"5-Methylcytosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.
| Descriptor ID |
D044503
|
| MeSH Number(s) |
D03.383.742.698.421.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "5-Methylcytosine".
Below are MeSH descriptors whose meaning is more specific than "5-Methylcytosine".
This graph shows the total number of publications written about "5-Methylcytosine" by people in this website by year, and whether "5-Methylcytosine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 4 | 4 | 8 |
| 2014 | 0 | 3 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 2 | 1 | 3 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "5-Methylcytosine" by people in Profiles.
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DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations. Nucleic Acids Res. 2024 Oct 28; 52(19):11442-11454.
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A 5-Hydroxymethylcytosine-Based Noninvasive Model for Early Detection of Colorectal Carcinomas and Advanced Adenomas: The METHOD-2 Study. Clin Cancer Res. 2024 Aug 01; 30(15):3337-3348.
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Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation. Nucleic Acids Res. 2023 06 23; 51(11):5469-5498.
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Active DNA demethylation promotes cell fate specification and the DNA damage response. Science. 2022 12 02; 378(6623):983-989.
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NT-seq: a chemical-based sequencing method for genomic methylome profiling. Genome Biol. 2022 05 30; 23(1):122.
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High-Dose Vitamin C Prevents Secondary Brain Damage After Stroke via Epigenetic Reprogramming of Neuroprotective Genes. Transl Stroke Res. 2022 12; 13(6):1017-1036.
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Recent Advances on DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications. Adv Exp Med Biol. 2022; 1389:295-315.
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Roles and Regulations of TET Enzymes in Solid Tumors. Trends Cancer. 2021 07; 7(7):635-646.
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TET2 chemically modifies tRNAs and regulates tRNA fragment levels. Nat Struct Mol Biol. 2021 01; 28(1):62-70.
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TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia. J Cereb Blood Flow Metab. 2021 03; 41(3):590-603.