"Phosphonoacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
| Descriptor ID |
D010746
|
| MeSH Number(s) |
D02.241.081.018.677 D02.705.429.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phosphonoacetic Acid".
Below are MeSH descriptors whose meaning is more specific than "Phosphonoacetic Acid".
This graph shows the total number of publications written about "Phosphonoacetic Acid" by people in this website by year, and whether "Phosphonoacetic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphonoacetic Acid" by people in Profiles.
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Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug; 47(2):782-90.
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Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Aug 16; 488(7411):337-42.
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Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. Oncogene. 2002 Oct 17; 21(47):7230-4.
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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 1992 Sep 18; 70(6):937-48.
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Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24.
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Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis. Cancer Chemother Pharmacol. 1987; 19(3):226-32.
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A comparative study of PALA, PALA plus 5-FU, and 5-FU in advanced breast cancer. Cancer. 1985 Sep 15; 56(6):1320-4.
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Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate. Biochem Pharmacol. 1982 Oct 15; 31(20):3317-21.
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Chemotherapy for colorectal cancer with a combination of PALA and 5-FU. Cancer Treat Rep. 1981 Sep-Oct; 65(9-10):747-53.
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Phase I clinical study of N-(phosphonacetyl)-L-aspartic acid (PALA). Cancer Treat Rep. 1980 Feb-Mar; 64(2-3):285-92.