STAT4 Transcription Factor
"STAT4 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important signaling molecule for differentiation in TH1 CELLS.
| Descriptor ID |
D050797
|
| MeSH Number(s) |
D12.644.360.024.342.400 D12.776.157.057.186.400 D12.776.476.024.430.400 D12.776.930.840.400
|
| Concept/Terms |
STAT4 Transcription Factor- STAT4 Transcription Factor
- Transcription Factor, STAT4
- Signal Transducer and Activator of Transcription 4
- STAT4 Protein
- Transcription Factor STAT4
|
Below are MeSH descriptors whose meaning is more general than "STAT4 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT4 Transcription Factor".
This graph shows the total number of publications written about "STAT4 Transcription Factor" by people in this website by year, and whether "STAT4 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "STAT4 Transcription Factor" by people in Profiles.
-
A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet. 2018 07 01; 27(13):2392-2404.
-
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis Rheumatol. 2016 Apr; 68(4):932-43.
-
STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol. 2014 Sep 01; 88(17):9655-72.
-
The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease. Blood. 2013 Dec 12; 122(25):4119-28.
-
TIP: a probabilistic method for identifying transcription factor target genes from ChIP-seq binding profiles. Bioinformatics. 2011 Dec 01; 27(23):3221-7.
-
Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans. Ann Rheum Dis. 2010 Apr; 69(4):625-6.
-
Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Arthritis Rheum. 2009 Dec; 60(12):3794-806.
-
Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. Blood. 2008 Apr 15; 111(8):4173-83.
-
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007 Sep 06; 357(10):977-86.
-
IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells. J Clin Invest. 2002 Oct; 110(7):983-92.