DAVID DURGAN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Anesthesiology
AddressOne Baylor Plaza
Houston, TX 77030
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    R01HL134838     (DURGAN, DAVID J)Jan 1, 2018 - Dec 31, 2022
    NIH/NHLBI
    EXAMINING THE ROLE OF GUT DYSBIOSIS IN OBSTRUCTIVE SLEEP APNEA INDUCED HYPERTENSION.
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee J, Venna VR, Durgan DJ, Shi H, Hudobenko J, Putluri N, Petrosino J, McCullough LD, Bryan RM. Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance. Gut Microbes. 2020 Sep 08; 1-14. PMID: 32897773.
      Citations:    Fields:    
    2. Blasco MP, Chauhan A, Honarpisheh P, Ahnstedt H, d'Aigle J, Ganesan A, Ayyaswamy S, Blixt F, Venable S, Major A, Durgan D, Haag A, Kofler J, Bryan R, McCullough LD, Ganesh BP. Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation. J Neuroinflammation. 2020 May 19; 17(1):160. PMID: 32429999.
      Citations:    Fields:    
    3. Lee J, d'Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino J, Putluri N, Zhu L, Durgan DJ, Bryan RM, McCullough LD, Venna VR. Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice. Circ Res. 2020 Jul 31; 127(4):453-465. PMID: 32354259.
      Citations: 1     Fields:    
    4. Durgan DJ. Evidence for a gut-immune-vascular axis in the development of hypertension. Acta Physiol (Oxf). 2019 09; 227(1):e13338. PMID: 31273923.
      Citations:    Fields:    Translation:Animals
    5. Durgan DJ, Lee J, McCullough LD, Bryan RM. Examining the Role of the Microbiota-Gut-Brain Axis in Stroke. Stroke. 2019 08; 50(8):2270-2277. PMID: 31272315.
      Citations: 5     Fields:    Translation:Humans
    6. Kitagawa MG, Reynolds JO, Durgan D, Rodney G, Karmouty-Quintana H, Bryan R, Pandit LM. Twik-2-/- mouse demonstrates pulmonary vascular heterogeneity in intracellular pathways for vasocontractility. Physiol Rep. 2019 01; 7(1):e13950. PMID: 30632293.
      Citations:    Fields:    Translation:AnimalsCells
    7. Ganesh BP, Nelson JW, Eskew JR, Ganesan A, Ajami NJ, Petrosino JF, Bryan RM, Durgan DJ. Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea. Hypertension. 2018 11; 72(5):1141-1150. PMID: 30354816.
      Citations: 4     Fields:    Translation:Animals
    8. Spychala MS, Venna VR, Jandzinski M, Doran SJ, Durgan DJ, Ganesh BP, Ajami NJ, Putluri N, Graf J, Bryan RM, McCullough LD. Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. Ann Neurol. 2018 07; 84(1):23-36. PMID: 29733457.
      Citations: 18     Fields:    Translation:Animals
    9. Durgan DJ. Obstructive Sleep Apnea-Induced Hypertension: Role of the Gut Microbiota. Curr Hypertens Rep. 2017 Apr; 19(4):35. PMID: 28365886.
      Citations: 1     Fields:    Translation:HumansAnimals
    10. Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM, Durgan DJ. Alterations in the gut microbiota can elicit hypertension in rats. Physiol Genomics. 2017 02 01; 49(2):96-104. PMID: 28011881.
      Citations: 39     Fields:    Translation:Animals
    11. Durgan DJ, Crossland RF, Bryan RM. The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea. J Cereb Blood Flow Metab. 2017 Aug; 37(8):2806-2819. PMID: 27798273.
      Citations: 3     Fields:    Translation:Animals
    12. Durgan DJ, Ganesh BP, Cope JL, Ajami NJ, Phillips SC, Petrosino JF, Hollister EB, Bryan RM. Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. Hypertension. 2016 Feb; 67(2):469-74. PMID: 26711739.
      Citations: 46     Fields:    Translation:Animals
    13. Lloyd EE, Durgan DJ, Martini SR, Bryan RM. Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease. Hypertension. 2015 Oct; 66(4):913-7. PMID: 26259594.
      Citations: 4     Fields:    Translation:Animals
    14. Durgan DJ, Crossland RF, Lloyd EE, Phillips SC, Bryan RM. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015 Mar; 35(3):402-11. PMID: 25425077.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Durgan DJ, Bryan RM. The same but different. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1485. PMID: 23778165.
      Citations:    Fields:    Translation:Animals
    16. Crossland RF, Durgan DJ, Lloyd EE, Phillips SC, Reddy AK, Marrelli SP, Bryan RM. A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. . 2013 Aug 15; 305(4):R334-42. PMID: 23761641.
      Citations:    
    17. Durgan DJ, Bryan RM. Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc. 2012 Aug; 1(4):e000091. PMID: 23130152.
      Citations: 39     Fields:    
    18. Durgan DJ, Pat BM, Laczy B, Bradley JA, Tsai JY, Grenett MH, Ratcliffe WF, Brewer RA, Nagendran J, Villegas-Montoya C, Zou C, Zou L, Johnson RL, Dyck JR, Bray MS, Gamble KL, Chatham JC, Young ME. O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. J Biol Chem. 2011 Dec 30; 286(52):44606-19. PMID: 22069332.
      Citations: 51     Fields:    Translation:AnimalsCells
    19. Durgan DJ, Tsai JY, Grenett MH, Pat BM, Ratcliffe WF, Villegas-Montoya C, Garvey ME, Nagendran J, Dyck JR, Bray MS, Gamble KL, Gimble JM, Young ME. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int. 2011 Apr; 28(3):187-203. PMID: 21452915.
      Citations: 34     Fields:    Translation:AnimalsCells
    20. Durgan DJ, Young ME. The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res. 2010 Mar 05; 106(4):647-58. PMID: 20203314.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    21. Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, Garvey ME, Frangogiannis NG, Michael LH, Chow CW, Dyck JR, Young ME. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res. 2010 Feb 19; 106(3):546-50. PMID: 20007913.
      Citations: 68     Fields:    Translation:AnimalsCells
    22. Tsai JY, Kienesberger PC, Pulinilkunnil T, Sailors MH, Durgan DJ, Villegas-Montoya C, Jahoor A, Gonzalez R, Garvey ME, Boland B, Blasier Z, McElfresh TA, Nannegari V, Chow CW, Heird WC, Chandler MP, Dyck JR, Bray MS, Young ME. Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock. J Biol Chem. 2010 Jan 29; 285(5):2918-29. PMID: 19940111.
      Citations: 43     Fields:    Translation:AnimalsCells
    23. Lockridge JB, Sailors ML, Durgan DJ, Egbejimi O, Jeong WJ, Bray MS, Stanley WC, Young ME. Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids. J Lipid Res. 2008 Jul; 49(7):1395-408. PMID: 18387886.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Durgan DJ, Young ME. Linking the cardiomyocyte circadian clock to myocardial metabolism. Cardiovasc Drugs Ther. 2008 Apr; 22(2):115-24. PMID: 18274886.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. . 2008 Feb; 294(2):H1036-47. PMID: 18156197.
      Citations:    
    26. Kung TA, Egbejimi O, Cui J, Ha NP, Durgan DJ, Essop MF, Bray MS, Shaw CA, Hardin PE, Stanley WC, Young ME. Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion. J Mol Cell Cardiol. 2007 Dec; 43(6):744-53. PMID: 17959196.
      Citations: 12     Fields:    Translation:Animals
    27. Durgan DJ, Moore MW, Ha NP, Egbejimi O, Fields A, Mbawuike U, Egbejimi A, Shaw CA, Bray MS, Nannegari V, Hickson-Bick DL, Heird WC, Dyck JR, Chandler MP, Young ME. Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate. . 2007 Oct; 293(4):H2385-93. PMID: 17616739.
      Citations:    
    28. Durgan DJ, Trexler NA, Egbejimi O, McElfresh TA, Suk HY, Petterson LE, Shaw CA, Hardin PE, Bray MS, Chandler MP, Chow CW, Young ME. The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J Biol Chem. 2006 Aug 25; 281(34):24254-69. PMID: 16798731.
      Citations: 66     Fields:    Translation:AnimalsCells
    29. Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. . 2006 Jun; 290(6):H2480-97. PMID: 16428347.
      Citations:    
    30. Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME. The intrinsic circadian clock within the cardiomyocyte. . 2005 Oct; 289(4):H1530-41. PMID: 15937094.
      Citations:    
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