"CD4 Immunoadhesins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.
| Descriptor ID |
D016860
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| MeSH Number(s) |
D12.644.541.500.697.249 D12.776.124.486.485.538.500.249 D12.776.124.486.485.680.697.249 D12.776.124.790.651.538.500.249 D12.776.124.790.651.680.660.249 D12.776.377.715.548.538.500.249 D12.776.377.715.548.680.660.249 D12.776.395.550.200.230 D12.776.543.550.200.230 D12.776.828.300.200 D23.050.301.350.230
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "CD4 Immunoadhesins".
Below are MeSH descriptors whose meaning is more specific than "CD4 Immunoadhesins".
This graph shows the total number of publications written about "CD4 Immunoadhesins" by people in this website by year, and whether "CD4 Immunoadhesins" was a major or minor topic of these publications.
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Below are the most recent publications written about "CD4 Immunoadhesins" by people in Profiles.
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Nonlinear pharmacokinetics of high-dose recombinant fusion protein CD4-IgG2 (PRO 542) observed in HIV-1-infected children. J Allergy Clin Immunol. 2007 Mar; 119(3):747-50.
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Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy. J Allergy Clin Immunol. 2006 Dec; 118(6):1369-74.
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Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140). J Allergy Clin Immunol. 2006 Aug; 118(2):518-21.
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Transport of recombinant human CD4-immunoglobulin G across the human placenta: pharmacokinetics and safety in six mother-infant pairs in AIDS clinical trial group protocol 146. Clin Diagn Lab Immunol. 1995 May; 2(3):281-5.