Microsatellite Instability
"Microsatellite Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.
| Descriptor ID |
D053842
|
| MeSH Number(s) |
C23.550.362.590 G05.365.590.335.590 G05.370.590
|
| Concept/Terms |
Replication Error Phenotype- Replication Error Phenotype
- Error Phenotype, Replication
- Error Phenotypes, Replication
- Phenotype, Replication Error
- Phenotypes, Replication Error
- Replication Error Phenotypes
|
Below are MeSH descriptors whose meaning is more general than "Microsatellite Instability".
Below are MeSH descriptors whose meaning is more specific than "Microsatellite Instability".
This graph shows the total number of publications written about "Microsatellite Instability" by people in this website by year, and whether "Microsatellite Instability" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 5 | 5 |
| 2019 | 1 | 4 | 5 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2024 | 2 | 3 | 5 |
| 2025 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Microsatellite Instability" by people in Profiles.
-
Next-Generation Sequencing-Based MSI Scoring Predicts Benefit in Mismatch Repair-Deficient Tumors Treated with Nivolumab: Follow-up on NCI-MATCH Arm Z1D. Clin Cancer Res. 2025 Feb 17; 31(4):667-677.
-
Mutational and co-mutational landscape of early onset colorectal cancer. Biomarkers. 2025 Feb; 30(1):64-76.
-
Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors. J Immunother Cancer. 2025 Jan 04; 13(1).
-
Microsatellite instability and high tumor mutational burden detected by next generation sequencing are concordant with loss of mismatch repair proteins by immunohistochemistry. Cancer Genet. 2025 Jan; 290-291:44-50.
-
Pembrolizumab versus chemotherapy in microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer: 5-year follow-up from the randomized phase III KEYNOTE-177 study. Ann Oncol. 2025 Mar; 36(3):277-284.
-
Duration of immunotherapy in dMMR/MSI-H metastatic colorectal cancer patients. Eur J Cancer. 2024 Nov; 212:114336.
-
Clinical Updates and Surveillance Recommendations for DNA Replication Repair Deficiency Syndromes in Children and Young Adults. Clin Cancer Res. 2024 Aug 15; 30(16):3378-3387.
-
Association of Tumor Mutational Burden and Microsatellite Instability With Response and Outcomes in Patients With Urothelial Carcinoma Treated With Immune Checkpoint Inhibitor. Clin Genitourin Cancer. 2024 Dec; 22(6):102198.
-
Three biomarkers (HER2, PD-L1, and microsatellite status) in a large cohort of metastatic gastroesophageal adenocarcinomas: The MD Anderson Cancer Center experience. Int J Cancer. 2024 Dec 15; 155(12):2277-2286.
-
Advances and prospects of biomarkers for immune checkpoint inhibitors. Cell Rep Med. 2024 Jul 16; 5(7):101621.