"Talin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.
| Descriptor ID |
D016608
|
| MeSH Number(s) |
D12.776.220.985
|
| Concept/Terms |
Talin- Talin
- Band 2 Protein
- Protein, Band 2
|
Below are MeSH descriptors whose meaning is more general than "Talin".
Below are MeSH descriptors whose meaning is more specific than "Talin".
This graph shows the total number of publications written about "Talin" by people in this website by year, and whether "Talin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Talin" by people in Profiles.
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Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis. Curr Biol. 2022 01 24; 32(2):412-427.e8.
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Relief of talin autoinhibition triggers a force-independent association with vinculin. J Cell Biol. 2020 01 06; 219(1).
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Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6786-6791.
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The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly. Cell Physiol Biochem. 2017; 43(6):2200-2211.
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Molecular Simulations Suggest a Force-Dependent Mechanism of Vinculin Activation. Biophys J. 2017 Oct 17; 113(8):1697-1710.
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Wdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897.
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Talin1 phosphorylation activates ?1 integrins: a novel mechanism to promote prostate cancer bone metastasis. Oncogene. 2015 Apr 02; 34(14):1811-21.
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Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila. Development. 2013 Feb 01; 140(3):627-38.
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Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol. 2013 Feb 18; 23(4):271-81.
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Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer. PLoS One. 2012; 7(7):e41170.