"CD146 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell adhesion molecule of the immunoglobulin superfamily that is expressed by ENDOTHELIAL CELLS where it functions to stabilize INTERCELLULAR JUNCTIONS. It is also highly expressed by melanoma tumor cells and may facilitate their METASTASIS.
| Descriptor ID |
D051929
|
| MeSH Number(s) |
D12.776.395.550.200.170 D12.776.543.550.200.140 D12.776.624.301.249 D23.050.285.439.249 D23.050.301.350.150
|
| Concept/Terms |
CD146 Antigen- CD146 Antigen
- Antigen, CD146
- S-Endo 1 Endothelial-Associated Antigen
- Melanoma Cell Adhesion Molecule
- CD146 Antigens
- Antigens, CD146
- Gicerin
- Glycoprotein MUC18
- MUC18, Glycoprotein
|
Below are MeSH descriptors whose meaning is more general than "CD146 Antigen".
Below are MeSH descriptors whose meaning is more specific than "CD146 Antigen".
This graph shows the total number of publications written about "CD146 Antigen" by people in this website by year, and whether "CD146 Antigen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "CD146 Antigen" by people in Profiles.
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Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition. JCI Insight. 2021 08 09; 6(15).
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Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res. 2011 May 15; 71(10):3494-504.
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Transforming growth factor-beta increases the expression of vascular smooth muscle cell markers in human multi-lineage progenitor cells. Med Sci Monit. 2011 Feb 25; 17(3):BR55-61.
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CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma. PLoS One. 2010 Aug 27; 5(8):e12452.
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Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem. 2009 Oct 16; 284(42):28845-55.
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A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction: evidence from mice and humans. Cancer Res. 2008 Oct 15; 68(20):8419-28.
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Tumor immunotherapy in melanoma: strategies for overcoming mechanisms of resistance and escape. Am J Clin Dermatol. 2008; 9(5):307-11.
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A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Hum Pathol. 2007 Jul; 38(7):1003-1013.
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Immunization against MUC18/MCAM, a novel antigen that drives melanoma invasion and metastasis. Gene Ther. 2007 Feb; 14(4):316-23.
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Bioimmunotherapy for melanoma using fully human antibodies targeting MCAM/MUC18 and IL-8. Pigment Cell Res. 2006 Oct; 19(5):395-405.