Microsatellite Instability
"Microsatellite Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.
| Descriptor ID |
D053842
|
| MeSH Number(s) |
C23.550.362.590 G05.365.590.335.590 G05.370.590
|
| Concept/Terms |
Replication Error Phenotype- Replication Error Phenotype
- Error Phenotype, Replication
- Error Phenotypes, Replication
- Phenotype, Replication Error
- Phenotypes, Replication Error
- Replication Error Phenotypes
|
Below are MeSH descriptors whose meaning is more general than "Microsatellite Instability".
Below are MeSH descriptors whose meaning is more specific than "Microsatellite Instability".
This graph shows the total number of publications written about "Microsatellite Instability" by people in this website by year, and whether "Microsatellite Instability" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 3 | 3 |
| 2008 | 1 | 2 | 3 |
| 2009 | 4 | 4 | 8 |
| 2010 | 4 | 2 | 6 |
| 2011 | 6 | 1 | 7 |
| 2012 | 2 | 2 | 4 |
| 2013 | 3 | 6 | 9 |
| 2014 | 2 | 7 | 9 |
| 2015 | 1 | 4 | 5 |
| 2016 | 1 | 6 | 7 |
| 2017 | 4 | 6 | 10 |
| 2018 | 3 | 11 | 14 |
| 2019 | 7 | 7 | 14 |
| 2020 | 2 | 9 | 11 |
| 2021 | 6 | 9 | 15 |
| 2022 | 3 | 14 | 17 |
| 2023 | 2 | 12 | 14 |
| 2024 | 4 | 10 | 14 |
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Below are the most recent publications written about "Microsatellite Instability" by people in Profiles.
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Duration of immunotherapy in dMMR/MSI-H metastatic colorectal cancer patients. Eur J Cancer. 2024 Nov; 212:114336.
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Clinical Updates and Surveillance Recommendations for DNA Replication Repair Deficiency Syndromes in Children and Young Adults. Clin Cancer Res. 2024 Aug 15; 30(16):3378-3387.
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Three biomarkers (HER2, PD-L1, and microsatellite status) in a large cohort of metastatic gastroesophageal adenocarcinomas: The MD Anderson Cancer Center experience. Int J Cancer. 2024 Dec 15; 155(12):2277-2286.
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Advances and prospects of biomarkers for immune checkpoint inhibitors. Cell Rep Med. 2024 Jul 16; 5(7):101621.
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Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial. Nat Med. 2024 Sep; 30(9):2558-2567.
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Nivolumab plus relatlimab in patients with previously treated microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: the phase II CheckMate 142 study. J Immunother Cancer. 2024 May 31; 12(5).
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Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer. Ann Oncol. 2024 Jul; 35(7):643-655.
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Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab in Patients With Advanced or Metastatic Microsatellite Stable Colorectal Cancer. Clin Colorectal Cancer. 2024 Sep; 23(3):285-294.
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Pembrolizumab Plus Binimetinib With or Without Chemotherapy for MSS/pMMR Metastatic Colorectal Cancer: Outcomes From KEYNOTE-651 Cohorts A, C, and E. Clin Colorectal Cancer. 2024 Jun; 23(2):183-193.
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Pembrolizumab Plus mFOLFOX7 or FOLFIRI for Microsatellite Stable/Mismatch Repair-Proficient Metastatic Colorectal Cancer: KEYNOTE-651 Cohorts B and D. Clin Colorectal Cancer. 2024 Jun; 23(2):118-127.e6.