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DOS SARBASSOV

TitleAssociate Professor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Begimbetova D, Burska AN, Baltabekova A, Kussainova A, Kukanova A, Fazyl F, Ibragimova M, Manekenova K, Makishev A, Bersimbaev RI, Sarbassov DD. The Vitamin C Enantiomers Possess a Comparable Potency in the Induction of Oxidative Stress in Cancer Cells but Differ in Their Toxicity. Int J Mol Sci. 2024 Feb 22; 25(5). PMID: 38473779; PMCID: PMC10931485.
      Citations:    Fields:    Translation:Animals
    2. Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 05 15; 146(10):2822-2828. PMID: 31472018; PMCID: PMC7365556.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Abetov DA, Kiyan VS, Zhylkibayev AA, Sarbassova DA, Alybayev SD, Spooner E, Song MS, Bersimbaev RI, Sarbassov DD. Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation. J Biol Chem. 2019 07 12; 294(28):10746-10757. PMID: 31076509; PMCID: PMC6635442.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    4. Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS. Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis. Breast Cancer Res. 2017 Jun 30; 19(1):74. PMID: 28666462; PMCID: PMC5493112.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    5. Zeng Z, Liu W, Tsao T, Qiu Y, Zhao Y, Samudio I, Sarbassov DD, Kornblau SM, Baggerly KA, Kantarjian HM, Konopleva M, Andreeff M. High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia. Haematologica. 2017 09; 102(9):1537-1548. PMID: 28659338; PMCID: PMC5685227.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    6. Morrison Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov dos D, Muller WJ, Brantley-Sieders D, Cook RS. Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers. Cancer Res. 2016 08 15; 76(16):4752-64. PMID: 27197158; PMCID: PMC5758362.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    7. Ishizawa J, Kojima K, Chachad D, Ruvolo P, Ruvolo V, Jacamo RO, Borthakur G, Mu H, Zeng Z, Tabe Y, Allen JE, Wang Z, Ma W, Lee HC, Orlowski R, Sarbassov dos D, Lorenzi PL, Huang X, Neelapu SS, McDonnell T, Miranda RN, Wang M, Kantarjian H, Konopleva M, Davis RE, Andreeff M. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Sci Signal. 2016 Feb 16; 9(415):ra17. PMID: 26884599; PMCID: PMC4815038.
      Citations: 86     Fields:    Translation:AnimalsCells
    8. Jin G, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov dos D, Lin HK, Ho YS. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Mol Cell. 2015 Jun 18; 58(6):989-1000. PMID: 26051179; PMCID: PMC4476372.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    9. Kazyken D, Kaz Y, Kiyan V, Zhylkibayev AA, Chen CH, Agarwal NK, Sarbassov dos D. The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget. 2014 Oct 30; 5(20):9577-93. PMID: 25294810; PMCID: PMC4259421.
      Citations: 7     Fields:    Translation:HumansCells
    10. Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res. 2014 Mar 15; 74(6):1682-93. PMID: 24448243; PMCID: PMC4087030.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    11. Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov DD. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism. J Biol Chem. 2013 Sep 20; 288(38):27019-27030. PMID: 23928304; PMCID: PMC3779703.
      Citations: 20     Fields:    Translation:HumansCells
    12. Agarwal NK, Kazyken D, Sarbassov dos D. Rictor encounters RhoGDI2: the second pilot is taking a lead. Small GTPases. 2013 Apr-Jun; 4(2):102-5. PMID: 23354413; PMCID: PMC3747249.
      Citations: 1     Fields:    Translation:HumansAnimals
    13. Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Sci Signal. 2013 Jan 08; 6(257):ra2. PMID: 23300339; PMCID: PMC3748614.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    14. Agarwal NK, Chen CH, Cho H, Boulbès DR, Spooner E, Sarbassov DD, Boulb?s DR. Rictor regulates cell migration by suppressing RhoGDI2. Oncogene. 2013 May 16; 32(20):2521-6. PMID: 22777355; PMCID: PMC3470753.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    15. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012 May 25; 149(5):1098-111. PMID: 22632973; PMCID: PMC3586339.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    16. Sarbassov dos D, Bulgakova O, Bersimbaev RI, Shaiken T. Isolation of the mTOR complexes by affinity purification. Methods Mol Biol. 2012; 821:59-74. PMID: 22125060.
      Citations: 4     Fields:    Translation:HumansCells
    17. Chen CH, Sarbassov dos D. The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2. J Biol Chem. 2011 Nov 18; 286(46):40386-94. PMID: 21965657; PMCID: PMC3220582.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    18. Aimbetov R, Chen CH, Bulgakova O, Abetov D, Bissenbaev AK, Bersimbaev RI, Sarbassov DD. Integrity of mTORC2 is dependent on the rictor Gly-934 site. Oncogene. 2012 Apr 19; 31(16):2115-20. PMID: 21909137; PMCID: PMC3305845.
      Citations: 13     Fields:    Translation:Humans
    19. Shaiken T, Sarbassov dos D, Boulb?s DR. Endoplasmic reticulum is a main localization site of mTORC2. Biochem Biophys Res Commun. 2011 Sep 16; 413(1):46-52. PMID: 21867682; PMCID: PMC3225125.
      Citations: 36     Fields:    Translation:HumansCells
    20. Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW, Wu J, Lin HK, Sarbassov dos D. ER stress inhibits mTORC2 and Akt signaling through GSK-3?-mediated phosphorylation of rictor. Sci Signal. 2011 Feb 22; 4(161):ra10. PMID: 21343617.
      Citations: 74     Fields:    Translation:HumansCells
    21. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65. PMID: 21317535; PMCID: PMC3049400.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    22. Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res. 2010 Jun; 8(6):896-906. PMID: 20501647; PMCID: PMC2896829.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    23. Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 2009 Jul 02; 28(26):2436-45. PMID: 19448664; PMCID: PMC2748248.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    24. Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood. 2007 Apr 15; 109(8):3509-12. PMID: 17179228; PMCID: PMC1852241.
      Citations: 155     Fields:    Translation:HumansCells
    25. Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006 Apr 21; 22(2):159-68. PMID: 16603397.
      Citations: 1273     Fields:    Translation:HumansAnimalsCells
    26. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol. 2005 Dec; 17(6):596-603. PMID: 16226444.
      Citations: 675     Fields:    Translation:HumansAnimalsCells
    27. Sarbassov DD, Sabatini DM. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem. 2005 Nov 25; 280(47):39505-9. PMID: 16183647.
      Citations: 118     Fields:    Translation:HumansCells
    28. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18; 307(5712):1098-101. PMID: 15718470.
      Citations: 2975     Fields:    Translation:HumansAnimalsCells
    29. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004 Jul 27; 14(14):1296-302. PMID: 15268862.
      Citations: 1200     Fields:    Translation:HumansAnimalsCells
    30. Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell. 2003 Apr; 11(4):895-904. PMID: 12718876.
      Citations: 417     Fields:    Translation:HumansCells
    31. Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002 Jul 26; 110(2):163-75. PMID: 12150925.
      Citations: 1396     Fields:    Translation:HumansCells
    32. Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS. FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13796-801. PMID: 11707573; PMCID: PMC61121.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    33. Sarbassov DD, Peterson CA. Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiation. Mol Endocrinol. 1998 Dec; 12(12):1870-8. PMID: 9849961.
      Citations: 17     Fields:    Translation:AnimalsCells
    34. Sarbassov DD, Jones LG, Peterson CA. Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts. Mol Endocrinol. 1997 Dec; 11(13):2038-47. PMID: 9415407.
      Citations: 22     Fields:    Translation:AnimalsCells
    35. Sarbassov DD, Stefanova R, Grigoriev VG, Peterson CA. Role of insulin-like growth factors and myogenin in the altered program of proliferation and differentiation in the NFB4 mutant muscle cell line. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10874-8. PMID: 7479901; PMCID: PMC40533.
      Citations: 4     Fields:    Translation:AnimalsCells
    36. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Molecular Cell.
    37. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Science Signaling. 9.
    38. Rictor encounters RhoGDI2. Small GTPases. 4.
    39. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. 19:38-51.
    40. Erratum. Cell. 151:913-914.
    41. Rictor/mTORC2 drives progression and therapeutic resistance of HER2-amplified breast cancers. Cancer Research. 76:4752-4764.
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