Somatic Hypermutation, Immunoglobulin
"Somatic Hypermutation, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.
| Descriptor ID |
D027041
|
| MeSH Number(s) |
G05.558.810 G12.500.780
|
| Concept/Terms |
Somatic Hypermutation, Immunoglobulin- Somatic Hypermutation, Immunoglobulin
- Hypermutation, Immunoglobulin Somatic
- Hypermutations, Immunoglobulin Somatic
- Immunoglobulin Somatic Hypermutations
- Somatic Hypermutations, Immunoglobulin
- Ig Somatic Hypermutation
- Immunoglobulin Somatic Hypermutation
- Hypermutation, Somatic, Immunoglobulin
- Somatic Hypermutation, Ig
- Hypermutation, Ig Somatic
- Hypermutations, Ig Somatic
- Ig Somatic Hypermutations
- Somatic Hypermutations, Ig
|
Below are MeSH descriptors whose meaning is more general than "Somatic Hypermutation, Immunoglobulin".
Below are MeSH descriptors whose meaning is more specific than "Somatic Hypermutation, Immunoglobulin".
This graph shows the total number of publications written about "Somatic Hypermutation, Immunoglobulin" by people in this website by year, and whether "Somatic Hypermutation, Immunoglobulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 2 | 4 |
| 2006 | 3 | 0 | 3 |
| 2007 | 2 | 4 | 6 |
| 2008 | 1 | 3 | 4 |
| 2009 | 1 | 3 | 4 |
| 2010 | 0 | 2 | 2 |
| 2012 | 4 | 0 | 4 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Somatic Hypermutation, Immunoglobulin" by people in Profiles.
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Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Nature. 2021 07; 595(7866):278-282.
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Defining HPV-specific B cell responses in patients with head and neck cancer. Nature. 2021 09; 597(7875):274-278.
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Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID. J Clin Invest. 2020 08 03; 130(8):4411-4422.
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Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies. J Immunother Cancer. 2019 10 22; 7(1):272.
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Tissue-specific expressed antibody variable gene repertoires. PLoS One. 2014; 9(6):e100839.
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Rearrangement and expression of the immunoglobulin ?-chain gene in human myeloid cells. Cell Mol Immunol. 2014 Jan; 11(1):94-104.
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Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia. Leukemia. 2013 Jan; 27(1):92-9.
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Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity. Genes Immun. 2012 Oct; 13(7):523-9.
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Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes. PLoS One. 2012; 7(5):e36750.
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Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res. 2012; 113:167-90.