Leukemia Inhibitory Factor Receptor alpha Subunit
"Leukemia Inhibitory Factor Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
| Descriptor ID |
D053680
|
| MeSH Number(s) |
D12.776.543.750.705.852.583.750 D12.776.543.750.750.400.550.250.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leukemia Inhibitory Factor Receptor alpha Subunit".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, OSM-LIF [D12.776.543.750.705.852.583]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852.583.750]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
- Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.750.400.550.250.750]
Below are MeSH descriptors whose meaning is more specific than "Leukemia Inhibitory Factor Receptor alpha Subunit".
This graph shows the total number of publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in this website by year, and whether "Leukemia Inhibitory Factor Receptor alpha Subunit" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Profiles.
-
LIFR regulates cholesterol-driven bidirectional hepatocyte-neutrophil cross-talk to promote liver regeneration. Nat Metab. 2024 Sep; 6(9):1756-1774.
-
A targetable LIFR-NF-?B-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nat Commun. 2021 12 17; 12(1):7333.
-
Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers. Genome Res. 2017 07; 27(7):1112-1125.
-
MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway. Oncotarget. 2015 Jul 10; 6(19):17366-78.
-
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012 Oct; 18(10):1511-7.
-
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15; 22(4):449-62.
-
Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood. 1999 Feb 01; 93(3):804-15.
-
Expression of leukemia inhibitory factor and its receptor in breast cancer: a potential autocrine and paracrine growth regulatory mechanism. Breast Cancer Res Treat. 1998 Mar; 48(2):165-74.
-
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. J Neurosurg. 1998 Mar; 88(3):541-8.
-
Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation. J Interferon Cytokine Res. 1995 Oct; 15(10):905-13.