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DAVID DURGAN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Anesthesiology
    DivisionAnesthesiology


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    R01HL134838     (DURGAN, DAVID J)Jan 1, 2018 - Dec 31, 2023
    NIH
    EXAMINING THE ROLE OF GUT DYSBIOSIS IN OBSTRUCTIVE SLEEP APNEA INDUCED HYPERTENSION.
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ayyaswamy S, Shi H, Zhang B, Bryan RM, Durgan DJ. Obstructive Sleep Apnea-Induced Hypertension Is Associated With Increased Gut and Neuroinflammation. J Am Heart Assoc. 2023 06 06; 12(11):e029218. PMID: 37260032; PMCID: PMC10381979.
      Citations:    Fields:    Translation:Animals
    2. Aryal S, Manandhar I, Mei X, Yeoh BS, Tummala R, Saha P, Osman I, Zubcevic J, Durgan DJ, Vijay-Kumar M, Joe B. Combating hypertension beyond genome-wide association studies: Microbiome and artificial intelligence as opportunities for precision medicine. Camb Prism Precis Med. 2023; 1:e26. PMID: 38550938; PMCID: PMC10953772.
      Citations:    
    3. Durgan DJ, Farr? R. Gut check: assessing the role of the gut microbiota in the adverse cardiovascular effects of obstructive sleep apnoea. Eur Respir J. 2023 01; 61(1). PMID: 36657778.
      Citations:    Fields:    Translation:HumansAnimals
    4. Shi H, Nelson JW, Phillips S, Petrosino JF, Bryan RM, Durgan DJ. Alterations of the gut microbial community structure and function with aging in the spontaneously hypertensive stroke prone rat. Sci Rep. 2022 05 20; 12(1):8534. PMID: 35595870; PMCID: PMC9122926.
      Citations: 1     Fields:    Translation:Animals
    5. Li N, Durgan DJ, Wehrens XHT. Gut microbiota: a key regulator of ageing-associated atrial fibrillation? Cardiovasc Res. 2022 02 21; 118(3):657-659. PMID: 34849621; PMCID: PMC8859633.
      Citations:    Fields:    Translation:Humans
    6. Shi H, Zhang B, Abo-Hamzy T, Nelson JW, Ambati CSR, Petrosino JF, Bryan RM, Durgan DJ. Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure. Circ Res. 2021 04 30; 128(9):1240-1254. PMID: 33596669; PMCID: PMC8085162.
      Citations: 11     Fields:    Translation:Animals
    7. Nelson JW, Phillips SC, Ganesh BP, Petrosino JF, Durgan DJ, Bryan RM. The gut microbiome contributes to blood-brain barrier disruption in spontaneously hypertensive stroke prone rats. FASEB J. 2021 02; 35(2):e21201. PMID: 33496989; PMCID: PMC8238036.
      Citations: 5     Fields:    Translation:Animals
    8. Lee J, Venna VR, Durgan DJ, Shi H, Hudobenko J, Putluri N, Petrosino J, McCullough LD, Bryan RM. Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance. Gut Microbes. 2020 11 09; 12(1):1-14. PMID: 32897773; PMCID: PMC7757789.
      Citations: 20     Fields:    Translation:AnimalsCells
    9. Blasco MP, Chauhan A, Honarpisheh P, Ahnstedt H, d'Aigle J, Ganesan A, Ayyaswamy S, Blixt F, Venable S, Major A, Durgan D, Haag A, Kofler J, Bryan R, McCullough LD, Ganesh BP. Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation. J Neuroinflammation. 2020 May 19; 17(1):160. PMID: 32429999; PMCID: PMC7236952.
      Citations: 10     Fields:    Translation:AnimalsCells
    10. Lee J, d'Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino J, Putluri N, Zhu L, Durgan DJ, Bryan RM, McCullough LD, Venna VR. Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice. Circ Res. 2020 07 31; 127(4):453-465. PMID: 32354259; PMCID: PMC7415518.
      Citations: 70     Fields:    Translation:AnimalsCells
    11. Durgan DJ. Evidence for a gut-immune-vascular axis in the development of hypertension. Acta Physiol (Oxf). 2019 09; 227(1):e13338. PMID: 31273923.
      Citations:    Fields:    Translation:Animals
    12. Durgan DJ, Lee J, McCullough LD, Bryan RM. Examining the Role of the Microbiota-Gut-Brain Axis in Stroke. Stroke. 2019 08; 50(8):2270-2277. PMID: 31272315; PMCID: PMC6646086.
      Citations: 27     Fields:    Translation:Humans
    13. Kitagawa MG, Reynolds JO, Durgan D, Rodney G, Karmouty-Quintana H, Bryan R, Pandit LM. Twik-2-/- mouse demonstrates pulmonary vascular heterogeneity in intracellular pathways for vasocontractility. Physiol Rep. 2019 01; 7(1):e13950. PMID: 30632293; PMCID: PMC6328926.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Ganesh BP, Nelson JW, Eskew JR, Ganesan A, Ajami NJ, Petrosino JF, Bryan RM, Durgan DJ. Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea. Hypertension. 2018 11; 72(5):1141-1150. PMID: 30354816; PMCID: PMC6209125.
      Citations: 39     Fields:    Translation:Animals
    15. Spychala MS, Venna VR, Jandzinski M, Doran SJ, Durgan DJ, Ganesh BP, Ajami NJ, Putluri N, Graf J, Bryan RM, McCullough LD. Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. Ann Neurol. 2018 07; 84(1):23-36. PMID: 29733457; PMCID: PMC6119509.
      Citations: 110     Fields:    Translation:Animals
    16. Durgan DJ. Obstructive Sleep Apnea-Induced Hypertension: Role of the Gut Microbiota. Curr Hypertens Rep. 2017 Apr; 19(4):35. PMID: 28365886.
      Citations: 11     Fields:    Translation:HumansAnimals
    17. Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM, Durgan DJ. Alterations in the gut microbiota can elicit hypertension in rats. Physiol Genomics. 2017 02 01; 49(2):96-104. PMID: 28011881; PMCID: PMC5336599.
      Citations: 121     Fields:    Translation:Animals
    18. Durgan DJ, Crossland RF, Bryan RM. The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea. J Cereb Blood Flow Metab. 2017 Aug; 37(8):2806-2819. PMID: 27798273; PMCID: PMC5536790.
      Citations: 9     Fields:    Translation:Animals
    19. Durgan DJ, Ganesh BP, Cope JL, Ajami NJ, Phillips SC, Petrosino JF, Hollister EB, Bryan RM. Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. Hypertension. 2016 Feb; 67(2):469-74. PMID: 26711739; PMCID: PMC4713369.
      Citations: 123     Fields:    Translation:Animals
    20. Lloyd EE, Durgan DJ, Martini SR, Bryan RM. Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease. Hypertension. 2015 Oct; 66(4):913-7. PMID: 26259594; PMCID: PMC4567494.
      Citations: 4     Fields:    Translation:Animals
    21. Durgan DJ, Crossland RF, Lloyd EE, Phillips SC, Bryan RM. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015 Mar; 35(3):402-11. PMID: 25425077; PMCID: PMC4348382.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Durgan DJ, Bryan RM. The same but different. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1485. PMID: 23778165; PMCID: PMC3790921.
      Citations:    Fields:    Translation:Animals
    23. Crossland RF, Durgan DJ, Lloyd EE, Phillips SC, Reddy AK, Marrelli SP, Bryan RM. A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15; 305(4):R334-42. PMID: 23761641; PMCID: PMC3833398.
      Citations: 18     Fields:    Translation:Animals
    24. Durgan DJ, Bryan RM. Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc. 2012 Aug; 1(4):e000091. PMID: 23130152; PMCID: PMC3487354.
      Citations: 57     Fields:    
    25. Durgan DJ, Pat BM, Laczy B, Bradley JA, Tsai JY, Grenett MH, Ratcliffe WF, Brewer RA, Nagendran J, Villegas-Montoya C, Zou C, Zou L, Johnson RL, Dyck JR, Bray MS, Gamble KL, Chatham JC, Young ME. O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. J Biol Chem. 2011 Dec 30; 286(52):44606-19. PMID: 22069332; PMCID: PMC3247942.
      Citations: 76     Fields:    Translation:AnimalsCells
    26. Durgan DJ, Tsai JY, Grenett MH, Pat BM, Ratcliffe WF, Villegas-Montoya C, Garvey ME, Nagendran J, Dyck JR, Bray MS, Gamble KL, Gimble JM, Young ME. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int. 2011 Apr; 28(3):187-203. PMID: 21452915; PMCID: PMC3230077.
      Citations: 47     Fields:    Translation:AnimalsCells
    27. Durgan DJ, Young ME. The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res. 2010 Mar 05; 106(4):647-58. PMID: 20203314; PMCID: PMC3223121.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    28. Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, Garvey ME, Frangogiannis NG, Michael LH, Chow CW, Dyck JR, Young ME. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res. 2010 Feb 19; 106(3):546-50. PMID: 20007913; PMCID: PMC3021132.
      Citations: 100     Fields:    Translation:AnimalsCells
    29. Tsai JY, Kienesberger PC, Pulinilkunnil T, Sailors MH, Durgan DJ, Villegas-Montoya C, Jahoor A, Gonzalez R, Garvey ME, Boland B, Blasier Z, McElfresh TA, Nannegari V, Chow CW, Heird WC, Chandler MP, Dyck JR, Bray MS, Young ME. Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock. J Biol Chem. 2010 Jan 29; 285(5):2918-29. PMID: 19940111; PMCID: PMC2823428.
      Citations: 50     Fields:    Translation:AnimalsCells
    30. Lockridge JB, Sailors ML, Durgan DJ, Egbejimi O, Jeong WJ, Bray MS, Stanley WC, Young ME. Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids. J Lipid Res. 2008 Jul; 49(7):1395-408. PMID: 18387886; PMCID: PMC2431101.
      Citations: 20     Fields:    Translation:AnimalsCells
    31. Durgan DJ, Young ME. Linking the cardiomyocyte circadian clock to myocardial metabolism. Cardiovasc Drugs Ther. 2008 Apr; 22(2):115-24. PMID: 18274886.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    32. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1036-47. PMID: 18156197.
      Citations: 155     Fields:    Translation:AnimalsCells
    33. Kung TA, Egbejimi O, Cui J, Ha NP, Durgan DJ, Essop MF, Bray MS, Shaw CA, Hardin PE, Stanley WC, Young ME. Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion. J Mol Cell Cardiol. 2007 Dec; 43(6):744-53. PMID: 17959196; PMCID: PMC2699675.
      Citations: 21     Fields:    Translation:Animals
    34. Durgan DJ, Moore MW, Ha NP, Egbejimi O, Fields A, Mbawuike U, Egbejimi A, Shaw CA, Bray MS, Nannegari V, Hickson-Bick DL, Heird WC, Dyck JR, Chandler MP, Young ME. Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2385-93. PMID: 17616739.
      Citations: 30     Fields:    Translation:AnimalsCells
    35. Durgan DJ, Trexler NA, Egbejimi O, McElfresh TA, Suk HY, Petterson LE, Shaw CA, Hardin PE, Bray MS, Chandler MP, Chow CW, Young ME. The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J Biol Chem. 2006 Aug 25; 281(34):24254-69. PMID: 16798731.
      Citations: 77     Fields:    Translation:AnimalsCells
    36. Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2480-97. PMID: 16428347.
      Citations: 49     Fields:    Translation:AnimalsCells
    37. Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME. The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1530-41. PMID: 15937094.
      Citations: 66     Fields:    Translation:AnimalsCells
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