InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address7200 CAMBRIDGE
Houston, TX 77030
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    Collapse Biography 
    Collapse education and training
    Universidad Nacional de Colombia, Bogota, ColombiaM.D.06/1991
    University of Miami, MiamiInternal Medicine06/1997
    Johns Hopkins Hospital, BaltimorePulmonary and Critical Care Medicine06/2002
    National Heart, Lung and Blood Institute, BethesdaPulmonary Research Fellowship06/2005
    Collapse awards and honors
    2013Fellow American College of Chest Physicians
    2016American Society of Clinical Investigation

    Collapse Overview 
    Collapse overview
    The long-term goal of our pulmonary research program is to better understand mechanisms that contribute to development and progression of parenchymal lung disease thereby enabling us to develop novel diagnostic and therapeutic strategies.

    Robust homeostatic mechanisms preserve human lung health from early age through adult years, however maturity can be associated with the development of parenchymal lung diseases. Our research studies focus on Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD), disorders commonly observed in aging males with a prior history of tobacco exposure. Our laboratory employs cutting edge genomic technologies and animal models to determine how select molecular derangements contribute to development and progression of parenchymal lung disease associated with established risk factors including smoking, aging, gender and the metabolic syndrome (Morse D, Rosas IO. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol. 2014; 76:493-513).

    Our clinical research studies have shown that subclinical pulmonary fibrosis can be detected in at-risk populations including families affected with pulmonary fibrosis, smokers and patients affected with rheumatoid arthritis (Doyle TJ, Hunninghake GM, Rosas IO. Subclinical interstitial lung disease: why you should care. Am J Respir Crit Care Med. 2012 Jun 1; 185(11):1147-53). These studies are transformative as they provide critical evidence that prevention is feasible in common parenchymal lung diseases associated with high morbidity and mortality (Rosas IO, Dellaripa PF, Lederer DJ et al. Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S169-77).

    Collapse Research 
    Collapse research activities and funding
    T32HL170991     (KHERADMAND, FARRAH)Jan 1, 2024 - Dec 31, 2028
    BCM-Respiratory Research Training
    Role: Co-Principal Investigator

    PR171782     (ROSAS, IVAN O.)Jun 1, 2018 - May 31, 2020
    Department of Defense
    Molecular Profiles of Smokers with Subclinical Interstitial Lung Disease

    U01HL133232     (DUNCAN, STEVEN R)Sep 1, 2017 - Jul 31, 2022
    Autoantibody-Targeted Therapy for Acute Exacerbations of Idiopathic Pulmonary Fibrosis
    Role: Co-Principal Investigator

    Genentech IIS     (ROSAS, IVAN ).)Mar 31, 2016 - Apr 1, 2022
    Brigham and Women's Hospital
    Phase II Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease
    Role: Overall Principal Investigator

    R01HL130974     (HUNNINGHAKE, GARY MATTHEW)Jan 1, 2016 - Nov 30, 2026
    Clinical Genetics and Screening for Pulmonary Fibrosis
    Role: Co-Principal Investigator

    R01HL129920     (ROSAS, IVAN O.)Sep 17, 2015 - Jun 30, 2018
    Clinical and Molecular Profiles of Smokers with Subclinical Interstitial Lung Disease
    Role: Principal Investigator

    U01HL105371     (ROSAS, IVAN O.)Sep 24, 2010 - Jun 30, 2015
    Phase II Study of Inhales Carbon Monoxide for the Treatment of Idiopathic Pulmona
    Role: Co-Principal Investigator

    K23HL087030     (ROSAS, IVAN O.)Feb 1, 2008 - Jan 31, 2013
    Syndecan-2 and Clinical Progression of Idiopathic Pulmonary Fibrosis
    Role: Principal Investigator

    T32HL007747     (ROSAS, IVAN O.)Jul 1, 1993 - Jun 30, 2021
    Research Training in Lung Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xu K, Ding L, Li W, Wang Y, Ma S, Lian H, Pan X, Wan R, Zhao W, Yang J, Rosas I, Wang L, Yu G. Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis. Am J Pathol. 2024 Jun 05. PMID: 38849030.
      Citations:    Fields:    
    2. Seasock MJ, Shafiquzzaman M, Ruiz-Echartea ME, Kanchi RS, Tran BT, Simon LM, Meyer MD, Erice PA, Lotlikar SL, Wenlock SC, Ochsner SA, Enright A, Carisey AF, Romero F, Rosas IO, King KY, McKenna NJ, Coarfa C, Rodriguez A. Let-7 restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis. bioRxiv. 2024 May 27. PMID: 38826218; PMCID: PMC11142151.
    3. Choi B, Liu GY, Sheng Q, Amancherla K, Perry A, Huang X, Ash SY, Guan W, Jacobs DR, Martinez FJ, Rosas IO, Bowler RP, Kropski JA, Banovich NE, Khan SS, Shah R, Thyagarajan B, Kalhan R, Washko GR, San Jos? Est?par R, San Jose Estepar R, Choi B, Liu GY, Sheng Q, Amancherla K, Perry A, Huang X, San Jos? Est?par R, Ash SY, Guan W, Jacobs DR, Martinez FJ, Rosas IO, Bowler RP, Kropski JA, Banovich NE, Khan SS, San Jos? Est?par R, Shah R, Thyagarajan B, Kalhan R, Washko GR. Proteomic Biomarkers of Quantitative Interstitial Abnormalities in COPDGene and CARDIA Lung Study. Am J Respir Crit Care Med. 2024 May 01; 209(9):1091-1100. PMID: 38285918; PMCID: PMC11092953.
      Citations:    Fields:    
    4. Adegunsoye A, Kropski JA, Behr J, Blackwell TS, Corte TJ, Cottin V, Glanville A, Glassberg MK, Griese M, Hunninghake GM, Johannson KA, Keane MP, Kim JS, Kolb M, Maher TM, Oldham JM, Podolanczuk AJ, Rosas IO, Martinez FJ, Noth I, Schwartz DA. Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine. Am J Respir Crit Care Med. 2024 Apr 04. PMID: 38573068.
      Citations: 1     Fields:    
    5. Kulkarni T, Criner GJ, Kass DJ, Rosas IO, Scholand MB, Dilling DF, Summer R, Duncan SR. Design of the STRIVE-IPF trial- study of therapeutic plasma exchange, rituximab, and intravenous immunoglobulin for acute exacerbations of idiopathic pulmonary fibrosis. BMC Pulm Med. 2024 Mar 20; 24(1):143. PMID: 38509495; PMCID: PMC10953157.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    6. Ash S, Doyle TJ, Choi B, San Jose Estepar R, Castro V, Enzer N, Kalhan R, Liu G, Bowler R, Wilson DO, San Jose Estepar R, Rosas IO, Washko GR. Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study. BMJ Open Respir Res. 2024 Mar 14; 11(1). PMID: 38485250; PMCID: PMC10941119.
      Citations:    Translation:Humans
    7. Kulkarni T, Criner GJ, Kass DJ, Rosas IO, Scholand MB, Dilling DF, Summer R, Duncan SR. Design of the STRIVE-IPF Trial- Study of Therapeutic Plasma Exchange, Rituximab, and Intravenous Immunoglobulin for Acute Exacerbations of Idiopathic Pulmonary Fibrosis. Res Sq. 2024 Feb 28. PMID: 38464052; PMCID: PMC10925430.
    8. Montesi SB, Gomez CR, Beers M, Brown R, Chattopadhyay I, Flaherty KR, Garcia CK, Gomperts B, Hariri LP, Hogaboam CM, Jenkins RG, Kaminski N, Kim GHJ, K?nigshoff M, Kolb M, Kotton DN, Kropski JA, Lasky J, Magin CM, Maher TM, McCormick M, Moore BB, Nickerson-Nutter C, Oldham J, Podolanczuk AJ, Raghu G, Rosas I, Rowe SM, Schmidt WT, Schwartz D, Shore JE, Spino C, Craig JM, Martinez FJ. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. Am J Respir Crit Care Med. 2024 Feb 15; 209(4):362-373. PMID: 38113442; PMCID: PMC10878386.
      Citations:    Fields:    Translation:Humans
    9. Tsoyi K, Rosas IO. Fibroblast heterogeneity in pulmonary fibrosis: a new target for therapeutics development? Eur Respir J. 2024 Feb; 63(2). PMID: 38331439.
      Citations:    Fields:    Translation:HumansCells
    10. Leung JM, Wu MJ, Kheradpour P, Chen C, Drake KA, Tong G, Ridaura VK, Zisser HC, Conrad WA, Hudson N, Allen J, Welberry C, Parsy-Kowalska C, Macdonald I, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Basit M, Krishnan JA, Parthasarathy S, Prabhakar BS, Salvatore M, Kim CC. Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals. Front Immunol. 2024; 15:1348041. PMID: 38318183; PMCID: PMC10838987.
      Citations: 1     Fields:    Translation:HumansCells
    11. Doyle TJ, Peljto AL, Lee S, Walts AD, Esposito AJ, Poli S, Gill R, Hatabu H, Nishino M, Dellaripa PF, Weinblatt ME, Shadick NA, Demoruelle MK, Sparks JA, Rosas IO, Deane KD, Wolters PJ, Lee JS, Juge PA, Granger B, Crestani B, Dieud? P. Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease. Thorax. 2024 01 18; 79(2):182-185. PMID: 38071573; PMCID: PMC10911453.
      Citations:    Fields:    Translation:HumansCells
    12. Wang L, Zhao W, Xia C, Ma S, Li Z, Wang N, Ding L, Wang Y, Cheng L, Liu H, Yang J, Li Y, Rosas I, Yu G. TRIOBP modulates ?-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis. Cell Mol Life Sci. 2023 Dec 29; 81(1):13. PMID: 38157020; PMCID: PMC10756874.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Zheng Y, Schupp JC, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer LJ, Rosas IO, Pineda R, Sembrat J, K?nigshoff M, McDonough JE, Vanaudenaerde BM, Wuyts WA, Kaminski N, Ding J. Unagi: Deep Generative Model for Deciphering Cellular Dynamics and In-Silico Drug Discovery in Complex Diseases. Res Sq. 2023 Dec 18. PMID: 38196613; PMCID: PMC10775382.
    14. Niu C, Xu K, Hu Y, Jia Y, Yang Y, Pan X, Wan R, Lian H, Wang Q, Yang J, Li Y, Rosas I, Wang L, Yu G. Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly. Respir Res. 2023 Dec 17; 24(1):318. PMID: 38105232; PMCID: PMC10726504.
      Citations:    Fields:    Translation:AnimalsCells
    15. Rojas-Quintero J, Ochsner SA, New F, Divakar P, Yang CX, Wu TD, Robinson J, Shimoga Chandrashekar D, Banovich NE, Rosas IO, Sauler M, Kheradmand F, Gaggar A, Margaroli C, San Jose Estepar R, McKenna NJ, Polverino F. Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD. Am J Respir Crit Care Med. 2023 Dec 08. PMID: 38064378.
      Citations:    Fields:    
    16. Kim JS, Montesi SB, Adegunsoye A, Humphries SM, Salisbury ML, Hariri LP, Kropski JA, Richeldi L, Wells AU, Walsh S, Jenkins RG, Rosas I, Noth I, Hunninghake GM, Martinez FJ, Podolanczuk AJ. Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis. Ann Am Thorac Soc. 2023 12; 20(12):1683-1693. PMID: 37703509; PMCID: PMC10704236.
      Citations: 1     Fields:    Translation:Humans
    17. Geary B, Sun B, Tilvawala RR, Barasa L, Tsoyi K, Rosas IO, Thompson PR, Ho IC. Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA. Front Immunol. 2023; 14:1290585. PMID: 38094295; PMCID: PMC10716219.
      Citations:    Fields:    Translation:HumansAnimals
    18. Wang L, Yuan H, Li W, Yan P, Zhao M, Li Z, Zhao H, Wang S, Wan R, Li Y, Yang J, Pan X, Rosas I, Yu G. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis. Biochim Biophys Acta Mol Basis Dis. 2024 02; 1870(2):166960. PMID: 37979225.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Choi B, Godbole S, Curtis JL, Wang JM, Rosas IO, Mayers JR, Hobbs BD, Hersh CP, Ash SY, Han MK, Bowler RP, Stringer KA, Washko GR, Labaki WW, San Jos? Est?par R, San Jos? Est?par R. Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers. Respir Res. 2023 Nov 04; 24(1):265. PMID: 37925418; PMCID: PMC10625195.
      Citations:    Fields:    Translation:Humans
    20. Chen C, Parthasarathy S, Leung JM, Wu MJ, Drake KA, Ridaura VK, Zisser HC, Conrad WA, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Prabhakar BS, Basit M, Salvatore M, Krishnan JA, Kim CC. Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection. Front Med (Lausanne). 2023; 10:1227883. PMID: 37908849; PMCID: PMC10614284.
      Citations: 1     
    21. Wang L, Li Z, Wan R, Pan X, Li B, Zhao H, Yang J, Zhao W, Wang S, Wang Q, Yan P, Ma C, Yuan H, Zhao M, Rosas I, Ding C, Sun B, Yu G. Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2023 10; 69(4):456-469. PMID: 37402274; PMCID: PMC10557923.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ, Hengstschl?ger M. SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells. Sci Transl Med. 2023 09 13; 15(713):eade2581. PMID: 37703351; PMCID: PMC11126869.
      Citations:    Fields:    Translation:HumansAnimalsCells
    23. Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience. 2023 Oct 20; 26(10):107813. PMID: 37810211; PMCID: PMC10551843.
      Citations: 1     
    24. Liu Y, Li N, Qi J, Xu G, Zhao J, Wang N, Huang X, Jiang W, Adams TS, Homer R, Amei A, Rosas IO, Kaminski N, Wang Z, Yan X, Justet A. A hybrid machine learning and regression method for cell type deconvolution of spatial barcoding-based transcriptomic data. bioRxiv. 2023 Aug 26. PMID: 37662370; PMCID: PMC10473707.
    25. Shivram H, Hackney JA, Rosenberger CM, Teterina A, Qamra A, Onabajo O, McBride J, Cai F, Bao M, Tsai L, Regev A, Rosas IO, Bauer RN. Transcriptomic and proteomic assessment of tocilizumab response in a randomized controlled trial of patients hospitalized with COVID-19. iScience. 2023 Sep 15; 26(9):107597. PMID: 37664617; PMCID: PMC10470387.
      Citations: 2     
    26. Chacon-Alberty L, Fernandez R, Jindra P, King M, Rosas I, Hochman-Mendez C, Loor G. Primary Graft Dysfunction in Lung Transplantation: A Review of Mechanisms and Future Applications. Transplantation. 2023 08 01; 107(8):1687-1697. PMID: 36650643.
      Citations: 1     Fields:    Translation:Humans
    27. Adduri RSR, Cai K, Velasco-Alzate K, Vasireddy R, Miller JW, de Fr?as SP, de Fr?as FP, Horimasu Y, Iwamoto H, Hattori N, Zhang Y, Gibson KF, Pal AK, Chen Z, Nicastro D, Li L, Cherian S, Sholl LM, Shetty S, Ndetan H, Maeda AH, Ferretto MAP, Hunninghake GM, Schwartz DA, Kass DJ, Rosas IO, Konduru NV. Plasma extracellular vesicle proteins as promising noninvasive biomarkers for diagnosis of idiopathic pulmonary fibrosis. J Extracell Biol. 2023 Jul; 2(7):e98. PMID: 38939072; PMCID: PMC11080873.
    28. Rosas I, Blanco-P?rez JJ, Fern?ndez-Gonz?lez-Cuevas L, Cala-Garc?a J. The Polyhedric Reality of Silicosis. Arch Bronconeumol. 2023 11; 59(11):705-706. PMID: 37394354.
      Citations:    Fields:    Translation:Humans
    29. Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland A, Short SA, Kheradpour P, Mumbach M, Franz K, Trifonov V, Lucas MV, Merson J, Kim CC, PRESCO Study Group . Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors. bioRxiv. 2023 May 26. PMID: 37292797; PMCID: PMC10246026.
    30. Wells AU, Denton CP, Hoffmann-Vold AM, Distler O, Johannson KA, Steen V, Shenoy PD, Ye W, Huang S, Allanore Y, Ingegnoli F, Korsten P, Ovalles-Bonilla J, Roofeh D, Brown KK, Kazerooni EA, Tashkin D, Assassi S, Martinez F, Raghu G, Chung L, Matteson EL, Kawano-Dourado L, Pauling JD, Seibold JR, Volkmann ER, Walsh SLF, Oddis CV, White ES, Barratt SL, Bernstein EJ, Domsic RT, Dellaripa PF, Conway R, Rosas I, Bhatt N, Hsu V, Kahaleh B, Garcha P, Gupta N, Khanna S, Lin C, Mathai SC, Strand V, Doyle TJ, Zoz DF, Rodriguez-Pinto I, Lewandoski A, Belloli E, Lescoat A, Nagaraja V, Maher T, Khanna D. Systemic sclerosis associated interstitial lung disease: a conceptual framework for subclinical, clinical and progressive disease. Rheumatology (Oxford). 2023 05 02; 62(5):1877-1886. PMID: 36173318; PMCID: PMC10152284.
      Citations: 1     Fields:    Translation:Humans
    31. Moss BJ, Rosas IO. Defining the Genetic Landscape of Idiopathic Pulmonary Fibrosis: Role of Common and Rare Variants. Am J Respir Crit Care Med. 2023 05 01; 207(9):1118-1120. PMID: 36796091; PMCID: PMC10161759.
      Citations: 1     Fields:    Translation:Humans
    32. Esposito AJ, Imani J, Shrestha S, Bagwe S, Lamattina AM, Vivero M, Goldberg HJ, Rosas IO, Henske EP, El-Chemaly SY. Lymphangioleiomyomatosis: circulating levels of FGF23 and pulmonary diffusion. J Bras Pneumol. 2023; 49(2):e20220356. PMID: 37132737; PMCID: PMC10171272.
      Citations:    Fields:    Translation:Humans
    33. De Man R, McDonough JE, Adams TS, Manning EP, Myers G, Vos R, Ceulemans L, Dupont L, Vanaudenaerde BM, Wuyts WA, Rosas IO, Hagood JS, Ambalavanan N, Niklason L, Hansen KC, Yan X, Kaminski N. A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs. bioRxiv. 2023 Apr 19. PMID: 37131739; PMCID: PMC10153177.
    34. Lee JH, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Lee CM, He CH, Park JW, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Elias JA, Lee CG. Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance. 2023 May; 6(5). PMID: 37037591; PMCID: PMC10088146.
      Citations:    Fields:    
    35. Kaul B, Petersen LA, Rosas IO, Lee JS, Martinez FJ, Bandi VD, Helmer DA, Wolters PJ, Collard HR, Whooley MA. Interstitial Lung Disease in Veterans: Leveraging Big Data to Bridge Evidence and Practice Gaps. Ann Am Thorac Soc. 2023 04; 20(4):504-507. PMID: 36623290.
      Citations:    Fields:    Translation:Humans
    36. Gordon O, Wildum S, Bauer RN, Teterina A, Shivram H, McBride J, Rosenberger CM, Cai F, Bao M, Tsai L, Lee IT, Wallin JJ, Porter D, Juneja K, Camus G, Rosas IO. Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19. Clin Transl Sci. 2023 06; 16(6):1049-1062. PMID: 36929625; PMCID: PMC10264938.
      Citations: 1     Fields:    Translation:HumansCells
    37. Hurwitz S, Maurer R, Solomon JJ, Rosas IO. Pirfenidone in rheumatoid arthritis-associated interstitial lung disease - Authors' reply. Lancet Respir Med. 2023 06; 11(6):e52. PMID: 37003284.
      Citations:    Fields:    Translation:Humans
    38. Zhao W, Wang L, Yang J, Chen X, Guo X, Xu K, Wang N, Zhao W, Xia C, Lian H, Rosas I, Yu G. Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration. Cell Commun Signal. 2023 03 13; 21(1):56. PMID: 36915092; PMCID: PMC10009991.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    39. Wang L, Zhu M, Li Y, Yan P, Li Z, Chen X, Yang J, Pan X, Zhao H, Wang S, Yuan H, Zhao M, Sun X, Wan R, Li F, Wang X, Yu H, Rosas I, Ding C, Yu G. Serum Proteomics Identifies Biomarkers Associated With the Pathogenesis of Idiopathic Pulmonary Fibrosis. Mol Cell Proteomics. 2023 04; 22(4):100524. PMID: 36870568; PMCID: PMC10113895.
      Citations: 2     Fields:    Translation:Humans
    40. Ahangari F, Price NL, Malik S, Chioccioli M, B?rnthaler T, Adams TS, Kim J, Pradeep SP, Ding S, Cosmos C, Rose KS, McDonough JE, Aurelien NR, Ibarra G, Omote N, Schupp JC, DeIuliis G, Villalba Nunez JA, Sharma L, Ryu C, Dela Cruz CS, Liu X, Prasse A, Rosas I, Bahal R, Fern?ndez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight. 2023 02 22; 8(4). PMID: 36626225; PMCID: PMC9977502.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    41. Lee JS, Petersen LA, McCulloch C, Rosas IO, Bandi VD, Zhang N, Kaul B, DeDent AM, Collard HR, Whooley MA. Disparities in Antifibrotic Medication Utilization Among Veterans With Idiopathic Pulmonary Fibrosis. Chest. 2023 08; 164(2):441-449. PMID: 36801465; PMCID: PMC10410245.
      Citations:    Fields:    Translation:Humans
    42. Rose JA, Planchart Ferretto MA, Maeda AH, Perez Garcia MF, Carmichael NE, Gulati S, Rice MB, Goldberg HJ, Putman RK, Hatabu H, Raby BA, Rosas IO, Hunninghake GM. Progressive Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 01 15; 207(2):211-214. PMID: 36099425; PMCID: PMC9893330.
    43. Rahaghi FF, Hsu VM, Kaner RJ, Mayes MD, Rosas IO, Saggar R, Steen VD, Strek ME, Bernstein EJ, Bhatt N, Castelino FV, Chung L, Domsic RT, Flaherty KR, Gupta N, Kahaleh B, Martinez FJ, Morrow LE, Moua T, Patel N, Shlobin OA, Southern BD, Volkmann ER, Khanna D. Expert consensus on the management of systemic sclerosis-associated interstitial lung disease. Respir Res. 2023 Jan 09; 24(1):6. PMID: 36624431; PMCID: PMC9830797.
      Citations: 3     Fields:    
    44. Rose JA, Menon AA, Hino T, Hata A, Nishino M, Lynch DA, Rosas IO, El-Chemaly S, Raby BA, Ash SY, Choi B, Washko GR, Silverman EK, Cho MH, Hatabu H, Putman RK, Hunninghake GM. Suspected Interstitial Lung Disease in COPDGene Study. Am J Respir Crit Care Med. 2023 01 01; 207(1):60-68. PMID: 35930450; PMCID: PMC9952869.
    45. Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP, Magnusson B. Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 12 15; 206(12):1463-1479. PMID: 35998281; PMCID: PMC9757097.
    46. Wang L, Zhao W, Xia C, Li Z, Zhao W, Xu K, Wang N, Lian H, Rosas IO, Yu G. TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF. Int J Mol Sci. 2022 Dec 11; 23(24). PMID: 36555349; PMCID: PMC9778945.
      Citations: 1     Fields:    
    47. Wang L, Xu K, Wang N, Ding L, Zhao W, Wan R, Zhao W, Guo X, Pan X, Yang J, Rosas I, Yu G. Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation. Int J Mol Sci. 2022 Nov 15; 23(22). PMID: 36430565; PMCID: PMC9693227.
      Citations:    Fields:    Translation:HumansAnimalsCells
    48. Jyothula SSK, Peters A, Liang Y, Bi W, Shivshankar P, Yau S, Garcha PS, Yuan X, Akkanti B, Collum S, Wareing N, Thandavarayan RA, Poli de Frias F, Rosas IO, Zhao B, Buja LM, Eltzschig HK, Huang HJ, Karmouty-Quintana H. Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation. EBioMedicine. 2022 Dec; 86:104351. PMID: 36375315; PMCID: PMC9667270.
      Citations: 2     Fields:    Translation:HumansCells
    49. Raghu G, Mouded M, Chambers DC, Martinez FJ, Lancaster LH, Hamblin MJ, Gibson KF, Rosas IO, Prasse A, Zhao G, Serenko M, Novikov N, McCurley A, Bansal P, Stebbins C, Arefayene M, Ibebunjo S, Violette SM, Gallagher D, Richeldi L, Behr J. A Phase IIb Randomized Clinical Study of an Anti-av?6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 11 01; 206(9):1128-1139. PMID: 35771569.
      Citations:    Fields:    
    50. Villalba JA, Hilburn CF, Garlin MA, Elliott GA, Li Y, Kunitoki K, Poli S, Alba GA, Madrigal E, Taso M, Price MC, Aviles AJ, Araujo-Medina M, Bonanno L, Boyraz B, Champion SN, Harris CK, Helland TL, Hutchison B, Jobbagy S, Marshall MS, Shepherd DJ, Barth JL, Hung YP, Ly A, Hariri LP, Turbett SE, Pierce VM, Branda JA, Rosenberg ES, Mendez-Pena J, Chebib I, Rosales IA, Smith RN, Miller MA, Rosas IO, Hardin CC, Baden LR, Medoff BD, Colvin RB, Little BP, Stone JR, Mino-Kenudson M, Shih AR. Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2022 10 01; 206(7):857-873. PMID: 35671465; PMCID: PMC9799276.
      Citations:    Fields:    
    51. Chacon-Alberty L, Kanchi RS, Ye S, Hochman-Mendez C, Daoud D, Coarfa C, Li M, Grimm SL, Baz M, Rosas I, Loor G. Plasma protein biomarkers for primary graft dysfunction after lung transplantation: a single-center cohort analysis. Sci Rep. 2022 09 27; 12(1):16137. PMID: 36167867; PMCID: PMC9515157.
      Citations:    Fields:    Translation:Humans
    52. Mehta P, Rosas IO, Singer M. Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity. Intensive Care Med. 2022 12; 48(12):1803-1806. PMID: 36074167; PMCID: PMC9453725.
    53. Solomon JJ, Danoff SK, Woodhead FA, Hurwitz S, Maurer R, Glaspole I, Dellaripa PF, Gooptu B, Vassallo R, Cox PG, Flaherty KR, Adamali HI, Gibbons MA, Troy L, Forrest IA, Lasky JA, Spencer LG, Golden J, Scholand MB, Chaudhuri N, Perrella MA, Lynch DA, Chambers DC, Kolb M, Spino C, Raghu G, Goldberg HJ, Rosas IO, TRAIL1 Network Investigators. Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study. Lancet Respir Med. 2023 01; 11(1):87-96. PMID: 36075242.
    54. Putman RK, Axelsson GT, Ash SY, Sanders JL, Menon AA, Araki T, Nishino M, Yanagawa M, Qiao D, O'Connor GT, Rosas IO, Washko GR, El-Chemaly S, Raby BA, Gudnason V, DeMeo DL, Silverman EK, Hatabu H, Cho MH, Gudmundsson G, Hunninghake GM, Gudmundsson EF, San Jos? Est?par R, Dupuis J, De Vivo I. Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 08; 60(2). PMID: 35115336; PMCID: PMC10052789.
      Citations:    Fields:    
    55. Esposito AJ, Sparks JA, Gill RR, Hatabu H, Schmidlin EJ, Hota PV, Poli S, Fletcher EA, Xiong W, Frits ML, Iannaccone CK, Prado M, Zaccardelli A, Marshall A, Dellaripa PF, Weinblatt ME, Shadick NA, Rosas IO, Doyle TJ. Screening for preclinical parenchymal lung disease in rheumatoid arthritis. Rheumatology (Oxford). 2022 08 03; 61(8):3234-3245. PMID: 34875040; PMCID: PMC9348774.
      Citations:    Fields:    
    56. Wu X, Jeong Y, Easthausen I, Hoffman K, Oromendia C, Taheri S, Esposito AJ, Quesada Arias L, Ayaub EA, Maurer R, Gill RR, Hatabu H, Nishino M, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Dellaripa PF, Choi AMK, Kim EY, Rosas IO, Martinez FJ, Doyle TJ, Poli de Fr?as S. Serum proteomic profiling of rheumatoid arthritis-interstitial lung disease with a comparison to idiopathic pulmonary fibrosis. Thorax. 2022 10; 77(10):1041-1044. PMID: 35907639; PMCID: PMC9976796.
    57. Choi B, Adan N, Doyle TJ, Humphries SM, Moll M, Cho MH, Putman RK, Hunninghake GM, Kalhan R, Liu GY, Diaz AA, Mason SE, Rahaghi FN, Pistenmaa CL, Enzer N, Poynton C, Ross JC, Martinez FJ, Han MK, Bowler RP, Wilson DO, Rosas IO, Washko GR, Ash SY, COPDGene Study and Pittsburgh Lung Screening Study Investigators, Harmouche R, Lynch DA, San Jos? Est?par R, S?nchez-Ferrero GV, San Jos? Est?par R. Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts. Chest. 2023 01; 163(1):164-175. PMID: 35780812; PMCID: PMC9859724.
      Citations:    Fields:    
    58. Imani J, Bodine SPM, Lamattina AM, Ma DD, Shrestha S, Maynard DM, Bishop K, Nwokeji A, Malicdan MCV, Testa LC, Sood R, Stump B, Rosas IO, Perrella MA, Handin R, Young LR, Gochuico BR, El-Chemaly S. Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility. Respir Res. 2022 Jun 23; 23(1):167. PMID: 35739508; PMCID: PMC9229912.
      Citations:    Fields:    Translation:HumansAnimalsCells
    59. Yang CX, Tomchaney M, Landecho MF, Zamacona BR, Marin Oto M, Zulueta J, Malo J, Knoper S, Contoli M, Papi A, Vasilescu DM, Sauler M, Straub C, Tan C, Martinez FD, Bhattacharya D, Rosas IO, Kheradmand F, Hackett TL, Polverino F. Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection. Cells. 2022 06 07; 11(12). PMID: 35740993; PMCID: PMC9220844.
      Citations:    Fields:    Translation:HumansCells
    60. Korsunsky I, Wei K, Pohin M, Kim EY, Barone F, Major T, Taylor E, Ravindran R, Kemble S, Watts GFM, Jonsson AH, Jeong Y, Athar H, Windell D, Kang JB, Friedrich M, Turner J, Nayar S, Fisher BA, Raza K, Marshall JL, Croft AP, Tamura T, Sholl LM, Vivero M, Rosas IO, Bowman SJ, Coles M, Frei AP, Lassen K, Filer A, Powrie F, Buckley CD, Brenner MB, Raychaudhuri S. Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases. Med. 2022 07 08; 3(7):481-518.e14. PMID: 35649411; PMCID: PMC9271637.
      Citations: 1     Translation:AnimalsCells
    61. Alba GA, Samokhin AO, Wang RS, Wertheim BM, Haley KJ, Padera RF, Vargas SO, Rosas IO, Hariri LP, Shih A, Thompson BT, Mitchell RN, Maron BA. Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection. Pulm Circ. 2022 Apr; 12(2):e12071. PMID: 35599981; PMCID: PMC9111030.
      Citations: 2     
    62. Tsoyi K, Rosas IO. Targeting Danger Signals to Rescue Fibrosis. Am J Respir Cell Mol Biol. 2022 05; 66(5):468-470. PMID: 35271415; PMCID: PMC9116361.
      Citations:    Fields:    Translation:HumansPHPublic Health
    63. Rosas IO, Waters M, Go RC, Malhotra A, Hunter BD, Bhagani S, Skiest D, Savic S, Douglas IS, Garcia-Diaz J, Aziz MS, Cooper N, Youngstein T, Sorbo LD, Zerda DJ, Ustianowski A, Blyth KG, Benfield T, Haslem D, Bonfanti P, van der Leest CH, Rohatgi N, Wiese L, Bauer RN, Cai F, Lee IT, Matharu B, Metcalf L, Wildum S, Graham E, Tsai L, Bao M, Br?u N, Gracian AC, Carratal? J, Fran?ois B, Luyt CE. Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA). EClinicalMedicine. 2022 May; 47:101409. PMID: 35475258; PMCID: PMC9022847.
      Citations: 1     
    64. Tom J, Bao M, Tsai L, Qamra A, Summers D, Carrasco-Triguero M, McBride J, Rosenberger CM, Lin CJF, Stubbings W, Blyth KG, Benfield T, Haslem D, Bonfanti P, van der Leest CH, Rohatgi N, Wiese L, Kheradmand F, Rosas IO, Cai F, Carratal? J, Fran?ois B, Luyt CE. Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial. Crit Care Med. 2022 03 01; 50(3):398-409. PMID: 34612846; PMCID: PMC8855771.
      Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
    65. Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO. Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Sci Rep. 2022 02 18; 12(1):2847. PMID: 35181688; PMCID: PMC8857282.
      Citations:    Fields:    Translation:HumansAnimalsCells
    66. Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nat Commun. 2022 01 25; 13(1):494. PMID: 35078977; PMCID: PMC8789871.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    67. Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y. Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis. Eur Respir J. 2021 12; 58(6). PMID: 34049947.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    68. Moss BJ, Ryter SW, Rosas IO. Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis. Annu Rev Pathol. 2022 01 24; 17:515-546. PMID: 34813355.
      Citations: 4     Fields:    Translation:HumansCells
    69. Imani J, Liu K, Cui Y, Assaker JP, Han J, Ghosh AJ, Ng J, Shrestha S, Lamattina AM, Louis PH, Hentschel A, Esposito AJ, Rosas IO, Liu X, Perrella MA, Azzi J, Visner G, El-Chemaly S. Blocking hyaluronan synthesis alleviates acute lung allograft rejection. JCI Insight. 2021 11 22; 6(22). PMID: 34665782; PMCID: PMC8663774.
      Citations:    Fields:    Translation:HumansAnimals
    70. Menon AA, Putman RK, Sanders JL, Hino T, Hata A, Nishino M, Ghosh AJ, Ash SY, Rosas IO, Cho MH, Lynch DA, Washko GR, Silverman EK, Hatabu H, Hunninghake GM. Interstitial Lung Abnormalities, Emphysema, and Spirometry in Smokers. Chest. 2022 04; 161(4):999-1010. PMID: 34742688; PMCID: PMC9005862.
      Citations: 1     Fields:    Translation:Humans
    71. Ng J, Pacheco-Rodriguez G, Begley L, Huang YJ, Poli S, Perrella MA, Rosas IO, Moss J, El-Chemaly S. The lung microbiome in end-stage Lymphangioleiomyomatosis. Respir Res. 2021 Oct 26; 22(1):277. PMID: 34702264; PMCID: PMC8549264.
      Citations:    Fields:    Translation:Humans
    72. Rosas IO, Diaz G, Gottlieb RL, Robinson P, Hunter BD, Overcash JS, Hanania NA, Skarbnik A, Garcia-Diaz J, Gordeev I, Gordon O, Graham E, Lewin-Koh N, Tsai L, Tuckwell K, Cao H, Brainard D, Olsson JK, Lobo SM, Cavalcante AW, Carratal? J. Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial. Intensive Care Med. 2021 11; 47(11):1258-1270. PMID: 34609549; PMCID: PMC8490137.
      Citations: 17     Fields:    Translation:Humans
    73. Han J, Li G, Hou M, Ng J, Kwon MY, Xiong K, Liang X, Taglauer E, Shi Y, Mitsialis SA, Kourembanas S, El-Chemaly S, Lederer JA, Rosas IO, Perrella MA, Liu X. Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice. Stem Cell Res Ther. 2021 08 30; 12(1):487. PMID: 34461993; PMCID: PMC8404310.
      Citations:    Fields:    Translation:AnimalsCells
    74. Rosas IO, Raby B, Tsai L. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. Reply. N Engl J Med. 2021 09 16; 385(12):1149. PMID: 34407336.
      Citations:    Fields:    Translation:HumansCells
    75. Han J, Shi Y, Willis G, Imani J, Kwon MY, Li G, Ayaub E, Ghanta S, Ng J, Hwang N, Tsoyi K, El-Chemaly S, Kourembanas S, Mitsialis SA, Rosas IO, Liu X, Perrella MA. Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation. FEBS J. 2022 01; 289(2):417-435. PMID: 34355516; PMCID: PMC8766882.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    76. Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO. CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 08 01; 204(3):312-325. PMID: 33784491; PMCID: PMC8513593.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    77. Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 08; 102:70-84. PMID: 34274450; PMCID: PMC8502204.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    78. Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE, Human Cell Atlas Lung Biological Network. Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Nat Commun. 2021 07 14; 12(1):4314. PMID: 34262047; PMCID: PMC8280215.
      Citations: 7     Fields:    Translation:HumansCells
    79. Shaghaghi H, Cuevas-Mora K, Para R, Tran C, Roque W, Robertson MJ, Rosas IO, Summer R, Romero F. A model of the aged lung epithelium in idiopathic pulmonary fibrosis. Aging (Albany NY). 2021 07 08; 13(13):16922-16937. PMID: 34238764; PMCID: PMC8312437.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    80. Hunninghake GM, Goldin JG, Kadoch MA, Kropski JA, Rosas IO, Wells AU, Yadav R, Lazarus HM, Abtin FG, Corte TJ, de Andrade JA, Johannson KA, Kolb MR, Lynch DA, Oldham JM, Spagnolo P, Strek ME, Tomassetti S, Washko GR, White ES, ILA Study Group. Detection and Early Referral of Patients With Interstitial Lung Abnormalities: An Expert Survey Initiative. Chest. 2022 02; 161(2):470-482. PMID: 34197782; PMCID: PMC10624930.
      Citations: 4     Fields:    Translation:Humans
    81. Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation. 2021 07 27; 144(4):286-302. PMID: 34030460; PMCID: PMC8300155.
      Citations: 22     Fields:    Translation:HumansCells
    82. Ebrahimpour A, Wang M, Li L, Jegga AG, Bonnen MD, Eissa NT, Raghu G, Jyothula S, Kheradmand F, Hanania NA, Rosas IO, Ghebre YT. Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway. J Inflamm (Lond). 2021 May 19; 18(1):17. PMID: 34011367; PMCID: PMC8136131.
      Citations: 3     
    83. Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis. Eur Respir J. 2021 04; 57(4). PMID: 33093124; PMCID: PMC8559259.
      Citations: 4     Fields:    Translation:HumansCells
    84. Wu TD, Fawzy A, Brigham E, McCormack MC, Rosas I, Villareal DT, Hanania NA. Association of Triglyceride-Glucose Index and Lung Health: A Population-Based Study. Chest. 2021 09; 160(3):1026-1034. PMID: 33839084; PMCID: PMC8449007.
      Citations: 4     Fields:    Translation:Humans
    85. Cottin V, Rosas I, Song JW, Tomassetti S, Wijsenbeek M, Schmitz M, Coeck C, Stowasser S, Schlenker-Herceg R, Kolb M, INBUILD Trial Investigators, Richeldi L, Otaola M. Nintedanib and immunomodulatory therapies in progressive fibrosing interstitial lung diseases. Respir Res. 2021 Mar 16; 22(1):84. PMID: 33726766; PMCID: PMC7962343.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    86. Muus C, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Torlai Triglia E, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Allon SJ, Andrusivova Z, Ashenberg O, Bassler K, Benhar I, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Cuoco MS, Cuomo ASE, Duclos G, Fine D, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Ludwig LS, Luo W, Madissoon E, Mamanova L, Manakongtreecheep K, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Sullivan TB, Sun D, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK, NHLBI LungMap Consortium, Human Cell Atlas Lung Biological Network, Luecken MD, Eraslan G, Sikkema L, Ansari M, Aliee H, Angelidis I, B?cavin C, Bergenstr?hle J, Bergenstr?hle L, Conlon TM, Deprez M, Fischer DS, Litvinukov? M, Lukassen S, Maatz H, Leroy S, Mayr CH, Strunz M, Talavera-L?pez C. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med. 2021 03; 27(3):546-559. PMID: 33654293; PMCID: PMC9469728.
      Citations: 79     Fields:    Translation:HumansCells
    87. Rosas IO, Waters M, Go RC, Hunter BD, Bhagani S, Skiest D, Aziz MS, Cooper N, Douglas IS, Savic S, Youngstein T, Del Sorbo L, Cubillo Gracian A, De La Zerda DJ, Ustianowski A, Bao M, Dimonaco S, Graham E, Matharu B, Spotswood H, Tsai L, Malhotra A, Br?u N. Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia. N Engl J Med. 2021 04 22; 384(16):1503-1516. PMID: 33631066; PMCID: PMC7953459.
      Citations: 270     Fields:    Translation:HumansCTClinical Trials
    88. Lee JS, Lau J, Sebastiani M, Koduri G, Matteson E, Cavagna L, Bozzalla Cassione E, Manfredi A, Gazal S, Marchand-Adam S, Dromer C, Truchetet ME, Richez C, Schaeverbeke T, Deane KD, Solomon JJ, Doyle T, Ryu JH, Rosas I, Holers VM, Schwartz DA, Vassallo R, Juge PA, Kawano-Dourado L, Rojas Serrano J, Bonfiglioli K, Sawamura M, Kairalla R, Mejia M, Rodr?guez-Henriquez P, Gonz?lez-P?rez MI, Falf?n-Valencia R, Buendia-Rold?n I, P?rez-Rubio G, Ebstein E, Borie R, Ottaviani S, Kannengiesser C, Wallaert B, Uzunhan Y, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Wemeau-Stervinou L, Flipo RM, Richette P, Allanore Y, Liot? H, Thabut G, Boileau C, Debray MP, Porcher R, Crestani B, Dieud? P. Methotrexate and rheumatoid arthritis associated interstitial lung disease. Eur Respir J. 2021 02; 57(2). PMID: 32646919; PMCID: PMC8212188.
      Citations: 16     Fields:    Translation:Humans
    89. Cuevas-Mora K, Roque W, Shaghaghi H, Gochuico BR, Rosas IO, Summer R, Romero F. Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung. Respir Res. 2021 Feb 08; 22(1):49. PMID: 33557836; PMCID: PMC7871590.
      Citations: 2     Fields:    Translation:AnimalsCells
    90. Carmichael N, Martinez Manzano JM, Quesada-Arias LD, Baumgartner MA, Planchart Ferretto MA, DiGianni L, Gampala-Sagar S, Leone DA, Gulati S, El-Chemaly SY, Goldberg HJ, Putman R, Hatabu H, Rosas IO, Hunninghake GM, Raby BA, Poli SF. Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals. Thorax. 2021 06; 76(6):621-623. PMID: 33483364; PMCID: PMC8238310.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    91. Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE, Human Cell Atlas Lung Biological Network . Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. bioRxiv. 2021 Jan 04. PMID: 33106805; PMCID: PMC7587778.
    92. Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. Am J Respir Crit Care Med. 2020 11 15; 202(10):1419-1429. PMID: 32603604; PMCID: PMC7667912.
      Citations: 16     Fields:    Translation:Humans
    93. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 11 01; 202(9):1225-1236. PMID: 32551799; PMCID: PMC7605184.
      Citations: 7     Fields:    Translation:HumansCells
    94. Hettiarachchi SU, Li YH, Roy J, Zhang F, Puchulu-Campanella E, Lindeman SD, Srinivasarao M, Tsoyi K, Liang X, Ayaub EA, Nickerson-Nutter C, Rosas IO, Low PS. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 10 28; 12(567). PMID: 33115948.
      Citations: 11     Fields:    Translation:AnimalsCells
    95. Billatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, Rosas IO, Ross JC, Xiao X, Liu H, Liu G, Sukumar G, Wilkerson M, Dalgard C, Stevenson C, Whitney D, Aberle D, Spira A, Lenburg ME, Washko GR, DECAMP and COPDGene Investigators, San Jos? Est?par R, San Jos? Est?par R. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features. Chest. 2021 02; 159(2):549-563. PMID: 32946850; PMCID: PMC8039011.
      Citations:    Fields:    Translation:Humans
    96. Shrestha S, Cho W, Stump B, Imani J, Lamattina AM, Louis PH, Pazzanese J, Rosas IO, Visner G, Perrella MA, El-Chemaly S. FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020 07 31; 26(1):75. PMID: 32736525; PMCID: PMC7395348.
      Citations:    Fields:    Translation:HumansAnimalsCells
    97. Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Sci Adv. 2020 07; 6(28):eaba1983. PMID: 32832599; PMCID: PMC7439502.
      Citations: 174     Fields:    Translation:HumansCells
    98. Zhang F, Ayaub EA, Wang B, Puchulu-Campanella E, Li YH, Hettiarachchi SU, Lindeman SD, Luo Q, Rout S, Srinivasarao M, Cox A, Tsoyi K, Nickerson-Nutter C, Rosas IO, Low PS. Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis. EMBO Mol Med. 2020 08 07; 12(8):e12034. PMID: 32597014; PMCID: PMC7411553.
      Citations: 12     Fields:    Translation:AnimalsCells
    99. Courtwright AM, Lamattina AM, Takahashi M, Trindade AJ, Hunninghake GM, Rosas IO, Agarwal S, Raby BA, Goldberg HJ, El-Chemaly S. Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival. ERJ Open Res. 2020 Apr; 6(2). PMID: 32577419; PMCID: PMC7293991.
      Citations: 6     
    100. El-Chemaly S, Taveira-DaSilva A, Bagwe S, Klonowska K, Machado T, Lamattina AM, Goldberg HJ, Jones AM, Julien-Williams P, Maurer R, Rosas IO, Henske EP, Moss J, Kwiatkowski DJ. Celecoxib in lymphangioleiomyomatosis: results of a phase I clinical trial. Eur Respir J. 2020 05; 55(5). PMID: 32060062.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    101. Doyle TJ, Rosas IO, Kawano-Dourado L, Bonfiglioli K, Sawamura MVY, Nakagawa RH, Arimura FE, Lee HJ, Rangel DAS, Bueno C, Carvalho CRR, Sabbag ML, Molina C, Kairalla RA. Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis. Chest. 2020 10; 158(4):1546-1554. PMID: 32428513; PMCID: PMC7545491.
      Citations: 11     Fields:    Translation:Humans
    102. Hunninghake GM, Quesada-Arias LD, Carmichael NE, Martinez Manzano JM, Baumgartner MA, DiGianni L, Gampala-Sagar SN, Leone DA, Gulati S, El-Chemaly S, Goldberg HJ, Putman RK, Hatabu H, Raby BA, Rosas IO, Poli De Fr?as S. Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 05 15; 201(10):1240-1248. PMID: 32011908; PMCID: PMC7233344.
      Citations: 15     Fields:    Translation:Humans
    103. Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020 05 13; 12(543). PMID: 32404506; PMCID: PMC8259900.
      Citations: 21     Fields:    Translation:AnimalsCells
    104. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun. 2020 04 21; 11(1):1920. PMID: 32317643; PMCID: PMC7174390.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    105. Hou M, Han J, Li G, Kwon MY, Jiang J, Emani S, Taglauer ES, Park JA, Choi EB, Vodnala M, Fong YW, Emani SM, Rosas IO, Perrella MA, Liu X. Multipotency of mouse trophoblast stem cells. Stem Cell Res Ther. 2020 02 13; 11(1):55. PMID: 32054514; PMCID: PMC7020558.
      Citations: 2     Fields:    Translation:AnimalsCells
    106. Kass DJ, Nouraie M, Glassberg MK, Ramreddy N, Fernandez K, Harlow L, Zhang Y, Chen J, Kerr GS, Reimold AM, England BR, Mikuls TR, Gibson KF, Dellaripa PF, Rosas IO, Oddis CV, Ascherman DP. Comparative Profiling of Serum Protein Biomarkers in Rheumatoid Arthritis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis. Arthritis Rheumatol. 2020 03; 72(3):409-419. PMID: 31532072.
      Citations: 9     Fields:    Translation:Humans
    107. Chu SG, Poli De Frias S, Raby BA, Rosas IO. An RNA-seq primer for pulmonologists. Eur Respir J. 2020 01; 55(1). PMID: 31601712.
      Citations:    Fields:    Translation:Humans
    108. Chu SG, Poli De Frias S, Sakairi Y, Kelly RS, Chase R, Konishi K, Blau A, Tsai E, Tsoyi K, Padera RF, Sholl LM, Goldberg HJ, Mallidi HR, Camp PC, El-Chemaly SY, Perrella MA, Choi AMK, Washko GR, Raby BA, Rosas IO. Biobanking and cryopreservation of human lung explants for omic analysis. Eur Respir J. 2020 01; 55(1). PMID: 31699836; PMCID: PMC7066468.
      Citations: 4     Fields:    Translation:Humans
    109. Solomon JJ, Matson S, Kelmenson LB, Chung JH, Hobbs SB, Rosas IO, Dellaripa PF, Doyle TJ, Poli S, Esposito AJ, Visser A, Marin AI, Amigues I, Brown KK, Mahler M, Heinz D, Cool C, Deane KD, Swigris JJ, Demoruelle MK, Fern?ndez P?rez ER. IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis. Chest. 2020 06; 157(6):1513-1521. PMID: 31877269; PMCID: PMC7268435.
      Citations: 8     Fields:    Translation:Humans
    110. Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Single-cell connectomic analysis of adult mammalian lungs. Sci Adv. 2019 12; 5(12):eaaw3851. PMID: 31840053; PMCID: PMC6892628.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    111. Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Xu H, O'Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O'Neal WK, Newell JD, Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM, Dupuis J. Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 12 01; 200(11):1402-1413. PMID: 31339356; PMCID: PMC6884045.
      Citations: 27     Fields:    Translation:HumansCells
    112. Chu SG, Villalba JA, Liang X, Xiong K, Tsoyi K, Ith B, Ayaub EA, Tatituri RV, Byers DE, Hsu FF, El-Chemaly S, Kim EY, Shi Y, Rosas IO. Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress. Am J Respir Cell Mol Biol. 2019 12; 61(6):737-746. PMID: 31461627; PMCID: PMC6890409.
      Citations: 20     Fields:    Translation:AnimalsCells
    113. Casanova N, Zhou T, Gonzalez-Garay ML, Rosas IO, Goldberg HJ, Ryter SW, Collard HR, El-Chemaly S, Flaherty KR, Hunninghake GM, Lasky JA, Lederer DJ, Machado RF, Martinez FJ, Noth I, Raghu G, Choi AMK, Garcia JGN. Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes. Sci Rep. 2019 10 15; 9(1):14802. PMID: 31615996; PMCID: PMC6794274.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    114. Solomon JJ, Danoff SK, Goldberg HJ, Woodhead F, Kolb M, Chambers DC, DiFranco D, Spino C, Haynes-Harp S, Hurwitz S, Peters EB, Dellaripa PF, Rosas IO, Trail Network. The Design and Rationale of the Trail1 Trial: A Randomized Double-Blind Phase 2 Clinical Trial of Pirfenidone in Rheumatoid Arthritis-Associated Interstitial Lung Disease. Adv Ther. 2019 11; 36(11):3279-3287. PMID: 31515704.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    115. Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, Iannaccone CK, Mahmoud TG, Frits ML, Lu B, Rosas IO, Dellaripa PF, Weinblatt ME, Karlson EW, Shadick NA, Doyle TJ. Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study. Arthritis Rheumatol. 2019 09; 71(9):1472-1482. PMID: 30951251; PMCID: PMC6716994.
      Citations: 26     Fields:    Translation:Humans
    116. Putman RK, Gudmundsson G, Axelsson GT, Hida T, Honda O, Araki T, Yanagawa M, Nishino M, Miller ER, Eiriksdottir G, Tomiyama N, Honda H, Rosas IO, Washko GR, Cho MH, Schwartz DA, Gudnason V, Hatabu H, Hunninghake GM, Gudmundsson EF. Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality. Am J Respir Crit Care Med. 2019 07 15; 200(2):175-183. PMID: 30673508; PMCID: PMC6635786.
      Citations: 39     Fields:    Translation:Humans
    117. Tang Y, El-Chemaly S, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Rosas IO, Moss J, Priolo C, Henske EP. Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient Cells. Chest. 2019 12; 156(6):1137-1148. PMID: 31299246; PMCID: PMC6904859.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    118. Harmouche R, Ash SY, Putman RK, Hunninghake GM, San Jose Estepar R, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Han MK, Bowler RP, Kalhan R, Rosas IO, Washko GR, San Jose Estepar R, COPDGene Investigators. Objectively Measured Chronic Lung Injury?on Chest CT. Chest. 2019 12; 156(6):1149-1159. PMID: 31233744; PMCID: PMC6904856.
      Citations: 4     Fields:    Translation:Humans
    119. Courtwright AM, Lamattina AM, Louis PH, Trindade AJ, Burkett P, Imani J, Shrestha S, Divo M, Keller S, Rosas IO, Goldberg HJ, El-Chemaly S. Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients. Sci Rep. 2019 06 21; 9(1):9003. PMID: 31227795; PMCID: PMC6588572.
      Citations: 3     Fields:    Translation:Humans
    120. Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO. Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness. Am J Respir Cell Mol Biol. 2019 06; 60(6):659-666. PMID: 30562054; PMCID: PMC6543747.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    121. Lee CM, He CH, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG. Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance. 2019 06; 2(3). PMID: 31085559; PMCID: PMC6516052.
      Citations: 9     Fields:    Translation:HumansCells
    122. Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S. Glycogen synthase kinase 3-? inhibition induces lymphangiogenesis through ?-catenin-dependent and mTOR-independent pathways. PLoS One. 2019; 14(4):e0213831. PMID: 30964887; PMCID: PMC6456176.
      Citations: 3     Fields:    Translation:HumansCells
    123. Miller ER, Putman RK, Diaz AA, Xu H, Araki T, Nishino M, Hida T, Ross J, Coxson H, O'Connor GT, Silverman EK, Rosas IO, Hatabu H, Washko G, Hunninghake GM, San Jos? Est?par R, Poli de Fr?as S, Dupuis J. Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2019 04; 16(4):447-454. PMID: 30543456; PMCID: PMC6441702.
      Citations: 13     Fields:    Translation:Humans
    124. Lamattina AM, Poli S, Kidambi P, Bagwe S, Courtwright A, Louis PH, Shrestha S, Stump B, Goldberg HJ, Thiele EA, Rosas I, Henske EP, El-Chemaly S. Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis. Orphanet J Rare Dis. 2019 03 29; 14(1):72. PMID: 30922357; PMCID: PMC6440133.
      Citations:    Fields:    Translation:Humans
    125. Sparks JA, Doyle TJ, He X, Pan B, Iannaccone C, Frits ML, Dellaripa PF, Rosas IO, Lu B, Weinblatt ME, Shadick NA, Karlson EW. Incidence and predictors of dyspnea on exertion in a prospective cohort of patients with rheumatoid arthritis. ACR Open Rheumatol. 2019 Mar; 1(1):4-15. PMID: 30923795; PMCID: PMC6433160.
      Citations: 2     
    126. Ryter SW, Rosas IO, Owen CA, Martinez FJ, Choi ME, Lee CG, Elias JA, Choi AMK. Mitochondrial Dysfunction as a Pathogenic Mediator of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2018 12; 15(Suppl 4):S266-S272. PMID: 30759019; PMCID: PMC6944396.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    127. Juge PA, Lee JS, Ebstein E, Furukawa H, Dobrinskikh E, Gazal S, Kannengiesser C, Ottaviani S, Oka S, Tohma S, Tsuchiya N, Rojas-Serrano J, Gonz?lez-P?rez MI, Mej?a M, Buend?a-Rold?n I, Falf?n-Valencia R, Ambrocio-Ortiz E, Manali E, Papiris SA, Karageorgas T, Boumpas D, Antoniou K, van Moorsel CHM, van der Vis J, de Man YA, Grutters JC, Wang Y, Borie R, Wemeau-Stervinou L, Wallaert B, Flipo RM, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Marchand-Adam S, Frazier A, Richette P, Allanore Y, Sibilia J, Dromer C, Richez C, Schaeverbeke T, Liot? H, Thabut G, Nathan N, Amselem S, Soubrier M, Cottin V, Cl?ment A, Deane K, Walts AD, Fingerlin T, Fischer A, Ryu JH, Matteson EL, Niewold TB, Assayag D, Gross A, Wolters P, Schwarz MI, Holers M, Solomon JJ, Doyle T, Rosas IO, Blauwendraat C, Nalls MA, Debray MP, Boileau C, Crestani B, Schwartz DA, Dieud? P. MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease. N Engl J Med. 2018 12 06; 379(23):2209-2219. PMID: 30345907; PMCID: PMC6371965.
      Citations: 99     Fields:    Translation:HumansCells
    128. Lee CM, Cho SJ, Cho WK, Park JW, Lee JH, Choi AM, Rosas IO, Zheng M, Peltz G, Lee CG, Elias JA. Laminin a1 is a genetic modifier of TGF-?1-stimulated pulmonary fibrosis. JCI Insight. 2018 09 20; 3(18). PMID: 30232270; PMCID: PMC6237225.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    129. Lamattina AM, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Cui Y, Rosas IO, Moss J, Henske EP, El-Chemaly S. Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis. Chest. 2018 11; 154(5):1070-1082. PMID: 30144422; PMCID: PMC6224706.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    130. Romero F, Hong X, Shah D, Kallen CB, Rosas I, Guo Z, Schriner D, Barta J, Shaghaghi H, Hoek JB, Mesaros C, Choi AM, Snyder NW, Summer R. Lipid Synthesis Is Required to Resolve Endoplasmic Reticulum Stress and Limit Fibrotic Responses in the Lung. Am J Respir Cell Mol Biol. 2018 08; 59(2):225-236. PMID: 29465261; PMCID: PMC6096342.
      Citations: 23     Fields:    Translation:HumansAnimals
    131. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899023; PMCID: PMC6223025.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    132. Ash SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Vegas Sanchez-Ferrero G, Putman RK, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR, COPDGene Investigators. Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. Radiology. 2018 08; 288(2):600-609. PMID: 29869957; PMCID: PMC6069608.
      Citations: 9     Fields:    Translation:Humans
    133. Courtwright AM, Kidambi P, Cui Y, Lamattina AM, Villalba JA, Bagwe S, Goldberg HJ, Rosas IO, Henske EP, El-Chemaly S, Baldi BG, Carvalho CRR. Characterization of lymphangioleiomyomatosis patients with discordance between spirometric and diffusion measurements of pulmonary function. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(3):206-212. PMID: 32476904; PMCID: PMC7170150.
      Citations: 1     Fields:    
    134. Doyle TJ, Dhillon N, Madan R, Cabral F, Fletcher EA, Koontz DC, Aggarwal R, Osorio JC, Rosas IO, Oddis CV, Dellaripa PF. Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review. J Rheumatol. 2018 06; 45(6):841-850. PMID: 29606668; PMCID: PMC5984657.
      Citations: 22     Fields:    Translation:Humans
    135. Miller ER, Putman RK, Vivero M, Hung Y, Araki T, Nishino M, Washko GR, Rosas IO, Hatabu H, Sholl LM, Hunninghake GM. Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections. Am J Respir Crit Care Med. 2018 04 01; 197(7):955-958. PMID: 28934558; PMCID: PMC6020414.
      Citations: 31     Fields:    Translation:Humans
    136. El-Chemaly S, O'Brien KJ, Nathan SD, Weinhouse GL, Goldberg HJ, Connors JM, Cui Y, Astor TL, Camp PC, Rosas IO, Lemma M, Speransky V, Merideth MA, Gahl WA, Gochuico BR. Clinical management and outcomes of patients with Hermansky-Pudlak syndrome pulmonary fibrosis evaluated for lung transplantation. PLoS One. 2018; 13(3):e0194193. PMID: 29547626; PMCID: PMC5856338.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    137. Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, Hunninghake GM, San Jose Estepar R, Washko GR, COPDGene Investigators. Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers. Thorax. 2018 11; 73(11):1071-1074. PMID: 29440587; PMCID: PMC6089672.
      Citations: 4     Fields:    Translation:HumansCells
    138. Ghanta S, Kwon MY, Rosas IO, Liu X, Perrella MA. Mesenchymal Stromal Cell Therapy: Does the Source Matter? Crit Care Med. 2018 02; 46(2):343-345. PMID: 29337802; PMCID: PMC5819753.
      Citations: 1     Fields:    Translation:HumansCells
    139. Tsoyi K, Chu SG, Patino-Jaramillo NG, Wilder J, Villalba J, Doyle-Eisele M, McDonald J, Liu X, El-Chemaly S, Perrella MA, Rosas IO. Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148. Am J Respir Cell Mol Biol. 2018 02; 58(2):208-215. PMID: 28886261; PMCID: PMC5805997.
      Citations: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    140. Courtwright AM, Burkett P, Divo M, Keller S, Rosas IO, Trindade A, Mody GN, Singh SK, El-Chemaly S, Camp PC, Goldberg HJ, Mallidi HR. Posttransplant Lymphoproliferative Disorders in Epstein-Barr Virus Donor Positive/Recipient Negative Lung Transplant Recipients. Ann Thorac Surg. 2018 Feb; 105(2):441-447. PMID: 29223419.
      Citations: 3     Fields:    Translation:HumansCells
    141. Rosas IO, Goldberg HJ, Collard HR, El-Chemaly S, Flaherty K, Hunninghake GM, Lasky JA, Lederer DJ, Machado R, Martinez FJ, Maurer R, Teller D, Noth I, Peters E, Raghu G, Garcia JGN, Choi AMK. A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis. Chest. 2018 01; 153(1):94-104. PMID: 29100885; PMCID: PMC6026220.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    142. Diaz AA, Strand M, Coxson HO, Ross JC, San Jose Estepar R, Lynch D, van Rikxoort EM, Rosas IO, Hunninghake GM, Putman RK, Hatabu H, Yen A, Kinney GL, Hokanson JE, Silverman EK, Crapo J, Washko GR. Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers. Chest. 2018 03; 153(3):638-645. PMID: 29066389; PMCID: PMC5989632.
      Citations: 9     Fields:    Translation:Humans
    143. Herazo-Maya JD, Sun J, Molyneaux PL, Li Q, Villalba JA, Tzouvelekis A, Lynn H, Juan-Guardela BM, Risquez C, Osorio JC, Yan X, Michel G, Aurelien N, Lindell KO, Klesen MJ, Moffatt MF, Cookson WO, Zhang Y, Garcia JGN, Noth I, Prasse A, Bar-Joseph Z, Gibson KF, Zhao H, Herzog EL, Rosas IO, Maher TM, Kaminski N. Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study. Lancet Respir Med. 2017 11; 5(11):857-868. PMID: 28942086; PMCID: PMC5677538.
      Citations: 37     Fields:    Translation:HumansCells
    144. Putman RK, Gudmundsson G, Araki T, Nishino M, Sigurdsson S, Aspelund T, Ross JC, Miller ER, Yamada Y, Yanagawa M, Tomiyama N, Launer LJ, Harris TB, El-Chemaly S, Raby BA, Cho MH, Rosas IO, Washko GR, Schwartz DA, Silverman EK, Gudnason V, Hatabu H, Hunninghake GM, Gudmundsson EF, Eir?ksdott?r G, San Jos? Est?par R. The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes. Eur Respir J. 2017 09; 50(3). PMID: 28893869; PMCID: PMC5687883.
      Citations: 26     Fields:    Translation:HumansCells
    145. Diaz AA, Rahaghi FN, Doyle TJ, Young TP, Maclean ES, Martinez CH, Guerra S, Tesfaigzi Y, Rosas IO, Washko GR, Wilson DO, San Jos? Est?par R. Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study. Chronic Obstr Pulm Dis. 2017 Sep 05; 4(4):297-304. PMID: 29354674; PMCID: PMC5764843.
      Citations: 2     
    146. Zazueta OE, Preston SE, Moniodis A, Fried S, Kim M, Townsend K, Wood I, Boukedes S, Guleria I, Camp P, El-Chemaly S, Rosas IO, Chandraker A, Milford E, Goldberg HJ. The Presence of Pretransplant HLA Antibodies Does Not Impact the Development of Chronic Lung Allograft Dysfunction or CLAD-Related Death. Transplantation. 2017 09; 101(9):2207-2212. PMID: 27893614.
      Citations: 8     Fields:    Translation:Humans
    147. Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA, ATS Assembly on Respiratory Cell and Molecular Biology. An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases. Ann Am Thorac Soc. 2017 Aug; 14(8):1239-1247. PMID: 28763267; PMCID: PMC5946685.
      Citations:    Fields:    Translation:HumansAnimals
    148. Ash SY, Harmouche R, Putman RK, Ross JC, Diaz AA, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, San Jose Estepar R, Washko GR, COPDGene Investigators. Clinical and Genetic Associations of Objectively Identified Interstitial Changes in?Smokers. Chest. 2017 10; 152(4):780-791. PMID: 28506611; PMCID: PMC5812756.
      Citations: 14     Fields:    Translation:HumansCells
    149. Gazourian L, Ash S, Meserve EEK, Diaz A, Estepar RSJ, El-Chemaly SY, Rosas IO, Divo M, Fuhlbrigge AL, Camp PC, Ho VT, Bhatt AS, Goldberg HJ, Sholl LM, Washko GR. Quantitative computed tomography assessment of bronchiolitis obliterans syndrome after lung transplantation. Clin Transplant. 2017 05; 31(5). PMID: 28244139; PMCID: PMC5723437.
      Citations: 6     Fields:    Translation:Humans
    150. Moniodis A, Townsend K, Rabin A, Aloum O, Stempel J, Burkett P, Camp P, Divo M, El-Chemaly S, Mallidi H, Rosas I, Fuhlbrigge A, Koo S, Goldberg HJ. Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction. J Heart Lung Transplant. 2018 03; 37(3):340-348. PMID: 28431983.
      Citations: 9     Fields:    Translation:Humans
    151. Ash SY, Harmouche R, Vallejo DL, Villalba JA, Ostridge K, Gunville R, Come CE, Onieva Onieva J, Ross JC, Hunninghake GM, El-Chemaly SY, Doyle TJ, Nardelli P, Sanchez-Ferrero GV, Goldberg HJ, Rosas IO, San Jose Estepar R, Washko GR. Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis. Respir Res. 2017 03 07; 18(1):45. PMID: 28264721; PMCID: PMC5340000.
      Citations: 28     Fields:    Translation:Humans
    152. Cui Y, Steagall WK, Lamattina AM, Pacheco-Rodriguez G, Stylianou M, Kidambi P, Stump B, Golzarri F, Rosas IO, Priolo C, Henske EP, Moss J, El-Chemaly S. Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation. Cancer Res. 2017 03 15; 77(6):1492-1502. PMID: 28202529; PMCID: PMC5358967.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    153. El-Chemaly S, Taveira-Dasilva A, Goldberg HJ, Peters E, Haughey M, Bienfang D, Jones AM, Julien-Williams P, Cui Y, Villalba JA, Bagwe S, Maurer R, Rosas IO, Moss J, Henske EP. Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis: Results of a Phase I Clinical Trial. Chest. 2017 06; 151(6):1302-1310. PMID: 28192114; PMCID: PMC6026235.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    154. Araki T, Putman RK, Hatabu H, Gao W, Latourelle JC, Nishino M, Zazueta OE, Kurugol S, Ross JC, Schwartz DA, Rosas IO, Washko GR, O'Connor GT, Hunninghake GM, Dupuis J, San Jos? Est?par R. Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study. Am J Respir Crit Care Med. 2016 12 15; 194(12):1514-1522. PMID: 27314401; PMCID: PMC5215030.
      Citations: 91     Fields:    Translation:Humans
    155. Ash SY, Harmouche R, Ross JC, Diaz AA, Hunninghake GM, Putman RK, Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, Estepar RSJ, Washko GR. The Objective Identification and Quantification of Interstitial Lung Abnormalities in Smokers. Acad Radiol. 2017 08; 24(8):941-946. PMID: 27989445; PMCID: PMC5472510.
      Citations: 18     Fields:    Translation:Humans
    156. White ES, Xia M, Murray S, Dyal R, Flaherty CM, Flaherty KR, Moore BB, Cheng L, Doyle TJ, Villalba J, Dellaripa PF, Rosas IO, Kurtis JD, Martinez FJ. Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med. 2016 11 15; 194(10):1242-1251. PMID: 27149370; PMCID: PMC5114439.
      Citations: 53     Fields:    Translation:Humans
    157. Rosas IO. Imaging and molecular biomarkers: a novel approach to screen populations at risk of pulmonary fibrosis? Eur Respir J. 2016 11; 48(5):1271-1273. PMID: 27799380.
      Citations:    Fields:    Translation:Humans
    158. Courtwright AM, Fried S, Villalba JA, Moniodis A, Guleria I, Wood I, Milford E, Mallidi HH, Hunninghake GM, Raby BA, Agarwal S, Camp PC, Rosas IO, Goldberg HJ, El-Chemaly S. Association of Donor and Recipient Telomere Length with Clinical Outcomes following Lung Transplantation. PLoS One. 2016; 11(9):e0162409. PMID: 27589328; PMCID: PMC5010211.
      Citations: 11     Fields:    Translation:HumansCells
    159. Stout-Delgado HW, Cho SJ, Chu SG, Mitzel DN, Villalba J, El-Chemaly S, Ryter SW, Choi AM, Rosas IO. Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation. Am J Respir Cell Mol Biol. 2016 08; 55(2):252-63. PMID: 26933834; PMCID: PMC4979364.
      Citations: 56     Fields:    Translation:AnimalsCells
    160. Travers TS, Harlow L, Rosas IO, Gochuico BR, Mikuls TR, Bhattacharya SK, Camacho CJ, Ascherman DP. Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes. J Immunol. 2016 09 01; 197(5):1926-36. PMID: 27448590; PMCID: PMC5061338.
      Citations: 16     Fields:    Translation:HumansCells
    161. Courtwright AM, Salomon S, Fuhlbrigge A, Divo M, Rosas IO, Camp PC, Mallidi HH, Burkett P, El-Chemaly S, Wolfe DJ, Goldberg HJ. Predictors and outcomes of unplanned early rehospitalization in the first year following lung transplantation. Clin Transplant. 2016 09; 30(9):1053-8. PMID: 27312895.
      Citations: 3     Fields:    Translation:Humans
    162. Ho JE, Gao W, Levy D, Santhanakrishnan R, Araki T, Rosas IO, Hatabu H, Latourelle JC, Nishino M, Washko GR, O'Connor GT, Hunninghake GM, Dupuis J. Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2016 07 01; 194(1):77-83. PMID: 26771117; PMCID: PMC4960628.
      Citations: 22     Fields:    Translation:Humans
    163. Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, K?nigshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim A?, Noessner E, Eickelberg O, Meiners S. Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 01; 193(11):1230-41. PMID: 26756824.
      Citations: 19     Fields:    Translation:HumansAnimals
    164. Chu SG, El-Chemaly S, Rosas IO. Genetics and Idiopathic Interstitial Pneumonias. Semin Respir Crit Care Med. 2016 06; 37(3):321-30. PMID: 27231858.
      Citations: 2     Fields:    Translation:Humans
    165. Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists. Am J Respir Cell Mol Biol. 2016 05; 54(5):656-63. PMID: 26550921; PMCID: PMC4942196.
      Citations: 22     Fields:    Translation:HumansCells
    166. Putman RK, Hatabu H, Araki T, Gudmundsson G, Gao W, Nishino M, Okajima Y, Latourelle JC, Cho MH, El-Chemaly S, Coxson HO, Celli BR, Zazueta OE, Ross JC, Harmouche R, Diaz AA, Sigurdsson S, Aspelund T, Budoff MJ, Kinney GL, Hokanson JE, Williams MC, Murchison JT, MacNee W, Hoffmann U, O'Donnell CJ, Launer LJ, Harrris TB, Gudnason V, Silverman EK, O'Connor GT, Washko GR, Rosas IO, Hunninghake GM, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, COPDGene Investigators, Dupuis J, Fernandez IE, Est?par RS, Gudmundsson EF, Eir?ksdott?r G. Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA. 2016 Feb 16; 315(7):672-81. PMID: 26881370; PMCID: PMC4828973.
      Citations: 130     Fields:    Translation:Humans
    167. Wells AU, Rosas IO. Broad Therapeutic Efficacy of Nintedanib in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Jan 15; 193(2):112-3. PMID: 26771414; PMCID: PMC4731716.
      Citations: 4     Fields:    Translation:Humans
    168. Bertero T, Cottrill KA, Annis S, Bhat B, Gochuico BR, Osorio JC, Rosas I, Haley KJ, Corey KE, Chung RT, Nelson Chau B, Chan SY. A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions. Sci Rep. 2015 Dec 15; 5:18277. PMID: 26667495; PMCID: PMC4678880.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    169. Kliment CR, Araki T, Doyle TJ, Gao W, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O'Connor GT, Hatabu H, Hunninghake GM, Dupuis J, Est?par RS. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015 Oct 29; 15:134. PMID: 26514822; PMCID: PMC4625729.
      Citations: 20     Fields:    Translation:HumansCells
    170. Cui Y, Liu K, Monzon-Medina ME, Padera RF, Wang H, George G, Toprak D, Abdelnour E, D'Agostino E, Goldberg HJ, Perrella MA, Forteza RM, Rosas IO, Visner G, El-Chemaly S. Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection. J Clin Invest. 2015 Nov 02; 125(11):4255-68. PMID: 26485284; PMCID: PMC4639995.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    171. Jacob S, Courtwright A, El-Chemaly S, Racila E, Divo M, Burkett P, Fuhlbrigge A, Goldberg HJ, Rosas IO, Camp P. Donor-acquired fat embolism syndrome after lung transplantation. Eur J Cardiothorac Surg. 2016 May; 49(5):1344-7. PMID: 26468269; PMCID: PMC6279222.
      Citations: 3     Fields:    Translation:Humans
    172. Sheikh AQ, Misra A, Rosas IO, Greif DM, Adams RH. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Sci Transl Med. 2015 Oct 07; 7(308):308ra159. PMID: 26446956; PMCID: PMC4629985.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    173. Rosas I, R?os B, Torres-Jard?n R, Ram?rez-Arriaga E, Mart?nez-Bernal A. Diurnal variations of airborne pollen concentration and the effect of ambient temperature in three sites of Mexico City. Int J Biometeorol. 2016 May; 60(5):771-87. PMID: 26431700.
      Citations: 2     Fields:    Translation:Animals
    174. Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Sholl L, Rosas IO, Celli BR, Owen CA, Agust? A. B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Sep 15; 192(6):695-705. PMID: 26073875; PMCID: PMC4595676.
      Citations: 48     Fields:    Translation:HumansCells
    175. Doyle TJ, Fletcher EA, Ascherman DP, Rosas IO, Paulin F. Rheumatoid Arthritis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: Shared Mechanistic and Phenotypic Traits Suggest Overlapping Disease Mechanisms. Rev Invest Clin. 2015 Sep-Oct; 67(5):280-6. PMID: 26696331; PMCID: PMC4690466.
      Citations: 20     Fields:    Translation:Humans
    176. Goldberg HJ, Harari S, Cottin V, Rosas IO, Peters E, Biswal S, Cheng Y, Khindri S, Kovarik JM, Ma S, McCormack FX, Henske EP. Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study. Eur Respir J. 2015 Sep; 46(3):783-94. PMID: 26113676.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    177. Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. Am J Respir Crit Care Med. 2015 Jun 15; 191(12):1403-12. PMID: 25822095; PMCID: PMC4476561.
      Citations: 58     Fields:    Translation:Humans
    178. George G, Rosas IO, Cui Y, McKane C, Hunninghake GM, Camp PC, Raby BA, Goldberg HJ, El-Chemaly S. Short telomeres, telomeropathy, and subclinical extrapulmonary organ damage in patients with interstitial lung disease. Chest. 2015 Jun; 147(6):1549-1557. PMID: 25393420; PMCID: PMC4451709.
      Citations: 19     Fields:    Translation:HumansCells
    179. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713. PMID: 25825391; PMCID: PMC4459813.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    180. Patel AS, Song JW, Chu SG, Mizumura K, Osorio JC, Shi Y, El-Chemaly S, Lee CG, Rosas IO, Elias JA, Choi AM, Morse D. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis. PLoS One. 2015; 10(3):e0121246. PMID: 25785991; PMCID: PMC4364993.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    181. Araki T, Nishino M, Zazueta OE, Gao W, Okajima Y, Latourelle JC, Rosas IO, Murakami T, O'Connor GT, Washko GR, Hunninghake GM, Hatabu H, Dupuis J. Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities. Eur J Radiol. 2015 Jul; 84(7):1413-8. PMID: 25868675; PMCID: PMC4450117.
      Citations: 26     Fields:    Translation:Humans
    182. Rosas IO, Kaminski N. Update in diffuse parenchymal lung disease, 2013. Am J Respir Crit Care Med. 2015 Feb 01; 191(3):270-4. PMID: 25635490; PMCID: PMC4351573.
      Citations: 1     Fields:    Translation:Humans
    183. Grewal AS, Padera RF, Boukedes S, Divo M, Rosas IO, Camp PC, Fuhlbrigge A, Goldberg H, El-Chemaly S. Prevalence and outcome of lung cancer in lung transplant recipients. Respir Med. 2015 Mar; 109(3):427-33. PMID: 25616348.
      Citations: 11     Fields:    Translation:Humans
    184. Chen J, Doyle TJ, Liu Y, Aggarwal R, Wang X, Shi Y, Ge SX, Huang H, Lin Q, Liu W, Cai Y, Koontz D, Fuhrman CR, Golzarri MF, Liu Y, Hatabu H, Nishino M, Araki T, Dellaripa PF, Oddis CV, Rosas IO, Ascherman DP. Biomarkers of rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol. 2015 Jan; 67(1):28-38. PMID: 25302945; PMCID: PMC4624107.
      Citations: 38     Fields:    Translation:Humans
    185. Liu F, Lagares D, Choi KM, Stopfer L, Marinkovic A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15; 308(4):L344-57. PMID: 25502501; PMCID: PMC4329470.
      Citations: 291     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    186. Cui Y, Wilder J, Rietz C, Gigliotti A, Tang X, Shi Y, Guilmette R, Wang H, George G, Nilo de Magaldi E, Chu SG, Doyle-Eisele M, McDonald JD, Rosas IO, El-Chemaly S. Radiation-induced impairment in lung lymphatic vasculature. Lymphat Res Biol. 2014 Dec; 12(4):238-50. PMID: 25412238; PMCID: PMC4267131.
      Citations: 12     Fields:    Translation:AnimalsPHPublic Health
    187. Li C, Zhang E, Sun Y, Lee PS, Zhan Y, Guo Y, Osorio JC, Rosas IO, Xu KF, Kwiatkowski DJ, Yu JJ. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. PLoS One. 2014; 9(10):e104809. PMID: 25347447; PMCID: PMC4210122.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    188. Harlow L, Gochuico BR, Rosas IO, Doyle TJ, Osorio JC, Travers TS, Camacho CC, Oddis CV, Ascherman DP. Anti-citrullinated heat shock protein 90 antibodies identified in bronchoalveolar lavage fluid are a marker of lung-specific immune responses. Clin Immunol. 2014 Nov; 155(1):60-70. PMID: 25150019; PMCID: PMC4629481.
      Citations: 11     Fields:    Translation:Humans
    189. Doyle TJ, Dellaripa PF, Batra K, Frits ML, Iannaccone CK, Hatabu H, Nishino M, Weinblatt ME, Ascherman DP, Washko GR, Hunninghake GM, Choi AMK, Shadick NA, Rosas IO. Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. Chest. 2014 Jul; 146(1):41-50. PMID: 24305643; PMCID: PMC4077411.
      Citations: 44     Fields:    Translation:Humans
    190. Moon HG, Kim SH, Gao J, Quan T, Qin Z, Osorio JC, Rosas IO, Wu M, Tesfaigzi Y, Jin Y. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15; 307(4):L326-37. PMID: 24973403; PMCID: PMC4137167.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    191. Craig VJ, Polverino F, Laucho-Contreras ME, Shi Y, Liu Y, Osorio JC, Tesfaigzi Y, Pinto-Plata V, Gochuico BR, Rosas IO, Owen CA. Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis. PLoS One. 2014; 9(5):e97485. PMID: 24828408; PMCID: PMC4020836.
      Citations: 19     Fields:    Translation:HumansCells
    192. Putman RK, Rosas IO, Hunninghake GM. Genetics and early detection in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Apr 01; 189(7):770-8. PMID: 24547893; PMCID: PMC4225831.
      Citations: 36     Fields:    Translation:Humans
    193. Rosas IO, Dellaripa PF, Lederer DJ, Khanna D, Young LR, Martinez FJ. Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S169-77. PMID: 24754826; PMCID: PMC4112506.
      Citations: 22     Fields:    Translation:HumansPHPublic Health
    194. Cui Y, Osorio JC, Risquez C, Wang H, Shi Y, Gochuico BR, Morse D, Rosas IO, El-Chemaly S. Transforming growth factor-?1 downregulates vascular endothelial growth factor-D expression in human lung fibroblasts via the Jun NH2-terminal kinase signaling pathway. Mol Med. 2014 Mar 20; 20:120-34. PMID: 24515257; PMCID: PMC3960396.
      Citations: 15     Fields:    Translation:HumansCells
    195. Cullinane AR, Yeager C, Dorward H, Carmona-Rivera C, Wu HP, Moss J, O'Brien KJ, Nathan SD, Meyer KC, Rosas IO, Helip-Wooley A, Huizing M, Gahl WA, Gochuico BR. Dysregulation of galectin-3. Implications for Hermansky-Pudlak syndrome pulmonary fibrosis. Am J Respir Cell Mol Biol. 2014 Mar; 50(3):605-13. PMID: 24134621; PMCID: PMC4068929.
      Citations: 23     Fields:    Translation:HumansCells
    196. Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014 Mar 01; 145(3):454-463. PMID: 24590021; PMCID: PMC3941243.
      Citations: 22     Fields:    Translation:Humans
    197. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577; discussion e1001577. PMID: 24391478; PMCID: PMC3876981.
      Citations: 187     Fields:    Translation:Humans
    198. Morse D, Rosas IO. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol. 2014; 76:493-513. PMID: 24274738.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    199. Rosas IO, Kottmann RM, Kottman RM, Sime PJ. New light is shed on the enigmatic origin of the lung myofibroblast. Am J Respir Crit Care Med. 2013 Oct 01; 188(7):765-6. PMID: 24083856; PMCID: PMC3826276.
      Citations: 4     Fields:    Translation:AnimalsCells
    200. Shi Y, Gochuico BR, Yu G, Tang X, Osorio JC, Fernandez IE, Risquez CF, Patel AS, Shi Y, Wathelet MG, Goodwin AJ, Haspel JA, Ryter SW, Billings EM, Kaminski N, Morse D, Rosas IO. Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-? receptor I internalization and inhibiting transforming growth factor-?1 signaling. Am J Respir Crit Care Med. 2013 Oct 01; 188(7):831-41. PMID: 23924348; PMCID: PMC3826270.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    201. El-Chemaly S, Malide D, Yao J, Nathan SD, Rosas IO, Gahl WA, Moss J, Gochuico BR. Glucose transporter-1 distribution in fibrotic lung disease: association with [?8F]-2-fluoro-2-deoxyglucose-PET scan uptake, inflammation, and neovascularization. Chest. 2013 Jun; 143(6):1685-1691. PMID: 23699745; PMCID: PMC3673664.
      Citations: 23     Fields:    Translation:Humans
    202. Hunninghake GM, Hatabu H, Okajima Y, Gao W, Latourelle JC, Nishino M, Araki T, Zazueta OE, Kurugol S, Ross JC, Murphy E, Steele MP, Loyd JE, Schwarz MI, Fingerlin TE, Rosas IO, Washko GR, O'Connor GT, Schwartz DA, Dupuis J, San Jos? Est?par R. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013 Jun 06; 368(23):2192-200. PMID: 23692170; PMCID: PMC3747636.
      Citations: 160     Fields:    Translation:Humans
    203. Mihalek AD, Rosas IO, Padera RF, Fuhlbrigge AL, Hunninghake GM, DeMeo DL, Camp PC, Goldberg HJ. Interstitial pneumonitis and the risk of chronic allograft rejection in lung transplant recipients. Chest. 2013 May; 143(5):1430-1435. PMID: 23715594; PMCID: PMC3653348.
      Citations: 2     Fields:    Translation:Humans
    204. Gansner JM, Rosas IO. Telomeres in lung disease. Transl Res. 2013 Dec; 162(6):343-52. PMID: 23618685.
      Citations: 18     Fields:    Translation:HumansCells
    205. Harlow L, Rosas IO, Gochuico BR, Mikuls TR, Dellaripa PF, Oddis CV, Ascherman DP. Identification of citrullinated hsp90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheum. 2013 Apr; 65(4):869-79. PMID: 23400887.
      Citations: 52     Fields:    Translation:HumansCells
    206. Rosas IO, Yang IV. The promise of epigenetic therapies in treatment of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):336-8. PMID: 23418324.
      Citations: 3     Fields:    Translation:HumansAnimals
    207. Doyle TJ, Pinto-Plata V, Morse D, Celli BR, Rosas IO. The expanding role of biomarkers in the assessment of smoking-related parenchymal lung diseases. Chest. 2012 Oct; 142(4):1027-1034. PMID: 23032451; PMCID: PMC3465104.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    208. Kovkarova-Naumovski E, Jara P, Parwani A, Kass D, Ruiz V, Rosas IO, Gibson KF, Cabrera S, Yousem SA, Richards TJ, Chensny LJ, Kaminski N, Pardo A, Yu G, Lopez-Ot?n C, Ram?rez R, Selman M. Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans. Am J Respir Crit Care Med. 2012 Oct 15; 186(8):752-62. PMID: 22859522; PMCID: PMC5450991.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    209. Patel AS, Lin L, Geyer A, Haspel JA, An CH, Cao J, Rosas IO, Morse D. Autophagy in idiopathic pulmonary fibrosis. PLoS One. 2012; 7(7):e41394. PMID: 22815997; PMCID: PMC3399849.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    210. Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D. Retinoic acid-related orphan receptor-a is induced in the setting of DNA damage and promotes pulmonary emphysema. Am J Respir Crit Care Med. 2012 Sep 01; 186(5):412-9. PMID: 22744720; PMCID: PMC5450975.
      Citations: 15     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    211. Gansner JM, Rosas IO, Ebert BL. Pulmonary fibrosis, bone marrow failure, and telomerase mutation. N Engl J Med. 2012 Apr 19; 366(16):1551-3. PMID: 22512499.
      Citations: 8     Fields:    Translation:HumansCells
    212. Doyle TJ, Hunninghake GM, Rosas IO. Subclinical interstitial lung disease: why you should care. Am J Respir Crit Care Med. 2012 Jun 01; 185(11):1147-53. PMID: 22366047; PMCID: PMC3373068.
      Citations: 61     Fields:    Translation:Humans
    213. Doyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, Hunninghake GM, COPDGene Investigators. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012 Apr 01; 185(7):756-62. PMID: 22268134; PMCID: PMC3326424.
      Citations: 51     Fields:    Translation:Humans
    214. Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM, COPDGene Investigators, Est?par RS. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):547-56. PMID: 22246178; PMCID: PMC3297101.
      Citations: 60     Fields:    Translation:HumansAnimals
    215. Rosas IO, Yao J, Avila NA, Chow CK, Gahl WA, Gochuico BR. Automated quantification of high-resolution CT scan findings in individuals at risk for pulmonary fibrosis. Chest. 2011 Dec; 140(6):1590-1597. PMID: 21622544; PMCID: PMC3231958.
      Citations: 22     Fields:    Translation:Humans
    216. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, COPDGene Investigators, Est?par RS. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011 Mar 10; 364(10):897-906. PMID: 21388308; PMCID: PMC3074462.
      Citations: 216     Fields:    Translation:Humans
    217. Xue J, Gochuico BR, Alawad AS, Feghali-Bostwick CA, Noth I, Nathan SD, Rosen GD, Rosas IO, Dacic S, Ocak I, Fuhrman CR, Cuenco KT, Smith MA, Jacobs SS, Zeevi A, Morel PA, Pilewski JM, Valentine VG, Gibson KF, Kaminski N, Sciurba FC, Zhang Y, Duncan SR. The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis. PLoS One. 2011 Feb 23; 6(2):e14715. PMID: 21373184; PMCID: PMC3044131.
      Citations: 28     Fields:    Translation:Humans
    218. Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med. 2010 Mar 15; 207(3):535-52. PMID: 20176803; PMCID: PMC2839145.
      Citations: 304     Fields:    Translation:AnimalsCells
    219. Washko GR, Lynch DA, Matsuoka S, Ross JC, Umeoka S, Diaz A, Sciurba FC, Hunninghake GM, Silverman EK, Rosas IO, Hatabu H, San Jos? Est?par R. Identification of early interstitial lung disease in smokers from the COPDGene Study. Acad Radiol. 2010 Jan; 17(1):48-53. PMID: 19781963; PMCID: PMC2790552.
      Citations: 98     Fields:    Translation:Humans
    220. Richards TJ, Eggebeen A, Gibson K, Yousem S, Fuhrman C, Gochuico BR, Fertig N, Oddis CV, Kaminski N, Rosas IO, Ascherman DP. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Arthritis Rheum. 2009 Jul; 60(7):2183-92. PMID: 19565490; PMCID: PMC2710404.
      Citations: 47     Fields:    Translation:Humans
    221. El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J. Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3958-63. PMID: 19237567; PMCID: PMC2646625.
      Citations: 60     Fields:    Translation:HumansCells
    222. Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem. 2009 Feb 06; 284(6):3537-45. PMID: 19073610; PMCID: PMC2635035.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    223. Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med. 2008 Apr 29; 5(4):e93. PMID: 18447576; PMCID: PMC2346504.
      Citations: 222     Fields:    Translation:Humans
    224. Gochuico BR, Avila NA, Chow CK, Novero LJ, Wu HP, Ren P, MacDonald SD, Travis WD, Stylianou MP, Rosas IO. Progressive preclinical interstitial lung disease in rheumatoid arthritis. Arch Intern Med. 2008 Jan 28; 168(2):159-66. PMID: 18227362.
      Citations: 121     Fields:    Translation:HumansCTClinical Trials
    225. Rosas IO, Ren P, Avila NA, Chow CK, Franks TJ, Travis WD, McCoy JP, May RM, Wu HP, Nguyen DM, Arcos-Burgos M, MacDonald SD, Gochuico BR. Early interstitial lung disease in familial pulmonary fibrosis. Am J Respir Crit Care Med. 2007 Oct 01; 176(7):698-705. PMID: 17641157; PMCID: PMC1994234.
      Citations: 69     Fields:    Translation:Humans
    226. Ren P, Rosas IO, Macdonald SD, Wu HP, Billings EM, Gochuico BR. Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2007 Jun 01; 175(11):1151-7. PMID: 17332483; PMCID: PMC1899274.
      Citations: 20     Fields:    Translation:HumansCells
    227. Rosas IO, Kaminski N. When it comes to genes--IPF or NSIP, familial or sporadic--they're all the same. Am J Respir Crit Care Med. 2007 Jan 01; 175(1):5-6. PMID: 17179494.
      Citations: 5     Fields:    Translation:Humans
    228. Kaminski N, Rosas IO. Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes? Proc Am Thorac Soc. 2006 Jun; 3(4):339-44. PMID: 16738198; PMCID: PMC2658685.
      Citations: 36     Fields:    Translation:Humans
    229. Studer SM, Orens JB, Rosas I, Krishnan JA, Cope KA, Yang S, Conte JV, Becker PB, Risby TH. Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection. J Heart Lung Transplant. 2001 Nov; 20(11):1158-66. PMID: 11704475.
      Citations: 15     Fields:    Translation:Humans
    230. Rosas V, Conte JV, Yang SC, Gaine SP, Borja M, Wigley FM, White B, Orens JB. Lung transplantation and systemic sclerosis. Ann Transplant. 2000; 5(3):38-43. PMID: 11147028.
      Citations: 11     Fields:    Translation:Humans
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