Over the last 10 years, we have focused our research on the identification of microRNAs with important roles in mammalian immunity and cardiopulmonary disease. Our approach is multipronged as we work with genetically modified mice and human samples. During the course of our work, we have identified novel miRNAs involved in adaptive and innate immunity (i.e. miR-155), heart failure (i.e. miR-22), and emphysema (i.e. miR-22). We are currently characterizing the pathophysiology of let-7 miRNA during emphysema/COPD with novel mouse models in collaboration with Drs. Corry and Kheradmand.