"DNA, Circular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)
Descriptor ID |
D004270
|
MeSH Number(s) |
D13.444.308.283 G02.111.570.820.486.212 G05.360.580.156
|
Concept/Terms |
DNA, Circular- DNA, Circular
- Circular DNAs
- DNAs, Circular
- Circular DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA, Circular".
Below are MeSH descriptors whose meaning is more specific than "DNA, Circular".
This graph shows the total number of publications written about "DNA, Circular" by people in this website by year, and whether "DNA, Circular" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2001 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2015 | 0 | 1 | 1 |
2016 | 1 | 0 | 1 |
2017 | 1 | 1 | 2 |
2019 | 1 | 0 | 1 |
2020 | 2 | 0 | 2 |
2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "DNA, Circular" by people in Profiles.
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MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis. J Exp Clin Cancer Res. 2024 Mar 05; 43(1):68.
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Suitability of double-stranded DNA as a molecular standard for the validation of analytical ultracentrifugation instruments. Eur Biophys J. 2023 Jul; 52(4-5):267-280.
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Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells. J Biol Chem. 2023 05; 299(5):104665.
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Complex mosaic structural variations in human fetal brains. Genome Res. 2020 12; 30(12):1695-1704.
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Discovery of several thousand highly diverse circular DNA viruses. Elife. 2020 02 04; 9.
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Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome. Nat Biotechnol. 2019 10; 37(10):1155-1162.
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Relative Abundance of Integrant-Derived Viral RNAs in Infected Tissues Harvested from Chronic Hepatitis B Virus Carriers. J Virol. 2018 05 15; 92(10).
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Influence of DNA sequence on the structure of minicircles under torsional stress. Nucleic Acids Res. 2017 Jul 27; 45(13):7633-7642.
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Looping-out mechanism for resolution of replicative stress at telomeres. EMBO Rep. 2017 08; 18(8):1412-1428.
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Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation. Mol Cancer Res. 2017 09; 15(9):1197-1205.