Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.

Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells. PLoS One. 2014; 9(3):e89064.

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subject areas

Apoptosis
Apoptosis Regulatory Proteins
bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein
Bcl-2-Like Protein 11
Benzamides
Boronic Acids
Bortezomib
Cell Line, Tumor
Checkpoint Kinase 1
Cytoprotection
Down-Regulation
Drug Resistance, Neoplasm
Humans
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Mitogen-Activated Protein Kinase Kinases
Multiple Myeloma
Myeloid Cell Leukemia Sequence 1 Protein
Protein Binding
Protein Kinase Inhibitors
Protein Kinases
Proto-Oncogene Proteins
Pyrazines
Syndecan-1
Up-Regulation

authors with profiles

ROBERT ORLOWSKI