"Receptor, Notch3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A notch receptor characterized by a large extracellular domain containing 34 EPIDERMAL GROWTH FACTOR-like repeats. It functions to regulate CELL DIFFERENTIATION; APOPTOSIS; and CELL PROLIFERATION. Mutations in the EGF repeats of Notch-3 are associated with CADASIL.
| Descriptor ID |
D000071656
|
| MeSH Number(s) |
D12.776.543.750.725.875 D12.776.930.770.875
|
| Concept/Terms |
Receptor, Notch3- Receptor, Notch3
- Notch-3 Protein
- Notch 3 Protein
- Notch3 Protein
- Notch-3 Receptor
- Notch 3 Receptor
- Notch3 Receptor
- Neurogenic Locus Notch Homolog Protein 3
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Notch3".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Notch3".
This graph shows the total number of publications written about "Receptor, Notch3" by people in this website by year, and whether "Receptor, Notch3" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Receptor, Notch3" by people in Profiles.
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Family Lore, a Variant of Uncertain Significance, and?CADASIL. Am J Med Genet C Semin Med Genet. 2024 Nov; 196(2-3):e32117.
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Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy. Cancer Discov. 2024 Oct 04; 14(10):1823-1837.
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CADASIL: A NOTCH3-associated cerebral small vessel disease. J Adv Res. 2024 Dec; 66:223-235.
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Expansion of the phenotype of lateral meningocele syndrome. Am J Med Genet A. 2020 05; 182(5):1259-1262.
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Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain. 2019 04 01; 142(4):1009-1023.
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Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4. Mol Cancer Ther. 2019 02; 18(2):421-436.
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Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer. Carcinogenesis. 2017 10 01; 38(10):1029-1035.
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Notch3 pathway alterations in ovarian cancer. Cancer Res. 2014 Jun 15; 74(12):3282-93.
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Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. Am J Hum Genet. 2013 Jun 06; 92(6):1001-7.
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A recurrent PDGFRB mutation causes familial infantile myofibromatosis. Am J Hum Genet. 2013 Jun 06; 92(6):996-1000.