Dr. Olutoye has a broad range of research endeavors ranging from basic science research using animal models of disease to robust clinical research. He has an active basic science laboratory currently focused on three main areas of research: wound healing, necrotizing enterocolitis (NEC) and fetal interventions. Hypertrophic scarring and keloids can be disfiguring conditions for many patients. Working with a pig model for hypertrophic scars he is studying the effects of Serum Amyloid P (SAP) on fibrocyte inhibition with hopes of developing a therapy that may be translated to treatment of keloids in humans.
Early diagnosis of Necrotizing Enterocolitis (NEC) continues to be a clinical challenge. Using a premature piglet model of NEC, he is attempting to identify non-invasive measure as well as serum biomarkers that will allow for early detection of neonates at risk for NEC. In collaboration with multiple subspecialty colleagues he is using time-dated pregnant sheep models to study innovative techniques in fetal intervention to treat conditions such as twin-twin transfusion syndrome (TTTS), spina bifida and congenital diaphragmatic hernia (CDH) as well as the effects of fetal anesthesia on the developing brain. Dr. Olutoye also has a great interest in the clinical application of NIRS technology for a variety of neonatal conditions: CDH patients before and after surgical correction, those undergoing extracorporeal membrane oxygenation (ECMO), neonates pre and post patent ductus arteriosus (PDA) ligation and neonates with congenital heart defects.