"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
| Descriptor ID |
D008687
|
| MeSH Number(s) |
D02.078.370.141.450
|
| Concept/Terms |
Metformin- Metformin
- Dimethylbiguanidine
- Dimethylguanylguanidine
|
Below are MeSH descriptors whose meaning is more general than "Metformin".
Below are MeSH descriptors whose meaning is more specific than "Metformin".
This graph shows the total number of publications written about "Metformin" by people in this website by year, and whether "Metformin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 7 | 0 | 7 |
| 2011 | 1 | 3 | 4 |
| 2012 | 4 | 1 | 5 |
| 2013 | 3 | 0 | 3 |
| 2014 | 5 | 1 | 6 |
| 2015 | 4 | 2 | 6 |
| 2016 | 4 | 4 | 8 |
| 2017 | 5 | 4 | 9 |
| 2018 | 2 | 4 | 6 |
| 2019 | 4 | 2 | 6 |
| 2020 | 7 | 5 | 12 |
| 2021 | 7 | 2 | 9 |
| 2022 | 2 | 1 | 3 |
| 2023 | 8 | 0 | 8 |
| 2024 | 5 | 4 | 9 |
| 2025 | 4 | 3 | 7 |
| 2026 | 4 | 2 | 6 |
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Below are the most recent publications written about "Metformin" by people in Profiles.
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Low-dose metformin requires brain Rap1 for its antidiabetic action. Sci Adv. 2025 Aug; 11(31):eadu3700.
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Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model. Am J Obstet Gynecol. 2024 09; 231(3):352.e1-352.e16.
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Lac-Phe mediates the effects of metformin on food intake and body weight. Nat Metab. 2024 Apr; 6(4):659-669.
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Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. Am J Respir Crit Care Med. 2021 09 15; 204(6):651-666.
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Long-Term Complications in Youth-Onset Type 2 Diabetes. N Engl J Med. 2021 07 29; 385(5):416-426.
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Postintervention Effects of Varying Treatment Arms on Glycemic Failure and ?-Cell Function in the TODAY Trial. Diabetes Care. 2021 01; 44(1):75-80.
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Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer. Breast Cancer Res Treat. 2021 Jan; 185(1):73-84.
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A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation. Cell Stem Cell. 2020 06 04; 26(6):910-925.e6.
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Reducing the Burden of Diabetes Treatment: A Review of Low-cost Oral Hypoglycemic Medications. Curr Diabetes Rev. 2020; 16(8):851-858.
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Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018 07 19; 132(3):321-333.