"Methylcholanthrene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carcinogen that is often used in experimental cancer studies.
| Descriptor ID |
D008748
|
| MeSH Number(s) |
D02.455.426.559.847.149.500 D04.615.149.500
|
| Concept/Terms |
3-Methylcholanthrene- 3-Methylcholanthrene
- 3 Methylcholanthrene
- 20-Methylcholanthrene
- 20 Methylcholanthrene
|
Below are MeSH descriptors whose meaning is more general than "Methylcholanthrene".
Below are MeSH descriptors whose meaning is more specific than "Methylcholanthrene".
This graph shows the total number of publications written about "Methylcholanthrene" by people in this website by year, and whether "Methylcholanthrene" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 3 | 0 | 3 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methylcholanthrene" by people in Profiles.
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T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-? Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma. Cell Rep. 2015 Dec 22; 13(11):2470-2479.
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Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature. 2012 Feb 08; 482(7385):400-4.
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Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther. 2010 Nov; 335(2):369-79.
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Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter. J Pharmacol Exp Ther. 2010 Apr; 333(1):99-109.
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Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1419-24.
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NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity. 2008 Apr; 28(4):571-80.
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Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Toxicol Sci. 2008 Apr; 102(2):337-44.
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3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1071-7.
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3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Res. 2006 Feb 15; 66(4):2459-67.
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Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses. Chem Res Toxicol. 2005 Nov; 18(11):1634-41.