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DOROTHY E LEWIS

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionImmunology
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Huang Y, Chen Z, Jang JH, Baig MS, Bertolet G, Schroeder C, Huang S, Hu Q, Zhao Y, Lewis DE, Qin L, Zhu MX, Liu D. PD-1 Blocks Lytic Granule Polarization with Concomitant Impairment of Integrin 'Outside-in' Signaling in Natural Killer Cell Immunological Synapse. J Allergy Clin Immunol. 2018 Apr 18. PMID: 29679656.
      View in: PubMed
    2. Couturier J, Winchester LC, Suliburk JW, Wilkerson GK, Podany AT, Agarwal N, Xuan Chua CY, Nehete PN, Nehete BP, Grattoni A, Sastry KJ, Fletcher CV, Lake JE, Balasubramanyam A, Lewis DE. Adipocytes impair efficacy of antiretroviral therapy. Antiviral Res. 2018 Apr 06; 154:140-148. PMID: 29630975.
      View in: PubMed
    3. Couturier J, Lewis DE. HIV Persistence in Adipose Tissue Reservoirs. Curr HIV/AIDS Rep. 2018 Feb; 15(1):60-71. PMID: 29423731.
      View in: PubMed
    4. Zhao S, Adebiyi MG, Zhang Y, Couturier JP, Fan X, Zhang H, Kellems RE, Lewis DE, Xia Y. Sphingosine-1-phosphate receptor 1 mediates elevated IL-6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease. FASEB J. 2018 May; 32(5):2855-2865. PMID: 29401601.
      View in: PubMed
    5. Fadul N, Couturier J, Yu X, Kozinetz C, Arduino R, Lewis DE. Treatment-Naïve HIV-Infected Patients Have Fewer Gut-Homing ß7 Memory CD4 T Cells than Healthy Controls. South Med J. 2017 11; 110(11):709-713. PMID: 29100221.
      View in: PubMed
    6. Agarwal N, Iyer D, Gabbi C, Saha P, Patel SG, Mo Q, Chang B, Goswami B, Schubert U, Kopp JB, Lewis DE, Balasubramanyam A. HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRa and PPARa dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017 Oct 17; 7(1):13362. PMID: 29042644.
      View in: PubMed
    7. Khan IM, Pokharel Y, Dadu RT, Lewis DE, Hoogeveen RC, Wu H, Ballantyne CM. Postprandial Monocyte Activation in Individuals With Metabolic Syndrome. J Clin Endocrinol Metab. 2016 Nov; 101(11):4195-4204. PMID: 27575945.
      View in: PubMed
    8. Couturier J, Agarwal N, Nehete PN, Baze WB, Barry MA, Jagannadha Sastry K, Balasubramanyam A, Lewis DE. Infectious SIV resides in adipose tissue and induces metabolic defects in chronically infected rhesus macaques. Retrovirology. 2016; 13:30. PMID: 27117277; PMCID: PMC4847269.
    9. Shi C, Li H, Couturier JP, Yang K, Guo X, He D, Lewis DE, Zhou X. Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism. Open Rheumatol J. 2015; 9:60-4. PMID: 26322142.
      View in: PubMed
    10. Shiue LH, Couturier J, Lewis DE, Wei C, Ni X, Duvic M. The effect of extracorporeal photopheresis alone or in combination therapy on circulating CD4(+) Foxp3(+) CD25(-) T cells in patients with leukemic cutaneous T-cell lymphoma. Photodermatol Photoimmunol Photomed. 2015 Jul; 31(4):184-94. PMID: 25772268.
      View in: PubMed
    11. Couturier J, Suliburk JW, Brown JM, Luke DJ, Agarwal N, Yu X, Nguyen C, Iyer D, Kozinetz CA, Overbeek PA, Metzker ML, Balasubramanyam A, Lewis DE. Human adipose tissue as a reservoir for memory CD4+ T cells and HIV. AIDS. 2015 Mar 27; 29(6):667-74. PMID: 25849830; PMCID: PMC4389783.
    12. Budhiraja S, Liu H, Couturier J, Malovannaya A, Qin J, Lewis DE, Rice AP. Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function. J Virol. 2015 Apr; 89(7):3557-67. PMID: 25589658; PMCID: PMC4403413.
    13. Lin L, Couturier J, Yu X, Medina MA, Kozinetz CA, Lewis DE. Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells. BMC Immunol. 2014; 15:36. PMID: 25245659; PMCID: PMC4195902.
    14. Couturier J, Hutchison AT, Medina MA, Gingaras C, Urvil P, Yu X, Nguyen C, Mahale P, Lin L, Kozinetz CA, Schmitz JE, Kimata JT, Savidge TC, Lewis DE. HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Virology. 2014 Aug; 462-463:175-88. PMID: 24999042; PMCID: PMC4158656.
    15. Li C, Peart N, Xuan Z, Lewis DE, Xia Y, Jin J. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 2014 Jul; 26(7):1369-78. PMID: 24637302; PMCID: PMC4074601.
    16. Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013 Nov 27; 5(213):213ra164. PMID: 24285483; PMCID: PMC4009012.
    17. Cimo AM, Ahmed Z, McIntyre BW, Lewis DE, Ladbury JE. CD25 and CD69 induction by ?4?1 outside-in signalling requires TCR early signalling complex proteins. Biochem J. 2013 Aug 15; 454(1):109-21. PMID: 23758320; PMCID: PMC3749870.
    18. Misra R, Chandra P, Riechman SE, Long DM, Shinde S, Pownall HJ, Coraza I, Lewis DE, Sekhar RV, Balasubramanyam A. Relationship of ethnicity and CD4 Count with glucose metabolism among HIV patients on Highly-Active Antiretroviral Therapy (HAART). BMC Endocr Disord. 2013; 13:13. PMID: 23607267; PMCID: PMC3751670.
    19. Elhaj M, Charles J, Pedroza C, Liu X, Zhou X, Estrada-Y-Martin RM, Gonzalez EB, Lewis DE, Draeger HT, Kim S, Arnett FC, Mayes MD, Assassi S. Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? J Rheumatol. 2013 Jul; 40(7):1114-20. PMID: 23588945; PMCID: PMC3728890.
    20. Wu H, Chen L, Zhou Q, Zhang X, Berger S, Bi J, Lewis DE, Xia Y, Zhang W. Aqp2-expressing cells give rise to renal intercalated cells. J Am Soc Nephrol. 2013 Feb; 24(2):243-52. PMID: 23308014; PMCID: PMC3559490.
    21. Zhu W, Shi G, Tang H, Lewis DE, Song XT. An effective vaccination approach augments anti-HIV systemic and vaginal immunity in mice with decreased HIV-1 susceptible ?4?7high CD4+ T cells. Curr HIV Res. 2013 Jan; 11(1):56-66. PMID: 23157585; PMCID: PMC3717605.
    22. Lewis DE. Sweat the small stuff. Cytometry A. 2012 Nov; 81(11):933-4. PMID: 22899596.
      View in: PubMed
    23. Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R. CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies. J Infect Dis. 2012 Jun; 205(11):1730-8. PMID: 22448010; PMCID: PMC3415854.
    24. Medina MA, Couturier J, Feske ML, Mahne AE, Turner M, Yu X, Kozinetz CA, Orozco AF, Hutchison AT, Savidge TC, Rodgers JR, Lewis DE. Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells. J Leukoc Biol. 2012 May; 91(5):759-71. PMID: 22416257; PMCID: PMC3336770.
    25. Feske ML, Medina M, Graviss EA, Lewis DE. IL-7 addition increases spot size and number as measured by T-SPOT.TB (®). Methods Mol Biol. 2012; 792:229-41. PMID: 21956514.
      View in: PubMed
    26. Couturier J, Patel SG, Iyer D, Balasubramanyam A, Lewis DE. Human monocytes accelerate proliferation and blunt differentiation of preadipocytes in association with suppression of C/EBP? mRNA. Obesity (Silver Spring). 2012 Feb; 20(2):253-62. PMID: 21869759; PMCID: PMC4364279.
    27. Estrella JL, Kan-Sutton C, Gong X, Rajagopalan M, Lewis DE, Hunter RL, Eissa NT, Jagannath C. A Novel in vitro Human Macrophage Model to Study the Persistence of Mycobacterium tuberculosis Using Vitamin D(3) and Retinoic Acid Activated THP-1 Macrophages. Front Microbiol. 2011; 2:67. PMID: 21747789; PMCID: PMC3128978.
    28. Montes M, Sanchez C, Lewis DE, Graviss EA, Seas C, Gotuzzo E, White AC. Normalization of FoxP3(+) regulatory T cells in response to effective antiretroviral therapy. J Infect Dis. 2011 Feb 15; 203(4):496-9. PMID: 21177309; PMCID: PMC3071220.
    29. Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y. Detrimental effects of adenosine signaling in sickle cell disease. Nat Med. 2011 Jan; 17(1):79-86. PMID: 21170046; PMCID: PMC4838392.
    30. Orozco AF, Lewis DE. Flow cytometric analysis of circulating microparticles in plasma. Cytometry A. 2010 Jun; 77(6):502-14. PMID: 20235276; PMCID: PMC2919894.
    31. Pantenburg B, Castellanos-Gonzalez A, Dann SM, Connelly RL, Lewis DE, Ward HD, White AC. Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells. Am J Trop Med Hyg. 2010 Apr; 82(4):600-7. PMID: 20348507; PMCID: PMC2844566.
    32. Montes M, Sanchez C, Verdonck K, Lake JE, Gonzalez E, Lopez G, Terashima A, Nolan T, Lewis DE, Gotuzzo E, White AC. Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl Trop Dis. 2009; 3(6):e456. PMID: 19513105; PMCID: PMC2686100.
    33. Orozco AF, Jorgez CJ, Horne C, Marquez-Do DA, Chapman MR, Rodgers JR, Bischoff FZ, Lewis DE. Membrane protected apoptotic trophoblast microparticles contain nucleic acids: relevance to preeclampsia. Am J Pathol. 2008 Dec; 173(6):1595-608. PMID: 18974299; PMCID: PMC2626372.
    34. Feske M, Nudelman RJ, Medina M, Lew J, Singh M, Couturier J, Graviss EA, Lewis DE. Enhancement of human antigen-specific memory T-cell responses by interleukin-7 may improve accuracy in diagnosing tuberculosis. Clin Vaccine Immunol. 2008 Oct; 15(10):1616-22. PMID: 18753334; PMCID: PMC2565935.
    35. Singh M, Basu S, Camell C, Couturier J, Nudelman RJ, Medina MA, Rodgers JR, Lewis DE. Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells. Eur J Immunol. 2008 Jun; 38(6):1522-32. PMID: 18446791; PMCID: PMC2735850.
    36. Castellanos-Gonzalez A, Yancey LS, Wang HC, Pantenburg B, Liscum KR, Lewis DE, White AC. Cryptosporidium infection of human intestinal epithelial cells increases expression of osteoprotegerin: a novel mechanism for evasion of host defenses. J Infect Dis. 2008 Mar 15; 197(6):916-23. PMID: 18288900.
      View in: PubMed
    37. Pantenburg B, Dann SM, Wang HC, Robinson P, Castellanos-Gonzalez A, Lewis DE, White AC. Intestinal immune response to human Cryptosporidium sp. infection. Infect Immun. 2008 Jan; 76(1):23-9. PMID: 17967863; PMCID: PMC2223661.
    38. Preidis GA, Wang HC, Lewis DE, Castellanos-Gonzalez A, Rogers KA, Graviss EA, Ward HD, White AC. Seropositive human subjects produce interferon gamma after stimulation with recombinant Cryptosporidium hominis gp15. Am J Trop Med Hyg. 2007 Sep; 77(3):583-5. PMID: 17827383.
      View in: PubMed
    39. Lewis DE, Gross KL, Diez MM, Martinez ML, Lukefahr HN, Kozinetz CA, Arduino RC. CD8 apoptosis may be a predictor of T cell number normalization after immune reconstitution in HIV. J Transl Med. 2007; 5:9. PMID: 17263884; PMCID: PMC1800849.
    40. Lewis DE. HIV vaccines: the future looks promising. Res Initiat Treat Action. 2007; 12(2):29-32. PMID: 17489121.
      View in: PubMed
    41. Corry DB, Lewis DE. Cytokine storm and an anti-CD28 monoclonal antibody. N Engl J Med. 2006 Dec 14; 355(24):2592; author reply 2593-4. PMID: 17171820.
      View in: PubMed
    42. Wang HC, Dann SM, Okhuysen PC, Lewis DE, Chappell CL, Adler DG, White AC. High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. Infect Immun. 2007 Jan; 75(1):481-7. PMID: 17043107; PMCID: PMC1828373.
    43. Montes M, Jaensson EA, Orozco AF, Lewis DE, Corry DB. A general method for bead-enhanced quantitation by flow cytometry. J Immunol Methods. 2006 Dec 20; 317(1-2):45-55. PMID: 17067632; PMCID: PMC2680352.
    44. Jorgez CJ, Dang DD, Simpson JL, Lewis DE, Bischoff FZ. Quantity versus quality: optimal methods for cell-free DNA isolation from plasma of pregnant women. Genet Med. 2006 Oct; 8(10):615-9. PMID: 17079877.
      View in: PubMed
    45. Orozco AF, Bischoff FZ, Horne C, Popek E, Simpson JL, Lewis DE. Hypoxia-induced membrane-bound apoptotic DNA particles: potential mechanism of fetal DNA in maternal plasma. Ann N Y Acad Sci. 2006 Sep; 1075:57-62. PMID: 17108192.
      View in: PubMed
    46. Montes M, Lewis DE, Sanchez C, Lopez de Castilla D, Graviss EA, Seas C, Gotuzzo E, White AC. Foxp3+ regulatory T cells in antiretroviral-naive HIV patients. AIDS. 2006 Aug 1; 20(12):1669-71. PMID: 16868450.
      View in: PubMed
    47. Dann SM, Wang HC, Gambarin KJ, Actor JK, Robinson P, Lewis DE, Caillat-Zucman S, White AC. Interleukin-15 activates human natural killer cells to clear the intestinal protozoan cryptosporidium. J Infect Dis. 2005 Oct 1; 192(7):1294-302. PMID: 16136475.
      View in: PubMed
    48. Okhuysen PC, Chappell CL, Lewis DE, Robinson P, White AC. Treatment of chronic cryptosporidiosis in AIDS with rIL-12 induces an immune response associated with improvement but severe side-effects. AIDS. 2005 Aug 12; 19(12):1333-4. PMID: 16052094.
      View in: PubMed
    49. Bischoff FZ, Lewis DE, Simpson JL. Cell-free fetal DNA in maternal blood: kinetics, source and structure. Hum Reprod Update. 2005 Jan-Feb; 11(1):59-67. PMID: 15569699.
      View in: PubMed
    50. Grumelli S, Corry DB, Song LZ, Song L, Green L, Huh J, Hacken J, Espada R, Bag R, Lewis DE, Kheradmand F. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004 Oct; 1(1):e8. PMID: 15526056; PMCID: PMC523885.
    51. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774; PMCID: PMC421650.
    52. Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN. Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription. J Biol Chem. 2004 Jul 9; 279(28):29130-8. PMID: 15128741.
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    53. Ling PD, Vilchez RA, Keitel WA, Poston DG, Peng RS, White ZS, Visnegarwala F, Lewis DE, Butel JS. Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy. Clin Infect Dis. 2003 Nov 1; 37(9):1244-9. PMID: 14557970.
      View in: PubMed
    54. Robinson P, Okhuysen PC, Chappell CL, Weinstock JV, Lewis DE, Actor JK, White AC. Substance P expression correlates with severity of diarrhea in cryptosporidiosis. J Infect Dis. 2003 Jul 15; 188(2):290-6. PMID: 12854086.
      View in: PubMed
    55. Lednicky JA, Vilchez RA, Keitel WA, Visnegarwala F, White ZS, Kozinetz CA, Lewis DE, Butel JS. Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy. AIDS. 2003 Apr 11; 17(6):801-7. PMID: 12660526.
      View in: PubMed
    56. Bischoff FZ, Dang DX, Marquez-Do D, Martinez D, Horne C, Lewis DE, Simpson JL. Detecting fetal DNA from dried maternal blood spots: another step towards broad scale non-invasive prenatal genetic screening and feasible testing. Reprod Biomed Online. 2003 Apr-May; 6(3):349-51. PMID: 12735873.
      View in: PubMed
    57. Bischoff FZ, Hahn S, Johnson KL, Simpson JL, Bianchi DW, Lewis DE, Weber WD, Klinger K, Elias S, Jackson LG, Evans MI, Holzgreve W, de la Cruz F. Intact fetal cells in maternal plasma: are they really there? Lancet. 2003 Jan 11; 361(9352):139-40. PMID: 12531583.
      View in: PubMed
    58. Bischoff FZ, Sinacori MK, Dang DD, Marquez-Do D, Horne C, Lewis DE, Simpson JL. Cell-free fetal DNA and intact fetal cells in maternal blood circulation: implications for first and second trimester non-invasive prenatal diagnosis. Hum Reprod Update. 2002 Nov-Dec; 8(6):493-500. PMID: 12498419.
      View in: PubMed
    59. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep; 36(3):592-601. PMID: 12198651.
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    60. Robinson P, White AC, Lewis DE, Thornby J, David E, Weinstock J. Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis. Infect Immun. 2002 Aug; 70(8):4534-8. PMID: 12117965; PMCID: PMC128166.
    61. Blutt SE, Warfield KL, Lewis DE, Conner ME. Early response to rotavirus infection involves massive B cell activation. J Immunol. 2002 Jun 1; 168(11):5716-21. PMID: 12023371.
      View in: PubMed
    62. Manotaya S, Elias S, Lewis DE, Simpson JL, Bischoff FZ. Evaluation of a culture system for enrichment of CD34+ hematopoietic progenitor cells present in maternal blood. Fetal Diagn Ther. 2002 Mar-Apr; 17(2):90-6. PMID: 11844912.
      View in: PubMed
    63. Bischoff FZ, Dang DX, Lewis DE, Simpson JL. Prenatal diagnosis of chromosomal abnormalities using maternal blood. Methods Mol Biol. 2002; 204:243-58. PMID: 12397802.
      View in: PubMed
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