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MIGUEL CRUZ

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address2002 HOLCOMBE
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Hematology & Oncology


    Collapse Research 
    Collapse research activities and funding
    R01HL154688     (CRUZ, MIGUEL ANGEL)Jun 1, 2021 - Apr 30, 2025
    NIH
    Molecular Studies of Hemolytic Thrombosis
    Role: Principal Investigator
    R41HL135942     (CRUZ, MIGUEL ANGEL)Aug 20, 2018 - Jul 31, 2020
    NIH
    Novel treatment for DIC
    Role: Principal Investigator
    T32HL139425     (RUMBAUT, ROLANDO E)Aug 1, 2018 - Jul 31, 2023
    NIH
    Collaborative Research Training in Thrombosis and Inflammation
    Role: Co-Principal Investigator
    R01NS094280     (CRUZ, MIGUEL ANGEL)Sep 1, 2016 - May 31, 2021
    NIH
    Role of vimentin in thrombosis and stroke
    Role: Principal Investigator
    R01GM112806     (CRUZ, MIGUEL ANGEL)Sep 25, 2014 - Jun 30, 2023
    NIH
    Microvascular Thrombosis in systemic inflammation
    Role: Principal Investigator
    R01HL072886     (CRUZ, MIGUEL ANGEL)Dec 8, 2003 - Nov 30, 2009
    NIH
    Molecular Basis of Platelet Adhesion
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin J, Ding X, Yang P, Liu S, Li Q, Cruz MA, Dong JF, Fang Y, Wu J. Force-induced biphasic regulation of VWF cleavage by ADAMTS13. Thromb Res. 2023 09; 229:99-106. PMID: 37421684.
      Citations:    Fields:    Translation:Cells
    2. Nguyen TC, Marini JC, Guillory B, Valladolid-Brown C, Martinez-Vargas M, Subramanyam D, Cohen D, Cirlos SC, Lam F, Stoll B, Didelija IC, Vonderohe C, Orellana R, Saini A, Pradhan S, Bashir D, Desai MS, Flores S, Virk M, Tcharmtchi H, Navaei A, Kaplan S, Lamberth L, Hulten KG, Scull BP, Allen CE, Akcan-Arikan A, Vijayan KV, Cruz MA. Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries. Crit Care Explor. 2023 Jun; 5(6):e0916. PMID: 37255626; PMCID: PMC10226618.
      Citations:    
    3. Martinez-Vargas M, Cebula A, Brubaker LS, Seshadri N, Lam FW, Loor M, Rosengart TK, Yee A, Rumbaut RE, Cruz MA. A novel interaction between extracellular vimentin and fibrinogen in fibrin formation. Thromb Res. 2023 01; 221:97-104. PMID: 36495717; PMCID: PMC9726209.
      Citations: 1     Fields:    Translation:HumansCells
    4. Bray M, Guzel MA, Lam F, Yee A, Cruz MA, Rumbaut RE. High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19. J Thromb Thrombolysis. 2022 Aug; 54(2):211-216. PMID: 35881214; PMCID: PMC9314532.
      Citations:    Fields:    
    5. Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Mamakou V, Mani KR, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W, FinnGen, eMERGE Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YI, Froguel P, Wilson JG, Sheu WHH, Kardia SLR, Wu JY, Hayes MG, Ma RCW, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Kato N, Laakso M, Koh WP, Palmer CNA, Liu S, Abecasis G, Kooner JS, Loos RJF, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris AP, R?eger S, Huerta-Chagoya A, Lecoeur C, Aguilar-Salinas CA, Canouil M, Eckardt KU, Gonz?lez-Villalpando C, Gonz?lez-Villalpando ME, J?rgensen ME, J?rgensen T, L?ll K, Lyssenko V, Meitinger T, Orozco L, Sch?nherr S, Stanc?kov? A, Tusie-Luna T, Wacher-Rodarte N, Yengo L, Par? G, Sale MM, Dupuis J, K?ttgen A, M?gi R. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022 05; 54(5):560-572. PMID: 35551307; PMCID: PMC9179018.
      Citations: 5     Fields:    Translation:Humans
    6. Yang M, Houck KL, Dong X, Hernandez M, Wang Y, Nathan SS, Wu X, Afshar-Kharghan V, Fu X, Cruz MA, Zhang J, Nascimbene A, Dong JF. Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis: Implication for LVAD-Induced Bleeding. JACC Basic Transl Sci. 2022 Mar; 7(3):247-261. PMID: 35411318; PMCID: PMC8993768.
      Citations:    
    7. Brubaker LS, Saini A, Nguyen TC, Martinez-Vargas M, Lam FW, Yao Q, Loor MM, Rosengart TK, Cruz MA. Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Crit Care Med. 2022 06 01; 50(6):e557-e568. PMID: 35170535; PMCID: PMC9112654.
      Citations:    Fields:    Translation:Humans
    8. Wu Y, Zeng Z, Guo Y, Song L, Weatherhead JE, Huang X, Zeng Y, Bimler L, Chang CY, Knight JM, Valladolid C, Sun H, Cruz MA, Hube B, Naglik JR, Luong AU, Kheradmand F, Corry DB. Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization. Immunity. 2021 11 09; 54(11):2595-2610.e7. PMID: 34506733; PMCID: PMC8585696.
      Citations: 9     Fields:    Translation:AnimalsCells
    9. Fang J, Sun X, Liu S, Yang P, Lin J, Feng J, Cruz MA, Dong JF, Fang Y, Wu J. Shear Stress Accumulation Enhances von Willebrand Factor-Induced Platelet P-Selectin Translocation in a PI3K/Akt Pathway-Dependent Manner. Front Cell Dev Biol. 2021; 9:642108. PMID: 34141704; PMCID: PMC8204100.
      Citations: 1     
    10. Brubaker L, Mortus J, Cruz M, Trautner B, Loor M, Rosengart T. Thromboelastography MightBe More Applicable to Guide Anticoagulant Therapy than Fibrinolytic Therapy in Critically Ill Patients with COVID-19. J Am Coll Surg. 2021 06; 232(6):1021-1022. PMID: 33839010; PMCID: PMC8025069.
      Citations:    Fields:    Translation:HumansCells
    11. Xu X, Wang C, Wu Y, Houck K, Hilton T, Zhou A, Wu X, Han C, Yang M, Yang W, Shi FD, Stolla M, Cruz MA, Li M, Zhang J, Dong JF. Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice. Blood. 2021 01 28; 137(4):544-555. PMID: 33507292; PMCID: PMC7845006.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Bashir DA, Da Q, Pradhan S, Sekhar N, Valladolid C, Lam F, Guffey D, Goldman J, Desai MS, Cruz MA, Allen C, Nguyen TC, Vijayan KV. Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin. Clin Appl Thromb Hemost. 2021 Jan-Dec; 27:1076029621992128. PMID: 33539188; PMCID: PMC7868463.
      Citations: 3     Fields:    Translation:HumansCells
    13. Brubaker L, Mortus J, Cruz M, Trautner B, Loor M, Rosengart T. Thromboelastography Might Be More Applicable to Guide Anticoagulant Therapy than Fibrinolytic Therapy in Critically Ill Patients with COVID-19. J Am Coll Surg. 2021 02; 232(2):227-229. PMID: 33246792; PMCID: PMC7686709.
      Citations: 1     Fields:    Translation:HumansCells
    14. Hubbard WB, Dong JF, Cruz MA, Rumbaut RE. Links between thrombosis and inflammation in traumatic brain injury. Thromb Res. 2021 02; 198:62-71. PMID: 33290884; PMCID: PMC7867616.
      Citations: 3     Fields:    Translation:HumansCells
    15. Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA. The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium. PLoS One. 2020; 15(10):e0240164. PMID: 33048962; PMCID: PMC7553327.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    16. Mortus JR, Manek SE, Brubaker LS, Loor M, Cruz MA, Trautner BW, Rosengart TK. Thromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill. JAMA Netw Open. 2020 06 01; 3(6):e2011192. PMID: 32501489; PMCID: PMC7275245.
      Citations: 43     Fields:    Translation:HumansCellsPHPublic Health
    17. Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA. Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation. Blood Adv. 2020 04 14; 4(7):1340-1349. PMID: 32259201; PMCID: PMC7160269.
      Citations: 5     Fields:    Translation:Animals
    18. Trevi?o-Becerra A, Espinosa-Larra?aga F, Cruz M, Rodr?guez-P?rez ME. Gaceta M?dica de M?xico in SARS-CoV-2 pandemic times. Gac Med Mex. 2020; 156(4):261-262. PMID: 32831332.
      Citations:    Fields:    Translation:PHPublic Health
    19. Tischer A, Brehm MA, Machha VR, Moon-Tasson L, Benson LM, Nelton KJ, Leger RR, Obser T, Martinez-Vargas M, Whitten ST, Chen D, Pruthi RK, Bergen HR, Cruz MA, Schneppenheim R, Auton M. Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease. J Mol Biol. 2020 01 17; 432(2):305-323. PMID: 31628947; PMCID: PMC7028320.
      Citations: 3     Fields:    Translation:HumansCells
    20. Li Z, Lin J, Sulchek T, Cruz MA, Wu J, Dong JF, Zhu C. Domain-specific mechanical modulation of VWF-ADAMTS13 interaction. Mol Biol Cell. 2019 07 22; 30(16):1920-1929. PMID: 31067148; PMCID: PMC6727775.
      Citations: 4     Fields:    Translation:HumansCells
    21. Da Q, Han H, Valladolid C, Khatlani T, Pradhan S, Nolasco J, Engler DA, Cruz MA, Vijayan KV, Fern?ndez M, Matsunami RK. In vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion. J Thromb Haemost. 2019 06; 17(6):866-877. PMID: 30864273; PMCID: PMC6545126.
      Citations: 4     Fields:    Translation:HumansCells
    22. Fasipe TA, Hong SH, Da Q, Valladolid C, Lahey MT, Richards LM, Dunn AK, Cruz MA, Marrelli SP. Extracellular Vimentin/VWF (von Willebrand Factor) Interaction Contributes to VWF String Formation and Stroke Pathology. Stroke. 2018 10; 49(10):2536-2540. PMID: 30355099; PMCID: PMC6207252.
      Citations: 16     Fields:    Translation:AnimalsCells
    23. Valladolid C, Yee A, Cruz MA. von Willebrand Factor, Free Hemoglobin and Thrombosis in ECMO. Front Med (Lausanne). 2018; 5:228. PMID: 30175099; PMCID: PMC6107708.
      Citations: 2     
    24. Lam FW, Da Q, Guillory B, Cruz MA. Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium. J Immunol. 2018 03 01; 200(5):1718-1726. PMID: 29335256; PMCID: PMC5821592.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    25. Nolasco JG, Nolasco LH, Da Q, Cirlos S, Ruggeri ZM, Moake JL, Cruz MA. Complement Component C3 Binds to the A3 Domain of von Willebrand Factor. TH Open. 2018; 2(3):e338-e345. PMID: 31080944; PMCID: PMC6508891.
      Citations: 2     
    26. Qin S, Hilton T, Tang L, Cruz M, Hernandez R, Moake JL, Tian Q, Frazier OH, Dong JF, Nascimbene A, Zhou Y. Quantification of Von Willebrand Factor Cleavage by adamts-13 in Patients Supported by Left Ventricular Assist Devices. ASAIO J. 2017 Nov/Dec; 63(6):849-853. PMID: 28682993; PMCID: PMC5662488.
      Citations: 4     Fields:    Translation:Humans
    27. Da Q, Shaw T, Pradhan S, Roche PA, Cruz MA, Vijayan KV. Disruption of protein complexes containing protein phosphatase?2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells. J Thromb Haemost. 2017 05; 15(5):1032-1039. PMID: 28294518; PMCID: PMC5413388.
      Citations: 2     Fields:    Translation:HumansCells
    28. Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan P. Wdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897. PMID: 27627652; PMCID: PMC5023164.
      Citations: 7     Fields:    Translation:Animals
    29. Khatlani T, Pradhan S, Da Q, Shaw T, Buchman VL, Cruz MA, Vijayan KV. A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in aIIb?3 Integrin Signaling. J Biol Chem. 2016 08 12; 291(33):17360-8. PMID: 27334924; PMCID: PMC5016133.
      Citations: 2     Fields:    Translation:HumansCells
    30. Lam FW, Cruz MA, Parikh K, Rumbaut RE. Histones stimulate von Willebrand factor release in vitro and in vivo. Haematologica. 2016 07; 101(7):e277-9. PMID: 27013650; PMCID: PMC5004471.
      Citations: 14     Fields:    Translation:HumansAnimals
    31. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P. Hemoglobin interaction with GP1ba induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica. 2015 Dec; 100(12):1526-33. PMID: 26341739; PMCID: PMC4666328.
      Citations: 13     Fields:    Translation:HumansCells
    32. Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA. Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices. Blood. 2015 Nov 12; 126(20):2338-41. PMID: 26307534; PMCID: PMC4643006.
      Citations: 23     Fields:    Translation:HumansCells
    33. Nguyen TC, Cruz MA, Carcillo JA. Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury. Crit Care Clin. 2015 Oct; 31(4):661-74. PMID: 26410136; PMCID: PMC5281060.
      Citations: 21     Fields:    Translation:Humans
    34. Ju L, Chen Y, Zhou F, Lu H, Cruz MA, Zhu C. Von Willebrand factor-A1 domain binds platelet glycoprotein Iba in multiple states with distinctive force-dependent dissociation kinetics. Thromb Res. 2015 Sep; 136(3):606-12. PMID: 26213126; PMCID: PMC4553094.
      Citations: 25     Fields:    Translation:HumansCells
    35. Nguyen TC, Gushiken F, Correa JI, Dong JF, Dasgupta SK, Thiagarajan P, Cruz MA. A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia. Thromb Res. 2015 May; 135(5):1025-30. PMID: 25769494; PMCID: PMC5270629.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    36. Cahua-Pablo G, Flores-Alfaro E, Cruz M, Moral-Hern?ndez OD, Leyva-V?zquez MA, Ant?nez-Ortiz DL, Cahua-Pablo JA, Alarc?n-Romero Ldel C, Ortu?o-Pineda C, Moreno-God?nez ME, Hern?ndez-Sotelo D. Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene. Clin Appl Thromb Hemost. 2016 Jul; 22(5):465-70. PMID: 25601895.
      Citations: 5     Fields:    Translation:HumansCells
    37. Da Q, Behymer M, Correa JI, Vijayan KV, Cruz MA. Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress. Blood. 2014 Apr 24; 123(17):2715-21. PMID: 24642750; PMCID: PMC3999756.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    38. Lo NC, Turner NA, Cruz MA, Moake J. Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor. J Biol Chem. 2013 Nov 15; 288(46):33118-23. PMID: 24097977; PMCID: PMC3829160.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    39. Ju L, Dong JF, Cruz MA, Zhu C. The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Iba. J Biol Chem. 2013 Nov 08; 288(45):32289-32301. PMID: 24062306; PMCID: PMC3820866.
      Citations: 48     Fields:    Translation:HumansCellsCTClinical Trials
    40. Chan HC, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH, Chen CH. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 2013 Nov 21; 122(22):3632-41. PMID: 24030386; PMCID: PMC3837512.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    41. Feng S, Liang X, Cruz MA, Vu H, Zhou Z, Pemmaraju N, Dong JF, Kroll MH, Afshar-Kharghan V. The interaction between factor H and Von Willebrand factor. PLoS One. 2013; 8(8):e73715. PMID: 23991205; PMCID: PMC3753316.
      Citations: 18     Fields:    Translation:HumansCells
    42. Tischer A, Cruz MA, Auton M. The linker between the D3 and A1 domains of vWF suppresses A1-GPIba catch bonds by site-specific binding to the A1 domain. Protein Sci. 2013 Aug; 22(8):1049-59. PMID: 23775931; PMCID: PMC3832041.
      Citations: 25     Fields:    Translation:HumansCells
    43. Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut RE. Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res. 2013 Jul; 132(1):69-76. PMID: 23673386.
      Citations: 33     Fields:    Translation:HumansCells
    44. Auton M, Sowa KE, Behymer M, Cruz MA. N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress. J Biol Chem. 2012 Apr 27; 287(18):14579-85. PMID: 22431729; PMCID: PMC3340263.
      Citations: 26     Fields:    Translation:HumansCellsCTClinical Trials
    45. Yan R, Mo X, Paredes AM, Dai K, Lanza F, Cruz MA, Li R. Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs. Biochemistry. 2011 Dec 13; 50(49):10598-606. PMID: 22080766; PMCID: PMC3552449.
      Citations: 16     Fields:    Translation:HumansCells
    46. Coburn LA, Damaraju VS, Dozic S, Eskin SG, Cruz MA, McIntire LV. GPIba-vWF rolling under shear stress shows differences between type 2B and 2M von Willebrand disease. Biophys J. 2011 Jan 19; 100(2):304-12. PMID: 21244826; PMCID: PMC3021665.
      Citations: 18     Fields:    Translation:HumansCells
    47. Auton M, Zhu C, Cruz MA. The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 2010 Aug 09; 99(4):1192-201. PMID: 20713003; PMCID: PMC2920722.
      Citations: 23     Fields:    Translation:AnimalsCells
    48. Auton M, Sowa KE, Smith SM, Vijayan KV, Cruz MA, Sedl?k E. Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. J Biol Chem. 2010 Jul 23; 285(30):22831-9. PMID: 20498367; PMCID: PMC2906274.
      Citations: 31     Fields:    Translation:HumansCells
    49. Gushiken FC, Hyojeong H, Pradhan S, Langlois KW, Alrehani N, Cruz MA, Rumbaut RE, Vijayan KV. The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PLoS One. 2009 Dec 15; 4(12):e8304. PMID: 20016849; PMCID: PMC2788699.
      Citations: 8     Fields:    Translation:AnimalsCells
    50. Wu T, Lin J, Cruz MA, Dong JF, Zhu C. Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. Blood. 2010 Jan 14; 115(2):370-8. PMID: 19897584; PMCID: PMC2808159.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    51. Auton M, Marek J, Wu T, Zhu C, Cruz MA, Sedl?k E. Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophys J. 2009 Jul 22; 97(2):618-27. PMID: 19619477; PMCID: PMC2711320.
      Citations: 25     Fields:    Translation:HumansCells
    52. Zhou Z, Han H, Cruz MA, Dong JF, Guchhait P, L?pez JA. Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease. Thromb Haemost. 2009 Jun; 101(6):1070-7. PMID: 19492149.
      Citations: 35     Fields:    Translation:HumansCells
    53. Yago T, Lou J, Wu T, Yang J, Miner JJ, Coburn L, Cruz MA, Dong JF, McIntire LV, McEver RP, Zhu C, L?pez JA. Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest. 2008 Sep; 118(9):3195-207. PMID: 18725999; PMCID: PMC2518822.
      Citations: 149     Fields:    Translation:HumansCells
    54. Dong JF, Cruz MA, Aboulfatova K, Martin C, Choi H, Bergeron AL, Martini SR, Kroll MH, Kent TA. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. Thromb Haemost. 2008 Mar; 99(3):586-93. PMID: 18327408.
      Citations: 14     Fields:    Translation:HumansCells
    55. Martin C, Morales LD, Cruz MA. Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha. J Thromb Haemost. 2007 Jul; 5(7):1363-70. PMID: 17389010.
      Citations: 52     Fields:    Translation:HumansCells
    56. Auton M, Cruz MA, Moake J. Conformational stability and domain unfolding of the Von Willebrand factor A domains. J Mol Biol. 2007 Feb 23; 366(3):986-1000. PMID: 17187823.
      Citations: 44     Fields:    Translation:HumansCells
    57. Morales LD, Martin C, Cruz MA. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. J Thromb Haemost. 2006 Feb; 4(2):417-25. PMID: 16420575.
      Citations: 25     Fields:    Translation:HumansCells
    58. Lasser G, Guchhait P, Ellsworth JL, Sheppard P, Lewis K, Bishop P, Cruz MA, Lopez JA, Fruebis J. C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood. 2006 Jan 15; 107(2):423-30. PMID: 16195328.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    59. Arya M, Kolomeisky AB, Romo GM, Cruz MA, Anvari B, L?pez JA. Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor. Biophys J. 2005 Jun; 88(6):4391-401. PMID: 15764659; PMCID: PMC1305666.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    60. Cruz MA, Chen J, Whitelock JL, Morales LD, L?pez JA. The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain. Blood. 2005 Mar 01; 105(5):1986-91. PMID: 15514009.
      Citations: 21     Fields:    Translation:HumansCells
    61. Peng Y, Berndt MC, Cruz MA, L?pez JA. The alpha1 helix-beta13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibalpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1. Blood. 2004 Dec 15; 104(13):3971-8. PMID: 15319289.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    62. Dong JF, Whitelock J, Bernardo A, Ball C, Cruz MA. Variations among normal individuals in the cleavage of endothelial-derived ultra-large von Willebrand factor under flow. J Thromb Haemost. 2004 Aug; 2(8):1460-6. PMID: 15304055.
      Citations: 7     Fields:    Translation:HumansCells
    63. Bernardo A, Bergeron AL, Sun CW, Guchhait P, Cruz MA, Dong JF, L?pez JA. Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. J Thromb Haemost. 2004 Apr; 2(4):660-9. PMID: 15102023.
      Citations: 10     Fields:    Translation:HumansCells
    64. Whitelock JL, Nolasco L, Bernardo A, Moake J, Dong JF, Cruz MA. ADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate. J Thromb Haemost. 2004 Mar; 2(3):485-91. PMID: 15009467.
      Citations: 14     Fields:    Translation:HumansCells
    65. Kumar RA, Dong JF, Thaggard JA, Cruz MA, McIntire LV, L?pez JA. Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates. Biophys J. 2003 Dec; 85(6):4099-109. PMID: 14645097; PMCID: PMC1303709.
      Citations: 31     Fields:    Translation:AnimalsCells
    66. Cruz MA, Whitelock J, Dong JF. Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate. Thromb Haemost. 2003 Dec; 90(6):1204-9. PMID: 14652658.
      Citations: 15     Fields:    Translation:HumansCells
    67. Arya M, Romo GM, Cruz MA, Kasirer-Friede A, Shattil SJ, Anvari B, L?pez JA. Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. J Thromb Haemost. 2003 Jun; 1(6):1150-7. PMID: 12871313.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    68. Borthakur G, Cruz MA, Dong JF, McIntire L, Li F, Thiagarajan P, L?pez JA. Sulfatides inhibit platelet adhesion to von Willebrand factor in flowing blood. J Thromb Haemost. 2003 Jun; 1(6):1288-95. PMID: 12871332.
      Citations: 7     Fields:    Translation:HumansCells
    69. Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, Cruz MA, L?pez JA. ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem. 2003 Aug 08; 278(32):29633-9. PMID: 12775718.
      Citations: 55     Fields:    Translation:HumansCells
    70. Schulte am Esch J, Robson SC, Cruz MA. Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561. Biochem Biophys Res Commun. 2003 Mar 21; 302(4):873-7. PMID: 12646253.
      Citations:    Fields:    Translation:HumansAnimalsCells
    71. Fukuda K, Doggett TA, Bankston LA, Cruz MA, Diacovo TG, Liddington RC. Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure. 2002 Jul; 10(7):943-50. PMID: 12121649.
      Citations: 26     Fields:    Translation:HumansCells
    72. Arya M, Anvari B, Romo GM, Cruz MA, Dong JF, McIntire LV, Moake JL, L?pez JA. Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. Blood. 2002 Jun 01; 99(11):3971-7. PMID: 12010796.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    73. Cruz MA, Diacovo TG, Emsley J, Liddington R, Handin RI. Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. J Biol Chem. 2000 Jun 23; 275(25):19098-105. PMID: 10764791.
      Citations: 41     Fields:    Translation:HumansCells
    74. Smith C, Estavillo D, Emsley J, Bankston LA, Liddington RC, Cruz MA. Mapping the collagen-binding site in the I domain of the glycoprotein Ia/IIa (integrin alpha(2)beta(1)). J Biol Chem. 2000 Feb 11; 275(6):4205-9. PMID: 10660584.
      Citations: 14     Fields:    Translation:HumansCells
    75. Estavillo D, Ritchie A, Diacovo TG, Cruz MA. Functional analysis of a recombinant glycoprotein Ia/IIa (Integrin alpha(2)beta(1)) I domain that inhibits platelet adhesion to collagen and endothelial matrix under flow conditions. J Biol Chem. 1999 Dec 10; 274(50):35921-6. PMID: 10585478.
      Citations: 2     Fields:    Translation:HumansCells
    76. Schulte am Esch J, Cruz MA, Siegel JB, Anrather J, Robson SC. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood. 1997 Dec 01; 90(11):4425-37. PMID: 9373253.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    77. Cruz MA, Yuan H, Lee JR, Wise RJ, Handin RI. Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides. J Biol Chem. 1995 May 05; 270(18):10822-7. PMID: 7738019.
      Citations: 28     Fields:    Translation:HumansCells
    78. Beacham DA, Cruz MA, Handin RI. Glycoprotein Ib can mediate endothelial cell attachment to a von Willebrand factor substratum. Thromb Haemost. 1995 Feb; 73(2):309-17. PMID: 7792748.
      Citations: 2     Fields:    Translation:HumansCells
    79. Cruz MA, Handin RI, Wise RJ. The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem. 1993 Oct 05; 268(28):21238-45. PMID: 8407961.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    80. Cruz MA, Petersen E, Turci SM, Handin RI. Functional analysis of a recombinant glycoprotein Ib alpha polypeptide which inhibits von Willebrand factor binding to the platelet glycoprotein Ib-IX complex and to collagen. J Biol Chem. 1992 Jan 15; 267(2):1303-9. PMID: 1730650.
      Citations: 1     Fields:    Translation:Cells
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