"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
|
| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2005 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Picrotoxin" by people in Profiles.
-
Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor. Sci Rep. 2020 08 19; 10(1):13999.
-
Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron. 2019 01 16; 101(2):246-259.e6.
-
A diversity of synaptic filters are created by temporal summation of excitation and inhibition. J Neurosci. 2011 Oct 12; 31(41):14721-34.
-
Activation of the infralimbic cortex in a fear context enhances extinction learning. Learn Mem. 2010 Nov; 17(11):591-9.
-
Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat. Stress. 2009 Sep; 12(5):445-50.
-
Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience. 2009 Feb 18; 158(4):1616-24.
-
Time-dependent activation of feed-forward inhibition in a looming-sensitive neuron. J Neurophysiol. 2005 Sep; 94(3):2150-61.
-
Picrotoxin-mediated antagonism of alpha3beta4 and alpha7 acetylcholine receptors. Neuroreport. 2004 Aug 26; 15(12):1969-73.
-
Multiplicative computation in a visual neuron sensitive to looming. Nature. 2002 Nov 21; 420(6913):320-4.
-
Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses. Nature. 2002 Mar 21; 416(6878):330-3.