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KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer.
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KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer.
KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res. 2013 Sep 01; 73(17):5532-43.
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PubMed
subject areas
Animals
Antirheumatic Agents
Apoptosis
Auranofin
Blotting, Western
Carcinoma, Non-Small-Cell Lung
Cell Proliferation
Fluorescent Antibody Technique
Genes, Lethal
Glutathione
Heterocyclic Compounds, 3-Ring
Humans
Immunoenzyme Techniques
Intracellular Signaling Peptides and Proteins
Kelch-Like ECH-Associated Protein 1
Luciferases
Lung Neoplasms
Mice
Microscopy, Fluorescence
Neoplasm Staging
NF-E2-Related Factor 2
Proto-Oncogene Proteins c-akt
Reactive Oxygen Species
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
RNA, Small Interfering
Thioredoxin Reductase 1
Tumor Cells, Cultured
authors with profiles
JACK A ROTH
BINGLIANG FANG
LIN JI
GEOFFREY BARTHOLOMEUSZ
BINGBING DAI