Nuclear Receptor Co-Repressor 2
"Nuclear Receptor Co-Repressor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear co-repressor protein that shows specificity for RETINOIC ACID RECEPTORS and THYROID HORMONE RECEPTORS. The dissociation of this co-repressor from nuclear receptors is generally ligand-dependent, but can also occur by way of its phosphorylation by members of the MAP KINASE SIGNALING SYSTEM. The protein contains two nuclear receptor interaction domains and four repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 1.
| Descriptor ID |
D056985
|
| MeSH Number(s) |
D12.776.930.780.625.400
|
| Concept/Terms |
Nuclear Receptor Co-Repressor 2- Nuclear Receptor Co-Repressor 2
- Nuclear Receptor Co Repressor 2
- TRAC Co-repressor
- Co-repressor, TRAC
- TRAC Co repressor
- SMRT Co-repressor
- Co-repressor, SMRT
- SMRT Co repressor
- Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor
- T3 Receptor-associating Factor
- Receptor-associating Factor, T3
- T3 Receptor associating Factor
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Co-Repressor 2".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Co-Repressor 2".
This graph shows the total number of publications written about "Nuclear Receptor Co-Repressor 2" by people in this website by year, and whether "Nuclear Receptor Co-Repressor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 3 | 0 | 3 |
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Below are the most recent publications written about "Nuclear Receptor Co-Repressor 2" by people in Profiles.
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Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717.
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The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism. J Mol Cell Biol. 2019 02 01; 11(2):133-143.
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Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019 02; 22(2):205-217.
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HP1? Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A. Cancer Res. 2018 07 15; 78(14):3834-3848.
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Tamoxifen Resistance Trumped and Oral Selective Estrogen Receptor Degraders Arrive. Clin Cancer Res. 2018 08 01; 24(15):3480-3482.
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PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71.
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Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. Cancer Epidemiol Biomarkers Prev. 2015 Jul; 24(7):1101-10.
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NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65.
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The SMRT coregulator enhances growth of estrogen receptor-a-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis. Endocrinology. 2014 Sep; 155(9):3251-61.
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Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor. Mol Cell Biol. 2014 Apr; 34(7):1246-61.