"G-Quadruplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
| Descriptor ID |
D054856
|
| MeSH Number(s) |
G02.111.570.820.486.550 G05.360.580.550
|
| Concept/Terms |
G-Quadruplexes- G-Quadruplexes
- G Quadruplexes
- Guanine-Quadruplexes
- Guanine Quadruplexes
Guanine-Tetrads- Guanine-Tetrads
- Guanine Tetrads
- Guanine-Tetrad
- Guanine-Quartets
- Guanine Quartets
- Guanine-Quartet
G-Quadruplexes, DNA- G-Quadruplexes, DNA
- G Quadruplexes, DNA
- Tetraplex DNA
- DNA, Tetraplex
- DNA G-Quadruplexes
- DNA G Quadruplexes
- DNA, Quadruplex
- Quadruplex DNA
G-Quadruplexes, RNA- G-Quadruplexes, RNA
- G Quadruplexes, RNA
- RNA G-Quadruplexes
- RNA, G-Quadruplexes
- G-Quadruplexes RNA
- G-Quadruplexes RNAs
- RNA, G Quadruplexes
- RNAs, G-Quadruplexes
|
Below are MeSH descriptors whose meaning is more general than "G-Quadruplexes".
Below are MeSH descriptors whose meaning is more specific than "G-Quadruplexes".
This graph shows the total number of publications written about "G-Quadruplexes" by people in this website by year, and whether "G-Quadruplexes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "G-Quadruplexes" by people in Profiles.
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Disruption of the Nucleolin-CXCR4 interaction by the DNA aptamer HY-4 halts colorectal cancer metastasis. Mol Ther. 2025 Oct 01; 33(10):4904-4922.
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Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD. Nucleic Acids Res. 2024 Aug 12; 52(14):8039-8051.
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A Non-G-Quadruplex DNA Aptamer Targeting NCL for Diagnosis and Therapy in Bladder Cancer. Adv Healthc Mater. 2023 08; 12(20):e2300791.
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Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons. Elife. 2020 02 11; 9.
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An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3' ends. Nucleic Acids Res. 2019 09 19; 47(16):8755-8769.
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Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. 2017 Jun 02; 45(10):5850-5862.
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The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 2015 Sep 03; 525(7567):56-61.
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Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron. 2014 Sep 03; 83(5):1043-50.
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A peroxidase-active aptazyme as an isothermally amplifiable label in an aptazyme-linked oligonucleotide assay for low-picomolar IgE detection. Analyst. 2012 Dec 21; 137(24):5710-2.
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Telomeres-structure, function, and regulation. Exp Cell Res. 2013 Jan 15; 319(2):133-41.