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JASON HEANEY

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
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    U42OD035581     (HEANEY, JASON D.)Dec 1, 2023 - Nov 30, 2028
    NIH
    BCM/RICE GENOME EDITING TESTING CENTER
    Role: Principal Investigator
    U54OD030165     (HEANEY, JASON D.)Sep 15, 2020 - Aug 31, 2025
    NIH
    BCM Center for Precision Medicine Models
    Role: Principal Investigator
    U42OD026645     (DICKINSON, MARY E;HEANEY, JASON D ;LAGOR, WILLIAM RAYMOND)Sep 18, 2018 - Jul 31, 2024
    NIH
    BCM-Rice resource for the analysis of somatic gene editing in mice
    Role: Principal Investigator
    R00HD059945     (HEANEY, JASON D)Mar 6, 2012 - Feb 28, 2015
    NIH
    Primordial germ cell differentiation and the initiation of testicular cancer
    Role: Principal Investigator
    UM1HG006348     (HEANEY, JASON D.)Sep 16, 2011 - Jun 30, 2027
    NIH
    The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2)
    Role: Co-Principal Investigator
    K99HD059945     (HEANEY, JASON D)Apr 14, 2010 - Mar 31, 2012
    NIH
    Primordial germ cell differentiation and the initiation of testicular cancer
    Role: Principal Investigator
    F32CA119623     (HEANEY, JASON D)Aug 1, 2006 - Jun 30, 2008
    NIH
    Testicular tumor susceptibility at the agouti locus
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Walkey CJ, Snow KJ, Bulcha J, Cox AR, Martinez AE, Ljungberg MC, Lanza DG, De Giorgi M, Chuecos MA, Alves-Bezerra M, Suarez CF, Hartig SM, Hilsenbeck SG, Hsu CW, Saville E, Gaitan Y, Duryea J, Hannigan S, Dickinson ME, Mirochnitchenko O, Wang D, Lutz CM, Heaney JD, Gao G, Murray SA, Lagor WR, Lanza DG, Hilsenbeck SG, Heaney JD, Lagor WR. A comprehensive atlas of AAV tropism in the mouse. Mol Ther. 2025 Jan 25. PMID: 39863928.
      Citations:    Fields:    
    2. Vo P, Imai-Leonard DM, Yang B, Briere A, Shao A, Casanova MI, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Braun R, Brown S, Burrill S, Cho SY, Clementson-Mobbs S, D'Souza A, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, H?rault Y, Angelis MH, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Murray S, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Ryan J, Salazar J, Seavey Z, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Udensi U, Wells S, White J, Willett A, Wotton J, Wurst W, Yoshiki A, International Mouse Phenotyping Consortium, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A. Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes. BMC Genomics. 2025 Jan 20; 26(1):48. PMID: 39833678; PMCID: PMC11744888.
      Citations:    Fields:    
    3. Chen YT, Jiang MM, Leynes C, Adeyeye M, Majano CF, Ibrahim B, Polak U, Hung G, Jin Z, Lanza DG, Liao L, Dawson B, Chen-Evenson Y, Ruiz OE, Gibbons RJ, Heaney JD, Bae Y, Lee B. ATRX silences Cartpt expression in osteoblastic cells during skeletal development. J Clin Invest. 2025 Jan 02; 135(1). PMID: 39744954; PMCID: PMC11684799.
      Citations:    Fields:    Translation:AnimalsCells
    4. Pave?kovic M, De-Paula RB, Ojelade SA, Tantry EK, Kochukov MY, Bao S, Veeraragavan S, Garza AR, Srivastava S, Song SY, Fujita M, Duong DM, Bennett DA, De Jager PL, Seyfried NT, Dickinson ME, Heaney JD, Arenkiel BR, Shulman JM. Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity. Hum Mol Genet. 2024 10 07; 33(20):1815-1832. PMID: 39146503; PMCID: PMC11458016.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, H?rault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA, International Mouse Phenotyping Consortium, Murray SA, Heaney JD, Nutter LMJ. Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines. Sci Rep. 2024 09 30; 14(1):22626. PMID: 39349521; PMCID: PMC11443006.
      Citations:    Fields:    Translation:Animals
    6. Walkey CJ, Snow KJ, Bulcha J, Cox AR, Martinez AE, Ljungberg MC, Lanza DG, Giorgi M, Chuecos MA, Alves-Bezerra M, Suarez CF, Hartig SM, Hilsenbeck SG, Hsu CW, Saville E, Gaitan Y, Duryea J, Hannigan S, Dickinson ME, Mirochnitchenko O, Wang D, Lutz CM, Heaney JD, Gao G, Murray SA, Lagor WR. A Comprehensive Atlas of AAV Tropism in the Mouse. bioRxiv. 2024 Sep 10. PMID: 39314496; PMCID: PMC11418986.
      Citations: 1     
    7. Marom R, Song IW, Busse EC, Washington ME, Berrier AS, Rossi VC, Ortinau L, Jeong Y, Jiang MM, Dawson BC, Adeyeye M, Leynes C, Lietman CD, Stroup BM, Batkovskyte D, Jain M, Chen Y, Cela R, Castellon A, Tran AA, Lorenzo I, Meyers DN, Huang S, Turner A, Shenava V, Wallace M, Orwoll E, Park D, Ambrose CG, Nagamani SC, Heaney JD, Lee BH, Marom R, Song IW, Busse EC, Washington ME, Berrier AS, Rossi VC, Ortinau L, Jeong Y, Jiang MM, Dawson BC, Adeyeye M, Leynes C, Lietman CD, Stroup BM, Batkovskyte D, Jain M, Chen Y, Cela R, Castellon A, Tran AA, Lorenzo I, Meyers DN, Huang S, Turner A, Shenava V, Wallace M, Orwoll E, Park D, Ambrose CG, Nagamani SC, Heaney JD, Lee BH. The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect. J Clin Invest. 2024 Jun 17; 134(15). PMID: 38885336; PMCID: PMC11290974.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Yang L, Leynes C, Pawelka A, Lorenzo I, Chou A, Lee B, Heaney JD. Machine learning in time-lapse imaging to differentiate embryos from young vs old mice?. Biol Reprod. 2024 Jun 12; 110(6):1115-1124. PMID: 38685607; PMCID: PMC11180621.
      Citations: 1     Fields:    Translation:Animals
    9. Lanza DG, Mao J, Lorenzo I, Liao L, Seavitt JR, Ljungberg MC, Simpson EM, DeMayo FJ, Heaney JD. An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing. Genesis. 2024 04; 62(2):e23589. PMID: 38523431; PMCID: PMC10987075.
      Citations:    Fields:    Translation:AnimalsCells
    10. Song IW, Washington M, Leynes C, Hsu J, Rayavara K, Bae Y, Haelterman N, Chen Y, Jiang MM, Drelich A, Tat V, Lanza DG, Lorenzo I, Heaney JD, Tseng CK, Lee B, Marom R. Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection. Mamm Genome. 2024 Jun; 35(2):113-121. PMID: 38488938.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Chadchan SB, Popli P, Liao Z, Andreas E, Dias M, Wang T, Gunderson SJ, Jimenez PT, Lanza DG, Lanz RB, Foulds CE, Monsivais D, DeMayo FJ, Yalamanchili HK, Jungheim ES, Heaney JD, Lydon JP, Moley KH, O'Malley BW, Kommagani R. A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis. Nat Commun. 2024 Mar 02; 15(1):1947. PMID: 38431630; PMCID: PMC10908778.
      Citations: 1     Fields:    Translation:HumansAnimals
    12. Rana N, Privitera G, Kondolf HC, Bulek K, Lechuga S, De Salvo C, Corridoni D, Antanaviciute A, Maywald RL, Hurtado AM, Zhao J, Huang EH, Li X, Chan ER, Simmons A, Bamias G, Abbott DW, Heaney JD, Ivanov AI, Pizarro TT. GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Cell. 2024 Feb 15; 187(4):1011-1015. PMID: 38364781.
      Citations:    Fields:    
    13. Ahmed AA, Salas E, Lanza DG, Heaney JD, Pangas SA. Generation of a novel Stra8-driven Cre recombinase strain for use in pre-meiotic germ cells in mice?. Biol Reprod. 2023 08 10; 109(2):184-191. PMID: 37279768; PMCID: PMC10427807.
      Citations:    Fields:    Translation:AnimalsCells
    14. Stroup BM, Li X, Ho S, Zhouyao H, Chen Y, Ani S, Dawson B, Jin Z, Marom R, Jiang MM, Lorenzo I, Rosen D, Lanza D, Aceves N, Koh S, Seavitt JR, Heaney JD, Lee B, Burrage LC. Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance. Dis Model Mech. 2023 08 01; 16(8). PMID: 37486182; PMCID: PMC10445726.
      Citations:    Fields:    Translation:Animals
    15. Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BE. Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 07; 21(7):e3002112. PMID: 37467291; PMCID: PMC10355383.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Peterson KA, Khalouei S, Hanafi N, Wood JA, Lanza DG, Lintott LG, Willis BJ, Seavitt JR, Braun RE, Dickinson ME, White JK, Lloyd KCK, Heaney JD, Murray SA, Ramani A, Nutter LMJ. Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity. Commun Biol. 2023 06 10; 6(1):626. PMID: 37301944; PMCID: PMC10257658.
      Citations: 3     Translation:Animals
    17. Oestereicher MA, Wotton JM, Ayabe S, Bou About G, Cheng TK, Choi JH, Clary D, Dew EM, Elfertak L, Guimond A, Haseli Mashhadi H, Heaney JD, Kelsey L, Keskivali-Bond P, Lopez Gomez F, Marschall S, McFarland M, Meziane H, Munoz Fuentes V, Nam KH, Nichtov? Z, Pimm D, Bower L, Prochazka J, Rozman J, Santos L, Stewart M, Tanaka N, Ward CS, Willett AME, Wilson R, Braun RE, Dickinson ME, Flenniken AM, Herault Y, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Sedlacek R, Seong JK, Sorg T, Tamura M, Wells S, Schneltzer E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, White JK, Spielmann N. Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. Mamm Genome. 2023 06; 34(2):180-199. PMID: 37294348; PMCID: PMC10290602.
      Citations:    Fields:    Translation:Animals
    18. Maurya VK, Ying Y, Lanza DG, Heaney JD, Lydon JP. A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor. Genesis. 2023 07; 61(3-4):e23515. PMID: 36949241; PMCID: PMC10514223.
      Citations:    Fields:    Translation:Animals
    19. Chee JM, Lanoue L, Clary D, Higgins K, Bower L, Flenniken A, Guo R, Adams DJ, Bosch F, Braun RE, Brown SDM, Chin HG, Dickinson ME, Hsu CW, Dobbie M, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Mammano F, Nutter LMJ, Parkinson H, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y, International Mouse Phenotyping Consortium, Brooks B, McKerlie C, Lloyd KCK, Westerberg H, Moshiri A. Genome-wide screening reveals the genetic basis of mammalian embryonic eye development. BMC Biol. 2023 02 03; 21(1):22. PMID: 36737727; PMCID: PMC9898963.
      Citations:    Fields:    Translation:HumansAnimals
    20. Lorincz R, Alvarez AB, Walkey CJ, Mendon?a SA, Lu ZH, Martinez AE, Ljungberg C, Heaney JD, Lagor WR, Curiel DT. In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector. Biomed Pharmacother. 2023 Feb; 158:114189. PMID: 36587560.
      Citations: 1     Fields:    Translation:AnimalsCells
    21. Higgins K, Moore BA, Berberovic Z, Adissu HA, Eskandarian M, Flenniken AM, Shao A, Imai DM, Clary D, Lanoue L, Newbigging S, Nutter LMJ, Adams DJ, Bosch F, Braun RE, Brown SDM, Dickinson ME, Dobbie M, Flicek P, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Chin HG, Mammano F, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y, IMPC Consortium, Lloyd KCK, McKerlie C, Moshiri A. Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes. Sci Rep. 2022 12 01; 12(1):20791. PMID: 36456625; PMCID: PMC9715561.
      Citations: 2     Fields:    Translation:AnimalsCells
    22. Cacheiro P, Westerberg CH, Mager J, Dickinson ME, Nutter LMJ, Mu?oz-Fuentes V, Hsu CW, Van den Veyver IB, Flenniken AM, McKerlie C, Murray SA, Teboul L, Heaney JD, Lloyd KCK, Lanoue L, Braun RE, White JK, Creighton AK, Laurin V, Guo R, Qu D, Wells S, Cleak J, Bunton-Stasyshyn R, Stewart M, Harrisson J, Mason J, Haseli Mashhadi H, Parkinson H, Mallon AM, International Mouse Phenotyping Consortium, Genomics England Research Consortium, Smedley D. Mendelian gene identification through mouse embryo viability screening. Genome Med. 2022 10 13; 14(1):119. PMID: 36229886; PMCID: PMC9563108.
      Citations: 2     Fields:    Translation:HumansAnimals
    23. Rana N, Privitera G, Kondolf HC, Bulek K, Lechuga S, De Salvo C, Corridoni D, Antanaviciute A, Maywald RL, Hurtado AM, Zhao J, Huang EH, Li X, Chan ER, Simmons A, Bamias G, Abbott DW, Heaney JD, Ivanov AI, Pizarro TT. GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Cell. 2022 01 20; 185(2):283-298.e17. PMID: 35021065; PMCID: PMC8879997.
      Citations: 9     Fields:    Translation:HumansCells
    24. Liang SQ, Walkey CJ, Martinez AE, Su Q, Dickinson ME, Wang D, Lagor WR, Heaney JD, Gao G, Xue W. AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Mol Ther. 2022 Jan 05; 30(1):238-243. PMID: 34695545; PMCID: PMC8753568.
      Citations: 1     Fields:    Translation:Animals
    25. Marom R, Burrage LC, Venditti R, Jain M, Scott DA, Rosenfeld JA, Sutton VR, Shinawi M, Mirzaa G, DeVile C, Roberts R, Calder AD, Allgrove J, Grafe I, Lanza DG, Li X, Joeng KS, Lee YC, Song IW, Sliepka JM, Batkovskyte D, Washington M, Dawson BC, Jin Z, Jiang MM, Chen S, Chen Y, Tran AA, Emrick LT, Murdock DR, Hanchard NA, Zapata GE, Mehta NR, Weis MA, Scott AA, Tremp BA, Phillips JB, Wegner J, Taylor-Miller T, Gibbs RA, Muzny DM, Jhangiani SN, Hicks J, Stottmann RW, Dickinson ME, Seavitt JR, Heaney JD, Eyre DR, Undiagnosed Diseases Network, Westerfield M, De Matteis MA, Lee B, Cl?ment A, Blanco-S?nchez B. COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. Am J Hum Genet. 2021 09 02; 108(9):1710-1724. PMID: 34450031; PMCID: PMC8456174.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    26. Karolak JA, Gambin T, Szafranski P, Maywald RL, Popek E, Heaney JD, Stankiewicz P. Perturbation of semaphorin and VEGF signaling in ACDMPV lungs due to FOXF1 deficiency. Respir Res. 2021 Jul 27; 22(1):212. PMID: 34315444; PMCID: PMC8314029.
      Citations: 1     Fields:    Translation:HumansCells
    27. Keehan L, Jiang MM, Li X, Marom R, Dai H, Murdock D, Liu P, Hunter JV, Heaney JD, Robak L, Emrick L, Lotze T, Blieden LS, Undiagnosed Diseases Network, Lewis RA, Levin AV, Capasso J, Craigen WJ, Rosenfeld JA, Lee B, Burrage LC. A novel de novo intronic variant in ITPR1 causes Gillespie syndrome. Am J Med Genet A. 2021 08; 185(8):2315-2324. PMID: 33949769; PMCID: PMC8562426.
      Citations:    Fields:    Translation:Humans
    28. Webster NJ, Maywald RL, Benton SM, Dawson EP, Murillo OD, LaPlante EL, Milosavljevic A, Lanza DG, Heaney JD. Testicular germ cell tumors arise in the absence of sex-specific differentiation. Development. 2021 05 01; 148(9). PMID: 33912935; PMCID: PMC8126408.
      Citations: 5     Fields:    Translation:AnimalsCells
    29. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium. The NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204. PMID: 33828315; PMCID: PMC8026397.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    30. Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Jiang ST, Justice MJ, Kasparek P, King RE, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Seavitt JR, Sedlacek R, Seong JK, Skarnes WC, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wells S, Wiles MV, Willis BJ, Wood JA, Xu Y, International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA, Birling MC, B?rger A, H?rault Y, de Angelis MH, K?hn R, Pavlovic G, Schick J, Seisenberger C, Sorg T, Wattenhofer-Donz? M, Wurst W. A resource of targeted mutant mouse lines for 5,061 genes. Nat Genet. 2021 04; 53(4):416-419. PMID: 33833456; PMCID: PMC8397259.
      Citations: 19     Fields:    Translation:AnimalsCells
    31. Swan AL, Brandmaier S, Simon M, Griffiths M, Keskivali-Bond P, Grallert H, Werner T, Teperino R, Moshiri A, Seavitt JR, Cissell DD, Meehan TF, Acar EF, Lelliott CJ, Flenniken AM, Braun RE, Cater H, Dickinson ME, Flicek P, Gallegos J, Ghirardello EJ, Heaney JD, Lally C, Logan JG, Teboul L, Mason J, McKerlie C, Murray SA, Nutter LMJ, Odfalk KF, Parkinson H, Prochazka J, Reynolds CL, Spoutil F, Svenson KL, Vales TS, Wells SE, White JK, Sedlacek R, Lloyd KCK, Croucher PI, Williams GR, Bassett JHD, Mallon AM, Brown SDM, IMPC Consortium, Sch?tt C, Rozman J, Del Mar Mu?iz Moreno M, Leuchtenberger S, Brommage R, Becker L, Miller G, Champy MF, Sorg T, Ayadi A, Jacquot S, Spielmann N, Selloum M, Wurst W, Fuchs H, Gailus-Durner V, Herault Y, Mayer-Kuckuk P, Hrabe de Angelis M. Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. PLoS Genet. 2020 12; 16(12):e1009190. PMID: 33370286; PMCID: PMC7822523.
      Citations: 4     Fields:    Translation:AnimalsCells
    32. Stroup BM, Marom R, Li X, Hsu CW, Chang CY, Truong LD, Dawson B, Grafe I, Chen Y, Jiang MM, Lanza D, Green JR, Sun Q, Barrish JP, Ani S, Christiansen AE, Seavitt JR, Dickinson ME, Kheradmand F, Heaney JD, Lee B, Burrage LC. A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance. Hum Mol Genet. 2020 08 03; 29(13):2171-2184. PMID: 32504080; PMCID: PMC7399531.
      Citations: 4     Fields:    Translation:HumansAnimals
    33. Haselimashhadi H, Mason JC, Munoz-Fuentes V, Babalola K, Acar EF, Kumar V, White J, Flenniken AM, King R, Straiton E, Seavitt JR, Gaspero A, Garza A, Christianson AE, Hsu CW, Reynolds CL, Lanza DG, Lorenzo I, Green JR, Gallegos JJ, Bohat R, Samaco RC, Veeraragavan S, Kim JK, Miller G, Fuchs H, Garrett L, Becker L, Kang YK, Clary D, Cho SY, Tamura M, Tanaka N, Soo KD, Bezginov A, Spielmann N, Maier H, Gailus-Durner V, Hiroshi M, Yuichi O, Heaney JD, Dickinson ME, Wolfgang W, Tocchini-Valentini GP, Lloyd KCK, McKerlie C, Seong JK, Brown SDM, Smedley D, Flicek P, Mallon AM, Parkinson H, Meehan TF, L?pez-G?mez F, About GB, Champy MF, Vasseur L, Leblanc S, Meziane H, Selloum M, Reilly PT, Sorg T, Yann H, de Angelis MH. Soft windowing application to improve analysis of high-throughput phenotyping data. Bioinformatics. 2020 03 01; 36(5):1492-1500. PMID: 31591642; PMCID: PMC7115897.
      Citations: 1     Fields:    Translation:HumansAnimals
    34. Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Lupski JR, Mallon AM, Mammano F, MacRae CA, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Xu Y, Brown SDM, Bosch F, Herault Y, de Angelis MH, Lyonnet S, McInnes R, Wurst W. The Deep Genome Project. Genome Biol. 2020 02 03; 21(1):18. PMID: 32008577; PMCID: PMC6996159.
      Citations: 12     Fields:    Translation:HumansAnimals
    35. Cacheiro P, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D, Genomics England Research Consortium, International Mouse Phenotyping Consortium, Mu?oz-Fuentes V, Fuchs H, Gailus-Durner V, Sorg T, Wurst W, Herault Y, de Angelis MH. Human and mouse essentiality screens as a resource for disease gene discovery. Nat Commun. 2020 01 31; 11(1):655. PMID: 32005800; PMCID: PMC6994715.
      Citations: 14     Fields:    Translation:HumansAnimals
    36. Cacheiro P, Haendel MA, Smedley D, International Mouse Phenotyping Consortium and the Monarch Initiative. New models for human disease from the International Mouse Phenotyping Consortium. Mamm Genome. 2019 06; 30(5-6):143-150. PMID: 31127358; PMCID: PMC6606664.
      Citations: 21     Fields:    Translation:HumansAnimals
    37. Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Shen W, Mao R, Heaney JD, Orange JS, University of Washington Center for Mendelian Genomics, Undiagnosed Diseases Network, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B, Huber C, Cormier-Daire V, Bertola D, Yamamoto GL, Baratela WAR. Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Am J Hum Genet. 2019 03 07; 104(3):422-438. PMID: 30773277; PMCID: PMC6408318.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    38. Hai L, Szwarc MM, Lanza DG, Heaney JD, Lydon JP. Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor. Genesis. 2019 03; 57(3):e23281. PMID: 30628160; PMCID: PMC6422732.
      Citations: 2     Fields:    Translation:Animals
    39. Lanza DG, Gaspero A, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C, Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, Heaney JD. Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. BMC Biol. 2018 Jun 21; 16(1):69. PMID: 29925370; PMCID: PMC6011517.
      Citations: 25     Fields:    Translation:AnimalsCells
    40. Cacheiro P, Meehan TF, Brown SDM, Flenniken AM, Flicek P, Galli A, Mashhadi HH, Kim JK, Lloyd KCK, McKerlie C, Morgan H, Murray SA, Nutter LMJ, Reilly PT, Seavitt JR, Seong JK, Simon M, Wardle-Jones H, Mallon AM, Smedley D, Parkinson HE, IMPC consortium, Mu?oz-Fuentes V, Aguilar-Pimentel JA, Hrabe de Angelis M. The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation. Conserv Genet. 2018; 19(4):995-1005. PMID: 30100824; PMCID: PMC6061128.
      Citations: 34     
    41. Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M. Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". Nat Methods. 2018 04; 15(4):235-236. PMID: 29600991.
      Citations: 15     Fields:    Translation:Cells
    42. Dawson EP, Lanza DG, Webster NJ, Benton SM, Suetake I, Heaney JD. Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency. Development. 2018 03 15; 145(6). PMID: 29545285; PMCID: PMC6514421.
      Citations: 9     Fields:    Translation:AnimalsCells
    43. Szafranski P, Karolak JA, Lanza D, Gajecka M, Heaney J, Stankiewicz P. CRISPR/Cas9-mediated deletion of lncRNA Gm26878 in the distant Foxf1 enhancer region. Mamm Genome. 2017 Aug; 28(7-8):275-282. PMID: 28405742; PMCID: PMC6502246.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    44. Santiago-Sim T, Burrage LC, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Nagakura H, Immken LL, Littlejohn RO, Roeder E, EuroEPINOMICS RES Consortium Autosomal Recessive working group, S. Hande Caglayan, Kara B, Hardies K, Weckhuysen S, May P, Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY, Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg MC, Wells S, Johnson SJ, Teboul L, Eng CM, Yang Y, Heaney JD, Walkiewicz MA, Ebstein F, Lehmann A, Cogn? B, K?ry S, Besnard T, Isidor B, B?zieau S, Hazart I, Kloetzel PM. Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. Am J Hum Genet. 2017 Apr 06; 100(4):676-688. PMID: 28343629; PMCID: PMC5384096.
      Citations: 27     Fields:    Translation:HumansAnimals
    45. Salz HK, Dawson EP, Heaney JD. Germ cell tumors: Insights from the Drosophila ovary and the mouse testis. Mol Reprod Dev. 2017 03; 84(3):200-211. PMID: 28079292; PMCID: PMC5365366.
      Citations: 6     Fields:    Translation:Animals
    46. Doerner SK, Reis ES, Leung ES, Ko JS, Heaney JD, Berger NA, Lambris JD, Nadeau JH. High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity. Mol Cancer Res. 2016 10; 14(10):953-965. PMID: 27535705; PMCID: PMC5330314.
      Citations: 19     Fields:    Translation:HumansAnimals
    47. Lanza DG, Dawson EP, Rao P, Heaney JD. Misexpression of cyclin D1 in embryonic germ cells promotes testicular teratoma initiation. Cell Cycle. 2016; 15(7):919-30. PMID: 26901436; PMCID: PMC4889263.
      Citations: 9     Fields:    Translation:AnimalsCells
    48. Maywald RL, Doerner SK, Pastorelli L, De Salvo C, Benton SM, Dawson EP, Lanza DG, Berger NA, Markowitz SD, Lenz HJ, Nadeau JH, Pizarro TT, Heaney JD. IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):E2487-96. PMID: 25918379; PMCID: PMC4434739.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    49. Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH. Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet. 2013 Jun 17; 14:54. PMID: 23773267; PMCID: PMC3693958.
      Citations: 13     Fields:    Translation:Animals
    50. Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH. Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2766-73. PMID: 22923694; PMCID: PMC3478648.
      Citations: 26     Fields:    Translation:Animals
    51. Heaney JD, Anderson EL, Michelson MV, Zechel JL, Conrad PA, Page DC, Nadeau JH. Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice. Development. 2012 May; 139(9):1577-86. PMID: 22438569; PMCID: PMC3317965.
      Citations: 30     Fields:    Translation:AnimalsCells
    52. Zechel JL, MacLennan GT, Heaney JD, Nadeau JH. Spontaneous metastasis in mouse models of testicular germ-cell tumours. Int J Androl. 2011 Aug; 34(4 Pt 2):e278-87. PMID: 21651572; PMCID: PMC3979466.
      Citations: 3     Fields:    Translation:AnimalsCells
    53. Zhu R, Heaney J, Nadeau JH, Ali S, Matin A. Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res. 2010 Sep 15; 70(18):7264-72. PMID: 20736371; PMCID: PMC2940986.
      Citations: 16     Fields:    Translation:AnimalsCells
    54. Millward CA, Desantis D, Hsieh CW, Heaney JD, Pisano S, Olswang Y, Reshef L, Beidelschies M, Puchowicz M, Croniger CM. Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. J Lipid Res. 2010 Jun; 51(6):1452-63. PMID: 20124556; PMCID: PMC3035508.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    55. Heaney JD, Michelson MV, Youngren KK, Lam MY, Nadeau JH. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet. 2009 Apr 15; 18(8):1395-404. PMID: 19168544; PMCID: PMC2664146.
      Citations: 27     Fields:    Translation:Animals
    56. Heaney JD, Lam MY, Michelson MV, Nadeau JH. Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice. Cancer Res. 2008 Jul 01; 68(13):5193-7. PMID: 18593919; PMCID: PMC2562736.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    57. Heaney JD, Nadeau JH. Testicular germ cell tumors in mice: new ways to study a genetically complex trait. Methods Mol Biol. 2008; 450:211-31. PMID: 18370062.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    58. Lam MY, Heaney JD, Youngren KK, Kawasoe JH, Nadeau JH. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet. 2007 Sep 15; 16(18):2233-40. PMID: 17616517.
      Citations: 25     Fields:    Translation:Animals
    59. Millward CA, Heaney JD, Sinasac DS, Chu EC, Bederman IR, Gilge DA, Previs SF, Croniger CM. Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity. Diabetes. 2007 Jan; 56(1):161-7. PMID: 17192478; PMCID: PMC2676912.
      Citations: 47     Fields:    Translation:AnimalsCells
    60. Woll NL, Heaney JD, Bronson SK. Osteogenic nodule formation from single embryonic stem cell-derived progenitors. Stem Cells Dev. 2006 Dec; 15(6):865-79. PMID: 17253949.
      Citations: 12     Fields:    Translation:HumansCells
    61. Heaney JD, Bronson SK. Artificial chromosome-based transgenes in the study of genome function. Mamm Genome. 2006 Aug; 17(8):791-807. PMID: 16897340.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    62. Heaney JD, Rettew AN, Bronson SK. Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells. Genomics. 2004 Jun; 83(6):1072-82. PMID: 15177560.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    63. Kelley ML, Winge P, Heaney JD, Stephens RE, Farell JH, Van Beneden RJ, Reinisch CL, Lesser MP, Walker CW. Expression of homologues for p53 and p73 in the softshell clam (Mya arenaria), a naturally-occurring model for human cancer. Oncogene. 2001 Feb 08; 20(6):748-58. PMID: 11314008.
      Citations: 27     Fields:    Translation:AnimalsCells
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