"Cyclosporins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
| Descriptor ID |
D003524
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| MeSH Number(s) |
D04.345.566.235 D12.644.641.235
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cyclosporins".
Below are MeSH descriptors whose meaning is more specific than "Cyclosporins".
This graph shows the total number of publications written about "Cyclosporins" by people in this website by year, and whether "Cyclosporins" was a major or minor topic of these publications.
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Below are the most recent publications written about "Cyclosporins" by people in Profiles.
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Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype. Leuk Res. 2003 May; 27(5):413-23.
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Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells. Cancer. 1999 Jul 15; 86(2):300-11.
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Treatment of refractory and relapsed acute myelogenous leukemia with combination chemotherapy plus the multidrug resistance modulator PSC 833 (Valspodar). Blood. 1999 Feb 01; 93(3):787-95.
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Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide, and cytarabine (PSC-MEC). Adv Exp Med Biol. 1999; 457:47-56.
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Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia. J Clin Oncol. 1997 May; 15(5):1796-802.
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Dynamics of soluble interleukin-2 receptor levels immediately after heart transplantation. Attenuation of increase by OKT3 therapy. Transplantation. 1991 Jul; 52(1):78-82.
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Role of the clinical laboratory in transplantation. Perspect Pediatr Pathol. 1991; 14:41-59.
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Evaluation of amphotericin B-cyclosporine interaction in the rat. Transplantation. 1990 Sep; 50(3):506-10.
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Cellular and molecular mechanisms of cyclosporin nephrotoxicity. J Am Soc Nephrol. 1990 Aug; 1(2):162-79.
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Methylprednisolone, cyclosporine and methotrexate for prophylaxis of acute graft-versus-host disease. Bone Marrow Transplant. 1990 Apr; 5(4):269-72.