Protein Tyrosine Phosphatase, Non-Receptor Type 22
"Protein Tyrosine Phosphatase, Non-Receptor Type 22" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
| Descriptor ID |
D054596
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| MeSH Number(s) |
D08.811.277.352.650.775.300.930 D12.644.360.585.930 D12.776.476.564.930
|
| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 22- Protein Tyrosine Phosphatase, Non-Receptor Type 22
- Protein Tyrosine Phosphatase, Non Receptor Type 22
- PTPase Lyp
- Lymphoid Phosphatase
- Tyrosine Protein Phosphatase, Non-Receptor Type 22
- Tyrosine Protein Phosphatase, Non Receptor Type 22
- PTPN-22 Protein
- PTPN 22 Protein
- Protein-Tyrosine Phosphatase Lyp
- Protein Tyrosine Phosphatase Lyp
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 22".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 22".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 22" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 22" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 22" by people in Profiles.
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Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol. 2017 05; 69(5):1054-1066.
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Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups. Ann Rheum Dis. 2016 Aug; 75(8):1558-66.
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Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol. 2015 Jun; 11(6):329-41.
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Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2013 Feb; 19(2):240-6.
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TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med. 2007 Sep 20; 357(12):1199-209.
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Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. Arthritis Rheum. 2006 Dec; 54(12):3820-7.
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PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet. 2005 Oct; 77(4):567-81.
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Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations. Arthritis Rheum. 2005 Jul; 52(7):1993-8.