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WILLIAM E MITCH

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Nephrology
AddressONE BAYLOR PLAZA
HOUSTON TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mindikoglu AL, Opekun AR, Mitch WE, Magder LS, Christenson RH, Dowling TC, Weir MR, Seliger SL, Howell CD, Raufman JP, Rana A, Goss JA, Khaderi SA, Vierling JM. Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis. Dig Dis Sci. 2018 Mar; 63(3):665-675. PMID: 29392554.
      View in: PubMed
    2. Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA. Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. JCI Insight. 2017 Nov 16; 2(22). PMID: 29202452.
      View in: PubMed
    3. Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017 Nov 14; 8(1):1493. PMID: 29138395.
      View in: PubMed
    4. Liang H, Zhang Z, Yan J, Wang Y, Hu Z, Mitch WE, Wang Y. The IL-4 receptor ? has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017 Jul 21. PMID: 28739140.
      View in: PubMed
    5. Wang Y, Jia L, Hu Z, Entman ML, Mitch WE, Wang Y. AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis. Kidney Int. 2017 Jul 21. PMID: 28739141.
      View in: PubMed
    6. Li J, An C, Kang L, Mitch WE, Wang Y. Recent Advances in Magnetic Resonance Imaging Assessment of Renal Fibrosis. Adv Chronic Kidney Dis. 2017 May; 24(3):150-153. PMID: 28501077.
      View in: PubMed
    7. Thomas SS, Mitch WE. Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting. Curr Opin Clin Nutr Metab Care. 2017 Mar 02. PMID: 28257332.
      View in: PubMed
    8. Dong J, Dong Y, Chen Z, Mitch WE, Zhang L. The pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease. Kidney Int. 2017 Jan; 91(1):119-128. PMID: 27653838.
      View in: PubMed
    9. Mitch WE, Remuzzi G. Diets for patients with chronic kidney disease, should we reconsider? BMC Nephrol. 2016; 17(1):80. PMID: 27401192; PMCID: PMC4940838.
    10. Fouque D, Chen J, Chen W, Garneata L, Hwang SJ, Kalantar-Zadeh K, Kopple JD, Mitch WE, Piccoli G, Teplan V, Chauveau P. Adherence to ketoacids/essential amino acids-supplemented low protein diets and new indications for patients with chronic kidney disease. BMC Nephrol. 2016; 17(1):63. PMID: 27388899; PMCID: PMC4936289.
    11. Wyatt CM, Mitch WE. In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia. Kidney Int. 2016 May; 89(5):973-5. PMID: 27083271.
      View in: PubMed
    12. Thomas SS, Zhang L, Mitch WE. Molecular mechanisms of insulin resistance in chronic kidney disease. Kidney Int. 2015 Dec; 88(6):1233-1239. PMID: 26444029.
      View in: PubMed
    13. Dong J, Dong Y, Dong Y, Chen F, Mitch WE, Zhang L. Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues. Int J Obes (Lond). 2016 Mar; 40(3):434-442. PMID: 26435323; PMCID: PMC4783239.
    14. Workeneh B, Shypailo R, DeCastro I, Shah M, Guffey D, Minard CG, Mitch WE. Adverse Effects of Sporadic Dialysis on Body Composition. Nephron. 2015; 131(1):73-7. PMID: 26314556.
      View in: PubMed
    15. Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z. CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation. J Am Soc Nephrol. 2016 Feb; 27(2):509-19. PMID: 26054539; PMCID: PMC4731120 [Available on 02/01/17].
    16. Yan J, Zhang Z, Yang J, Mitch WE, Wang Y. JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis. J Am Soc Nephrol. 2015 Dec; 26(12):3060-71. PMID: 26032813.
      View in: PubMed
    17. Workeneh B, Guffey D, Minard CG, Mitch WE. Causes for Withdrawal in an Urban Peritoneal Dialysis Program. Int J Nephrol. 2015; 2015:652953. PMID: 26064683.
      View in: PubMed
    18. Liang M, Wang Y, Liang A, Mitch WE, Roy-Chaudhury P, Han G, Cheng J. Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima. Kidney Int. 2015 Sep; 88(3):490-502. PMID: 25786100.
      View in: PubMed
    19. Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24; 290(17):11177-87. PMID: 25787076; PMCID: PMC4409274.
    20. Luo J, Liang M, Mitch WE, Danesh FR, Yu M, Cheng J. FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice. Endocrinology. 2015 Jun; 156(6):2200-10. PMID: 25774552; PMCID: PMC4430603.
    21. Liang M, Woodard LE, Liang A, Luo J, Wilson MH, Mitch WE, Cheng J. Protective role of insulin-like growth factor-1 receptor in endothelial cells against unilateral ureteral obstruction-induced renal fibrosis. Am J Pathol. 2015 May; 185(5):1234-50. PMID: 25783760; PMCID: PMC4419212.
    22. Ikizler TA, Lovett DH, Chertow GM, Mitch WE, Schiller B. Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology. Am J Kidney Dis. 2015 Mar; 65(3):381-3. PMID: 25542413.
      View in: PubMed
    23. Fouque D, Mitch WE. Low-protein diets in chronic kidney disease: are we finally reaching a consensus? Nephrol Dial Transplant. 2015 Jan; 30(1):6-8. PMID: 25358494.
      View in: PubMed
    24. Weiner ID, Mitch WE, Sands JM. Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion. Clin J Am Soc Nephrol. 2015 Aug 7; 10(8):1444-58. PMID: 25078422.
      View in: PubMed
    25. Rondon-Berrios H, Wang Y, Mitch WE. Can muscle-kidney crosstalk slow progression of CKD? J Am Soc Nephrol. 2014 Dec; 25(12):2681-3. PMID: 25012171; PMCID: PMC4243363.
    26. Wang XH, Mitch WE. Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol. 2014 Sep; 10(9):504-16. PMID: 24981816; PMCID: PMC4269363.
    27. Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH. MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways. Aging (Albany NY). 2014 Mar; 6(3):160-75. PMID: 24659628; PMCID: PMC4012934.
    28. Wang Y, Liang A, Luo J, Liang M, Han G, Mitch WE, Cheng J. Blocking Notch in endothelial cells prevents arteriovenous fistula failure despite CKD. J Am Soc Nephrol. 2014 Apr; 25(4):773-83. PMID: 24480830; PMCID: PMC3968498.
    29. Attaix D, Mitch WE. A dedication to Alfred L. Goldberg. Int J Biochem Cell Biol. 2013 Oct; 45(10):2120. PMID: 24137800.
      View in: PubMed
    30. Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch W, Teplan V, Yu X, Zakar G. Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients? Semin Dial. 2013 Nov-Dec; 26(6):714-9. PMID: 24016150.
      View in: PubMed
    31. Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE. Stat3 activation links a C/EBP? to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013 Sep 3; 18(3):368-79. PMID: 24011072; PMCID: PMC3794464.
    32. Wang XH, Mitch WE. Muscle wasting from kidney failure-a model for catabolic conditions. Int J Biochem Cell Biol. 2013 Oct; 45(10):2230-8. PMID: 23872437; PMCID: PMC3919551.
    33. Workeneh B, Mitch WE. High-protein diet in diabetic nephropathy: what is really safe? Am J Clin Nutr. 2013 Aug; 98(2):266-8. PMID: 23824718.
      View in: PubMed
    34. Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, Delafontaine P. Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 2013 Oct; 45(10):2322-32. PMID: 23769949; PMCID: PMC3759646.
    35. Han HQ, Zhou X, Mitch WE, Goldberg AL. Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. Int J Biochem Cell Biol. 2013 Oct; 45(10):2333-47. PMID: 23721881.
      View in: PubMed
    36. Thomas SS, Dong Y, Zhang L, Mitch WE. Signal regulatory protein-? interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease. Kidney Int. 2013 Aug; 84(2):308-16. PMID: 23515050; PMCID: PMC3777429.
    37. Carrero JJ, Stenvinkel P, Cuppari L, Ikizler TA, Kalantar-Zadeh K, Kaysen G, Mitch WE, Price SR, Wanner C, Wang AY, ter Wee P, Franch HA. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013 Mar; 23(2):77-90. PMID: 23428357.
      View in: PubMed
    38. Moore LW, Byham-Gray LD, Scott Parrott J, Rigassio-Radler D, Mandayam S, Jones SL, Mitch WE, Osama Gaber A. The mean dietary protein intake at different stages of chronic kidney disease is higher than current guidelines. Kidney Int. 2013 Apr; 83(4):724-32. PMID: 23302719.
      View in: PubMed
    39. Thomas SS, Mitch WE. Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin. Clin Exp Nephrol. 2013 Apr; 17(2):174-82. PMID: 23292175; PMCID: PMC3628947.
    40. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J. Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J Pathol. 2012 Dec; 228(4):448-58. PMID: 22711583; PMCID: PMC3760987.
    41. Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X. Keto acid therapy in predialysis chronic kidney disease patients: final consensus. J Ren Nutr. 2012 Mar; 22(2 Suppl):S22-4. PMID: 22365372.
      View in: PubMed
    42. Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X. Protein-restricted diets plus keto/amino acids--a valid therapeutic approach for chronic kidney disease patients. J Ren Nutr. 2012 Mar; 22(2 Suppl):S1-21. PMID: 22365371.
      View in: PubMed
    43. Han HQ, Mitch WE. Targeting the myostatin signaling pathway to treat muscle wasting diseases. Curr Opin Support Palliat Care. 2011 Dec; 5(4):334-41. PMID: 22025090; PMCID: PMC3273421.
    44. Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Dec; 17(12):1619-26. PMID: 22081021; PMCID: PMC3348956.
    45. Wang XH, Hu Z, Klein JD, Zhang L, Fang F, Mitch WE. Decreased miR-29 suppresses myogenesis in CKD. J Am Soc Nephrol. 2011 Nov; 22(11):2068-76. PMID: 21965375; PMCID: PMC3231783.
    46. Tabony AM, Yoshida T, Galvez S, Higashi Y, Sukhanov S, Chandrasekar B, Mitch WE, Delafontaine P. Angiotensin II upregulates protein phosphatase 2C? and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting. Hypertension. 2011 Oct; 58(4):643-9. PMID: 21844485; PMCID: PMC3182768.
    47. Kopple JD, Cheung AK, Christiansen JS, Djurhuus CB, El Nahas M, Feldt-Rasmussen B, Mitch WE, Wanner C, Göthberg M, Ikizler TA. OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients. Nephrol Dial Transplant. 2011 Dec; 26(12):4095-103. PMID: 21750157.
      View in: PubMed
    48. Wang Y, Mitch WE. Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis. Kidney Int. 2011 May; 79(9):933-4. PMID: 21490612; PMCID: PMC3558977.
    49. Lecker SH, Mitch WE. Proteolysis by the ubiquitin-proteasome system and kidney disease. J Am Soc Nephrol. 2011 May; 22(5):821-4. PMID: 21474563.
      View in: PubMed
    50. Zhang L, Rajan V, Lin E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch WE. Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. FASEB J. 2011 May; 25(5):1653-63. PMID: 21282204; PMCID: PMC3079306.
    51. Wang XH, Zhang L, Mitch WE, LeDoux JM, Hu J, Du J. Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity. J Biol Chem. 2010 Jul 9; 285(28):21249-57. PMID: 20424172; PMCID: PMC2898444.
    52. Hu Z, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE. PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes. 2010 Jun; 59(6):1312-20. PMID: 20200318; PMCID: PMC2874691.
    53. Workeneh BT, Mitch WE. Review of muscle wasting associated with chronic kidney disease. Am J Clin Nutr. 2010 Apr; 91(4):1128S-1132S. PMID: 20181807.
      View in: PubMed
    54. Zhang L, Wang XH, Wang H, Du J, Mitch WE. Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy. J Am Soc Nephrol. 2010 Mar; 21(3):419-27. PMID: 20056750; PMCID: PMC2831855.
    55. Zhang L, Ran L, Garcia GE, Wang XH, Han S, Du J, Mitch WE. Chemokine CXCL16 regulates neutrophil and macrophage infiltration into injured muscle, promoting muscle regeneration. Am J Pathol. 2009 Dec; 175(6):2518-27. PMID: 19893053; PMCID: PMC2789607.
    56. Hu Z, Wang H, Lee IH, Du J, Mitch WE. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest. 2009 Oct; 119(10):3059-69. PMID: 19759515; PMCID: PMC2752071.
    57. Wang XH, Du J, Klein JD, Bailey JL, Mitch WE. Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function. Kidney Int. 2009 Oct; 76(7):751-9. PMID: 19641484; PMCID: PMC3835682.
    58. Leal VO, Delgado AG, Leite M, Mitch WE, Mafra D. Influence of renal function and diet on acid-base status in chronic kidney disease patients. J Ren Nutr. 2009 Mar; 19(2):178-82. PMID: 19218046.
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    59. Zhang L, Du J, Hu Z, Han G, Delafontaine P, Garcia G, Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol. 2009 Mar; 20(3):604-12. PMID: 19158350; PMCID: PMC2653674.
    60. Franch HA, Mitch WE. Navigating between the Scylla and Charybdis of prescribing dietary protein for chronic kidney diseases. Annu Rev Nutr. 2009; 29:341-64. PMID: 19575595.
      View in: PubMed
    61. Kopple JD, Cheung AK, Christiansen JS, Djurhuus CB, El Nahas M, Feldt-Rasmussen B, Lange M, Mitch WE, Wanner C, Wiedemann J, Ikizler TA. OPPORTUNITY: a randomized clinical trial of growth hormone on outcome in hemodialysis patients. Clin J Am Soc Nephrol. 2008 Nov; 3(6):1741-51. PMID: 18945992; PMCID: PMC2572295.
    62. Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD. Cachexia: a new definition. Clin Nutr. 2008 Dec; 27(6):793-9. PMID: 18718696.
      View in: PubMed
    63. Rajan V, Mitch WE. Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease. Biochim Biophys Acta. 2008 Dec; 1782(12):795-9. PMID: 18723090; PMCID: PMC2637460.
    64. Deboer MD, Zhu X, Levasseur PR, Inui A, Hu Z, Han G, Mitch WE, Taylor JE, Halem HA, Dong JZ, Datta R, Culler MD, Marks DL. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology. 2008 Feb; 149(2):827-35. PMID: 18039782; PMCID: PMC2219314.
    65. Rajan VR, Mitch WE. Muscle wasting in chronic kidney disease: the role of the ubiquitin proteasome system and its clinical impact. Pediatr Nephrol. 2008 Apr; 23(4):527-35. PMID: 17987322; PMCID: PMC2259254.
    66. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007 Oct; 56(10):2449-56. PMID: 17623817.
      View in: PubMed
    67. Mitch WE. Malnutrition is an unusual cause of decreased muscle mass in chronic kidney disease. J Ren Nutr. 2007 Jan; 17(1):66-9. PMID: 17198936.
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    68. Kaysen GA, Levin NW, Mitch WE, Chapman AL, Kubala L, Eiserich JP. Evidence that C-reactive protein or IL-6 are not surrogates for all inflammatory cardiovascular risk factors in hemodialysis patients. Blood Purif. 2006; 24(5-6):508-16. PMID: 17077623.
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    69. Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE. Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions. J Am Soc Nephrol. 2006 Nov; 17(11):3233-9. PMID: 17005936.
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    70. Marinovic AC, Zheng B, Mitch WE, Price SR. Tissue-specific regulation of ubiquitin (UbC) transcription by glucocorticoids: in vivo and in vitro analyses. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F660-6. PMID: 16954342.
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    71. Löfberg E, Gutierrez A, Anderstam B, Wernerman J, Bergström J, Price SR, Mitch WE, Alvestrand A. Effect of bicarbonate on muscle protein in patients receiving hemodialysis. Am J Kidney Dis. 2006 Sep; 48(3):419-29. PMID: 16931215.
      View in: PubMed
    72. Mitch WE. Proteolytic mechanisms, not malnutrition, cause loss of muscle mass in kidney failure. J Ren Nutr. 2006 Jul; 16(3):208-11. PMID: 16825021.
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    73. Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006 Sep; 147(9):4160-8. PMID: 16777975.
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    74. Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 2006 Jul; 17(7):1807-19. PMID: 16738015.
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    75. Keane WF, Zhang Z, Lyle PA, Cooper ME, de Zeeuw D, Grunfeld JP, Lash JP, McGill JB, Mitch WE, Remuzzi G, Shahinfar S, Snapinn SM, Toto R, Brenner BM. Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy: the RENAAL study. Clin J Am Soc Nephrol. 2006 Jul; 1(4):761-7. PMID: 17699284.
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    76. Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy. J Am Soc Nephrol. 2006 May; 17(5):1388-94. PMID: 16611720.
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    77. Mitch WE. Metabolic and clinical consequences of metabolic acidosis. J Nephrol. 2006 Mar-Apr; 19 Suppl 9:S70-5. PMID: 16736444.
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    78. Mandayam S, Mitch WE. Dietary protein restriction benefits patients with chronic kidney disease. Nephrology (Carlton). 2006 Feb; 11(1):53-7. PMID: 16509933.
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    79. Mandayam S, Mitch WE. Is cystatin C more effective than creatinine in predicting adverse cardiovascular outcomes in elderly people? Nat Clin Pract Nephrol. 2005 Nov; 1(1):8-9. PMID: 16932354.
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    80. Du J, Hu Z, Mitch WE. Cellular signals activating muscle proteolysis in chronic kidney disease: a two-stage process. Int J Biochem Cell Biol. 2005 Oct; 37(10):2147-55. PMID: 15982920.
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    81. Du J, Mitch WE. Identification of pathways controlling muscle protein metabolism in uremia and other catabolic conditions. Curr Opin Nephrol Hypertens. 2005 Jul; 14(4):378-82. PMID: 15931008.
      View in: PubMed
    82. Mitch WE. Cachexia in chronic kidney disease: a link to defective central nervous system control of appetite. J Clin Invest. 2005 Jun; 115(6):1476-8. PMID: 15931387; PMCID: PMC1137008.
    83. Li PK, Weening JJ, Dirks J, Lui SL, Szeto CC, Tang S, Atkins RC, Mitch WE, Chow KM, D'Amico G, Freedman BI, Harris DC, Hooi LS, Jong PE, Kincaid-Smith P, Lai KN, Lee E, Li FK, Lin SY, Lo WK, Mani MK, Mathew T, Murakami M, Qian JQ, Ramirez S, Reiser T, Tomino Y, Tong MK, Tsang WK, Tungsanga K, Wang H, Wong AK, Wong KM, Yang WC, de Zeeuw D, Yu AW, Remuzzi G. A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004. Kidney Int Suppl. 2005 Apr; (94):S2-7. PMID: 15752234.
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    84. Mitch WE. Beneficial responses to modified diets in treating patients with chronic kidney disease. Kidney Int Suppl. 2005 Apr; (94):S133-5. PMID: 15752230.
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    85. Song YH, Li Y, Du J, Mitch WE, Rosenthal N, Delafontaine P. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest. 2005 Feb; 115(2):451-8. PMID: 15650772; PMCID: PMC544037.
    86. Mitch WE. 2004 Presidential Address: An evaluation of progress toward goals. J Am Soc Nephrol. 2005 Mar; 16(3):576-82. PMID: 15677306.
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    87. Mitch WE, Hu Z, Lee SW, Du J. Strategies for suppressing muscle atrophy in chronic kidney disease: mechanisms activating distinct proteolytic systems. J Ren Nutr. 2005 Jan; 15(1):23-7. PMID: 15648002.
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    88. Workeneh B, Balakumaran A, Bichet DG, Mitch WE. The dilemma of diagnosing the cause of hypernatraemia: drinking habits vs diabetes insipidus. Nephrol Dial Transplant. 2004 Dec; 19(12):3165-7. PMID: 15575005.
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    89. Mitch WE, Shahinfar S, Dickson TZ, de Zeeuw D, Zhang Z. Detecting and managing patients with type 2 diabetic kidney disease: proteinuria and cardiovascular disease. Kidney Int Suppl. 2004 Nov; (92):S97-8. PMID: 15485428.
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    90. Ahuja TS, Mitch WE. The evidence against malnutrition as a prominent problem for chronic dialysis patients. Semin Dial. 2004 Nov-Dec; 17(6):427-31. PMID: 15660572.
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    91. Mitch WE. Treating diabetic nephropathy--are there only economic issues? N Engl J Med. 2004 Nov 4; 351(19):1934-6. PMID: 15516698.
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    92. Ahuja TS, Mitch WE. Protein catabolism in chronic uremia: is it due to malnutrition? Arch Immunol Ther Exp (Warsz). 2004 Sep-Oct; 52(5):326-31. PMID: 15507873.
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    93. Mitch WE, Du J. Cellular mechanisms causing loss of muscle mass in kidney disease. Semin Nephrol. 2004 Sep; 24(5):484-7. PMID: 15490416.
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    94. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, Snapinn S, Cooper ME, Mitch WE, Brenner BM. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation. 2004 Aug 24; 110(8):921-7. PMID: 15302780.
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    95. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, Snapinn S, Cooper ME, Mitch WE, Brenner BM. Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL. Kidney Int. 2004 Jun; 65(6):2309-20. PMID: 15149345.
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    96. Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE. Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. J Am Soc Nephrol. 2004 Jun; 15(6):1537-45. PMID: 15153564.
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    97. Kaysen GA, Dubin JA, Müller HG, Rosales L, Levin NW, Mitch WE. Inflammation and reduced albumin synthesis associated with stable decline in serum albumin in hemodialysis patients. Kidney Int. 2004 Apr; 65(4):1408-15. PMID: 15086482.
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    98. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest. 2004 Jan; 113(1):115-23. PMID: 14702115; PMCID: PMC300763.
    99. Mitch WE, Remuzzi G. Diets for patients with chronic kidney disease, still worth prescribing. J Am Soc Nephrol. 2004 Jan; 15(1):234-7. PMID: 14694178.
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    100. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004 Jan; 18(1):39-51. PMID: 14718385.
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    101. Keane WF, Brenner BM, de Zeeuw D, Grunfeld JP, McGill J, Mitch WE, Ribeiro AB, Shahinfar S, Simpson RL, Snapinn SM, Toto R. The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study. Kidney Int. 2003 Apr; 63(4):1499-507. PMID: 12631367.
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    102. Mitch WE. Getting beyond cross-sectional studies of abnormal nutritional indexes in dialysis patients. Am J Clin Nutr. 2003 Apr; 77(4):760-1. PMID: 12663268.
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    103. Mitch WE, Price SR. Mechanisms activating proteolysis to cause muscle atrophy in catabolic conditions. J Ren Nutr. 2003 Apr; 13(2):149-52. PMID: 12671840.
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    104. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest. 2003 Apr; 111(8):1201-9. PMID: 12697739; PMCID: PMC152929.
    105. Kaysen GA, Dubin JA, Müller HG, Mitch WE, Rosales L, Levin NW. Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients. Kidney Int. 2003 Jan; 63(1):315-22. PMID: 12472798.
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    106. Masud T, Manatunga A, Cotsonis G, Mitch WE. The precision of estimating protein intake of patients with chronic renal failure. Kidney Int. 2002 Nov; 62(5):1750-6. PMID: 12371976.
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    107. Mitch WE. Malnutrition: a frequent misdiagnosis for hemodialysis patients. J Clin Invest. 2002 Aug; 110(4):437-9. PMID: 12189236; PMCID: PMC150424.
    108. Kaysen GA, Dubin JA, Müller HG, Mitch WE, Rosales LM, Levin NW. Relationships among inflammation nutrition and physiologic mechanisms establishing albumin levels in hemodialysis patients. Kidney Int. 2002 Jun; 61(6):2240-9. PMID: 12028466.
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    109. Bonow RO, Mitch WE, Nesto RW, O'Gara PT, Becker RC, Clark LT, Hunt S, Jialal I, Lipshultz SE, Loh E. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group V: management of cardiovascular-renal complications. Circulation. 2002 May 7; 105(18):e159-64. PMID: 11994267.
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    110. Pickering WP, Price SR, Bircher G, Marinovic AC, Mitch WE, Walls J. Nutrition in CAPD: serum bicarbonate and the ubiquitin-proteasome system in muscle. Kidney Int. 2002 Apr; 61(4):1286-92. PMID: 11918735.
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    111. Marinovic AC, Zheng B, Mitch WE, Price SR. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. J Biol Chem. 2002 May 10; 277(19):16673-81. PMID: 11872750.
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    112. Mitch WE. Insights into the abnormalities of chronic renal disease attributed to malnutrition. J Am Soc Nephrol. 2002 Jan; 13 Suppl 1:S22-7. PMID: 11792758.
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    113. Mitch WE, Levy CC. Residue specificity of an endonuclease isolated from aerobacter Sp. Biochim Biophys Acta. 1972 Jan 18; 259(1):69-75. PMID: 5011975.
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    114. Mitch WE, Levy CC. Anomalous behavior or ribonuclease A on Sephadex G-100. Biochim Biophys Acta. 1971 Dec 28; 251(3):388-92. PMID: 11452881.
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    115. Mitch WE, Serpick AA. Leukemic infiltration of the prostate: a reversible form of urinary obstruction. Cancer. 1970 Dec; 26(6):1361-5. PMID: 4098491.
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