Institute for Clinical and Translational Research

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MIGUEL CRUZ

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Thrombosis Research
Address2002 Holcombe Blvd.
HOUSTON TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Hematology & Oncology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou Y, Qin S, Hilton T, Tang L, Cruz M, Hernandez R, Moake JL, Tian Q, Frazier OH, Dong JF, Nascimbene A. Quantification of Von Willebrand Factor Cleavage by adamts-13 in Patients Supported by Left Ventricular Assist Devices. ASAIO J. 2017 Jul 01. PMID: 28682993.
      View in: PubMed
    2. Da Q, Shaw T, Pradhan S, Roche PA, Cruz MA, Vijayan KV. Disruption of protein complexes containing protein phosphatase 2B and Munc18c dampens the secretion of von Willebrand factor from endothelial cells. J Thromb Haemost. 2017 Mar 12. PMID: 28294518.
      View in: PubMed
    3. Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan P. Wdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897. PMID: 27627652.
      View in: PubMed
    4. Khatlani T, Pradhan S, Da Q, Shaw T, Buchman VL, Cruz MA, Vijayan KV. A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in ?IIb?3 Integrin Signaling. J Biol Chem. 2016 Aug 12; 291(33):17360-8. PMID: 27334924.
      View in: PubMed
    5. Lam FW, Cruz MA, Parikh K, Rumbaut RE. Histones stimulate von Willebrand factor release in vitro and in vivo. Haematologica. 2016 Mar 24. PMID: 27013650.
      View in: PubMed
    6. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P. Hemoglobin interaction with GP1ba induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica. 2015 Sep 4. PMID: 26341739.
      View in: PubMed
    7. Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA. Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices. Blood. 2015 Aug 25. PMID: 26307534.
      View in: PubMed
    8. Nguyen TC, Cruz MA, Carcillo JA. Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury. Crit Care Clin. 2015 Oct; 31(4):661-74. PMID: 26410136.
      View in: PubMed
    9. Ju L, Chen Y, Zhou F, Lu H, Cruz MA, Zhu C. Von Willebrand factor-A1 domain binds platelet glycoprotein Ib? in multiple states with distinctive force-dependent dissociation kinetics. Thromb Res. 2015 Sep; 136(3):606-12. PMID: 26213126.
      View in: PubMed
    10. Nguyen TC, Gushiken F, Correa JI, Dong JF, Dasgupta SK, Thiagarajan P, Cruz MA. A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia. Thromb Res. 2015 May; 135(5):1025-30. PMID: 25769494.
      View in: PubMed
    11. Da Q, Behymer M, Correa JI, Vijayan KV, Cruz MA. Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress. Blood. 2014 Apr 24; 123(17):2715-21. PMID: 24642750; PMCID: PMC3999756.
      View in: PubMed, PubMed Central
    12. Lo NC, Turner NA, Cruz MA, Moake J. Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor. J Biol Chem. 2013 Nov 15; 288(46):33118-23. PMID: 24097977; PMCID: PMC3829160.
      View in: PubMed, PubMed Central
    13. Ju L, Dong JF, Cruz MA, Zhu C. The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ib?. J Biol Chem. 2013 Nov 8; 288(45):32289-301. PMID: 24062306; PMCID: PMC3820866.
      View in: PubMed, PubMed Central
    14. Chan HC, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH, Chen CH. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 2013 Nov 21; 122(22):3632-41. PMID: 24030386; PMCID: PMC3837512.
      View in: PubMed, PubMed Central
    15. Feng S, Liang X, Cruz MA, Vu H, Zhou Z, Pemmaraju N, Dong JF, Kroll MH, Afshar-Kharghan V. The interaction between factor H and Von Willebrand factor. PLoS One. 2013; 8(8):e73715. PMID: 23991205; PMCID: PMC3753316.
      View in: PubMed, PubMed Central
    16. Tischer A, Cruz MA, Auton M. The linker between the D3 and A1 domains of vWF suppresses A1-GPIb? catch bonds by site-specific binding to the A1 domain. Protein Sci. 2013 Aug; 22(8):1049-59. PMID: 23775931; PMCID: PMC3832041.
      View in: PubMed, PubMed Central
    17. Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut RE. Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res. 2013 Jul; 132(1):69-76. PMID: 23673386.
      View in: PubMed
    18. Auton M, Sowa KE, Behymer M, Cruz MA. N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress. J Biol Chem. 2012 Apr 27; 287(18):14579-85. PMID: 22431729; PMCID: PMC3340263.
      View in: PubMed, PubMed Central
    19. Yan R, Mo X, Paredes AM, Dai K, Lanza F, Cruz MA, Li R. Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs. Biochemistry. 2011 Dec 13; 50(49):10598-606. PMID: 22080766; PMCID: PMC3552449.
      View in: PubMed, PubMed Central
    20. Coburn LA, Damaraju VS, Dozic S, Eskin SG, Cruz MA, McIntire LV. GPIb?-vWF rolling under shear stress shows differences between type 2B and 2M von Willebrand disease. Biophys J. 2011 Jan 19; 100(2):304-12. PMID: 21244826; PMCID: PMC3021665.
      View in: PubMed, PubMed Central
    21. Auton M, Zhu C, Cruz MA. The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 2010 Aug 9; 99(4):1192-201. PMID: 20713003; PMCID: PMC2920722.
      View in: PubMed, PubMed Central
    22. Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA. Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. J Biol Chem. 2010 Jul 23; 285(30):22831-9. PMID: 20498367; PMCID: PMC2906274.
      View in: PubMed, PubMed Central
    23. Gushiken FC, Hyojeong H, Pradhan S, Langlois KW, Alrehani N, Cruz MA, Rumbaut RE, Vijayan KV. The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PLoS One. 2009; 4(12):e8304. PMID: 20016849; PMCID: PMC2788699.
      View in: PubMed, PubMed Central
    24. Wu T, Lin J, Cruz MA, Dong JF, Zhu C. Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. Blood. 2010 Jan 14; 115(2):370-8. PMID: 19897584; PMCID: PMC2808159.
      View in: PubMed, PubMed Central
    25. Auton M, Sedlák E, Marek J, Wu T, Zhu C, Cruz MA. Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophys J. 2009 Jul 22; 97(2):618-27. PMID: 19619477; PMCID: PMC2711320.
      View in: PubMed, PubMed Central
    26. Zhou Z, Han H, Cruz MA, López JA, Dong JF, Guchhait P. Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease. Thromb Haemost. 2009 Jun; 101(6):1070-7. PMID: 19492149.
      View in: PubMed
    27. Yago T, Lou J, Wu T, Yang J, Miner JJ, Coburn L, López JA, Cruz MA, Dong JF, McIntire LV, McEver RP, Zhu C. Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest. 2008 Sep; 118(9):3195-207. PMID: 18725999; PMCID: PMC2518822.
      View in: PubMed, PubMed Central
    28. Dong JF, Cruz MA, Aboulfatova K, Martin C, Choi H, Bergeron AL, Martini SR, Kroll MH, Kent TA. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. Thromb Haemost. 2008 Mar; 99(3):586-93. PMID: 18327408.
      View in: PubMed
    29. Martin C, Morales LD, Cruz MA. Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha. J Thromb Haemost. 2007 Jul; 5(7):1363-70. PMID: 17389010.
      View in: PubMed
    30. Auton M, Cruz MA, Moake J. Conformational stability and domain unfolding of the Von Willebrand factor A domains. J Mol Biol. 2007 Feb 23; 366(3):986-1000. PMID: 17187823.
      View in: PubMed
    31. Morales LD, Martin C, Cruz MA. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. J Thromb Haemost. 2006 Feb; 4(2):417-25. PMID: 16420575.
      View in: PubMed
    32. Lasser G, Guchhait P, Ellsworth JL, Sheppard P, Lewis K, Bishop P, Cruz MA, Lopez JA, Fruebis J. C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood. 2006 Jan 15; 107(2):423-30. PMID: 16195328.
      View in: PubMed
    33. Arya M, Kolomeisky AB, Romo GM, Cruz MA, López JA, Anvari B. Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor. Biophys J. 2005 Jun; 88(6):4391-401. PMID: 15764659; PMCID: PMC1305666.
      View in: PubMed, PubMed Central
    34. Cruz MA, Chen J, Whitelock JL, Morales LD, López JA. The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain. Blood. 2005 Mar 1; 105(5):1986-91. PMID: 15514009.
      View in: PubMed
    35. Peng Y, Berndt MC, Cruz MA, López JA. The alpha1 helix-beta13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibalpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1. Blood. 2004 Dec 15; 104(13):3971-8. PMID: 15319289.
      View in: PubMed
    36. Dong JF, Whitelock J, Bernardo A, Ball C, Cruz MA. Variations among normal individuals in the cleavage of endothelial-derived ultra-large von Willebrand factor under flow. J Thromb Haemost. 2004 Aug; 2(8):1460-6. PMID: 15304055.
      View in: PubMed
    37. Bernardo A, Bergeron AL, Sun CW, Guchhait P, Cruz MA, López JA, Dong JF. Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. J Thromb Haemost. 2004 Apr; 2(4):660-9. PMID: 15102023.
      View in: PubMed
    38. Whitelock JL, Nolasco L, Bernardo A, Moake J, Dong JF, Cruz MA. ADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate. J Thromb Haemost. 2004 Mar; 2(3):485-91. PMID: 15009467.
      View in: PubMed
    39. Kumar RA, Dong JF, Thaggard JA, Cruz MA, López JA, McIntire LV. Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates. Biophys J. 2003 Dec; 85(6):4099-109. PMID: 14645097; PMCID: PMC1303709.
      View in: PubMed, PubMed Central
    40. Cruz MA, Whitelock J, Dong JF. Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate. Thromb Haemost. 2003 Dec; 90(6):1204-9. PMID: 14652658.
      View in: PubMed
    41. Arya M, López JA, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari B. Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J Thromb Haemost. 2003 Jun; 1(6):1150-7. PMID: 12871313.
      View in: PubMed
    42. Borthakur G, Cruz MA, Dong JF, McIntire L, Li F, López JA, Thiagarajan P. Sulfatides inhibit platelet adhesion to von Willebrand factor in flowing blood. J Thromb Haemost. 2003 Jun; 1(6):1288-95. PMID: 12871332.
      View in: PubMed
    43. Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, López JA, Cruz MA. ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem. 2003 Aug 8; 278(32):29633-9. PMID: 12775718.
      View in: PubMed
    44. Schulte am Esch J, Robson SC, Cruz MA. Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561. Biochem Biophys Res Commun. 2003 Mar 21; 302(4):873-7. PMID: 12646253.
      View in: PubMed
    45. Shrimpton CN, Borthakur G, Larrucea S, Cruz MA, Dong JF, López JA. Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J Exp Med. 2002 Oct 21; 196(8):1057-66. PMID: 12391017; PMCID: PMC2194038.
      View in: PubMed, PubMed Central
    46. Fukuda K, Doggett TA, Bankston LA, Cruz MA, Diacovo TG, Liddington RC. Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure. 2002 Jul; 10(7):943-50. PMID: 12121649.
      View in: PubMed
    47. Arya M, Anvari B, Romo GM, Cruz MA, Dong JF, McIntire LV, Moake JL, López JA. Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. Blood. 2002 Jun 1; 99(11):3971-7. PMID: 12010796.
      View in: PubMed
    48. Cruz MA, Diacovo TG, Emsley J, Liddington R, Handin RI. Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. J Biol Chem. 2000 Jun 23; 275(25):19098-105. PMID: 10764791.
      View in: PubMed
    49. Smith C, Estavillo D, Emsley J, Bankston LA, Liddington RC, Cruz MA. Mapping the collagen-binding site in the I domain of the glycoprotein Ia/IIa (integrin alpha(2)beta(1)). J Biol Chem. 2000 Feb 11; 275(6):4205-9. PMID: 10660584.
      View in: PubMed
    50. Estavillo D, Ritchie A, Diacovo TG, Cruz MA. Functional analysis of a recombinant glycoprotein Ia/IIa (Integrin alpha(2)beta(1)) I domain that inhibits platelet adhesion to collagen and endothelial matrix under flow conditions. J Biol Chem. 1999 Dec 10; 274(50):35921-6. PMID: 10585478.
      View in: PubMed
    51. Schulte am Esch J, Cruz MA, Siegel JB, Anrather J, Robson SC. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood. 1997 Dec 1; 90(11):4425-37. PMID: 9373253.
      View in: PubMed
    52. Cruz MA, Yuan H, Lee JR, Wise RJ, Handin RI. Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides. J Biol Chem. 1995 May 5; 270(18):10822-7. PMID: 7738019.
      View in: PubMed
    53. Beacham DA, Cruz MA, Handin RI. Glycoprotein Ib can mediate endothelial cell attachment to a von Willebrand factor substratum. Thromb Haemost. 1995 Feb; 73(2):309-17. PMID: 7792748.
      View in: PubMed
    54. Cruz MA, Handin RI, Wise RJ. The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem. 1993 Oct 5; 268(28):21238-45. PMID: 8407961.
      View in: PubMed
    55. Cruz MA, Petersen E, Turci SM, Handin RI. Functional analysis of a recombinant glycoprotein Ib alpha polypeptide which inhibits von Willebrand factor binding to the platelet glycoprotein Ib-IX complex and to collagen. J Biol Chem. 1992 Jan 15; 267(2):1303-9. PMID: 1730650.
      View in: PubMed
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