NAV1.6 Voltage-Gated Sodium Channel
"NAV1.6 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype found widely expressed in neurons of the central and peripheral nervous systems. Defects in the SCN8A gene which codes for the alpha subunit of this sodium channel are associated with ATAXIA and cognitive deficits.
| Descriptor ID |
D062557
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| MeSH Number(s) |
D12.776.157.530.400.875.750.600 D12.776.543.550.450.875.750.600 D12.776.543.585.400.875.750.600 D12.776.631.960.600
|
| Concept/Terms |
NAV1.6 Voltage-Gated Sodium Channel- NAV1.6 Voltage-Gated Sodium Channel
- NAV1.6 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 8
- Voltage Gated Sodium Channel Type 8
- Type 8 Voltage-Gated Sodium Channel
- Type 8 Voltage Gated Sodium Channel
|
Below are MeSH descriptors whose meaning is more general than "NAV1.6 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.6 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.6 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.6 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2020 | 3 | 0 | 3 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "NAV1.6 Voltage-Gated Sodium Channel" by people in Profiles.
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TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria. J Neuroinflammation. 2023 Dec 19; 20(1):306.
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Inhibition of the Akt/PKB Kinase Increases Nav1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons. Int J Mol Sci. 2022 Feb 01; 23(3).
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Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation. Int J Mol Sci. 2021 Dec 17; 22(24).
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Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na+ Channel 1.2 Macromolecular Complex. Cells. 2021 11 10; 10(11).
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Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6. J Med Chem. 2020 10 22; 63(20):11522-11547.
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Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics. Molecules. 2020 Jul 24; 25(15).
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JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation. Biochim Biophys Acta Mol Cell Res. 2020 10; 1867(10):118786.
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Reassembly of Excitable Domains after CNS Axon Regeneration. J Neurosci. 2016 08 31; 36(35):9148-60.
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SCN8A Epileptic Encephalopathy: Detection of Fetal Seizures Guides Multidisciplinary Approach to Diagnosis and Treatment. Pediatr Neurol. 2016 11; 64:87-91.
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Skin-derived precursor Schwann cell myelination capacity in focal tibial demyelination. Muscle Nerve. 2014 Aug; 50(2):262-72.