"Genes, Lethal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
| Descriptor ID |
D005804
|
| MeSH Number(s) |
G05.360.340.024.340.350
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Genes, Lethal".
Below are MeSH descriptors whose meaning is more specific than "Genes, Lethal".
This graph shows the total number of publications written about "Genes, Lethal" by people in this website by year, and whether "Genes, Lethal" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 4 | 5 |
| 1995 | 3 | 8 | 11 |
| 1996 | 0 | 3 | 3 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 2 | 3 |
| 2001 | 1 | 2 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 2 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 3 | 5 |
| 2006 | 2 | 2 | 4 |
| 2008 | 0 | 2 | 2 |
| 2009 | 2 | 1 | 3 |
| 2010 | 1 | 1 | 2 |
| 2011 | 2 | 2 | 4 |
| 2012 | 1 | 3 | 4 |
| 2013 | 0 | 3 | 3 |
| 2014 | 1 | 5 | 6 |
| 2016 | 1 | 3 | 4 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, Lethal" by people in Profiles.
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Lethal phenotypes in Mendelian disorders. Genet Med. 2024 Jul; 26(7):101141.
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Mendelian gene identification through mouse embryo viability screening. Genome Med. 2022 10 13; 14(1):119.
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Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. Elife. 2020 02 19; 9.
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Siva plays a critical role in mouse embryonic development. Cell Death Differ. 2020 01; 27(1):297-309.
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Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019; 14(2):e0212017.
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.
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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature. 2016 Oct 06; 538(7623):114-117.
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Three-dimensional microCT imaging of mouse development from early post-implantation to early postnatal stages. Dev Biol. 2016 11 15; 419(2):229-236.
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High-throughput discovery of novel developmental phenotypes. Nature. 2016 09 22; 537(7621):508-514.
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CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice. Sci Rep. 2016 Aug 17; 6:31666.