2022 | 0 | 4 | 4 |
| 2023 | 3 | 2 | 5 |
| 2024 | 3 | 3 | 6 |
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click here.
Below are the most recent publications written about "tau Proteins" by people in Profiles.
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APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI. Sci Rep. 2024 11 25; 14(1):29150.
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TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model. Nat Neurosci. 2024 Dec; 27(12):2417-2429.
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Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nat Neurosci. 2024 Oct; 27(10):1918-1933.
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MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study. Lancet Neurol. 2024 May; 23(5):487-499.
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TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. Acta Neuropathol. 2024 03 25; 147(1):61.
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Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology. Neurology. 2024 Apr 09; 102(7):e209203.
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Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study. Am J Geriatr Psychiatry. 2024 08; 32(8):909-919.
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Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. Am J Hum Genet. 2024 02 01; 111(2):259-279.
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DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau. Mol Neurobiol. 2024 May; 61(5):2978-2995.
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Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology. 2023 Dec 12; 101(24):e2533-e2544.