"Hydrolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of cleaving a chemical compound by the addition of a molecule of water.
| Descriptor ID |
D006868
|
| MeSH Number(s) |
G02.380
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hydrolysis".
Below are MeSH descriptors whose meaning is more specific than "Hydrolysis".
This graph shows the total number of publications written about "Hydrolysis" by people in this website by year, and whether "Hydrolysis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 7 | 7 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 7 | 7 |
| 2004 | 0 | 6 | 6 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 5 | 5 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 5 | 5 |
| 2009 | 0 | 8 | 8 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 6 | 6 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 3 | 3 |
| 2016 | 0 | 6 | 6 |
| 2017 | 0 | 3 | 3 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 3 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 3 | 3 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hydrolysis" by people in Profiles.
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The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrob Agents Chemother. 2024 03 06; 68(3):e0110823.
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Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair. J Am Chem Soc. 2022 12 28; 144(51):23543-23550.
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An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M ?-lactamase drug-resistance enzymes. Nat Commun. 2022 11 07; 13(1):6726.
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Evaluation of Tebipenem Hydrolysis by ?-Lactamases Prevalent in Complicated Urinary Tract Infections. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0239621.
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Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives. J Biol Chem. 2022 03; 298(3):101719.
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Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife. 2021 07 19; 10.
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Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ?-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799.
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Mechanistic Basis of OXA-48-like ?-Lactamases' Hydrolysis of Carbapenems. ACS Infect Dis. 2021 02 12; 7(2):445-460.
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Ougan juice debittering using ultrasound-aided enzymatic hydrolysis: Impacts on aroma and taste. Food Chem. 2021 May 30; 345:128767.
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Mechanism of Catalysis by l-Asparaginase. Biochemistry. 2020 05 26; 59(20):1927-1945.