"Biguanides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
| Descriptor ID |
D001645
|
| MeSH Number(s) |
D02.078.370.141
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Biguanides".
Below are MeSH descriptors whose meaning is more specific than "Biguanides".
This graph shows the total number of publications written about "Biguanides" by people in this website by year, and whether "Biguanides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Biguanides" by people in Profiles.
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First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2022 Oct; 40(5):1001-1010.
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Antiviral Activity of Olanexidine-Containing Hand Rub against Human Noroviruses. mBio. 2022 04 26; 13(2):e0284821.
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A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres. J Neurooncol. 2022 Jan; 156(1):139-151.
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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun. 2017 12 22; 8(1):2270.
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Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget. 2016 Aug 09; 7(32):51435-51449.
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Contact lens care solution killing efficacy against Acanthamoeba castellanii by in vitro testing and live-imaging. Cont Lens Anterior Eye. 2015 Dec; 38(6):442-50.
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Prospective randomized phase II Trial of accelerated reepithelialization of superficial second-degree burn wounds using extracorporeal shock wave therapy. Ann Surg. 2012 Jan; 255(1):23-9.
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Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis. Ophthalmology. 2008 May; 115(5):866-9.
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Polyhexamethylene biguanide in the treatment of Acanthamoeba keratitis. Aust N Z J Ophthalmol. 1993 Nov; 21(4):277-8.