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THEODORE WENSEL

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology
    DivisionOphthalmology


    Collapse Biography 
    Collapse awards and honors
    2005Barbara and Corbin J. Robertson Jr. Presidential Award for Excellence in Education , Baylor College of Medicine
    2013Proctor Medal, Association for Research in Vision and Ophthalmology
    2013Alcon Research Award, Alcon Research Institute

    Collapse Overview 
    Collapse overview
    Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2012, it ranked 11th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research.
    The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include:
    Visual transduction in the vertebrate retina
    G protein pathways and proteins that regulate them in the retina and the brain
    RGS proteins: GAPs for heterotrimeric G proteins
    Biomembranes
    Ocular Proteomics
    Gene repair in neurons
    Time-resolved fluorescence and luminescence
    Electron and x-ray crystallography
    Cryo-electron tomography
    Gene engineering in mice and frogs
    TRP Channels

    Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2013, it ranked 10th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research.
    The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include:
    Visual transduction in the vertebrate retina
    G protein pathways and proteins that regulate them in the retina and the brain
    RGS proteins: GAPs for heterotrimeric G proteins
    Biomembranes
    Ocular Proteomics
    Gene repair in neurons
    Time-resolved fluorescence and luminescence
    Electron and x-ray crystallography
    Cryo-electron tomography
    Gene engineering in mice and frogs
    TRP Channels

    Collapse Research 
    Collapse research activities and funding
    R01GM146315     (WENSEL, THEODORE G)Aug 1, 2022 - Apr 30, 2026
    NIH
    Cardiovascular drug target, TRPV2
    Role: Principal Investigator
    R01EY031949     (WENSEL, THEODORE G)Sep 30, 2020 - Jun 30, 2024
    NIH
    REGULATION AND FUNCTION OF RETINAL PHOSPHOINOSITIDES
    Role: Principal Investigator
    R01EY026545     (WENSEL, THEODORE G)Apr 1, 2016 - Mar 31, 2025
    NIH
    Cilium-associated structures in rod cells
    Role: Principal Investigator
    R01EY025218     (WENSEL, THEODORE G)Dec 1, 2015 - Nov 30, 2019
    NIH
    Light regulation of retinal phosphoinositides
    Role: Principal Investigator
    R01GM097207     (WENSEL, THEODORE G)Aug 1, 2012 - May 31, 2021
    NIH
    EXPLORING STRUCTURE AND SEQUENCE SPACES OF G PROTEIN-COUPLED RECEPTOR SIGNALING
    Role: Co-Principal Investigator
    U13EY021709     (WENSEL, THEODORE G)May 1, 2011 - Apr 30, 2012
    NIH
    FASEB SRC on Biology and Chemistry of Vision
    Role: Principal Investigator
    R01DA015189     (WENSEL, THEODORE G)Jul 15, 2002 - Apr 30, 2007
    NIH
    RGS Domain Function in Mammalian Brain
    Role: Principal Investigator
    R01EY011900     (WENSEL, THEODORE G)Jul 1, 1998 - Jun 30, 2012
    NIH
    RGS Protein Function in Mammalian Retina
    Role: Principal Investigator
    U13EY010618     (WENSEL, THEODORE G.)Apr 1, 1994 - Jun 30, 2015
    NIH
    Course on Fundamental Issues in Vision Research
    Role: Principal Investigator
    R01EY007981     (WENSEL, THEODORE G)Aug 1, 1989 - Feb 28, 2018
    NIH
    Trasnducin Interactions with Photoreceptor Membranes
    Role: Principal Investigator
    T32GM008280     (WENSEL, THEODORE G)Sep 30, 1988 - Jun 30, 2025
    NIH
    Houston Area Molecular Biophysics Program
    Role: Principal Investigator
    F32EY005815     (WENSEL, THEODORE G)Jun 24, 1985
    NIH
    PROTEIN INTERACTIONS IN VISUAL TRANSDUCTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pathan SS, Pugazenthi A, Dixon BREA, Wensel TG, Rosengart TK, Mathison M. Activation of a GPCR, ORL1 Receptor: A Novel Therapy to Prevent Heart Failure Progression. J Cardiovasc Dev Dis. 2024 Nov 05; 11(11). PMID: 39590198; PMCID: PMC11595155.
      Citations:    
    2. Pathan S, Pugazenthi A, Dixon BR, Wensel TG, Rosengart TK, Mathison M. Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression. Res Sq. 2024 Jul 18. PMID: 39070633; PMCID: PMC11275996.
      Citations:    
    3. Megaw R, Moye A, Zhang Z, Newton F, McPhie F, Murphy LC, McKie L, He F, Jungnickel MK, von Kriegsheim A, Tennant PA, Brotherton C, Gurniak C, Gross AK, Machesky LM, Wensel TG, Mill P. Ciliary tip actin dynamics regulate photoreceptor outer segment integrity. Nat Commun. 2024 May 21; 15(1):4316. PMID: 38773095; PMCID: PMC11109262.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Zhang Z, Moye AR, He F, Chen M, Agosto MA, Wensel TG. Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography. Life Sci Alliance. 2024 03; 7(3). PMID: 38182160; PMCID: PMC10770417.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Konecki DM, Hamrick S, Wang C, Agosto MA, Wensel TG, Lichtarge O. CovET: A covariation-evolutionary trace method that identifies protein structure-function modules. J Biol Chem. 2023 07; 299(7):104896. PMID: 37290531; PMCID: PMC10338321.
      Citations:    Fields:    Translation:Cells
    6. Huh E, Agosto MA, Wensel TG, Lichtarge O. Coevolutionary signals in metabotropic glutamate receptors capture residue contacts and long-range functional interactions. J Biol Chem. 2023 04; 299(4):103030. PMID: 36806686; PMCID: PMC10060750.
      Citations:    Fields:    Translation:Cells
    7. Robichaux MA, Wensel T, Moye AR. Expansion Microscopy of Mouse Photoreceptor Cilia. Adv Exp Med Biol. 2023; 1415:395-402. PMID: 37440063; PMCID: PMC10697808.
      Citations:    Fields:    Translation:AnimalsCells
    8. Moye AR, Robichaux MA, Wensel T. Correction to: Expansion Microscopy of Mouse Photoreceptor Cilia. Adv Exp Med Biol. 2023; 1415:C1. PMID: 37656405.
      Citations:    Fields:    
    9. Salinas SA, Mace EM, Conte MI, Park CS, Li Y, Rosario-Sepulveda JI, Mahapatra S, Moore EK, Hernandez ER, Chinn IK, Reed AE, Lee BJ, Frumovitz A, Gibbs RA, Posey JE, Forbes Satter LR, Thatayatikom A, Allenspach EJ, Wensel TG, Lupski JR, Lacorazza HD, Orange JS. An ELF4 hypomorphic variant results in NK cell deficiency. JCI Insight. 2022 12 08; 7(23). PMID: 36477361; PMCID: PMC9746917.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Robichaux MA, Nguyen V, Chan F, Kailasam L, He F, Wilson JH, Wensel TG. Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa. Dis Model Mech. 2022 05 01; 15(5). PMID: 35275162; PMCID: PMC9092655.
      Citations: 1     Fields:    Translation:HumansAnimals
    11. Huh E, Gallion J, Agosto MA, Wright SJ, Wensel TG, Lichtarge O. Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors. Proc Natl Acad Sci U S A. 2021 12 21; 118(51). PMID: 34916293; PMCID: PMC8713800.
      Citations: 1     Fields:    Translation:HumansCells
    12. Agosto MA, Adeosun AAR, Kumar N, Wensel TG. The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells. J Biol Chem. 2021 12; 297(6):101418. PMID: 34793838; PMCID: PMC8671642.
      Citations:    Fields:    Translation:AnimalsCells
    13. Potter VL, Moye AR, Robichaux MA, Wensel TG. Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP290. JCI Insight. 2021 10 22; 6(20). PMID: 34520396; PMCID: PMC8564900.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Wensel TG, Potter VL, Moye A, Zhang Z, Robichaux MA. Structure and dynamics of photoreceptor sensory cilia. Pflugers Arch. 2021 09; 473(9):1517-1537. PMID: 34050409; PMCID: PMC11216635.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    15. Rajala A, He F, Anderson RE, Wensel TG, Rajala RVS. Loss of Class III Phosphoinositide 3-Kinase Vps34 Results in Cone Degeneration. Biology (Basel). 2020 Nov 07; 9(11). PMID: 33171845; PMCID: PMC7695136.
      Citations: 1     
    16. Go YM, Zhang J, Fernandes J, Litwin C, Chen R, Wensel TG, Jones DP, Cai J, Chen Y. MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. FASEB J. 2020 09; 34(9):12502-12520. PMID: 32721041; PMCID: PMC7811279.
      Citations: 9     Fields:    Translation:AnimalsCells
    17. Agosto MA, Wensel TG. LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells. J Comp Neurol. 2021 01; 529(1):221-233. PMID: 32390181; PMCID: PMC7652719.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Wensel TG. Phosphoinositides in Retinal Function and Disease. Cells. 2020 04 02; 9(4). PMID: 32252387; PMCID: PMC7226789.
      Citations: 12     Fields:    Translation:HumansCells
    19. Robichaux MA, Potter VL, Zhang Z, He F, Liu J, Schmid MF, Wensel TG. Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23562-23572. PMID: 31690665; PMCID: PMC6876244.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Wright SJ, Agosto MA, Lichtarge O, Wensel TG, Terr?n-D?az ME. Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. J Biol Chem. 2019 12 13; 294(50):19279-19291. PMID: 31676688; PMCID: PMC6916503.
      Citations:    Fields:    Translation:HumansCells
    21. Tang J, Robichaux MA, Wu KL, Pei J, Nguyen NT, Zhou Y, Wensel TG, Xiao H. Single-Atom Fluorescence Switch: A General Approach toward Visible-Light-Activated Dyes for Biological Imaging. J Am Chem Soc. 2019 09 18; 141(37):14699-14706. PMID: 31450884; PMCID: PMC6812504.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. He F, Nichols RM, Kailasam L, Wensel TG, Agosto MA. Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells. Invest Ophthalmol Vis Sci. 2019 07 01; 60(8):2861-2874. PMID: 31260037; PMCID: PMC6607926.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 01; 26(1):40-49. PMID: 30598551; PMCID: PMC6458597.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    24. Agosto MA, Anastassov IA, Robichaux MA, Wensel TG. A Large Endoplasmic Reticulum-Resident Pool of TRPM1 in Retinal ON-Bipolar Cells. eNeuro. 2018 May-Jun; 5(3). PMID: 30027108; PMCID: PMC6051591.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. J Cell Biol. 2018 08 06; 217(8):2851-2865. PMID: 29899041; PMCID: PMC6080925.
      Citations: 17     Fields:    Translation:AnimalsCells
    26. Yu B, Egbejimi A, Dharmat R, Xu P, Zhao Z, Long B, Miao H, Chen R, Wensel TG, Cai J, Chen Y. Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium. Sci Signal. 2018 05 29; 11(532). PMID: 29844054; PMCID: PMC6198651.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    27. Agosto MA, Anastassov IA, Wensel TG. Differential epitope masking reveals synapse-specific complexes of TRPM1. Vis Neurosci. 2018 01; 35:E001. PMID: 29370879; PMCID: PMC5788301.
      Citations: 3     Fields:    Translation:AnimalsCells
    28. Tse DY, Kim SJ, Chung I, He F, Wensel TG, Wu SM. The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int J Ophthalmol. 2017; 10(9):1361-1369. PMID: 28944193; PMCID: PMC5596219.
      Citations: 2     
    29. Galaz-Montoya M, Wright SJ, Rodriguez GJ, Lichtarge O, Wensel TG. ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017 06 16; 292(24):9967-9974. PMID: 28442571; PMCID: PMC5473248.
      Citations: 12     Fields:    Translation:HumansCells
    30. Wensel TG, Zhang Z, Anastassov IA, Gilliam JC, He F, Schmid MF, Robichaux MA. Structural and molecular bases of rod photoreceptor morphogenesis and disease. Prog Retin Eye Res. 2016 11; 55:32-51. PMID: 27352937; PMCID: PMC5112133.
      Citations: 27     Fields:    Translation:HumansCells
    31. He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG. Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Rep. 2016 06 01; 6:26978. PMID: 27245220; PMCID: PMC4887901.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Sung YM, Wilkins AD, Rodriguez GJ, Wensel TG, Lichtarge O. Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3539-44. PMID: 26979958; PMCID: PMC4822589.
      Citations: 21     Fields:    Translation:HumansCells
    33. Zhao L, Chen Y, Bajaj AO, Eblimit A, Xu M, Soens ZT, Wang F, Ge Z, Jung SY, He F, Li Y, Wensel TG, Qin J, Chen R. Integrative subcellular proteomic analysis allows accurate prediction of human disease-causing genes. Genome Res. 2016 05; 26(5):660-9. PMID: 26912414; PMCID: PMC4864458.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    34. Roman-Sanchez R, Wensel TG, Wilson JH. Nonsense mutations in the rhodopsin gene that give rise to mild phenotypes trigger mRNA degradation in human cells by nonsense-mediated decay. Exp Eye Res. 2016 04; 145:444-449. PMID: 26416182; PMCID: PMC4808503.
      Citations: 4     Fields:    Translation:HumansCells
    35. Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem. 2015 Jul 10; 290(28):17131-2. PMID: 26163476; PMCID: PMC4498051.
      Citations: 5     Fields:    
    36. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. Correction: the retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2015 May; 13(5):e1002170. PMID: 26020534; PMCID: PMC4447419.
      Citations:    Fields:    
    37. Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem. 2015 May 15; 290(20):12833-43. PMID: 25809480; PMCID: PMC4432299.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    38. Wensel TG, Gilliam JC. Three-dimensional architecture of murine rod cilium revealed by cryo-EM. Methods Mol Biol. 2015; 1271:267-92. PMID: 25697530; PMCID: PMC6292516.
      Citations: 5     Fields:    Translation:AnimalsCells
    39. Kang HJ, Wilkins AD, Lichtarge O, Wensel TG. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30; 290(5):2870-8. PMID: 25519912; PMCID: PMC4317032.
      Citations: 11     Fields:    Translation:HumansCells
    40. Sandoval IM, Price BA, Gross AK, Chan F, Sammons JD, Wilson JH, Wensel TG. Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. PLoS One. 2014; 9(9):e108135. PMID: 25264759; PMCID: PMC4180260.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    41. Kang HJ, Menlove K, Ma J, Wilkins A, Lichtarge O, Wensel TG. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24; 289(43):29961-74. PMID: 25193666; PMCID: PMC4208005.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    42. Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG. Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision. J Biol Chem. 2014 Sep 26; 289(39):27019-27033. PMID: 25112866; PMCID: PMC4175340.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    43. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2014 Apr; 12(4):e1001847. PMID: 24781186; PMCID: PMC4004542.
      Citations: 35     Fields:    Translation:AnimalsCells
    44. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, WENSEL TG, Bellen HJ;. Research Article. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. 2014; 12(4):e1001847.
    45. Arshavsky VY, Wensel TG. Timing is everything: GTPase regulation in phototransduction. Invest Ophthalmol Vis Sci. 2013 Nov 21; 54(12):7725-33. PMID: 24265205; PMCID: PMC3837634.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    46. Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG. Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012 Nov 21; 151(5):1029-41. PMID: 23178122; PMCID: PMC3582337.
      Citations: 92     Fields:    Translation:AnimalsCells
    47. Price BA, Sandoval IM, Chan F, Nichols R, Roman-Sanchez R, Wensel TG, Wilson JH. Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant. PLoS One. 2012; 7(11):e49889. PMID: 23185477; PMCID: PMC3503812.
      Citations: 34     Fields:    Translation:AnimalsCells
    48. Price BA, Sandoval IM, Chan F, Simons DL, Wu SM, Wensel TG, Wilson JH. Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011 Dec 28; 52(13):9728-36. PMID: 22110080; PMCID: PMC3341127.
      Citations: 38     Fields:    Translation:AnimalsCells
    49. Gilliam JC, Wensel TG. TRP channel gene expression in the mouse retina. Vision Res. 2011 Dec 08; 51(23-24):2440-52. PMID: 22037305; PMCID: PMC3458651.
      Citations: 37     Fields:    Translation:Animals
    50. Chan F, Hauswirth WW, Wensel TG, Wilson JH. Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice. Nucleic Acids Res. 2011 Aug; 39(14):5955-66. PMID: 21478169; PMCID: PMC3152346.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    51. Moiseenkova-Bell V, Wensel TG. Functional and structural studies of TRP channels heterologously expressed in budding yeast. Adv Exp Med Biol. 2011; 704:25-40. PMID: 21290288; PMCID: PMC3615646.
      Citations: 9     Fields:    Translation:AnimalsCells
    52. Mojumder DK, Concepcion FA, Patel SK, Barkmeier AJ, Carvounis PE, Wilson JH, Holz ER, Wensel TG. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5796-803. PMID: 20505203; PMCID: PMC2932784.
      Citations: 2     Fields:    Translation:AnimalsCells
    53. Rodriguez GJ, Yao R, Lichtarge O, Wensel TG. Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7787-92. PMID: 20385837; PMCID: PMC2867884.
      Citations: 59     Fields:    Translation:HumansCells
    54. Budzynski E, Gross AK, McAlear SD, Peachey NS, Shukla M, He F, Edwards M, Won J, Hicks WL, Wensel TG, Naggert JK, Nishina PM. Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 2010 May 07; 285(19):14521-33. PMID: 20207741; PMCID: PMC2863193.
      Citations: 28     Fields:    Translation:AnimalsCells
    55. Jeffrey BG, Morgans CW, Puthussery T, Wensel TG, Burke NS, Brown RL, Duvoisin RM. R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells. Vis Neurosci. 2010 Mar; 27(1-2):9-17. PMID: 20100392; PMCID: PMC3108797.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    56. Mancuso JJ, Qian Y, Long C, Wu GY, Wensel TG. Distribution of RGS9-2 in neurons of the mouse striatum. J Neurochem. 2010 Feb; 112(3):651-61. PMID: 19912469; PMCID: PMC3642247.
      Citations: 10     Fields:    Translation:AnimalsCells
    57. Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell. 2009 Sep 04; 138(5):947-60. PMID: 19737521; PMCID: PMC2749961.
      Citations: 70     Fields:    Translation:AnimalsCells
    58. Mojumder DK, Wensel TG. Topical mydriatics affect light-evoked retinal responses in anesthetized mice. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):567-76. PMID: 19661232; PMCID: PMC2869068.
      Citations: 11     Fields:    Translation:Animals
    59. Mojumder DK, Qian Y, Wensel TG. Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling. J Neurosci. 2009 Jun 17; 29(24):7753-65. PMID: 19535587; PMCID: PMC2717019.
      Citations: 31     Fields:    Translation:AnimalsCells
    60. Mancuso JJ, Larson AM, Wensel TG, Saggau P. Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging. J Biomed Opt. 2009 May-Jun; 14(3):034048. PMID: 19566340; PMCID: PMC3651892.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    61. Moiseenkova-Bell VY, Wensel TG. Hot on the trail of TRP channel structure. J Gen Physiol. 2009 Mar; 133(3):239-44. PMID: 19237588; PMCID: PMC2654091.
      Citations: 19     Fields:    Translation:Cells
    62. Sakamoto K, McCluskey M, Wensel TG, Nishina PM, Naggert JK. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet. 2009 Jan 01; 18(1):178-92. PMID: 18849587; PMCID: PMC2644649.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    63. Mojumder DK, Wensel TG, Frishman LJ. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. Mol Vis. 2008 Aug 31; 14:1600-13. PMID: 18769561; PMCID: PMC2528027.
      Citations: 23     Fields:    Translation:AnimalsCells
    64. Wang Q, Zhang X, Zhang L, He F, Zhang G, Jamrich M, Wensel TG. Activation-dependent hindrance of photoreceptor G protein diffusion by lipid microdomains. J Biol Chem. 2008 Oct 31; 283(44):30015-24. PMID: 18713731; PMCID: PMC2573089.
      Citations: 29     Fields:    Translation:AnimalsCells
    65. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7451-5. PMID: 18490661; PMCID: PMC2396679.
      Citations: 100     Fields:    Translation:AnimalsCells
    66. Benfield AP, Macleod MC, Liu Y, Wu Q, Wensel TG, Vasquez KM. Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides. Biochemistry. 2008 Jun 10; 47(23):6279-88. PMID: 18473480; PMCID: PMC2662494.
      Citations: 4     Fields:    
    67. Wensel TG. Signal transducing membrane complexes of photoreceptor outer segments. Vision Res. 2008 Sep; 48(20):2052-61. PMID: 18456304; PMCID: PMC2615670.
      Citations: 58     Fields:    Translation:HumansCells
    68. Jedema HP, Gold SJ, Gonzalez-Burgos G, Sved AF, Tobe BJ, Wensel T, Grace AA. Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons. Eur J Neurosci. 2008 May; 27(9):2433-43. PMID: 18461718; PMCID: PMC2879008.
      Citations: 16     Fields:    Translation:AnimalsCells
    69. Abd-El-Barr MM, Albini TA, Carvounis PE, He F, Manzano RP, Chevez-Barrios P, Wensel TG, Wu SM, Holz ER. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr; 24(2):197-205. PMID: 18355133.
      Citations: 1     Fields:    Translation:Animals
    70. Morgans CW, Weiwei Liu, Wensel TG, Brown RL, Perez-Leon JA, Bearnot B, Duvoisin RM. Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. Eur J Neurosci. 2007 Nov; 26(10):2899-905. PMID: 18001285; PMCID: PMC2435197.
      Citations: 45     Fields:    Translation:AnimalsCells
    71. Khajavi M, Shiga K, Wiszniewski W, He F, Shaw CA, Yan J, Wensel TG, Snipes GJ, Lupski JR. Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy. Am J Hum Genet. 2007 Sep; 81(3):438-53. PMID: 17701891; PMCID: PMC1950845.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    72. Marc RE, Jones BW, Anderson JR, Kinard K, Marshak DW, Wilson JH, Wensel T, Lucas RJ. Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3364-71. PMID: 17591910; PMCID: PMC2408857.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    73. Song JH, Song H, Wensel TG, Sokolov M, Martemyanov KA. Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol Cell Neurosci. 2007 Jun; 35(2):311-9. PMID: 17442586.
      Citations: 30     Fields:    Translation:AnimalsCells
    74. Zhang X, Wensel TG, Yuan C. Tokay gecko photoreceptors achieve rod-like physiology with cone-like proteins. Photochem Photobiol. 2006 Nov-Dec; 82(6):1452-60. PMID: 16553462.
      Citations: 16     Fields:    Translation:AnimalsCells
    75. Gross AK, Decker G, Chan F, Sandoval IM, Wilson JH, Wensel TG. Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration. Vision Res. 2006 Dec; 46(27):4510-8. PMID: 16979686.
      Citations: 13     Fields:    Translation:AnimalsCells
    76. Krispel CM, Chen D, Melling N, Chen YJ, Martemyanov KA, Quillinan N, Arshavsky VY, Wensel TG, Chen CK, Burns ME. RGS expression rate-limits recovery of rod photoresponses. Neuron. 2006 Aug 17; 51(4):409-16. PMID: 16908407.
      Citations: 165     Fields:    Translation:AnimalsCells
    77. Meltzer RH, Thompson E, Soman KV, Song XZ, Ebalunode JO, Wensel TG, Briggs JM, Pedersen SE. Electrostatic steering at acetylcholine binding sites. Biophys J. 2006 Aug 15; 91(4):1302-14. PMID: 16751247; PMCID: PMC1518644.
      Citations: 9     Fields:    Translation:Cells
    78. Meltzer RH, Lurtz MM, Wensel TG, Pedersen SE. Nicotinic acetylcholine receptor channel electrostatics determined by diffusion-enhanced luminescence energy transfer. Biophys J. 2006 Aug 15; 91(4):1315-24. PMID: 16751249; PMCID: PMC1518635.
      Citations: 9     Fields:    Translation:Cells
    79. Iyer MN, He F, Wensel TG, Mieler WF, Benz MS, Holz ER. Clearance of intravitreal moxifloxacin. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):317-9. PMID: 16384979.
      Citations: 10     Fields:    Translation:Animals
    80. Wensel TG, Gross AK, Chan F, Sykoudis K, Wilson JH. Rhodopsin-EGFP knock-ins for imaging quantal gene alterations. Vision Res. 2005 Dec; 45(28):3445-53. PMID: 16139321.
      Citations: 9     Fields:    Translation:AnimalsCells
    81. Wiszniewski W, Zaremba CM, Yatsenko AN, Jamrich M, Wensel TG, Lewis RA, Lupski JR. ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies. Hum Mol Genet. 2005 Oct 01; 14(19):2769-78. PMID: 16103129.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    82. Iyer MN, He F, Wensel TG, Mieler WF, Benz MS, Holz ER. Intravitreal clearance of moxifloxacin. Trans Am Ophthalmol Soc. 2005; 103:76-81; discussion 81-3. PMID: 17057790; PMCID: PMC1447561.
      Citations: 7     Fields:    Translation:Animals
    83. Wensel TG, He F, Malinski JA. Purification, reconstitution on lipid vesicles, and assays of PDE6 and its activator G protein, transducin. Methods Mol Biol. 2005; 307:289-313. PMID: 15988071.
      Citations: 8     Fields:    Translation:AnimalsCells
    84. Chan F, Bradley A, Wensel TG, Wilson JH. Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9109-14. PMID: 15184660; PMCID: PMC428481.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    85. Zhang Z, Melia TJ, He F, Yuan C, McGough A, Schmid MF, Wensel TG. How a G protein binds a membrane. J Biol Chem. 2004 Aug 06; 279(32):33937-45. PMID: 15173184.
      Citations: 14     Fields:    Translation:AnimalsCells
    86. Hu G, Wensel TG. Characterization of R9AP, a membrane anchor for the photoreceptor GTPase-accelerating protein, RGS9-1. Methods Enzymol. 2004; 390:178-96. PMID: 15488178.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    87. He F, Mao M, Wensel TG. Enhancement of phototransduction g protein-effector interactions by phosphoinositides. J Biol Chem. 2004 Mar 05; 279(10):8986-90. PMID: 14699118.
      Citations: 18     Fields:    Translation:AnimalsCells
    88. Madabushi S, Gross AK, Philippi A, Meng EC, Wensel TG, Lichtarge O. Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. J Biol Chem. 2004 Feb 27; 279(9):8126-32. PMID: 14660595.
      Citations: 76     Fields:    Translation:AnimalsCells
    89. Wilson JH, Wensel TG. The nature of dominant mutations of rhodopsin and implications for gene therapy. Mol Neurobiol. 2003 Oct; 28(2):149-58. PMID: 14576453.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    90. Zhang L, El-Hodiri HM, Ma HF, Zhang X, Servetnick M, Wensel TG, Jamrich M. Targeted expression of the dominant-negative FGFR4a in the eye using Xrx1A regulatory sequences interferes with normal retinal development. Development. 2003 Sep; 130(17):4177-86. PMID: 12874136.
      Citations: 11     Fields:    Translation:Animals
    91. Burns ME, Wensel TG. From molecules to behavior: new clues for RGS function in the striatum. Neuron. 2003 Jun 19; 38(6):853-6. PMID: 12818171.
      Citations: 3     Fields:    Translation:AnimalsCells
    92. Chen CK, Eversole-Cire P, Zhang H, Mancino V, Chen YJ, He W, Wensel TG, Simon MI. Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6604-9. PMID: 12738888; PMCID: PMC164494.
      Citations: 125     Fields:    Translation:AnimalsCells
    93. Kennedy MJ, Sowa ME, Wensel TG, Hurley JB. Acceleration of key reactions as a strategy to elucidate the rate-limiting chemistry underlying phototransduction inactivation. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1016-22. PMID: 12601023.
      Citations: 5     Fields:    Translation:AnimalsCells
    94. Zhang X, Wensel TG, Kraft TW. GTPase regulators and photoresponses in cones of the eastern chipmunk. J Neurosci. 2003 Feb 15; 23(4):1287-97. PMID: 12598617; PMCID: PMC6742256.
      Citations: 57     Fields:    Translation:AnimalsCells
    95. Hu G, Zhang Z, Wensel TG. Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP. J Biol Chem. 2003 Apr 18; 278(16):14550-4. PMID: 12560335.
      Citations: 33     Fields:    Translation:AnimalsCells
    96. Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem. 2003 Mar 07; 278(10):8316-25. PMID: 12499365.
      Citations: 13     Fields:    Translation:AnimalsCells
    97. Hu G, Wensel TG. R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9755-60. PMID: 12119397; PMCID: PMC125004.
      Citations: 81     Fields:    Translation:AnimalsCells
    98. Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb; 79(2):177-85. PMID: 11829488.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    99. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78. PMID: 11860507; PMCID: PMC1363676.
      Citations: 63     Translation:HumansAnimalsCells
    100. Wensel TG. RGS9-1 phosphorylation and Ca2+. Adv Exp Med Biol. 2002; 514:125-9. PMID: 12596919.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    101. He W, Wensel TG. RGS function in visual signal transduction. Methods Enzymol. 2002; 344:724-40. PMID: 11771423.
      Citations: 3     Fields:    Translation:AnimalsCells
    102. Shroyer NF, Lewis RA, Yatsenko AN, Wensel TG, Lupski JR. Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration. Hum Mol Genet. 2001 Nov 01; 10(23):2671-8. PMID: 11726554.
      Citations: 53     Fields:    Translation:HumansCells
    103. He W, Melia TJ, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. J Biol Chem. 2001 Dec 28; 276(52):48961-6. PMID: 11677233.
      Citations: 1     Fields:    Translation:AnimalsCells
    104. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22; 276(25):22287-95. PMID: 11292825; PMCID: PMC1364467.
      Citations: 12     Fields:    Translation:AnimalsCells
    105. Lyubarsky AL, Naarendorp F, Zhang X, Wensel T, Simon MI, Pugh EN. RGS9-1 is required for normal inactivation of mouse cone phototransduction. Mol Vis. 2001 Mar 20; 7:71-8. PMID: 11262419.
      Citations: 32     Fields:    Translation:AnimalsCells
    106. Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG. Prediction and confirmation of a site critical for effector regulation of RGS domain activity. Nat Struct Biol. 2001 Mar; 8(3):234-7. PMID: 11224568.
      Citations: 44     Fields:    Translation:Cells
    107. Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 2001 Feb 22; 409(6823):1071-7. PMID: 11234020.
      Citations: 106     Fields:    Translation:AnimalsCells
    108. Cowan CW, He W, Wensel TG. RGS proteins: lessons from the RGS9 subfamily. Prog Nucleic Acid Res Mol Biol. 2001; 65:341-59. PMID: 11008492.
      Citations: 14     Fields:    Translation:HumansAnimals
    109. He W, Lu L, Zhang X, El-Hodiri HM, Chen CK, Slep KC, Simon MI, Jamrich M, Wensel TG. Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability. J Biol Chem. 2000 Nov 24; 275(47):37093-100. PMID: 10978345.
      Citations: 36     Fields:    Translation:AnimalsCells
    110. Intody Z, Perkins BD, Wilson JH, Wensel TG. Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking. Nucleic Acids Res. 2000 Nov 01; 28(21):4283-90. PMID: 11058128; PMCID: PMC113126.
      Citations: 7     Fields:    Translation:HumansCells
    111. He F, Seryshev AB, Cowan CW, Wensel TG. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta. J Biol Chem. 2000 Jul 07; 275(27):20572-7. PMID: 10787404.
      Citations: 10     Fields:    Translation:AnimalsCells
    112. Womack KB, Gordon SE, He F, Wensel TG, Lu CC, Hilgemann DW. Do phosphatidylinositides modulate vertebrate phototransduction? J Neurosci. 2000 Apr 15; 20(8):2792-9. PMID: 10751430; PMCID: PMC6772201.
      Citations: 46     Fields:    Translation:AnimalsCells
    113. Sowa ME, He W, Wensel TG, Lichtarge O. A regulator of G protein signaling interaction surface linked to effector specificity. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1483-8. PMID: 10677488; PMCID: PMC26460.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    114. Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA. Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem. 2000 Feb 04; 275(5):3397-402. PMID: 10652332.
      Citations: 31     Fields:    Translation:AnimalsCells
    115. Melia TJ, Malinski JA, He F, Wensel TG. Enhancement of phototransduction protein interactions by lipid surfaces. J Biol Chem. 2000 Feb 04; 275(5):3535-42. PMID: 10652348.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    116. Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI. Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature. 2000 Feb 03; 403(6769):557-60. PMID: 10676965.
      Citations: 156     Fields:    Translation:AnimalsCells
    117. Cowan CW, Wensel TG, Arshavsky VY. Enzymology of GTPase acceleration in phototransduction. Methods Enzymol. 2000; 315:524-38. PMID: 10736724.
      Citations: 11     Fields:    Translation:AnimalsCells
    118. Melia TJ, Sowa ME, Schutze L, Wensel TG. Formation of helical protein assemblies of IgG and transducin on varied lipid tubules. J Struct Biol. 1999 Dec 01; 128(1):119-30. PMID: 10600566.
      Citations: 3     Fields:    Translation:Cells
    119. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. PMID: 10564809.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    120. Perkins BD, Wensel TG, Vasquez KM, Wilson JH. Psoralen photo-cross-linking by triplex-forming oligonucleotides at multiple sites in the human rhodopsin gene. Biochemistry. 1999 Sep 28; 38(39):12850-9. PMID: 10504255.
      Citations: 8     Fields:    Translation:HumansCells
    121. Rahman Z, Gold SJ, Potenza MN, Cowan CW, Ni YG, He W, Wensel TG, Nestler EJ. Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. J Neurosci. 1999 Mar 15; 19(6):2016-26. PMID: 10066255; PMCID: PMC6782559.
      Citations: 55     Fields:    Translation:AnimalsCells
    122. DeMar JC, Rundle DR, Wensel TG, Anderson RE. Heterogeneous N-terminal acylation of retinal proteins. Prog Lipid Res. 1999 Jan; 38(1):49-90. PMID: 10396602.
      Citations: 4     Fields:    Translation:HumansCells
    123. Perkins BD, Wilson JH, Wensel TG, Vasquez KM. Triplex targets in the human rhodopsin gene. Biochemistry. 1998 Aug 11; 37(32):11315-22. PMID: 9698379.
      Citations: 9     Fields:    Translation:HumansCells
    124. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5351-6. PMID: 9560279; PMCID: PMC20264.
      Citations: 64     Fields:    Translation:AnimalsCells
    125. He W, Cowan CW, Wensel TG. RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan; 20(1):95-102. PMID: 9459445.
      Citations: 108     Fields:    Translation:AnimalsCells
    126. Melia TJ, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophys J. 1997 Dec; 73(6):3182-91. PMID: 9414230; PMCID: PMC1181221.
      Citations: 60     Fields:    Translation:AnimalsCells
    127. Vasquez KM, Wensel TG, Hogan ME, Wilson JH. High-efficiency triple-helix-mediated photo-cross-linking at a targeted site within a selectable mammalian gene. Biochemistry. 1996 Aug 20; 35(33):10712-9. PMID: 8718860.
      Citations: 16     Fields:    Translation:AnimalsCells
    128. Malinski JA, Zera EM, Angleson JK, Wensel TG. High affinity interactions of GTPgammaS with the heterotrimeric G protein, transducin. Evidence at high and low protein concentrations. J Biol Chem. 1996 May 31; 271(22):12919-24. PMID: 8662740.
      Citations: 7     Fields:    Translation:Cells
    129. Zera EM, Molloy DP, Angleson JK, Lamture JB, Wensel TG, Malinski JA. Low affinity interactions of GDPbetaS and ribose- or phosphoryl-substituted GTP analogues with the heterotrimeric G protein, transducin. J Biol Chem. 1996 May 31; 271(22):12925-31. PMID: 8662741.
      Citations: 4     Fields:    Translation:AnimalsCells
    130. DeMar JC, Wensel TG, Anderson RE. Biosynthesis of the unsaturated 14-carbon fatty acids found on the N termini of photoreceptor-specific proteins. J Biol Chem. 1996 Mar 01; 271(9):5007-16. PMID: 8617777.
      Citations: 6     Fields:    Translation:AnimalsCells
    131. Vasquez KM, Wensel TG, Hogan ME, Wilson JH. High-affinity triple helix formation by synthetic oligonucleotides at a site within a selectable mammalian gene. Biochemistry. 1995 May 30; 34(21):7243-51. PMID: 7766635.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    132. Lamture JB, Wensel TG. Intensely luminescent immunoreactive conjugates of proteins and dipicolinate-based polymeric Tb (III) chelates. Bioconjug Chem. 1995 Jan-Feb; 6(1):88-92. PMID: 7711110.
      Citations: 2     Fields:    
    133. Angleson JK, Wensel TG. Enhancement of rod outer segment GTPase accelerating protein activity by the inhibitory subunit of cGMP phosphodiesterase. J Biol Chem. 1994 Jun 10; 269(23):16290-6. PMID: 8206935.
      Citations: 21     Fields:    Translation:AnimalsCells
    134. Angleson JK, Wensel TG. A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes. Neuron. 1993 Nov; 11(5):939-49. PMID: 8240815.
      Citations: 21     Fields:    Translation:AnimalsCells
    135. Yang Z, Wensel TG. Molecular cloning and functional expression of cDNA encoding a mammalian inorganic pyrophosphatase. J Biol Chem. 1992 Dec 05; 267(34):24641-7. PMID: 1339444.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    136. Yang Z, Wensel TG. Inorganic pyrophosphatase from bovine retinal rod outer segments. J Biol Chem. 1992 Dec 05; 267(34):24634-40. PMID: 1360011.
      Citations: 5     Fields:    Translation:AnimalsCells
    137. Yang Z, Wensel TG. N-myristoylation of the rod outer segment G protein, transducin, in cultured retinas. J Biol Chem. 1992 Nov 15; 267(32):23197-201. PMID: 1429667.
      Citations: 11     Fields:    Translation:AnimalsCells
    138. Malinski JA, Wensel TG. Membrane stimulation of cGMP phosphodiesterase activation by transducin: comparison of phospholipid bilayers to rod outer segment membranes. Biochemistry. 1992 Oct 06; 31(39):9502-12. PMID: 1327116.
      Citations: 20     Fields:    Translation:AnimalsCells
    139. Ramdas L, Disher RM, Wensel TG. Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin. Biochemistry. 1991 Dec 17; 30(50):11637-45. PMID: 1661143.
      Citations: 11     Fields:    Translation:AnimalsCells
    140. Keating SM, Wensel TG. Nanosecond fluorescence microscopy. Emission kinetics of fura-2 in single cells. Biophys J. 1991 Jan; 59(1):186-202. PMID: 2015383; PMCID: PMC1281130.
      Citations: 17     Fields:    Translation:AnimalsCells
    141. Northrup SH, Wensel TG, Meares CF, Wendoloski JJ, Matthew JB. Electrostatic field around cytochrome c: theory and energy transfer experiment. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9503-7. PMID: 2174564; PMCID: PMC55195.
      Citations: 11     Fields:    Translation:AnimalsCells
    142. Holowka D, Wensel T, Baird B. A nanosecond fluorescence depolarization study on the segmental flexibility of receptor-bound immunoglobulin E. Biochemistry. 1990 May 15; 29(19):4607-12. PMID: 2142605.
      Citations: 6     Fields:    Translation:AnimalsCells
    143. Wensel TG, Stryer L. Activation mechanism of retinal rod cyclic GMP phosphodiesterase probed by fluorescein-labeled inhibitory subunit. Biochemistry. 1990 Feb 27; 29(8):2155-61. PMID: 2158346.
      Citations: 21     Fields:    Translation:AnimalsCells
    144. Meyer T, Wensel T, Stryer L. Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate. Biochemistry. 1990 Jan 09; 29(1):32-7. PMID: 1691015.
      Citations: 48     Fields:    Translation:AnimalsCells
    145. Dangl JL, Wensel TG, Morrison SL, Stryer L, Herzenberg LA, Oi VT. Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies. EMBO J. 1988 Jul; 7(7):1989-94. PMID: 3138110; PMCID: PMC454472.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    146. Schneider WP, Wensel TG, Stryer L, Oi VT. Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2509-13. PMID: 3128789; PMCID: PMC280026.
      Citations: 11     Fields:    Translation:AnimalsCells
    147. Wensel TG, Stryer L. Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin. Proteins. 1986 Sep; 1(1):90-9. PMID: 2835761.
      Citations: 39     Fields:    Translation:AnimalsCells
    148. Wensel TG, Meares CF, Vlachy V, Matthew JB. Distribution of ions around DNA, probed by energy transfer. Proc Natl Acad Sci U S A. 1986 May; 83(10):3267-71. PMID: 3458180; PMCID: PMC323494.
      Citations: 6     Fields:    Translation:AnimalsCells
    149. Haseman MK, Goodwin DA, Meares CF, Kaminski MS, Wensel TG, McCall MJ, Levy R. Metabolizable 111In chelate conjugated anti-idiotype monoclonal antibody for radioimmunodetection of lymphoma in mice. Eur J Nucl Med. 1986; 12(9):455-60. PMID: 3102237.
      Citations: 5     Fields:    Translation:AnimalsCells
    150. Wensel TG, Chang CH, Meares CF. Diffusion-enhanced lanthanide energy-transfer study of DNA-bound cobalt(III) bleomycins: comparisons of accessibility and electrostatic potential with DNA complexes of ethidium and acridine orange. Biochemistry. 1985 Jun 04; 24(12):3060-9. PMID: 2410019.
      Citations: 10     Fields:    Translation:AnimalsCells
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