"Antibody Diversity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
| Descriptor ID |
D000916
|
| MeSH Number(s) |
G05.365.036 G12.500.199
|
| Concept/Terms |
Antibody Diversity- Antibody Diversity
- Antibody Diversities
- Diversities, Antibody
- Diversity, Antibody
Germ Line Theory- Germ Line Theory
- Germ Line Theories
- Theories, Germ Line
- Theory, Germ Line
|
Below are MeSH descriptors whose meaning is more general than "Antibody Diversity".
Below are MeSH descriptors whose meaning is more specific than "Antibody Diversity".
This graph shows the total number of publications written about "Antibody Diversity" by people in this website by year, and whether "Antibody Diversity" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2012 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Antibody Diversity" by people in Profiles.
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Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires. MAbs. 2020 Jan-Dec; 12(1):1758291.
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Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science. 2019 11 01; 366(6465):599-606.
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Influenza Virus-Specific Human Antibody Repertoire Studies. J Immunol. 2019 01 15; 202(2):368-373.
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Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth. PLoS One. 2018; 13(12):e0209437.
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High-throughput antibody sequencing reveals genetic evidence of global regulation of the na?ve and memory repertoires that extends across individuals. Genes Immun. 2012 Sep; 13(6):469-73.
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Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res. 2012; 113:167-90.
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Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22; 31(4):474-484.
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The B12/23 restriction is critically dependent on recombination signal nonamer and spacer sequences. J Immunol. 2003 Dec 15; 171(12):6604-10.
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Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires. J Immunol. 2003 Nov 01; 171(9):4680-8.
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Molecular signatures of anti-nuclear antibodies: contributions of specific light chain residues and a novel New Zealand Black V kappa 1 germline gene. J Immunol. 2003 Oct 01; 171(7):3886-94.