Protein Tyrosine Phosphatase, Non-Receptor Type 2
"Protein Tyrosine Phosphatase, Non-Receptor Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative splicing of the mRNA for this phosphatase results in the production at two gene products, one of which includes a C-terminal nuclear localization domain that may be involved in the transport of the protein to the CELL NUCLEUS. Although initially referred to as T-cell protein tyrosine phosphatase the expression of this subtype occurs widely.
Descriptor ID |
D054578
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MeSH Number(s) |
D08.811.277.352.650.775.300.200 D12.644.360.585.200 D12.776.476.564.200
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 2".
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This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 2" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2017 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 2" by people in Profiles.
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Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. 2020 07; 583(7814):90-95.
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Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. Sci Rep. 2017 04 11; 7(1):825.
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Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 Dec; 123(12):5082-97.
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Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet. 2010 Jun; 42(6):530-5.