TitleAssistant Professor
InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2020 Oct 01. PMID: 33000412.
      Citations:    Fields:    
    2. Lee H, Zhuang L, Gan B. Energy stress inhibits ferroptosis via AMPK. Mol Cell Oncol. 2020; 7(4):1761242. PMID: 32944623.
    3. Zhang Y, Shi J, Liu X, Xiao Z, Lei G, Lee H, Koppula P, Cheng W, Mao C, Zhuang L, Ma L, Li W, Gan B. H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death. Cancer Res. 2020 06 01; 80(11):2243-2256. PMID: 32273282.
      Citations:    Fields:    
    4. Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 04; 22(4):476-486. PMID: 32231310.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Chauhan AS, Zhuang L, Gan B. Spatial control of AMPK signaling at subcellular compartments. Crit Rev Biochem Mol Biol. 2020 02; 55(1):17-32. PMID: 32069425.
      Citations:    Fields:    
    6. Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020 02; 22(2):225-234. PMID: 32029897.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    7. Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res. 2020 02; 30(2):146-162. PMID: 31949285.
      Citations: 10     Fields:    
    8. Chauhan AS, Zhuang L, Gan B. Antagonism between Antiviral Signaling and Glycolysis. Trends Endocrinol Metab. 2019 09; 30(9):571-573. PMID: 31349923.
      Citations:    Fields:    Translation:Cells
    9. Gan B. DUBbing Ferroptosis in Cancer Cells. Cancer Res. 2019 04 15; 79(8):1749-1750. PMID: 30987975.
      Citations: 2     Fields:    Translation:HumansCells
    10. Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. . 2019 04; 18(8):773-783. PMID: 30907299.
    11. Zhang Y, Zhuang L, Gan B. BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. Mol Cell Oncol. 2019; 6(1):1536845. PMID: 30788415.
    12. Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 12; 50(12):1705-1715. PMID: 30349115.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    13. Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J. 2019 02; 33(2):2957-2970. PMID: 30335546.
      Citations: 7     Fields:    Translation:HumansCells
    14. Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018 10; 20(10):1181-1192. PMID: 30202049.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    15. Koppula P, Zhang Y, Zhuang L, Gan B. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond). 2018 04 25; 38(1):12. PMID: 29764521.
      Citations: 35     Fields:    Translation:HumansCells
    16. Yadav RK, Chauhan AS, Zhuang L, Gan B. FoxO transcription factors in cancer metabolism. Semin Cancer Biol. 2018 06; 50:65-76. PMID: 29309929.
      Citations: 14     Fields:    Translation:Humans
    17. Xiao ZD, Han L, Lee H, Zhuang L, Zhang Y, Baddour J, Nagrath D, Wood CG, Gu J, Wu X, Liang H, Gan B. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nat Commun. 2017 10 04; 8(1):783. PMID: 28978906.
      Citations: 28     Fields:    Translation:HumansCells
    18. Koppula P, Zhang Y, Shi J, Li W, Gan B. The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem. 2017 08 25; 292(34):14240-14249. PMID: 28630042.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    19. Dai F, Lee H, Zhang Y, Zhuang L, Yao H, Xi Y, Xiao ZD, You MJ, Li W, Su X, Gan B. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3192-3197. PMID: 28275095.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. Liu X, Gan B. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. . 2016 Dec 16; 15(24):3471-3481. PMID: 27792451.
    21. Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res. 2016 11 01; 76(21):6424-6435. PMID: 27569213.
      Citations: 18     Fields:    Translation:AnimalsCells
    22. Xiao ZD, Zhuang L, Gan B. Long non-coding RNAs in cancer metabolism. Bioessays. 2016 10; 38(10):991-6. PMID: 27550823.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Xiao ZD, Liu X, Zhuang L, Gan B. NBR2: A former junk gene emerges as a key player in tumor suppression. Mol Cell Oncol. 2016 Jul; 3(4):e1187322. PMID: 27652330.
    24. Liu X, Xiao ZD, Gan B. An lncRNA switch for AMPK activation. . 2016 08 02; 15(15):1948-9. PMID: 27152502.
    25. Lee H, Dai F, Zhuang L, Xiao ZD, Kim J, Zhang Y, Ma L, You MJ, Wang Z, Gan B. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 2016 Apr 12; 7(15):19134-46. PMID: 26992241.
      Citations: 16     Fields:    Translation:AnimalsCells
    26. Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016 Apr; 18(4):431-42. PMID: 26999735.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    27. Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol. 2015 Apr; 17(4):490-9. PMID: 25751139.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    28. Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res. 2014 Mar 15; 74(6):1682-93. PMID: 24448243.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    29. Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14520-7. PMID: 23918370.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    30. Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW, Gan B. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene. 2014 Jun 12; 33(24):3183-94. PMID: 23851496.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    31. Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, Maurer M, Parsons R. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev. 2013 Apr 15; 27(8):916-27. PMID: 23630076.
      Citations: 14     Fields:    Translation:HumansCells
    32. Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood. 2013 May 02; 121(18):3619-30. PMID: 23444404.
      Citations: 25     Fields:    Translation:AnimalsCells
    33. Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Apr 27; 149(3):656-70. PMID: 22541435.
      Citations: 570     Fields:    Translation:HumansAnimalsCells
    34. Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63. PMID: 22341440.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    35. Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012 Mar 02; 148(5):896-907. PMID: 22341455.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    36. Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology. 2012 Feb; 153(2):631-46. PMID: 22147007.
      Citations: 54     Fields:    Translation:AnimalsCells
    37. Zhang Y, Gan B, Liu D, Paik JH. FoxO family members in cancer. . 2011 Aug 15; 12(4):253-9. PMID: 21613825.
    38. Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev. 2011 Jul 15; 25(14):1510-27. PMID: 21764854.
      Citations: 142     Fields:    Translation:AnimalsCells
    39. Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 2010 Dec 02; 468(7324):701-4. PMID: 21124456.
      Citations: 178     Fields:    Translation:AnimalsCells
    40. Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell. 2010 Nov 16; 18(5):472-84. PMID: 21075312.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    41. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 2010 May 18; 17(5):497-509. PMID: 20478531.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    42. Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem. 2010 Jan 29; 285(5):3499-509. PMID: 19940130.
      Citations: 76     Fields:    Translation:AnimalsCells
    43. Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. . 2009 Apr 01; 8(7):1003-6. PMID: 19270523.
    44. Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. J Biol Chem. 2009 Feb 27; 284(9):6004-13. PMID: 19106106.
      Citations: 23     Fields:    Translation:AnimalsCells
    45. Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19384-9. PMID: 19052232.
      Citations: 103     Fields:    Translation:AnimalsCells
    46. Martin N, Schwamborn K, Urlaub H, Gan B, Guan JL, Dejean A. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Mol Cell Biol. 2008 Apr; 28(8):2771-81. PMID: 18285457.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    47. Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal. 2008 May; 20(5):787-94. PMID: 18036779.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    48. Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J Biol Chem. 2007 Oct 26; 282(43):31766-76. PMID: 17716968.
      Citations: 34     Fields:    Translation:AnimalsCells
    49. Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. J Biol Chem. 2006 Dec 08; 281(49):37321-9. PMID: 17043358.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    50. Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol. 2006 Oct 09; 175(1):121-33. PMID: 17015619.
      Citations: 86     Fields:    Translation:AnimalsCells
    51. Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. J Biol Chem. 2006 Jun 16; 281(24):16664-71. PMID: 16617055.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    52. Wu X, Gan B, Yoo Y, Guan JL. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev Cell. 2005 Aug; 9(2):185-96. PMID: 16054026.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    53. Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Res. 2005 Aug 01; 65(15):6676-84. PMID: 16061648.
      Citations: 36     Fields:    Translation:HumansCells
    54. Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol. 2005 Aug 01; 170(3):379-89. PMID: 16043512.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    55. Isolation and characterization of a potential transposable element from Wolbachia. Progress in Natural Science. 11:523-524.
    56. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 7:19134-19146.
    57. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology.
    58. An lncRNA switch for AMPK activation. Cell Cycle. 1-2.
    59. Ablation of miR-10b suppresses oncogene-induced mammary tumorigenesis and metastasis and reactivates tumor-suppressive pathways. Cancer Research. 76:6424-6435.
    60. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle. 15:3471-3481.
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