"Receptor, Notch3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A notch receptor characterized by a large extracellular domain containing 34 EPIDERMAL GROWTH FACTOR-like repeats. It functions to regulate CELL DIFFERENTIATION; APOPTOSIS; and CELL PROLIFERATION. Mutations in the EGF repeats of Notch-3 are associated with CADASIL.
| Descriptor ID |
D000071656
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| MeSH Number(s) |
D12.776.543.750.725.875 D12.776.930.770.875
|
| Concept/Terms |
Receptor, Notch3- Receptor, Notch3
- Notch-3 Protein
- Notch 3 Protein
- Notch3 Protein
- Notch-3 Receptor
- Notch 3 Receptor
- Notch3 Receptor
- Neurogenic Locus Notch Homolog Protein 3
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Notch3".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Notch3".
This graph shows the total number of publications written about "Receptor, Notch3" by people in this website by year, and whether "Receptor, Notch3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptor, Notch3" by people in Profiles.
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The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice. PLoS Genet. 2025 Aug; 21(8):e1011806.
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Family Lore, a Variant of Uncertain Significance, and?CADASIL. Am J Med Genet C Semin Med Genet. 2024 Nov; 196(2-3):e32117.
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CADASIL: A NOTCH3-associated cerebral small vessel disease. J Adv Res. 2024 Dec; 66:223-235.
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Expansion of the phenotype of lateral meningocele syndrome. Am J Med Genet A. 2020 05; 182(5):1259-1262.
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Notch3 pathway alterations in ovarian cancer. Cancer Res. 2014 Jun 15; 74(12):3282-93.
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A recurrent PDGFRB mutation causes familial infantile myofibromatosis. Am J Hum Genet. 2013 Jun 06; 92(6):996-1000.
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Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. PLoS One. 2013; 8(4):e61807.
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Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res. 2010 Dec 01; 70(23):9937-48.
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The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction. Oncogene. 2011 Jan 20; 30(3):287-300.
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Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem. 2008 Mar 21; 283(12):8046-54.