DOROTHY LEWIS

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address
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    R01AI022549     (LEWIS, DOROTHY E)Jul 1, 1985 - Jun 30, 1988
    NIH/NIAID
    IMMUNOREGULATION IN ASYMPTOMATIC HIV-INFECTED PEOPLE
    Role: Principal Investigator

    S10RR003980     (LEWIS, DOROTHY E)May 16, 1988 - May 15, 1989
    NIH/NCRR
    PURCHASE OF A FLOW CYTOMETER
    Role: Principal Investigator

    R01AI036682     (LEWIS, DOROTHY E)Jul 1, 1995 - Jun 30, 2000
    NIH/NIAID
    ANERGY, APOPTOSIS AND CD28 IN CD8+ T CELLS DURING AIDS
    Role: Principal Investigator

    R37AI036682     (LEWIS, DOROTHY E.)Jul 1, 1995 - Mar 31, 2012
    NIH/NIAID
    ANERGY, APOPTOSIS AND CD28 IN CD8+ T CELLS DURING AIDS
    Role: Principal Investigator

    S10RR011909     (LEWIS, DOROTHY E)Jun 1, 1997 - May 31, 1998
    NIH/NCRR
    FLOW CYTOMETER FOR MOLECULAR MEDICINE AND HIV RESEARCH
    Role: Principal Investigator

    R21AI054251     (LEWIS, DOROTHY E)Aug 15, 2003 - Jul 31, 2006
    NIH/NIAID
    Formation and Function of Human CD28-Negative T Cells
    Role: Principal Investigator

    R01HD046623     (LEWIS, DOROTHY E)Dec 1, 2004 - Nov 30, 2009
    NIH/NICHD
    Molecular Nature of Fetal DNA in Maternal Plasma
    Role: Principal Investigator

    R21AI116208     (LEWIS, DOROTHY E.)Sep 1, 2014 - Aug 31, 2016
    NIH/NIAID
    Adipose Tissue is a significant reservoir for HIV
    Role: Principal Investigator

    R33AI116208     (LEWIS, DOROTHY E.)Sep 1, 2014 - Aug 31, 2019
    NIH/NIAID
    Adipose Tissue is a significant reservoir for HIV
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu H, Hu PW, Couturier J, Lewis DE, Rice AP. HIV-1 replication in CD4+ T cells exploits the down-regulation of antiviral NEAT1 long non-coding RNAs following T cell activation. Virology. 2018 09; 522:193-198. PMID: 30036787.
      Citations: 5     Fields:    Translation:HumansCells
    2. Fadul N, Couturier J, Yu X, Kozinetz C, Arduino R, Lewis DE. Treatment-Naïve HIV-Infected Patients Have Fewer Gut-Homing ß7 Memory CD4 T Cells than Healthy Controls. South Med J. 2017 11; 110(11):709-713. PMID: 29100221.
      Citations:    Fields:    Translation:HumansCells
    3. Agarwal N, Iyer D, Gabbi C, Saha P, Patel SG, Mo Q, Chang B, Goswami B, Schubert U, Kopp JB, Lewis DE, Balasubramanyam A. HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRa and PPARa dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017 10 17; 7(1):13362. PMID: 29042644.
      Citations: 6     Fields:    Translation:AnimalsCells
    4. Khan IM, Pokharel Y, Dadu RT, Lewis DE, Hoogeveen RC, Wu H, Ballantyne CM. Postprandial Monocyte Activation in Individuals With Metabolic Syndrome. J Clin Endocrinol Metab. 2016 11; 101(11):4195-4204. PMID: 27575945.
      Citations: 11     Fields:    Translation:HumansCells
    5. Shiue LH, Couturier J, Lewis DE, Wei C, Ni X, Duvic M. The effect of extracorporeal photopheresis alone or in combination therapy on circulating CD4(+) Foxp3(+) CD25(-) T cells in patients with leukemic cutaneous T-cell lymphoma. Photodermatol Photoimmunol Photomed. 2015 Jul; 31(4):184-94. PMID: 25772268.
      Citations: 2     Fields:    Translation:HumansCells
    6. Couturier J, Suliburk JW, Brown JM, Luke DJ, Agarwal N, Yu X, Nguyen C, Iyer D, Kozinetz CA, Overbeek PA, Metzker ML, Balasubramanyam A, Lewis DE. Human adipose tissue as a reservoir for memory CD4+ T cells and HIV. AIDS. 2015 Mar 27; 29(6):667-74. PMID: 25849830.
      Citations: 42     Fields:    Translation:HumansCells
    7. Budhiraja S, Liu H, Couturier J, Malovannaya A, Qin J, Lewis DE, Rice AP. Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function. J Virol. 2015 Apr; 89(7):3557-67. PMID: 25589658.
      Citations: 14     Fields:    Translation:HumansCells
    8. Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013 Nov 27; 5(213):213ra164. PMID: 24285483.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    9. Cimo AM, Ahmed Z, McIntyre BW, Lewis DE, Ladbury JE. CD25 and CD69 induction by a4ß1 outside-in signalling requires TCR early signalling complex proteins. Biochem J. 2013 Aug 15; 454(1):109-21. PMID: 23758320.
      Citations: 3     Fields:    Translation:HumansCells
    10. Zhu W, Shi G, Tang H, Lewis DE, Song XT. An effective vaccination approach augments anti-HIV systemic and vaginal immunity in mice with decreased HIV-1 susceptible a4ß7high CD4+ T cells. Curr HIV Res. 2013 Jan; 11(1):56-66. PMID: 23157585.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    11. Montes M, Sanchez C, Verdonck K, Lake JE, Gonzalez E, Lopez G, Terashima A, Nolan T, Lewis DE, Gotuzzo E, White AC. Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl Trop Dis. 2009 Jun 09; 3(6):e456. PMID: 19513105.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    12. Orozco AF, Jorgez CJ, Horne C, Marquez-Do DA, Chapman MR, Rodgers JR, Bischoff FZ, Lewis DE. Membrane protected apoptotic trophoblast microparticles contain nucleic acids: relevance to preeclampsia. Am J Pathol. 2008 Dec; 173(6):1595-608. PMID: 18974299.
      Citations: 20     Fields:    Translation:HumansCells
    13. Singh M, Basu S, Camell C, Couturier J, Nudelman RJ, Medina MA, Rodgers JR, Lewis DE. Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells. Eur J Immunol. 2008 Jun; 38(6):1522-32. PMID: 18446791.
      Citations: 5     Fields:    Translation:HumansCells
    14. Castellanos-Gonzalez A, Yancey LS, Wang HC, Pantenburg B, Liscum KR, Lewis DE, White AC. Cryptosporidium infection of human intestinal epithelial cells increases expression of osteoprotegerin: a novel mechanism for evasion of host defenses. J Infect Dis. 2008 Mar 15; 197(6):916-23. PMID: 18288900.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    15. Preidis GA, Wang HC, Lewis DE, Castellanos-Gonzalez A, Rogers KA, Graviss EA, Ward HD, White AC. Seropositive human subjects produce interferon gamma after stimulation with recombinant Cryptosporidium hominis gp15. Am J Trop Med Hyg. 2007 Sep; 77(3):583-5. PMID: 17827383.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    16. Lewis DE, Gross KL, Diez MM, Martinez ML, Lukefahr HN, Kozinetz CA, Arduino RC. CD8 apoptosis may be a predictor of T cell number normalization after immune reconstitution in HIV. J Transl Med. 2007 Jan 30; 5:9. PMID: 17263884.
      Citations:    Fields:    Translation:HumansCells
    17. Lewis DE. HIV vaccines: the future looks promising. Res Initiat Treat Action. 2007; 12(2):29-32. PMID: 17489121.
      Citations:    Fields:    Translation:HumansCells
    18. Wang HC, Dann SM, Okhuysen PC, Lewis DE, Chappell CL, Adler DG, White AC. High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. Infect Immun. 2007 Jan; 75(1):481-7. PMID: 17043107.
      Citations: 11     Fields:    Translation:HumansAnimals
    19. Montes M, Jaensson EA, Orozco AF, Lewis DE, Corry DB. A general method for bead-enhanced quantitation by flow cytometry. J Immunol Methods. 2006 Dec 20; 317(1-2):45-55. PMID: 17067632.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    20. Jorgez CJ, Dang DD, Simpson JL, Lewis DE, Bischoff FZ. Quantity versus quality: optimal methods for cell-free DNA isolation from plasma of pregnant women. Genet Med. 2006 Oct; 8(10):615-9. PMID: 17079877.
      Citations: 18     Fields:    Translation:Humans
    21. Orozco AF, Bischoff FZ, Horne C, Popek E, Simpson JL, Lewis DE. Hypoxia-induced membrane-bound apoptotic DNA particles: potential mechanism of fetal DNA in maternal plasma. Ann N Y Acad Sci. 2006 Sep; 1075:57-62. PMID: 17108192.
      Citations: 10     Fields:    Translation:HumansCells
    22. Dann SM, Wang HC, Gambarin KJ, Actor JK, Robinson P, Lewis DE, Caillat-Zucman S, White AC. Interleukin-15 activates human natural killer cells to clear the intestinal protozoan cryptosporidium. J Infect Dis. 2005 Oct 01; 192(7):1294-302. PMID: 16136475.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    23. Bischoff FZ, Lewis DE, Simpson JL. Cell-free fetal DNA in maternal blood: kinetics, source and structure. Hum Reprod Update. 2005 Jan-Feb; 11(1):59-67. PMID: 15569699.
      Citations: 35     Fields:    Translation:HumansCells
    24. Grumelli S, Corry DB, Song LZ, Song L, Green L, Huh J, Hacken J, Espada R, Bag R, Lewis DE, Kheradmand F. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004 Oct; 1(1):e8. PMID: 15526056.
      Citations: 151     Fields:    Translation:HumansCells
    25. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774.
      Citations: 16     Fields:    Translation:AnimalsCells
    26. Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN. Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription. J Biol Chem. 2004 Jul 09; 279(28):29130-8. PMID: 15128741.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    27. Ling PD, Vilchez RA, Keitel WA, Poston DG, Peng RS, White ZS, Visnegarwala F, Lewis DE, Butel JS. Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy. Clin Infect Dis. 2003 Nov 01; 37(9):1244-9. PMID: 14557970.
      Citations: 16     Fields:    Translation:HumansCells
    28. Robinson P, Okhuysen PC, Chappell CL, Weinstock JV, Lewis DE, Actor JK, White AC. Substance P expression correlates with severity of diarrhea in cryptosporidiosis. J Infect Dis. 2003 Jul 15; 188(2):290-6. PMID: 12854086.
      Citations: 9     Fields:    Translation:HumansAnimals
    29. Lednicky JA, Vilchez RA, Keitel WA, Visnegarwala F, White ZS, Kozinetz CA, Lewis DE, Butel JS. Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy. AIDS. 2003 Apr 11; 17(6):801-7. PMID: 12660526.
      Citations: 8     Fields:    Translation:HumansCells
    30. Bischoff FZ, Dang DX, Marquez-Do D, Martinez D, Horne C, Lewis DE, Simpson JL. Detecting fetal DNA from dried maternal blood spots: another step towards broad scale non-invasive prenatal genetic screening and feasible testing. Reprod Biomed Online. 2003 Apr-May; 6(3):349-51. PMID: 12735873.
      Citations: 5     Fields:    Translation:HumansCells
    31. Bischoff FZ, Hahn S, Johnson KL, Simpson JL, Bianchi DW, Lewis DE, Weber WD, Klinger K, Elias S, Jackson LG, Evans MI, Holzgreve W, de la Cruz F. Intact fetal cells in maternal plasma: are they really there? Lancet. 2003 Jan 11; 361(9352):139-40. PMID: 12531583.
      Citations: 5     Fields:    Translation:Humans
    32. Bischoff FZ, Sinacori MK, Dang DD, Marquez-Do D, Horne C, Lewis DE, Simpson JL. Cell-free fetal DNA and intact fetal cells in maternal blood circulation: implications for first and second trimester non-invasive prenatal diagnosis. Hum Reprod Update. 2002 Nov-Dec; 8(6):493-500. PMID: 12498419.
      Citations: 12     Fields:    Translation:Humans
    33. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep; 36(3):592-601. PMID: 12198651.
      Citations: 99     Fields:    Translation:HumansCells
    34. Robinson P, White AC, Lewis DE, Thornby J, David E, Weinstock J. Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis. Infect Immun. 2002 Aug; 70(8):4534-8. PMID: 12117965.
      Citations: 12     Fields:    Translation:Animals
    35. Blutt SE, Warfield KL, Lewis DE, Conner ME. Early response to rotavirus infection involves massive B cell activation. J Immunol. 2002 Jun 01; 168(11):5716-21. PMID: 12023371.
      Citations: 19     Fields:    Translation:AnimalsCells
    36. Manotaya S, Elias S, Lewis DE, Simpson JL, Bischoff FZ. Evaluation of a culture system for enrichment of CD34+ hematopoietic progenitor cells present in maternal blood. Fetal Diagn Ther. 2002 Mar-Apr; 17(2):90-6. PMID: 11844912.
      Citations:    Fields:    Translation:HumansCells
    37. Bischoff FZ, Dang DX, Lewis DE, Simpson JL. Prenatal diagnosis of chromosomal abnormalities using maternal blood. Methods Mol Biol. 2002; 204:243-58. PMID: 12397802.
      Citations:    Fields:    Translation:Humans
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