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UMA RAJU

TitleAssistant Professor
InstitutionMD Anderson
DepartmentRadiation Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Welsh JW, Tang C, de Groot P, Naing A, Hess KR, Heymach JV, Papadimitrakopoulou VA, Cushman TR, Subbiah V, Chang JY, Simon GR, Ramapriyan R, Barsoumian HB, Menon H, Cortez MA, Massarelli E, Nguyen Q, Sharma P, Allison JP, Diab A, Verma V, Raju U, Shaaban SG, Dadu R, Cabanillas ME, Wang K, Anderson C, Gomez DR, Hahn S, Komaki R, Hong DS. Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation-Related Abscopal Responses. Cancer Immunol Res. 2019 12; 7(12):1903-1909. PMID: 31658994; PMCID: PMC6891218.
      Citations: 23     Fields:    Translation:HumansCTClinical Trials
    2. Welsh JW, Heymach JV, Chen D, Verma V, Cushman TR, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, Menon H, Nguyen QN, Chang JY, Altan M, Papadimitrakopoulou VA, Simon GR, Raju U, Byers L, Glisson B. Phase I Trial of Pembrolizumab and Radiation Therapy after Induction Chemotherapy for Extensive-Stage Small Cell Lung Cancer. J Thorac Oncol. 2020 02; 15(2):266-273. PMID: 31605794.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    3. Wang L, Zhang P, Molkentine DP, Chen C, Molkentine JM, Piao H, Raju U, Zhang J, Valdecanas DR, Tailor RC, Thames HD, Buchholz TA, Chen J, Ma L, Mason KA, Ang KK, Meyn RE, Skinner HD. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. 2017 02 09; 36(6):820-828. PMID: 27425591; PMCID: PMC5434711.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    4. Hao C, Shao R, Raju U, Fang B, Swisher SG, Pataer A. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 2016 Jun 21; 7(25):38235-38242. PMID: 27203671; PMCID: PMC5122385.
      Citations: 3     Fields:    Translation:HumansCells
    5. Deorukhkar A, Ahuja N, Mercado AL, Diagaradjane P, Raju U, Patel N, Mohindra P, Diep N, Guha S, Krishnan S. Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. Cancer Med. 2015 Feb; 4(2):278-92. PMID: 25450478; PMCID: PMC4329011.
      Citations: 20     Fields:    Translation:HumansCells
    6. Wang ZQ, Johnson CL, Kumar A, Molkentine DP, Molkentine JM, Rabin T, Mason KA, Milas L, Raju U. Inhibition of P-TEFb by DRB suppresses SIRT1/CK2a pathway and enhances radiosensitivity of human cancer cells. Anticancer Res. 2014 Dec; 34(12):6981-9. PMID: 25503124.
      Citations: 4     Fields:    Translation:HumansCells
    7. Raju U, Molkentine DP, Valdecanas DR, Deorukhkar A, Mason KA, Buchholz TA, Meyn RE, Ang KK, Skinner H. Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and neck cancer models but concurrent inhibition has no added benefit. Cancer Med. 2015 Jan; 4(1):65-74. PMID: 25355701; PMCID: PMC4312119.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Raju U, Buchholz TA, Wang L, Milas ZL, Milas L, Mason KA. Poly (ADP-ribose) polymerase inhibitors in cancer treatment. Am J Clin Oncol. 2014 Feb; 37(1):90-100. PMID: 22495455.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Raju U, Riesterer O, Wang ZQ, Molkentine DP, Molkentine JM, Johnson FM, Glisson B, Milas L, Ang KK. Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways. Radiother Oncol. 2012 Nov; 105(2):241-9. PMID: 23010482.
      Citations: 22     Fields:    Translation:HumansCells
    10. Bhardwaj V, Zhan Y, Cortez MA, Ang KK, Molkentine D, Munshi A, Raju U, Komaki R, Heymach JV, Welsh J. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression. J Thorac Oncol. 2012 Aug; 7(8):1211-7. PMID: 22617250; PMCID: PMC3399033.
      Citations: 20     Fields:    Translation:HumansCells
    11. Matsumoto F, Valdecanas DN, Mason KA, Milas L, Ang KK, Raju U. The impact of timing of EGFR and IGF-1R inhibition for sensitizing head and neck cancer to radiation. Anticancer Res. 2012 Aug; 32(8):3029-35. PMID: 22843870.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Wang L, Raju U, Milas L, Molkentine D, Zhang Z, Yang P, Cohen L, Meng Z, Liao Z. Huachansu, containing cardiac glycosides, enhances radiosensitivity of human lung cancer cells. Anticancer Res. 2011 Jun; 31(6):2141-8. PMID: 21737634.
      Citations: 14     Fields:    Translation:HumansCells
    13. Moeller BJ, Yordy JS, Williams MD, Giri U, Raju U, Molkentine DP, Byers LA, Heymach JV, Story MD, Lee JJ, Sturgis EM, Weber RS, Garden AS, Ang KK, Schwartz DL. DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. Clin Cancer Res. 2011 Apr 01; 17(7):2035-43. PMID: 21349997; PMCID: PMC3092475.
      Citations: 40     Fields:    Translation:HumansCells
    14. Koto M, Cho H, Riesterer O, Giri U, Story MD, Ha CS, Raju U. Human lymphoma cells develop resistance to radiation in the presence of astrocytes in vitro. Anticancer Res. 2011 Jan; 31(1):33-8. PMID: 21273577.
      Citations: 3     Fields:    Translation:HumansCells
    15. Riesterer O, Yang Q, Raju U, Torres M, Molkentine D, Patel N, Valdecanas D, Milas L, Ang KK. Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers. Int J Radiat Oncol Biol Phys. 2011 Mar 15; 79(4):1179-87. PMID: 21129859; PMCID: PMC3046226.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    16. Skvortsova I, Skvortsov S, Raju U, Stasyk T, Riesterer O, Schottdorf EM, Popper BA, Schiestl B, Eichberger P, Debbage P, Neher A, Bonn GK, Huber LA, Milas L, Lukas P. Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse. Radiother Oncol. 2010 Jul; 96(1):108-15. PMID: 20451273.
      Citations: 21     Fields:    Translation:AnimalsCells
    17. Torres MA, Raju U, Molkentine D, Riesterer O, Milas L, Ang KK. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug; 29(4):554-61. PMID: 20119866.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    18. Riesterer O, Matsumoto F, Wang L, Pickett J, Molkentine D, Giri U, Milas L, Raju U. A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. Invest New Drugs. 2011 Jun; 29(3):514-22. PMID: 20024691.
      Citations: 17     Fields:    Translation:HumansCells
    19. Cho H, Koto M, Riesterer O, Molkentine DP, Giri U, Milas L, Story MD, Ha CS, Raju U. Imexon augments sensitivity of human lymphoma cells to ionizing radiation: in vitro experimental study. Anticancer Res. 2009 Nov; 29(11):4409-15. PMID: 20032386.
      Citations: 3     Fields:    Translation:HumansCells
    20. Riesterer O, Mason KA, Raju U, Yang Q, Wang L, Hittelman WN, Ang KK, Milas L. Enhanced response to C225 of A431 tumor xenografts growing in irradiated tumor bed. Radiother Oncol. 2009 Sep; 92(3):383-7. PMID: 19695723.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Skvortsova I, Skvortsov S, Stasyk T, Raju U, Popper BA, Schiestl B, von Guggenberg E, Neher A, Bonn GK, Huber LA, Lukas P. Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells. Proteomics. 2008 Nov; 8(21):4521-33. PMID: 18821526.
      Citations: 50     Fields:    Translation:HumansCells
    22. Mayer C, Ohneseit PA, Raju U, Andratschke NH, Milas L, Rodemann HP, Dittmann KH. Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism. Int J Radiat Oncol Biol Phys. 2008 Jan 01; 70(1):203-12. PMID: 17996386.
      Citations: 36     Fields:    Translation:HumansCells
    23. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res. 2007 Oct 15; 13(20):6032-9. PMID: 17947465.
      Citations: 12     Fields:    Translation:AnimalsCells
    24. Wiedenmann N, Koto M, Raju U, Milas L, Mason KA. Modulation of tumor radiation response with G3139, a bcl-2 antisense oligonucleotide. Invest New Drugs. 2007 Oct; 25(5):411-6. PMID: 17492397.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Raju U, Ariga H, Koto M, Lu X, Pickett J, Valdecanas D, Mason KA, Milas L. Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases. Radiother Oncol. 2006 Aug; 80(2):185-91. PMID: 16905211.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    26. Apisarnthanarax S, Alauddin MM, Mourtada F, Ariga H, Raju U, Mawlawi O, Han D, Bornmann WG, Ajani JA, Milas L, Gelovani JG, Chao KS. Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Clin Cancer Res. 2006 Aug 01; 12(15):4590-7. PMID: 16899606.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    27. Milas L, Raju U, Liao Z, Ajani J. Targeting molecular determinants of tumor chemo-radioresistance. Semin Oncol. 2005 Dec; 32(6 Suppl 9):S78-81. PMID: 16399438.
      Citations: 16     Fields:    Translation:HumansAnimals
    28. Raju U, Ariga H, Dittmann K, Nakata E, Ang KK, Milas L. Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib. Int J Radiat Oncol Biol Phys. 2005 Oct 01; 63(2):520-8. PMID: 16168844.
      Citations: 17     Fields:    Translation:HumansCells
    29. Mayer C, Fehrenbacher B, Schaller M, Raju U, Milas L, Chen DJ, Kehlbach R, Rodemann HP, Dittmann K. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem. 2005 Sep 02; 280(35):31182-9. PMID: 16000298.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    30. Mason KA, Hunter NR, Raju U, Ariga H, Husain A, Valdecanas D, Neal R, Ang KK, Milas L. Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1181-9. PMID: 15234054.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Ismail SM, Puppi M, Prithivirajsingh S, Munshi A, Raju U, Meyn RE, Buchholz TA, Story MD, Brock WA, Milas L, Thames HD, Stevens CW. Predicting radiosensitivity using DNA end-binding complex analysis. Clin Cancer Res. 2004 Feb 15; 10(4):1226-34. PMID: 14977819.
      Citations: 2     Fields:    Translation:HumansCells
    32. Nakata E, Mason KA, Hunter N, Husain A, Raju U, Liao Z, Ang KK, Milas L. Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors. Int J Radiat Oncol Biol Phys. 2004 Feb 01; 58(2):369-75. PMID: 14751505.
      Citations: 29     Fields:    Translation:HumansAnimals
    33. Raju U, Nakata E, Mason KA, Ang KK, Milas L. Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Cancer Res. 2003 Jun 15; 63(12):3263-7. PMID: 12810657.
      Citations: 20     Fields:    Translation:AnimalsCells
    34. Nasu S, Milas L, Kawabe S, Raju U, Newman R. Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process. Cancer Lett. 2002 Nov 28; 185(2):145-51. PMID: 12169388.
      Citations: 13     Fields:    Translation:HumansCells
    35. Raju U, Nakata E, Yang P, Newman RA, Ang KK, Milas L. In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations. Int J Radiat Oncol Biol Phys. 2002 Nov 01; 54(3):886-94. PMID: 12377342.
      Citations: 18     Fields:    Translation:AnimalsCells
    36. Russell JS, Raju U, Gumin GJ, Lang FF, Wilson DR, Huet T, Tofilon PJ. Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. Cancer Res. 2002 Apr 15; 62(8):2318-26. PMID: 11956090.
      Citations: 8     Fields:    Translation:HumansCells
    37. Raju U, Gumin GJ, Tofilon PJ. Radiation-induced transcription factor activation in the rat cerebral cortex. Int J Radiat Biol. 2000 Aug; 76(8):1045-53. PMID: 10947117.
      Citations: 24     Fields:    Translation:AnimalsCells
    38. Noel F, Raju U, Happel E, Marchionni MA, Tofilon PJ. X-irradiation-induced loss of O-2A progenitor cells in rat spinal cord is inhibited by implants of cells engineered to secrete glial growth factor 2. Neuroreport. 1999 Feb 25; 10(3):535-40. PMID: 10208585.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    39. Raju U, Gumin GJ, Tofilon PJ. NF kappa B activity and target gene expression in the rat brain after one and two exposures to ionizing radiation. Radiat Oncol Investig. 1999; 7(3):145-52. PMID: 10406055.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    40. Noel F, Gumin GJ, Raju U, Tofilon PJ. Increased expression of prohormone convertase-2 in the irradiated rat brain. FASEB J. 1998 Dec; 12(15):1725-30. PMID: 9837862.
      Citations: 4     Fields:    Translation:Animals
    41. Raju U, Gumin GJ, Noel F, Tofilon PJ. IkappaBalpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappaB in normal rat astrocytes and human brain tumour cells. Int J Radiat Biol. 1998 Nov; 74(5):617-24. PMID: 9848280.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    42. Singh S, Raju U, Mendoza J, Pantazis P, Aggarwal BB. Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells. Anticancer Drugs. 1998 Sep; 9(8):703-14. PMID: 9823429.
      Citations:    Fields:    Translation:HumansCells
    43. Lang FF, Yung WK, Raju U, Libunao F, Terry NH, Tofilon PJ. Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene. J Neurosurg. 1998 Jul; 89(1):125-32. PMID: 9647183.
      Citations: 17     Fields:    Translation:HumansCells
    44. Raju U, Lu R, Noel F, Gumin GJ, Tofilon PJ. Failure of a second X-ray dose to activate nuclear factor kappaB in normal rat astrocytes. J Biol Chem. 1997 Sep 26; 272(39):24624-30. PMID: 9305931.
      Citations: 4     Fields:    Translation:AnimalsCells
    45. McClain K, Estrov Z, Raju U, Kelley PK, Aggarwal BB. Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes. Methods. 1997 Jan; 11(1):83-7. PMID: 8990093.
      Citations:    Fields:    Translation:HumansCells
    46. Chainy GB, Singh S, Raju U, Aggarwal BB. Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors. J Immunol. 1996 Sep 15; 157(6):2410-7. PMID: 8805640.
      Citations: 2     Fields:    Translation:HumansCells
    47. Koumenis C, Nunez-Regueiro M, Raju U, Cook R, Eskin A. Identification of three proteins in the eye of Aplysia, whose synthesis is altered by serotonin (5-HT). Possible involvement of these proteins in the ocular circadian system. J Biol Chem. 1995 Jun 16; 270(24):14619-27. PMID: 7782325.
      Citations:    Fields:    Translation:HumansAnimalsCells
    48. Noel F, Koumenis C, Nunez-Regueiro M, Raju U, Byrne JH, Eskin A. Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4150-4. PMID: 8183885; PMCID: PMC43742.
      Citations: 1     Fields:    Translation:AnimalsCells
    49. Raju U, Nunez-Regueiro M, Cook R, Kaetzel MA, Yeung SC, Eskin A. Identification of an annexin-like protein and its possible role in the Aplysia eye circadian system. J Neurochem. 1993 Oct; 61(4):1236-45. PMID: 8376982.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Raju U, Koumenis C, Nunez-Regueiro M, Eskin A. Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor. Science. 1991 Aug 09; 253(5020):673-5. PMID: 1871602.
      Citations: 15     Fields:    Translation:AnimalsCells
    51. Raju U, Yeung SJ, Eskin A. Involvement of proteins in light resetting ocular circadian oscillators of Aplysia. Am J Physiol. 1990 Jan; 258(1 Pt 2):R256-62. PMID: 2154135.
      Citations: 5     Fields:    Translation:Animals
    52. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene.
    53. E16 - Integration of molecular targeting with radiotherapy. Strahlentherapie und Onkologie. 183:70-72.
    54. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 7:38235-38242.
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