"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
| Descriptor ID |
D016922
|
| MeSH Number(s) |
G04.043
|
| Concept/Terms |
Cell Aging- Cell Aging
- Cellular Ageing
- Ageing, Cellular
- Aging, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Cell Ageing
- Ageing, Cell
Senescence-Associated Secretory Phenotype- Senescence-Associated Secretory Phenotype
- Phenotype, Senescence-Associated Secretory
- Secretory Phenotype, Senescence-Associated
- Senescence Associated Secretory Phenotype
|
Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".
Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".
This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 |
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 2 | 4 |
| 1998 | 0 | 3 | 3 |
| 1999 | 4 | 1 | 5 |
| 2000 | 1 | 4 | 5 |
| 2001 | 1 | 4 | 5 |
| 2002 | 1 | 4 | 5 |
| 2003 | 2 | 1 | 3 |
| 2004 | 4 | 5 | 9 |
| 2005 | 6 | 3 | 9 |
| 2006 | 7 | 8 | 15 |
| 2007 | 9 | 7 | 16 |
| 2008 | 6 | 4 | 10 |
| 2009 | 3 | 11 | 14 |
| 2010 | 6 | 12 | 18 |
| 2011 | 5 | 5 | 10 |
| 2012 | 2 | 2 | 4 |
| 2013 | 1 | 8 | 9 |
| 2014 | 6 | 12 | 18 |
| 2015 | 1 | 7 | 8 |
| 2016 | 3 | 6 | 9 |
| 2017 | 1 | 6 | 7 |
| 2018 | 2 | 4 | 6 |
| 2019 | 7 | 4 | 11 |
| 2020 | 5 | 4 | 9 |
| 2021 | 6 | 4 | 10 |
| 2022 | 0 | 4 | 4 |
| 2023 | 3 | 5 | 8 |
| 2024 | 3 | 3 | 6 |
To return to the timeline,
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Below are the most recent publications written about "Cellular Senescence" by people in Profiles.
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CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia. Blood. 2024 09 12; 144(11):1168-1182.
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Single-cell total-RNA profiling unveils regulatory hubs of transcription factors. Nat Commun. 2024 Jul 15; 15(1):5941.
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TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024 Jul 25; 187(15):4030-4042.e13.
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IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy. Clin Cancer Res. 2024 Jun 03; 30(11):2558-2570.
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Human platelet lysate enhances in vivo activity of CAR-Vd2 T cells by reducing cellular senescence and apoptosis. Cytotherapy. 2024 Aug; 26(8):858-868.
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Tissue mosaicism following stem cell aging: blood as an exemplar. Nat Aging. 2024 Mar; 4(3):295-308.
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D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1?-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024 Jan 08; 59(1):33-47.e5.
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Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells. Haematologica. 2023 10 01; 108(10):2626-2638.
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Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice. Sci Rep. 2023 08 30; 13(1):14186.
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Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Sci Adv. 2023 07 21; 9(29):eadf7195.