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XINCHUN PI

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
    Collapse research activities and funding
    R01DK123186     (PI, XINCHUN)Sep 15, 2020 - Aug 31, 2023
    NIH
    Metabolic crosstalk through vascular endothelium-secreted factors
    Role: Principal Investigator
    R01HL112890     (PI, XINCHUN)Aug 1, 2013 - May 31, 2019
    NIH
    LRP1 and endothelial function
    Role: Principal Investigator
    R01HL061656     (PI, XINCHUN)Jul 1, 1999 - Dec 31, 2018
    NIH
    Signaling in endothelial growth & angiogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mao H, Angelini A, Li S, Wang G, Li L, Patterson C, Pi X, Xie L. CRAT links cholesterol metabolism to innate immune responses in the heart. Nat Metab. 2023 08; 5(8):1382-1394. PMID: 37443356; PMCID: PMC10685850.
      Citations: 1     Fields:    Translation:Animals
    2. Angelini A, Pi X, Xie L. Evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument. STAR Protoc. 2022 06 17; 3(2):101392. PMID: 35600933; PMCID: PMC9120230.
      Citations:    Fields:    Translation:AnimalsCells
    3. Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L. PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell Rep. 2021 10 05; 37(1):109767. PMID: 34610308; PMCID: PMC8658754.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi X. Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nat Commun. 2021 09 06; 12(1):5296. PMID: 34489478; PMCID: PMC8421392.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X. Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nat Commun. 2021 03 26; 12(1):1927. PMID: 33772019; PMCID: PMC7997910.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442. PMID: 31356139; PMCID: PMC6699770.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X, Patterson C. Correction: BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions. PLoS One. 2018; 13(11):e0207504. PMID: 30496196; PMCID: PMC6264504.
      Citations:    Fields:    
    8. Fan Q, Mao H, Xie L, Pi X. Prolyl Hydroxylase Domain-2 Protein Regulates Lipopolysaccharide-Induced Vascular Inflammation. Am J Pathol. 2019 01; 189(1):200-213. PMID: 30339838; PMCID: PMC6315327.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Pi X, Xie L, Patterson C. Emerging Roles of Vascular Endothelium in Metabolic Homeostasis. Circ Res. 2018 08 03; 123(4):477-494. PMID: 30355249; PMCID: PMC6205216.
      Citations: 57     Fields:    Translation:HumansAnimals
    10. Angelini A, Pi X, Xie L. Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease. Front Physiol. 2017; 8:1044. PMID: 29311974; PMCID: PMC5732914.
      Citations: 1     
    11. Lockyer P, Mao H, Fan Q, Li L, Yu-Lee LY, Eissa NT, Patterson C, Xie L, Pi X. LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1524-1535. PMID: 28596374; PMCID: PMC5532067.
      Citations: 16     Fields:    Translation:AnimalsCells
    12. Mao H, Xie L, Pi X. Low-Density Lipoprotein Receptor-Related Protein-1 Signaling in Angiogenesis. Front Cardiovasc Med. 2017; 4:34. PMID: 28589128; PMCID: PMC5438976.
      Citations: 12     
    13. Mao H, Lockyer P, Li L, Ballantyne CM, Patterson C, Xie L, Pi X. Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR?. Nat Commun. 2017 04 10; 8:14960. PMID: 28393867; PMCID: PMC5394236.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    14. Mao H, Lockyer P, Townley-Tilson WH, Xie L, Pi X. LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):350-60. PMID: 26634655; PMCID: PMC4732907.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    15. Gomes AV, Rajasekaran NS, Pi X. Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015; 2015:849095. PMID: 26523200; PMCID: PMC4617440.
      Citations: 2     Fields:    Translation:HumansCells
    16. Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X, Patterson C. BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions. PLoS One. 2015; 10(9):e0139209. PMID: 26418455; PMCID: PMC4587915.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Townley-Tilson WH, Pi X, Xie L. The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease. Oxid Med Cell Longev. 2015; 2015:676893. PMID: 26491535; PMCID: PMC4600863.
      Citations: 6     Fields:    Translation:Humans
    18. Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71. PMID: 26075818; PMCID: PMC4563684.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    19. Xie L, Pi X, Wang Z, He J, Willis MS, Patterson C. Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. J Mol Cell Cardiol. 2015 Mar; 80:156-65. PMID: 25633836; PMCID: PMC4374643.
      Citations: 24     Fields:    Translation:AnimalsCells
    20. Cai Y, Nagel DJ, Zhou Q, Cygnar KD, Zhao H, Li F, Pi X, Knight PA, Yan C. Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Circ Res. 2015 Mar 27; 116(7):1120-32. PMID: 25608528; PMCID: PMC4702253.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    21. Dyer L, Pi X, Patterson C. Connecting the coronaries: how the coronary plexus develops and is functionalized. Dev Biol. 2014 Nov 01; 395(1):111-9. PMID: 25173872; PMCID: PMC4410768.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    22. Pi X, Xie L, Portbury AL, Kumar S, Lockyer P, Li X, Patterson C. NADPH oxidase-generated reactive oxygen species are required for stromal cell-derived factor-1a-stimulated angiogenesis. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):2023-32. PMID: 24990230; PMCID: PMC4149803.
      Citations: 16     Fields:    Translation:AnimalsCells
    23. Dyer LA, Pi X, Patterson C. The role of BMPs in endothelial cell function and dysfunction. Trends Endocrinol Metab. 2014 Sep; 25(9):472-80. PMID: 24908616; PMCID: PMC4149816.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    24. Xie L, Pi X, Mishra A, Fong G, Peng J, Patterson C. PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest. 2012 Aug; 122(8):2827-36. PMID: 22797300; PMCID: PMC3408739.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    25. Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ, Jin SW, Patterson C. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circ Res. 2012 Aug 17; 111(5):564-74. PMID: 22777006; PMCID: PMC3495066.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    26. Pi X, Lockyer P, Dyer LA, Schisler JC, Russell B, Carey S, Sweet DT, Chen Z, Tzima E, Willis MS, Homeister JW, Moser M, Patterson C. Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2214-22. PMID: 22772758; PMCID: PMC3514404.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    27. Bode M, Wu Y, Pi X, Lockyer P, Dechyapirom W, Portbury AL, Patterson C. Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen. Cell Biochem Funct. 2011 Jun; 29(4):334-41. PMID: 21506136; PMCID: PMC3115492.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. Aitsebaomo J, Srivastava S, Zhang H, Jha S, Wang Z, Winnik S, Veleva AN, Pi X, Lockyer P, Faber JE, Patterson C. Recombinant human interleukin-11 treatment enhances collateral vessel growth after femoral artery ligation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):306-12. PMID: 21071685; PMCID: PMC3025756.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    29. Pi X, Wu Y, Ferguson JE, Portbury AL, Patterson C. SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5675-80. PMID: 19307591; PMCID: PMC2667036.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    30. Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009 Feb 23; 184(4):597-609. PMID: 19221194; PMCID: PMC2654123.
      Citations: 57     Fields:    Translation:AnimalsCells
    31. Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil AB, Divito M, Cheney RE, Patterson C. Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J Cell Biol. 2007 Dec 31; 179(7):1569-82. PMID: 18158328; PMCID: PMC2373493.
      Citations: 61     Fields:    Translation:AnimalsCells
    32. Pi X, Patterson C. Twin layers of lightning: a new role for the chaperone Hsp90 in angiogenesis. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):6-7. PMID: 17975116.
      Citations:    Fields:    Translation:HumansCells
    33. Wang H, Charles PC, Wu Y, Ren R, Pi X, Moser M, Barshishat-Kupper M, Rubin JS, Perou C, Bautch V, Patterson C. Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res. 2006 May 26; 98(10):1331-9. PMID: 16601226.
      Citations: 28     Fields:    Translation:AnimalsCells
    34. Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC. BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha. Circ Res. 2005 Jun 10; 96(11):1145-51. PMID: 15879308.
      Citations: 29     Fields:    Translation:AnimalsCells
    35. Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C. Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol. 2005 Jan; 38(1):175-84. PMID: 15623434; PMCID: PMC4144401.
      Citations: 20     Fields:    Translation:AnimalsCells
    36. Pi X, Yan C, Berk BC. Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res. 2004 Feb 20; 94(3):362-9. PMID: 14670836.
      Citations: 65     Fields:    Translation:AnimalsCells
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