"Platelet Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
| Descriptor ID |
D010978
|
| MeSH Number(s) |
D12.644.276.374.200.120.900 D12.776.124.125.720 D12.776.467.374.200.120.900 D23.119.940 D23.125.300.120.900 D23.469.200.120.900 D23.529.374.200.120.900
|
| Concept/Terms |
Platelet Factor 4- Platelet Factor 4
- Chemokine CXCL4
- CXCL4, Chemokine
- PF4 (Platelet Factor 4)
- gamma-Thromboglobulin
- gamma Thromboglobulin
- Heparin Neutralizing Protein
- Antiheparin Factor
- CXCL4 Chemokine
- Chemokine, CXCL4
|
Below are MeSH descriptors whose meaning is more general than "Platelet Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Platelet Factor 4".
This graph shows the total number of publications written about "Platelet Factor 4" by people in this website by year, and whether "Platelet Factor 4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Platelet Factor 4" by people in Profiles.
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The impact of Gam-COVID-Vac, an Adv5/Adv26 COVID-19 vaccine, on the biomarkers of endothelial function, coagulation and platelet activation. PLoS One. 2023; 18(10):e0293074.
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Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis. Front Immunol. 2022; 13:910993.
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Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus. Front Immunol. 2022; 13:885307.
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CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021 07; 125(2):176-189.
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Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis. Arthritis Res Ther. 2018 01 11; 20(1):6.
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Performance of 4T score and heparin-platelet factor 4 antibody in the diagnosis of heparin-induced thrombocytopenia (HIT) in cancer. J Thromb Thrombolysis. 2017 Aug; 44(2):261-266.
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Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera. Biomed Res Int. 2017; 2017:9876819.
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The prognostic significance of circulating serum amyloid A and CXC chemokine ligand 4 in osteosarcoma. Pediatr Blood Cancer. 2017 Dec; 64(12).
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Predictions and presumptive treatment of heparin-induced thrombocytopenia. Am J Health Syst Pharm. 2016 May 15; 73(10):614.
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Evaluation of clinical and laboratory data for early diagnosis of heparin-induced thrombocytopenia. Am J Health Syst Pharm. 2015 Oct 01; 72(19):1649-55.