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BINGLIANG FANG

TitleProfessor
InstitutionMD Anderson
DepartmentThoracic & Cardiovascular Surgery
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek JR, Poyurovsky MV, Olszewski K, Gan B. Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers. Mol Cell. 2024 May 16; 84(10):1964-1979.e6. PMID: 38759628; PMCID: PMC11104512.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Meraz IM, Majidi M, Fang B, Meng F, Gao L, Shao R, Song R, Li F, Lissanu Y, Chen H, Ha MJ, Wang Q, Wang J, Shpall E, Jung SY, Haderk F, Gui P, Riess JW, Olivas V, Bivona TG, Roth JA. Author Correction: 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib. Commun Biol. 2023 Jun 06; 6(1):608. PMID: 37280434; PMCID: PMC10244399.
      Citations:    
    3. Meraz IM, Majidi M, Fang B, Meng F, Gao L, Shao R, Song R, Li F, Lissanu Y, Chen H, Ha MJ, Wang Q, Wang J, Shpall E, Jung SY, Haderk F, Gui P, Riess JW, Olivas V, Bivona TG, Roth JA. 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib. Commun Biol. 2023 05 11; 6(1):509. PMID: 37169941; PMCID: PMC10175489.
      Citations:    
    4. Huang L, Wang J, Fang B, Meric-Bernstam F, Roth JA, Ha MJ. CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts. Sci Rep. 2022 07 29; 12(1):12984. PMID: 35906256; PMCID: PMC9338066.
      Citations:    Fields:    
    5. Shukla SP, Zhang H, Fang B, Minna JD, Gomika Udugamasooriya D. Unbiased peptoid cell screen identifies a peptoid targeting newly appeared cell surface vimentin on tumor transformed early lung cancer cells. Bioorg Med Chem. 2022 03 15; 58:116673. PMID: 35189561; PMCID: PMC9040685.
      Citations:    Fields:    Translation:HumansCells
    6. Pairawan S, Akcakanat A, Kopetz S, Tapia C, Zheng X, Chen H, Ha MJ, Rizvi Y, Holla V, Wang J, Evans KW, Zhao M, Busaidy N, Fang B, Roth JA, Dumbrava EI, Meric-Bernstam F. Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations. Sci Rep. 2022 01 24; 12(1):1248. PMID: 35075200; PMCID: PMC8786858.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Robichaux JP, Le X, Vijayan RSK, Hicks JK, Heeke S, Elamin YY, Lin HY, Udagawa H, Skoulidis F, Tran H, Varghese S, He J, Zhang F, Nilsson MB, Hu L, Poteete A, Rinsurongkawong W, Zhang X, Ren C, Liu X, Hong L, Zhang J, Diao L, Madison R, Schrock AB, Saam J, Raymond V, Fang B, Wang J, Ha MJ, Cross JB, Gray JE, Heymach JV. Structure-based classification predicts drug response in EGFR-mutant NSCLC. Nature. 2021 09; 597(7878):732-737. PMID: 34526717; PMCID: PMC8481125.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    8. Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021 Aug; 596(7873):E13. PMID: 34341547.
      Citations: 2     Fields:    
    9. Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, Das M, Fang B, Poyurovsky MV, Gan B. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience. 2021 Jun 25; 24(6):102649. PMID: 34151236; PMCID: PMC8193145.
      Citations: 9     
    10. Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021 05; 593(7860):586-590. PMID: 33981038; PMCID: PMC8895686.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    11. Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021 03 11; 12(1):1589. PMID: 33707434; PMCID: PMC7952727.
      Citations: 37     Fields:    Translation:HumansCells
    12. Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell. 2021 04 15; 81(8):1698-1714.e6. PMID: 33626321; PMCID: PMC8052288.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    13. Nilsson MB, Robichaux J, Herynk MH, Cascone T, Le X, Elamin Y, Patel S, Zhang F, Xu L, Hu L, Diao L, Shen L, He J, Yu X, Nikolinakos P, Fang B, Girard L, Wang J, Minna JD, Wistuba II, Heymach JV, Saintigny P. Altered Regulation of HIF-1a in Naive- and Drug-Resistant EGFR-Mutant NSCLC: Implications for a Vascular Endothelial Growth Factor-Dependent Phenotype. J Thorac Oncol. 2021 03; 16(3):439-451. PMID: 33309987; PMCID: PMC8207565.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Kawakami M, Mustachio LM, Chen Y, Chen Z, Liu X, Wei CH, Roszik J, Kittai AS, Danilov AV, Zhang X, Fang B, Wang J, Heymach JV, Tyutyunyk-Massey L, Freemantle SJ, Kurie JM, Liu X, Dmitrovsky E. A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers. Mol Cancer Ther. 2021 03; 20(3):477-489. PMID: 33277443; PMCID: PMC8011823.
      Citations: 3     Fields:    Translation:HumansAnimals
    15. Zhang X, Zhang R, Chen H, Wang L, Ren C, Pataer A, Wu S, Meng QH, Ha MJ, Morris J, Xi Y, Wang J, Zhang J, Gibbons DL, Heymach JV, Meric-Bernstam F, Minna J, Swisher SG, Roth JA, Fang B. KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. Am J Cancer Res. 2020; 10(12):4464-4475. PMID: 33415011; PMCID: PMC7783771.
      Citations: 7     
    16. Liu X, Hong L, Nilsson M, Hubert SM, Wu S, Rinsurongkawong W, Lewis J, Spelman A, Roth J, Swisher S, He Y, Jack Lee J, Fang B, Heymach JV, Zhang J, Le X. Concurrent use of aspirin with osimertinib is associated with improved survival in advanced EGFR-mutant non-small cell lung cancer. Lung Cancer. 2020 11; 149:33-40. PMID: 32956986; PMCID: PMC7577964.
      Citations: 2     Fields:    Translation:Humans
    17. Fang B, Meng QH. The laboratory's role in combating COVID-19. Crit Rev Clin Lab Sci. 2020 09; 57(6):400-414. PMID: 32662342.
      Citations: 19     Fields:    Translation:HumansCellsPHPublic Health
    18. Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 04; 22(4):476-486. PMID: 32231310; PMCID: PMC7194135.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    19. Fang B. Introduction to this Special Issue: "Biomarker Discovery and Precision Medicine". J Cancer Metastasis Treat. 2020; 6. PMID: 34778566; PMCID: PMC8589333.
      Citations:    
    20. Wang J, Wang J, Lopez E, Guo H, Zhang H, Liu Y, Chen Z, Huang S, Zhou S, Leeming A, Zhang RJ, Jung D, Shi H, Grundman H, Doakes D, Cui K, Jiang C, Ahmed M, Nomie K, Fang B, Wang M, Yao Y, Zhang L. Repurposing auranofin to treat TP53-mutated or PTEN-deleted refractory B-cell lymphoma. Blood Cancer J. 2019 11 28; 9(12):95. PMID: 31780660; PMCID: PMC6882812.
      Citations: 7     Fields:    Translation:HumansCells
    21. Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. 2020 01; 39(4):801-813. PMID: 31554935; PMCID: PMC6976521.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    22. Chen Y, Zhang R, Wang L, Correa AM, Pataer A, Xu Y, Zhang X, Ren C, Wu S, Meng QH, Fujimoto J, Jensen VB, Antonoff MB, Hofstetter WL, Mehran RJ, Pisimisis G, Rice DC, Sepesi B, Vaporciyan AA, Walsh GL, Swisher SG, Roth JA, Heymach JV, Fang B. Tumor characteristics associated with engraftment of patient-derived non-small cell lung cancer xenografts in immunocompromised mice. Cancer. 2019 11 01; 125(21):3738-3748. PMID: 31287557; PMCID: PMC7294643.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    23. Meraz IM, Majidi M, Meng F, Shao R, Ha MJ, Neri S, Fang B, Lin SH, Tinkey PT, Shpall EJ, Morris J, Roth JA. An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses. Cancer Immunol Res. 2019 08; 7(8):1267-1279. PMID: 31186248; PMCID: PMC7213862.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    24. Baity M, Wang L, Correa AM, Zhang X, Zhang R, Pataer A, Wu S, Meng QH, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Zhao M, Gu J, Fang B. Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization. Am J Cancer Res. 2019; 9(6):1201-1211. PMID: 31285952; PMCID: PMC6610060.
      Citations: 1     
    25. Singh R, Peng S, Viswanath P, Sambandam V, Shen L, Rao X, Fang B, Wang J, Johnson FM. Non-canonical cMet regulation by vimentin mediates Plk1 inhibitor-induced apoptosis. EMBO Mol Med. 2019 05; 11(5). PMID: 31040125; PMCID: PMC6505578.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    26. Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL, Hung MC. Targeting PKCd as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 2018 12 10; 34(6):954-969.e4. PMID: 30537515; PMCID: PMC6886126.
      Citations: 26     Fields:    Translation:HumansCells
    27. Pu X, Wu L, Su D, Mao W, Fang B. Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance. BMC Cancer. 2018 Nov 08; 18(1):1082. PMID: 30409126; PMCID: PMC6225701.
      Citations: 20     Fields:    Translation:HumansCells
    28. Yan X, Zhang X, Wang L, Zhang R, Pu X, Wu S, Li L, Tong P, Wang J, Meng QH, Jensen VB, Girard L, Minna JD, Roth JA, Swisher SG, Heymach JV, Fang B. Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis. Cancer Res. 2019 01 01; 79(1):125-132. PMID: 30401714; PMCID: PMC7293542.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    29. Deribe YL, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, Inoue A, Kochat V, Liu CG, Asara JM, Moran C, Muller F, Wang J, Fang B, Papadimitrakopoulou V, Wistuba II, Rai K, Marszalek J, Futreal PA. Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 Oct; 24(10):1627. PMID: 30104769.
      Citations: 5     Fields:    
    30. Hu J, Zhang H, Cao M, Wang L, Wu S, Fang B. Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma. Mol Cancer Ther. 2018 10; 17(10):2156-2163. PMID: 30065099.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    31. Lissanu Deribe Y, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, Inoue A, Kochat V, Liu CG, Asara JM, Moran C, Muller F, Wang J, Fang B, Papadimitrakopoulou V, Wistuba II, Rai K, Marszalek J, Futreal PA. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 07; 24(7):1047-1057. PMID: 29892061; PMCID: PMC6650267.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    32. Goltsov AA, Fang B, Pandita TK, Maru DM, Swisher SG, Hofstetter WL. HER2 Confers Resistance to Foretinib Inhibition of MET-Amplified Esophageal Adenocarcinoma Cells. Ann Thorac Surg. 2018 Feb; 105(2):363-370. PMID: 29223420.
      Citations: 5     Fields:    Translation:HumansCells
    33. Wang JF, Pu X, Zhang X, Chen K, Xi Y, Wang J, Mao X, Zhang J, Heymach JV, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Meng QH, Shaw KR, Eterovic AK, Fang B. Variants with a low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell-free DNA by next-generation sequencing. Cancer. 2018 03 01; 124(5):1061-1069. PMID: 29178133; PMCID: PMC5821585.
      Citations: 4     Fields:    Translation:HumansCells
    34. Huang X, Cao M, Wu S, Wang L, Hu J, Mehran RJ, Roth JA, Swisher SG, Wang RY, Kantarjian HM, Andreeff M, Sun X, Fang B. Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities. Oncotarget. 2017 Nov 24; 8(60):102150-102160. PMID: 29254232; PMCID: PMC5731942.
      Citations: 3     Fields:    
    35. Yan X, Wang L, Zhang R, Pu X, Wu S, Yu L, Meraz IM, Zhang X, Wang JF, Gibbons DL, Mehran RJ, Swisher SG, Roth JA, Fang B. Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Oncoimmunology. 2017; 7(1):e1376156. PMID: 29296537; PMCID: PMC5739569.
      Citations: 8     Fields:    
    36. Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang CC, Qian J, Lie N, Lanzillotta C, Rabinowitz JD, Sun Z. Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. 2018 08 15; 471:22-32. PMID: 28554803; PMCID: PMC5702591.
      Citations: 3     Fields:    Translation:AnimalsCells
    37. Zhang L, Nomie K, Zhang H, Bell T, Pham L, Kadri S, Segal J, Li S, Zhou S, Santos D, Richard S, Sharma S, Chen W, Oriabure O, Liu Y, Huang S, Guo H, Chen Z, Tao W, Li C, Wang J, Fang B, Wang J, Li L, Badillo M, Ahmed M, Thirumurthi S, Huang SY, Shao Y, Lam L, Yi Q, Wang YL, Wang M. B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy. Clin Cancer Res. 2017 Aug 01; 23(15):4212-4223. PMID: 28348046; PMCID: PMC5540787.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    38. Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017 Feb; 23(2):223-234. PMID: 27991918; PMCID: PMC5540654.
      Citations: 43     Fields:    Translation:AnimalsCells
    39. Xiaobo C, Majidi M, Feng M, Shao R, Wang J, Zhao Y, Baladandayuthapani V, Song J, Fang B, Ji L, Mehran R, Roth JA. TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin. Sci Rep. 2016 11 15; 6:35741. PMID: 27845352; PMCID: PMC5109231.
      Citations: 10     Fields:    Translation:HumansCells
    40. Hao C, Shao R, Raju U, Fang B, Swisher SG, Pataer A. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 2016 Jun 21; 7(25):38235-38242. PMID: 27203671; PMCID: PMC5122385.
      Citations: 3     Fields:    Translation:HumansCells
    41. Li H, Hu J, Wu S, Wang L, Cao X, Zhang X, Dai B, Cao M, Shao R, Zhang R, Majidi M, Ji L, Heymach JV, Wang M, Pan S, Minna J, Mehran RJ, Swisher SG, Roth JA, Fang B. Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget. 2016 Jan 19; 7(3):3548-58. PMID: 26657290; PMCID: PMC4823126.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    42. Fang B. RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies. Acta Biochim Biophys Sin (Shanghai). 2016 Jan; 48(1):27-38. PMID: 26350096; PMCID: PMC4689157.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    43. Fang B, Mehran RJ, Heymach JV, Swisher SG. Predictive biomarkers in precision medicine and drug development against lung cancer. Chin J Cancer. 2015 Jul 02; 34(7):295-309. PMID: 26134262; PMCID: PMC4593363.
      Citations: 18     Fields:    Translation:Humans
    44. Guo C, Hao C, Shao R, Fang B, Correa AM, Hofstetter WL, Roth JA, Behrens C, Kalhor N, Wistuba II, Swisher SG, Pataer A. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 2015 May 10; 6(13):11114-24. PMID: 25798539; PMCID: PMC4484443.
      Citations: 3     Fields:    Translation:HumansCells
    45. Gao L, Xie E, Yu T, Chen D, Zhang L, Zhang B, Wang F, Xu J, Huang P, Liu X, Fang B, Pan S. Methylated APC and RASSF1A in multiple specimens contribute to the differential diagnosis of patients with undetermined solitary pulmonary nodules. J Thorac Dis. 2015 Mar; 7(3):422-32. PMID: 25922721; PMCID: PMC4387414.
      Citations: 7     
    46. Huang X, Cao M, Wang L, Wu S, Liu X, Li H, Zhang H, Wang RY, Sun X, Wei C, Baggerly KA, Roth JA, Wang M, Swisher SG, Fang B. Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380. Oncotarget. 2015 Jan 01; 6(1):345-54. PMID: 25514600; PMCID: PMC4381599.
      Citations: 8     Fields:    Translation:HumansCells
    47. Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG, Vaporciyan A, Walsh GL, Johnson FM, Fang B. Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett. 2015 Feb 01; 357(1):179-185. PMID: 25444907; PMCID: PMC4301580.
      Citations: 52     Fields:    Translation:HumansAnimals
    48. Gao W, Wang M, Wang L, Lu H, Wu S, Dai B, Ou Z, Zhang L, Heymach JV, Gold KA, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B. Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells. J Natl Cancer Inst. 2014 Sep; 106(9). PMID: 25214559; PMCID: PMC4200057.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    49. Wu S, Wang L, Huang X, Cao M, Hu J, Li H, Zhang H, Sun X, Meng QH, Hofstetter WL, Roth JA, Swisher SG, Fang B. Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380. Bioorg Med Chem. 2014 Oct 01; 22(19):5234-40. PMID: 25182964; PMCID: PMC4172508.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    50. Fang B. Development of synthetic lethality anticancer therapeutics. J Med Chem. 2014 Oct 09; 57(19):7859-73. PMID: 24893124; PMCID: PMC4205018.
      Citations: 21     Fields:    Translation:HumansAnimals
    51. Fang B. Genetic Interactions of STAT3 and Anticancer Drug Development. Cancers (Basel). 2014 Mar 06; 6(1):494-525. PMID: 24662938; PMCID: PMC3980611.
      Citations: 15     
    52. Lin SH, Fang B, Gillin M, Mohan R, Chang JY, Zhang X. Therapy-resistant cancer stem cells have differing sensitivity to photon versus proton beam radiation. J Thorac Oncol. 2013 Dec; 8(12):1484-91. PMID: 24389430; PMCID: PMC3882687.
      Citations: 20     Fields:    Translation:HumansCells
    53. Meng J, Majidi M, Fang B, Ji L, Bekele BN, Minna JD, Roth JA. The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner. PLoS One. 2013; 8(10):e77067. PMID: 24146957; PMCID: PMC3798310.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    54. Lu H, Wang L, Gao W, Meng J, Dai B, Wu S, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B. IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells. Mol Cancer Ther. 2013 Dec; 12(12):2864-73. PMID: 24130049; PMCID: PMC3858413.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    55. Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, Pataer A, Huang M, El-Zein R, Lin T, Roth JA, Mehran R, Hofstetter W, Swisher SG, Wu X, Fang B. Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. PLoS One. 2013; 8(9):e74973. PMID: 24069370; PMCID: PMC3775736.
      Citations: 20     Fields:    Translation:Humans
    56. Dai B, Yoo SY, Bartholomeusz G, Graham RA, Majidi M, Yan S, Meng J, Ji L, Coombes K, Minna JD, Fang B, Roth JA. KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res. 2013 Sep 01; 73(17):5532-43. PMID: 23824739; PMCID: PMC3868367.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    57. Seurin D, Lombet A, Babajko S, Ricort JM, Godeau F. Insulin-like growth factor binding proteins increase intracellular calcium levels in two different cell lines. PLoS One. 2013; 8(3):e59323. PMID: 23527161; PMCID: PMC3602172.
      Citations: 6     Fields:    Translation:HumansCells
    58. Guo C, Shao R, Correa AM, Behrens C, Johnson FM, Raso MG, Prudkin L, Solis LM, Nunez MI, Fang B, Roth JA, Wistuba II, Swisher SG, Lin T, Pataer A. Prognostic significance of combinations of RNA-dependent protein kinase and EphA2 biomarkers for NSCLC. J Thorac Oncol. 2013 Mar; 8(3):301-8. PMID: 23370317; PMCID: PMC3573252.
      Citations: 12     Fields:    Translation:HumansCells
    59. Hunt KK, Wingate H, Yokota T, Liu Y, Mills GB, Zhang F, Fang B, Su CH, Zhang M, Yi M, Keyomarsi K. Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer. Breast Cancer Res. 2013 Jan 15; 15(1):R3. PMID: 23320734; PMCID: PMC3672770.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    60. Zhang X, Fang B, Mohan R, Chang JY. Coxsackie-adenovirus receptor as a novel marker of stem cells in treatment-resistant non-small cell lung cancer. Radiother Oncol. 2012 Nov; 105(2):250-7. PMID: 23022172; PMCID: PMC3845342.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    61. Liu X, Guo W, Wu S, Wang L, Wang J, Dai B, Kim ES, Heymach JV, Wang M, Girard L, Minna J, Roth JA, Swisher SG, Fang B. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells. Biochem Pharmacol. 2012 May 15; 83(10):1456-64. PMID: 22387047; PMCID: PMC3391570.
      Citations: 20     Fields:    Translation:HumansCells
    62. Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One. 2011; 6(12):e28487. PMID: 22174819; PMCID: PMC3236185.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    63. Li JT, Bian K, Zhang AL, Kim DH, Ashley WW, Nath R, McCutcheon I, Fang B, Murad F. Targeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter. Cancer Cell Int. 2011 Oct 28; 11(1):35. PMID: 22035360; PMCID: PMC3283457.
      Citations: 5     
    64. Zhao ZG, Xu W, Yu HP, Fang BL, Wu SH, Li F, Li WM, Li QB, Chen ZC, Zou P. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes. Cancer Lett. 2012 Apr 28; 317(2):136-43. PMID: 22240014.
      Citations: 30     Fields:    Translation:HumansCells
    65. Wu S, Wang L, Guo W, Liu X, Liu J, Wei X, Fang B. Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities. J Med Chem. 2011 Apr 28; 54(8):2668-79. PMID: 21443218; PMCID: PMC3082393.
      Citations: 16     Fields:    Translation:HumansCells
    66. Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res. 2011 May 15; 71(10):3658-68. PMID: 21444672; PMCID: PMC3392199.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    67. Zhou W, Zhu H, Chen W, Hu X, Pang X, Zhang J, Huang X, Fang B, He C. Treatment of patient tumor-derived colon cancer xenografts by a TRAIL gene-armed oncolytic adenovirus. Cancer Gene Ther. 2011 May; 18(5):336-45. PMID: 21183948.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    68. Ang J, Fang BL, Ashman LK, Frauman AG. The migration and invasion of human prostate cancer cell lines involves CD151 expression. Oncol Rep. 2010 Dec; 24(6):1593-7. PMID: 21042756.
      Citations: 12     Fields:    Translation:HumansCells
    69. Meng J, Dai B, Fang B, Bekele BN, Bornmann WG, Sun D, Peng Z, Herbst RS, Papadimitrakopoulou V, Minna JD, Peyton M, Roth JA. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PLoS One. 2010 Nov 29; 5(11):e14124. PMID: 21124782; PMCID: PMC2993951.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    70. Ji H, Wang J, Fang B, Fang X, Lu Z. a-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of ?-catenin transactivation. J Neurooncol. 2011 Jul; 103(3):445-51. PMID: 20872274.
      Citations: 16     Fields:    Translation:HumansCells
    71. Ziauddin MF, Guo ZS, O'Malley ME, Austin F, Popovic PJ, Kavanagh MA, Li J, Sathaiah M, Thirunavukarasu P, Fang B, Lee YJ, Bartlett DL. TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer. Gene Ther. 2010 Apr; 17(4):550-9. PMID: 20182517; PMCID: PMC3250063.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    72. De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53. PMID: 19242409; PMCID: PMC3594767.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    73. Guo W, Fang B. Potentiation of oncolytic virotherapy with armed shRNA. Cancer Biol Ther. 2009 Jan; 8(1):92-3. PMID: 19127117.
      Citations:    Fields:    Translation:HumansCells
    74. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. Cancer Gene Ther. 2008 Sep; 15(9):616-24. PMID: 18535619; PMCID: PMC2553758.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    75. Wagener M, Zhang X, Villarreal HG, Levy L, Allen P, Shentu S, Fang B, Krishnan S, Chang JY, Cheung MR. Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer. Oncol Rep. 2008 May; 19(5):1071-7. PMID: 18425360.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    76. Shamimi-Noori S, Yeow WS, Ziauddin MF, Xin H, Tran TL, Xie J, Loehfelm A, Patel P, Yang J, Schrump DS, Fang BL, Nguyen DM. Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway. Cancer Gene Ther. 2008 Jun; 15(6):356-70. PMID: 18309355.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    77. Guo W, Fang B. Enhancing anti-cancer virotherapy with heat-shock protein-mediated immune response. Cancer Biol Ther. 2008 Feb; 7(2):196-7. PMID: 18347427.
      Citations:    Fields:    Translation:AnimalsCells
    78. Hu W, Davis JJ, Zhu H, Dong F, Guo W, Ang J, Peng H, Guo ZS, Bartlett DL, Swisher SG, Fang B. Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy. Cancer Biol Ther. 2007 Nov; 6(11):1773-9. PMID: 17986853; PMCID: PMC2387205.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    79. Hannay J, Davis JJ, Yu D, Liu J, Fang B, Pollock RE, Lev D. Isolated limb perfusion: a novel delivery system for wild-type p53 and fiber-modified oncolytic adenoviruses to extremity sarcoma. Gene Ther. 2007 Apr; 14(8):671-81. PMID: 17287860.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    80. Guo W, Fang B. Dominant Negative RAS as an anticancer agent. Cancer Biol Ther. 2006 Nov; 5(11):1492-3. PMID: 17204860.
      Citations:    Fields:    Translation:Humans
    81. Fang B. Targeting apoptosis to cancer via hTERT promoter. Cancer Biol Ther. 2006 Nov; 5(11):1554-5. PMID: 17204859.
      Citations:    Fields:    Translation:HumansAnimals
    82. Wu S, Guo W, Teraishi F, Pang J, Kaluarachchi K, Zhang L, Davis J, Dong F, Yan B, Fang B. Anticancer activity of 5-benzylidene-2-phenylimino-1, 3-thiazolidin-4-one (BPT) analogs. Med Chem. 2006 Nov; 2(6):597-605. PMID: 17105441.
      Citations: 2     Fields:    Translation:HumansCells
    83. Davis JJ, Wang L, Dong F, Zhang L, Guo W, Teraishi F, Xu K, Ji L, Fang B. Oncolysis and suppression of tumor growth by a GFP-expressing oncolytic adenovirus controlled by an hTERT and CMV hybrid promoter. Cancer Gene Ther. 2006 Jul; 13(7):720-3. PMID: 16485010; PMCID: PMC1617001.
      Citations: 21     Fields:    Translation:HumansCells
    84. Chen B, He C, Lao WF, Huang XF, Fang BL. [Activity of the TNF-related apoptosis-inducing ligand gene expressed from the hTERT promoter on colon cancer cell line HT-29]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 01; 35(1):45-9. PMID: 16470920.
      Citations: 1     Fields:    Translation:HumansCells
    85. Guo W, Zhu H, Zhang L, Davis J, Teraishi F, Roth JA, Stephens C, Fueyo J, Jiang H, Conrad C, Fang B. Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models. Cancer Gene Ther. 2006 Jan 01; 13(1):82-90. PMID: 16037823; PMCID: PMC1343537.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    86. Davis JJ, Fang B. Oncolytic virotherapy for cancer treatment: challenges and solutions. J Gene Med. 2005 Nov; 7(11):1380-9. PMID: 16025557.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    87. Teraishi F, Wu S, Sasaki J, Zhang L, Davis JJ, Guo W, Dong F, Fang B. JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. Cell Mol Life Sci. 2005 Oct; 62(19-20):2382-9. PMID: 16179969; PMCID: PMC1351099.
      Citations: 8     Fields:    Translation:HumansCells
    88. Jacob D, Schumacher G, Bahra M, Davis J, Zhu HB, Zhang LD, Teraishi F, Neuhaus P, Fang BL. Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells. World J Gastroenterol. 2005 May 07; 11(17):2552-6. PMID: 15849810; PMCID: PMC4305742.
      Citations: 4     Fields:    Translation:HumansCells
    89. Zhang L, Fang B. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther. 2005 Mar; 12(3):228-37. PMID: 15550937.
      Citations: 224     Fields:    Translation:HumansCells
    90. Jacob D, Davis JJ, Zhang L, Zhu H, Teraishi F, Fang B. Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter. Cancer Gene Ther. 2005 Feb; 12(2):109-15. PMID: 15486557.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    91. Davis J, Schumacher G, Bahra M, Neuhaus P, Fang B, Jacob D. [Adenoviral vector expressing the TRAIL gene driven by the hTERT promoter]. Z Gastroenterol. 2004 Dec; 42(12):1363-70. PMID: 15592959.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    92. Han J, Goldstein LA, Gastman BR, Rabinovitz A, Wang GQ, Fang B, Rabinowich H. Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells. Leukemia. 2004 Oct; 18(10):1671-80. PMID: 15356645.
      Citations: 13     Fields:    Translation:HumansCells
    93. Zhu H, Zhang L, Wu S, Teraishi F, Davis JJ, Jacob D, Fang B. Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. Oncogene. 2004 Jun 24; 23(29):4984-92. PMID: 15122344.
      Citations: 38     Fields:    Translation:HumansCells
    94. Tsunemitsu Y, Kagawa S, Tokunaga N, Otani S, Umeoka T, Roth JA, Fang B, Tanaka N, Fujiwara T. Molecular therapy for peritoneal dissemination of xenotransplanted human MKN-45 gastric cancer cells with adenovirus mediated Bax gene transfer. Gut. 2004 Apr; 53(4):554-60. PMID: 15016751; PMCID: PMC1774013.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    95. Honda T, Coppola S, Ghibelli L, Cho SH, Kagawa S, Spurgers KB, Brisbay SM, Roth JA, Meyn RE, Fang B, McDonnell TJ. GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells. Cancer Gene Ther. 2004 Apr; 11(4):249-55. PMID: 15002033.
      Citations: 14     Fields:    Translation:HumansCells
    96. He C, Lao WF, Hu XT, Xu XM, Xu J, Fang BL. Anti-liver cancer activity of TNF-related apoptosis-inducing ligand gene and its bystander effects. World J Gastroenterol. 2004 Mar 01; 10(5):654-9. PMID: 14991932; PMCID: PMC4716903.
      Citations: 4     Fields:    Translation:HumansCells
    97. Gu J, Zhang L, Swisher SG, Liu J, Roth JA, Fang B. Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis. Oncogene. 2004 Feb 12; 23(6):1300-7. PMID: 14676844.
      Citations: 7     Fields:    Translation:HumansCells
    98. Fang B, Roth JA. The role of gene therapy in combined modality treatment strategies for cancer. Curr Opin Mol Ther. 2003 Oct; 5(5):475-82. PMID: 14601515.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    99. Yang G, Thompson JA, Fang B, Liu J. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer. Oncogene. 2003 Aug 28; 22(36):5694-701. PMID: 12944918.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    100. Xu XM, He C, Hu XT, Fang BL. Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29. World J Gastroenterol. 2003 May; 9(5):965-9. PMID: 12717839; PMCID: PMC4611406.
      Citations: 3     Fields:    Translation:HumansCells
    101. Krieg A, Krieg T, Wenzel M, Schmitt M, Ramp U, Fang B, Gabbert HE, Gerharz CD, Mahotka C. TRAIL-beta and TRAIL-gamma: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential. Br J Cancer. 2003 Mar 24; 88(6):918-27. PMID: 12644830; PMCID: PMC2377072.
      Citations: 18     Fields:    Translation:HumansCells
    102. Huang X, Lin T, Gu J, Zhang L, Roth JA, Stephens LC, Yu Y, Liu J, Fang B. Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. Gene Ther. 2002 Oct; 9(20):1379-86. PMID: 12365003.
      Citations: 13     Fields:    Translation:HumansAnimals
    103. Zhang L, Gu J, Lin T, Huang X, Roth JA, Fang B. Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. Gene Ther. 2002 Sep; 9(18):1262-70. PMID: 12215894.
      Citations: 19     Fields:    Translation:HumansCells
    104. Tanyi JL, Lapushin R, Eder A, Auersperg N, Tabassam FH, Roth JA, Gu J, Fang B, Mills GB, Wolf J. Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells. Gynecol Oncol. 2002 Jun; 85(3):451-8. PMID: 12051873.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    105. Nikitina EY, Chada S, Muro-Cacho C, Fang B, Zhang R, Roth JA, Gabrilovich DI. An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53. Gene Ther. 2002 Mar; 9(5):345-52. PMID: 11938454.
      Citations: 11     Fields:    Translation:AnimalsCells
    106. Gu J, Andreeff M, Roth JA, Fang B. hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity. Gene Ther. 2002 Jan; 9(1):30-7. PMID: 11850720.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    107. Li Z, Xia W, Fang B, Yan DH. Targeting HER-2/neu-overexpressing breast cancer cells by an antisense iron responsive element-directed gene expression. Cancer Lett. 2001 Dec 28; 174(2):151-8. PMID: 11689290.
      Citations: 1     Fields:    Translation:HumansCells
    108. Wang GQ, Wieckowski E, Goldstein LA, Gastman BR, Rabinovitz A, Gambotto A, Li S, Fang B, Yin XM, Rabinowich H. Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med. 2001 Nov 05; 194(9):1325-37. PMID: 11696597; PMCID: PMC2195982.
      Citations: 27     Fields:    Translation:HumansCells
    109. Andriani F, Nan B, Yu J, Li X, Weigel NL, McPhaul MJ, Kasper S, Kagawa S, Fang B, Matusik RJ, Denner L, Marcelli M. Use of the probasin promoter ARR2PB to express Bax in androgen receptor-positive prostate cancer cells. J Natl Cancer Inst. 2001 Sep 05; 93(17):1314-24. PMID: 11535706.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    110. Mohiuddin I, Cao X, Fang B, Nishizaki M, Smythe WR. Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma. Cancer Gene Ther. 2001 Aug; 8(8):547-54. PMID: 11571532.
      Citations: 7     Fields:    Translation:HumansCells
    111. Wang GQ, Gastman BR, Wieckowski E, Goldstein LA, Gambotto A, Kim TH, Fang B, Rabinovitz A, Yin XM, Rabinowich H. A role for mitochondrial Bak in apoptotic response to anticancer drugs. J Biol Chem. 2001 Sep 07; 276(36):34307-17. PMID: 11447222.
      Citations: 33     Fields:    Translation:HumansCells
    112. Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA, Fang B. Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res. 2001 May; 7(5):1474-80. PMID: 11350920.
      Citations: 45     Fields:    Translation:HumansCells
    113. Kagawa S, He C, Gu J, Koch P, Rha SJ, Roth JA, Curley SA, Stephens LC, Fang B. Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene. Cancer Res. 2001 Apr 15; 61(8):3330-8. PMID: 11309289.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    114. Koch PE, Guo ZS, Kagawa S, Gu J, Roth JA, Fang B. Augmenting transgene expression from carcinoembryonic antigen (CEA) promoter via a GAL4 gene regulatory system. Mol Ther. 2001 Mar; 3(3):278-83. PMID: 11273768.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    115. Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg. 2001 Jan; 121(1):61-7. PMID: 11135160.
      Citations: 2     Fields:    Translation:HumansCells
    116. Li X, Marani M, Yu J, Nan B, Roth JA, Kagawa S, Fang B, Denner L, Marcelli M. Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer. Cancer Res. 2001 Jan 01; 61(1):186-91. PMID: 11196158.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    117. Gu J, Kagawa S, Takakura M, Kyo S, Inoue M, Roth JA, Fang B. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res. 2000 Oct 01; 60(19):5359-64. PMID: 11034071.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    118. Sueoka N, Lee HY, Wiehle S, Cristiano RJ, Fang B, Ji L, Roth JA, Hong WK, Cohen P, Kurie JM. Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene. 2000 Sep 07; 19(38):4432-6. PMID: 10980619.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    119. Sueoka N, Lee HY, Walsh GL, Fang B, Ji L, Roth JA, LaPushin R, Hong WK, Cohen P, Kurie JM. Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment. Am J Respir Cell Mol Biol. 2000 Sep; 23(3):297-303. PMID: 10970819.
      Citations: 8     Fields:    Translation:HumansCells
    120. Yen N, Ioannides CG, Xu K, Swisher SG, Lawrence DD, Kemp BL, El-Naggar AK, Cristiano RJ, Fang B, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Merritt JA, Mukhopadhyay T, Nesbitt JC, Nguyen D, Perez-Soler R, Pisters KM, Putnam JB, Schrump DS, Shin DM, Walsh GL, Roth JA. Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type. P53 (Ad-p53). Cancer Gene Ther. 2000 Apr; 7(4):530-6. PMID: 10811470.
      Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
    121. Kagawa S, Gu J, Swisher SG, Ji L, Roth JA, Lai D, Stephens LC, Fang B. Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines. Cancer Res. 2000 Mar 01; 60(5):1157-61. PMID: 10728665.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    122. Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG. Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res. 2000 Feb 15; 60(4):788-92. PMID: 10706081.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    123. Kagawa S, Pearson SA, Ji L, Xu K, McDonnell TJ, Swisher SG, Roth JA, Fang B. A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther. 2000 Jan; 7(1):75-9. PMID: 10680019.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    124. Pearson AS, Koch PE, Atkinson N, Xiong M, Finberg RW, Roth JA, Fang B. Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines. Clin Cancer Res. 1999 Dec; 5(12):4208-13. PMID: 10632362.
      Citations: 17     Fields:    Translation:HumansCells
    125. Mohan PM, Chintala SK, Mohanam S, Gladson CL, Kim ES, Gokaslan ZL, Lakka SS, Roth JA, Fang B, Sawaya R, Kyritsis AP, Rao JS. Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Res. 1999 Jul 15; 59(14):3369-73. PMID: 10416596.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    126. Ji L, Fang B, Yen N, Fong K, Minna JD, Roth JA. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res. 1999 Jul 15; 59(14):3333-9. PMID: 10416589.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    127. Ji L, Fang B, Roth JA. A rapid, sensitive, and nonradioactive method for assay of FHIT Ap3A hydrolase activity by fluorescence thin-layer chromatographic image analysis. Anal Biochem. 1999 Jun 15; 271(1):114-6. PMID: 10361018.
      Citations: 1     Fields:    Translation:HumansCells
    128. Chen YQ, Hsieh JT, Yao F, Fang B, Pong RC, Cipriano SC, Krepulat F. Induction of apoptosis and G2/M cell cycle arrest by DCC. Oncogene. 1999 Apr 29; 18(17):2747-54. PMID: 10348349.
      Citations: 23     Fields:    Translation:HumansCells
    129. Ji L, Bouvet M, Price RE, Roth JA, Fang B. Reduced toxicity, attenuated immunogenicity and efficient mediation of human p53 gene expression in vivo by an adenovirus vector with deleted E1-E3 and inactivated E4 by GAL4-TATA promoter replacement. Gene Ther. 1999 Mar; 6(3):393-402. PMID: 10435089.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    130. Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. Ann Surg Oncol. 1998 Dec; 5(8):681-8. PMID: 9869513.
      Citations: 26     Fields:    Translation:HumansCells
    131. Yuan L, Fang B, Wang M, Wang T, Huang S, Yang T, Zhao S. [Comparison of genotype and intellectual phenotype in untreated phenylketonuric children]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Oct 10; 15(5):297-9. PMID: 9758878.
      Citations:    Fields:    Translation:Humans
    132. Fang B, Xu B, Koch P, Roth JA. Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther. 1998 Oct; 5(10):1420-4. PMID: 9930348.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    133. Bouvet M, Ellis LM, Nishizaki M, Fujiwara T, Liu W, Bucana CD, Fang B, Lee JJ, Roth JA. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res. 1998 Jun 01; 58(11):2288-92. PMID: 9622060.
      Citations: 44     Fields:    Translation:HumansCells
    134. Fang B, Ji L, Bouvet M, Roth JA. Evaluation of GAL4/TATA in vivo. Induction of transgene expression by adenovirally mediated gene codelivery. J Biol Chem. 1998 Feb 27; 273(9):4972-5. PMID: 9478943.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    135. Bouvet M, Fang B, Ekmekcioglu S, Ji L, Bucana CD, Hamada K, Grimm EA, Roth JA. Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide. Gene Ther. 1998 Feb; 5(2):189-95. PMID: 9578838.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    136. Fang B, Koch P, Bouvet M, Ji L, Roth JA. A packaging system for SV40 vectors without viral coding sequences. Anal Biochem. 1997 Dec 01; 254(1):139-43. PMID: 9398356.
      Citations:    Fields:    Translation:AnimalsCells
    137. Fang B, Koch P, Roth JA. Diminishing adenovirus gene expression and viral replication by promoter replacement. J Virol. 1997 Jun; 71(6):4798-803. PMID: 9151874; PMCID: PMC191702.
      Citations: 2     Fields:    Translation:HumansCells
    138. Fang B, Wang H, Gordon G, Bellinger DA, Read MS, Brinkhous KM, Woo SL, Eisensmith RC. Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. Gene Ther. 1996 Mar; 3(3):217-22. PMID: 8646552.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    139. Huang S, Miao S, Xu L, Fang B, Liu G, Luo H. [Analysis of the A/C polymorphic site within the phenylalanine hydroxylase gene]. Yi Chuan Xue Bao. 1996; 23(3):169-73. PMID: 8950848.
      Citations:    Fields:    Translation:HumansCells
    140. Yuan L, Gao Y, Lo S, Fang B, Ye J. [Prediction of retinoblastoma: linkage analysis of families with hereditary retinoblastoma by using polymorphic sites within the Rb gene]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Oct; 17(5):338-42. PMID: 8706167.
      Citations:    Fields:    Translation:HumansCells
    141. Fang B, Eisensmith RC, Wang H, Kay MA, Cross RE, Landen CN, Gordon G, Bellinger DA, Read MS, Hu PC, et al. Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression. Hum Gene Ther. 1995 Aug; 6(8):1039-44. PMID: 7578416.
      Citations: 18     Fields:    Translation:AnimalsCells
    142. Li J, Fang B, Eisensmith RC, Li XH, Nasonkin I, Lin-Lee YC, Mims MP, Hughes A, Montgomery CD, Roberts JD, et al. In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene. J Clin Invest. 1995 Feb; 95(2):768-73. PMID: 7860759; PMCID: PMC295550.
      Citations: 12     Fields:    Translation:AnimalsCells
    143. Huang S, Fang B, Chu H. [Analysis of short tandem repeats polymorphism in the phenylalanine hydroxylase gene and its application to prenatal gene diagnosis of phenylketonuria]. Zhonghua Yi Xue Za Zhi. 1995 Jan; 75(1):22-4, 61. PMID: 7600314.
      Citations:    Fields:    Translation:HumansCells
    144. Fang B, Eisensmith RC, Li XH, Finegold MJ, Shedlovsky A, Dove W, Woo SL. Gene therapy for phenylketonuria: phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer. Gene Ther. 1994 Jul; 1(4):247-54. PMID: 7584088.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    145. Kay MA, Landen CN, Rothenberg SR, Taylor LA, Leland F, Wiehle S, Fang B, Bellinger D, Finegold M, Thompson AR, et al. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2353-7. PMID: 8134398; PMCID: PMC43369.
      Citations: 45     Fields:    Translation:AnimalsCells
    146. Fang B, Yuan L, Wang M, Huang S, Wang T, Miao S, Ye J, Sun N, Lo H, Savio LC. Detection of point mutations of the phenylalanine hydroxylase gene and prenatal diagnosis of phenylketonuria. Chin Med Sci J. 1992 Dec; 7(4):205-8. PMID: 1307495.
      Citations: 1     Fields:    Translation:HumansCells
    147. Fang BL. [Tightly linked DNA probe for presymptomatic diagnosis and carrier detection of Wilson disease]. Zhonghua Yi Xue Za Zhi. 1992 Dec; 72(12):746-8, 774. PMID: 1363748.
      Citations:    Fields:    Translation:Humans
    148. Fang B. [Polymorphisms of the D13S26 locus in Chinese and its application to linkage analysis of Wilson disease]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1992 Jun; 14(3):206-9. PMID: 1356645.
      Citations:    Fields:    Translation:Humans
    149. Fang B. [Analysis of RFLP haplotypes and point mutations at the phenylalanine hydroxylase (PAH) locus in PKU families from north China]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1992 Feb; 14(1):46-50. PMID: 1350519.
      Citations:    Fields:    Translation:HumansCells
    150. Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, Bhatia K, Chen LZ, Fang B, Lisker R, Goedde HW, et al. Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet. 1992 Jan; 88(3):344-6. PMID: 1733836.
      Citations: 147     Fields:    Translation:HumansCells
    151. Fritze G, Fang BL, Harada S, Paik YK, Eckey R, Agarwal DP, Goedde HW, Singh S. Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. Hum Genet. 1989 Sep; 83(2):119-21. PMID: 2777251.
      Citations: 16     Fields:    Translation:HumansCells
    152. Ye LZ, Zhang AD, Shi HP, Zhao SM, Luo HY, Yuan LF, Ma SW, Li SH, Cheng ZY, Zhao Y, et al. Analysis of 4628 cases in the genetic counselling clinic of PUMC Hospital. Proc Chin Acad Med Sci Peking Union Med Coll. 1989; 4(3):126-30. PMID: 2594733.
      Citations: 2     Fields:    Translation:Humans
    153. Fang BL, Shi HP, Luo HY. [Diagnosis and classification of mucopolysaccharidoses using the 35S-sulfate incorporation test]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1986 Jun; 8(3):226-9. PMID: 2946466.
      Citations:    Fields:    Translation:HumansCells
    154. Fang BL, Guo YF, Luo HY. [35S sulfate incorporation in cultured normal human skin fibroblasts and normal amniotic fluid cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1986 Jun; 8(3):223-5. PMID: 2946465.
      Citations:    Fields:    Translation:HumansCells
    155. Fang BL, Guo YF, Luo HY. 35S-sulfate incorporation in cultured normal human skin fibroblasts and amniotic fluid cells. Proc Chin Acad Med Sci Peking Union Med Coll. 1986; 1(2):120-2. PMID: 3432235.
      Citations:    Fields:    Translation:HumansCells
    156. Fang BL, Shi HP, Luo HY. Diagnosis and classification of mucopolysaccharidoses using 35S-sulfate incorporation. Proc Chin Acad Med Sci Peking Union Med Coll. 1986; 1(2):116-9. PMID: 3124094.
      Citations: 1     Fields:    Translation:Humans
    157. Shi HP, Zhang GX, Guo YF, Fang BL, Zhang WM, Chen F, Luo HY. [Laboratory diagnosis of lysosomal storage disease (glycoproteinosis Pompe's disease and Gaucher disease)]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1985 Dec; 7(6):475-7. PMID: 2940012.
      Citations:    Fields:    Translation:Humans
    158. Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget. 7:3548-3558.
    159. Harnessing plasma genotyping for precision therapy against lung cancer. Journal of Thoracic Disease. 8:E1387-E1390.
    160. Enhancing TRAIL-induced apoptosis by Bcl-XL siRNA. Cancer Biology and Therapy. 4.
    161. Correction. PLoS One. 9.
    162. Genetic interactions of STAT3 and anticancer drug development. Cancers. 6:494-525.
    163. TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin. Scientific Reports. 6.
    164. RAS signaling and anti-RAS therapy. Acta Biochimica et Biophysica Sinica. 48:27-38.
    165. Predictive biomarkers in precision medicine and drug development against lung cancer. Chinese Journal of Cancer. 34.
    166. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 6:11114-11124.
    167. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 7:38235-38242.
    168. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1033-1034:106-111.
    169. Analysis of the A / C Polymorphic Site within the Phenylalanine Hydroxylase Gene. Acta Genetica Sinica. 23:173.
    170. Methylated APC and RASSF1A in multiple specimens contribute to the differential diagnosis of patients with undetermined solitary pulmonary nodules. Journal of Thoracic Disease. 7:422-432.
    171. Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380. Oncotarget. 6:345-354.
    172. Phenylketonuria. Mental Retardation and Developmental Disabilities Research Reviews. 1:56-61.
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