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MINGJIAN JAMES YOU

TitleAssociate Professor
InstitutionMD Anderson
DepartmentHematopathology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B, Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495. PMID: 38552003; PMCID: PMC11296921.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Tian C, Li Y, Si J, Kang J, Chen Z, Nuermaimaiti R, Wang Y, Yu Y, Zhao Z, Wang X, Zhang Y, Zhao H, Yang H, You MJ, Zheng G, Wang L. Knockdown of let-7b in leukemia associated macrophages inhibit acute myeloid leukemia progression. Hematol Oncol. 2023 Aug; 41(3):510-519. PMID: 36579468.
      Citations:    Fields:    Translation:HumansCells
    3. Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun. 2018 09 27; 9(1):3953. PMID: 30262850; PMCID: PMC6160420.
      Citations: 16     Fields:    Translation:HumansAnimals
    4. Dong B, Gao Y, Kang X, Gao H, Zhang J, Guo H, You MJ, Xue W, Cheng J, Huang Y. SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Oncotarget. 2016 Dec 06; 7(49):80435-80449. PMID: 27741516; PMCID: PMC5348332.
      Citations: 10     Fields:    Translation:HumansCells
    5. Tian C, Zheng G, Zhuang H, Li X, Hu D, Zhu L, Wang T, You MJ, Zhang Y. MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells. J Cell Physiol. 2017 Jun; 232(6):1387-1395. PMID: 27696394.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    6. You MJ, Medeiros LJ, Hsi ED. T-lymphoblastic leukemia/lymphoma. Am J Clin Pathol. 2015 Sep; 144(3):411-22. PMID: 26276771.
      Citations: 25     Fields:    Translation:HumansAnimals
    7. Kang X, Lu Z, Cui C, Deng M, Fan Y, Dong B, Han X, Xie F, Coligan JE, Collins RH, Xiao X, You MJ, Zhang CC, Tyner JW. The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development. Nat Cell Biol. 2015 May; 17(5):665-77. PMID: 25915125; PMCID: PMC4417000.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    8. Blonska M, Zhu Y, Chuang HH, You MJ, Kunkalla K, Vega F, Lin X. Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment. Blood. 2015 Feb 05; 125(6):981-91. PMID: 25533033; PMCID: PMC4319238.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    9. Zhang Y, Xiong S, Li Q, Hu S, Tashakori M, Van Pelt C, You MJ, Pageon L, Lozano G. Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol. 2014 Aug; 233(4):380-91. PMID: 24789767; PMCID: PMC4151977.
      Citations: 23     Fields:    Translation:Animals
    10. Warner K, Crispatzu G, Al-Ghaili N, Weit N, Florou V, You MJ, Newrzela S, Herling M. Models for mature T-cell lymphomas--a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts. Crit Rev Oncol Hematol. 2013 Dec; 88(3):680-95. PMID: 23972664.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    11. Yost AJ, Shevchuk OO, Gooch R, Gusscott S, You MJ, Ince TA, Aster JC, Weng AP. Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts. Leukemia. 2013 Jun; 27(6):1437-40. PMID: 23246990; PMCID: PMC4704859.
      Citations: 9     Fields:    Translation:Humans
    12. Patel KP, Khokhar FA, Muzzafar T, James You M, Bueso-Ramos CE, Ravandi F, Pierce S, Medeiros LJ. TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation. Mod Pathol. 2013 Feb; 26(2):195-203. PMID: 22936064; PMCID: PMC5485410.
      Citations: 6     Fields:    Translation:Humans
    13. Yeung SC, Elsayem A, Fuller GN, Lu G, You MJ. Fatal acute monocytic leukaemia with t(6;11) (q27;q23) translocation and KRAS mutation. J Clin Pathol. 2013 Jan; 66(1):73-5. PMID: 22923764.
      Citations:    Fields:    Translation:HumansCells
    14. Qiu X, Sun X, He Z, Huang J, Hu F, Chen L, Lin P, You MJ, Medeiros LJ, Yin CC. Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia. Leukemia. 2013 Jan; 27(1):92-9. PMID: 22772058.
      Citations: 21     Fields:    Translation:HumansCells
    15. Lu G, Zhang XX, You MJ, Chen W. Correlation of assessment of plasma cells by flow cytometry and detection of cytogenomic abnormalities by fluorescence in situ hybridization in plasma cell neoplasms. Int J Lab Hematol. 2011 Oct; 33(5):545-50. PMID: 21470373.
      Citations: 1     Fields:    Translation:Humans
    16. Chen H, You MJ, Jiang Y, Wang W, Li L. RMI1 attenuates tumor development and is essential for early embryonic survival. Mol Carcinog. 2011 Feb; 50(2):80-8. PMID: 21229605; PMCID: PMC3079784.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood. 2010 Feb 11; 115(6):1175-84. PMID: 20008304; PMCID: PMC2826229.
      Citations: 39     Fields:    Translation:AnimalsCells
    18. Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 2009 May; 41(5):544-52. PMID: 19282848; PMCID: PMC2705918.
      Citations: 542     Fields:    Translation:AnimalsCells
    19. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA. Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol. 2008; 73:427-37. PMID: 19150964.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    20. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Oct 23; 455(7216):1129-33. PMID: 18948956; PMCID: PMC4051433.
      Citations: 368     Fields:    Translation:HumansAnimalsCells
    21. He H, Wang Y, Guo X, Ramchandani S, Ma J, Shen MF, Garcia DA, Deng Y, Multani AS, You MJ, Chang S. Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol. 2009 Jan; 29(1):229-40. PMID: 18936156; PMCID: PMC2612488.
      Citations: 55     Fields:    Translation:AnimalsCells
    22. Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A, de la Iglesia N. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15; 22(4):449-62. PMID: 18258752; PMCID: PMC2238667.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    23. Tong S, Liss AS, You M, Bose HR. The activation of TC10, a Rho small GTPase, contributes to v-Rel-mediated transformation. Oncogene. 2007 Apr 05; 26(16):2318-29. PMID: 17016434.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    24. Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 2006 May; 9(5):379-90. PMID: 16697958.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    25. Majid SM, Liss AS, You M, Bose HR. The suppression of SH3BGRL is important for v-Rel-mediated transformation. Oncogene. 2006 Feb 02; 25(5):756-68. PMID: 16186799.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    26. Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9625-30. PMID: 15983384; PMCID: PMC1160520.
      Citations: 168     Fields:    Translation:HumansCells
    27. Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA. Common and contrasting genomic profiles among the major human lung cancer subtypes. Cold Spring Harb Symp Quant Biol. 2005; 70:11-24. PMID: 16869734.
      Citations: 10     Fields:    Translation:HumansCells
    28. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002 Apr; 1(3):269-77. PMID: 12086863.
      Citations: 283     Fields:    Translation:HumansAnimalsCells
    29. You MJ, Castrillon DH, Bastian BC, Bosenberg MW, Parsons R, Chin L, DePinho RA, O'Hagan RC. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1455-60. PMID: 11818530; PMCID: PMC122212.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    30. Ku PT, You M, Bose HR. Role and regulation of Rel/NF-kappaB activity in anti-immunoglobulin-induced apoptosis in WEHI-231 B lymphoma cells. Cell Signal. 2000 Apr; 12(4):245-53. PMID: 10781932.
      Citations:    Fields:    Translation:HumansCells
    31. You M, Bose HR. Identification of v-Rel oncogene-induced inhibitor of apoptosis by differential display. Methods. 1998 Dec; 16(4):373-85. PMID: 10049645.
      Citations: 1     Fields:    Translation:AnimalsCells
    32. You M, Ku PT, Bose HR, Hrdlickov? R. ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein. Mol Cell Biol. 1997 Dec; 17(12):7328-41. PMID: 9372964; PMCID: PMC232589.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    33. Ablation of miR-10b suppresses oncogene-induced mammary tumorigenesis and metastasis and reactivates tumor-suppressive pathways. Cancer Research. 76:6424-6435.
    34. MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression. Oncogene.
    35. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 7:19134-19146.
    36. Decreased TSPAN1 promotes prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy. Oncotarget. 7:63294-63305.
    37. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans (DOI. Cancer Cell. 10:171.
    38. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. Journal of Pathology.
    39. SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Oncotarget. 7:80435-80449.
    40. Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene.
    41. MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells. Journal of Cellular Physiology.
    42. p53 activity dominates that of p73 upon Mdm4 loss in development and tumorigenesis. Molecular Cancer Research. 14:56-65.
    43. Human Pathology. 60:160-166.
    44. Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo. Leukemia.
    45. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. 19:38-51.
    46. MicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1. Tumor Biology. 1-11.
    47. Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia.
    48. High Expression of Human Homologue of Murine Double Minute 4 and the Short Splicing Variant, HDM4-S, in Bone Marrow in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome. Clinical Lymphoma, Myeloma and Leukemia.
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