"Cystine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
| Descriptor ID |
D003553
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| MeSH Number(s) |
D01.248.497.158.874.390.369 D01.875.350.850.150.369 D02.886.030.230.369 D02.886.520.150.087 D12.125.095.369 D12.125.119.369 D12.125.166.230.369
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cystine".
Below are MeSH descriptors whose meaning is more specific than "Cystine".
This graph shows the total number of publications written about "Cystine" by people in this website by year, and whether "Cystine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 2 | 0 | 2 |
| 2022 | 0 | 2 | 2 |
| 2023 | 2 | 1 | 3 |
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Below are the most recent publications written about "Cystine" by people in Profiles.
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Disulfidptosis: disulfide stress-induced cell death. Trends Cell Biol. 2024 Apr; 34(4):327-337.
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The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis. Oncogene. 2023 09; 42(36):2688-2700.
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SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun. 2023 06 21; 14(1):3673.
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Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. Cancer Res. 2022 06 15; 82(12):2254-2268.
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The solute carrier family 7 member 11 (SLC7A11) is regulated by LH/androgen and required for cystine/glutathione homeostasis in mouse Sertoli cells. Mol Cell Endocrinol. 2022 06 01; 549:111641.
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Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS. Signal Transduct Target Ther. 2021 05 28; 6(1):188.
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mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021 03 11; 12(1):1589.
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Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021 08; 12(8):599-620.
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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 04; 22(4):476-486.
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The Staphylococcus aureus Cystine Transporters TcyABC and TcyP Facilitate Nutrient Sulfur Acquisition during Infection. Infect Immun. 2020 02 20; 88(3).