"Asparagine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
| Descriptor ID |
D001216
|
| MeSH Number(s) |
D12.125.068.060 D12.125.095.165 D12.125.154.049
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Asparagine".
Below are MeSH descriptors whose meaning is more specific than "Asparagine".
This graph shows the total number of publications written about "Asparagine" by people in this website by year, and whether "Asparagine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Asparagine" by people in Profiles.
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Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nat Cancer. 2022 11; 3(11):1386-1403.
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Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway. Cell Death Dis. 2021 07 10; 12(7):693.
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The N-linked glycosylations of TIGIT Asn32 and Asn101 facilitate PVR/TIGIT interaction. Biochem Biophys Res Commun. 2021 07 12; 562:9-14.
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Amino acid metabolism in hematologic malignancies and the era of targeted therapy. Blood. 2019 09 26; 134(13):1014-1023.
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Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019 09; 18(9):1587-1592.
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Serum metabolomic profile of incident diabetes. Diabetologia. 2018 05; 61(5):1046-1054.
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Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene. BMC Med Genet. 2017 10 18; 18(1):116.
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Asp263 missense variants perturb the active site of human phosphoglucomutase 1. FEBS J. 2017 03; 284(6):937-947.
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Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase. J Mol Biol. 2015 Aug 28; 427(17):2867-85.
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Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus. Front Cell Infect Microbiol. 2014; 4:105.