"beta-Lactamases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
| Descriptor ID |
D001618
|
| MeSH Number(s) |
D08.811.277.087.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "beta-Lactamases".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactamases".
This graph shows the total number of publications written about "beta-Lactamases" by people in this website by year, and whether "beta-Lactamases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 0 | 4 |
| 1997 | 2 | 0 | 2 |
| 1998 | 3 | 2 | 5 |
| 1999 | 2 | 2 | 4 |
| 2000 | 1 | 1 | 2 |
| 2001 | 3 | 2 | 5 |
| 2002 | 2 | 0 | 2 |
| 2003 | 3 | 2 | 5 |
| 2004 | 4 | 1 | 5 |
| 2005 | 3 | 0 | 3 |
| 2007 | 4 | 2 | 6 |
| 2008 | 2 | 0 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 2 | 1 | 3 |
| 2011 | 5 | 2 | 7 |
| 2012 | 3 | 1 | 4 |
| 2013 | 2 | 2 | 4 |
| 2014 | 3 | 0 | 3 |
| 2015 | 6 | 2 | 8 |
| 2016 | 5 | 0 | 5 |
| 2017 | 7 | 2 | 9 |
| 2018 | 4 | 0 | 4 |
| 2019 | 3 | 3 | 6 |
| 2020 | 6 | 5 | 11 |
| 2021 | 4 | 3 | 7 |
| 2022 | 2 | 4 | 6 |
| 2023 | 3 | 6 | 9 |
| 2024 | 1 | 3 | 4 |
| 2025 | 3 | 2 | 5 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "beta-Lactamases" by people in Profiles.
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Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers. J Infect Dis. 2026 Jan 17; 233(1):e164-e173.
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Multidrug-resistant gram-negative organisms: A primer on mechanisms of resistance and emerging therapies for the non-infectious diseases clinician. Am J Med Sci. 2026 Feb; 371(2):140-150.
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Molecular characterization of blaNDM and other carbapenemases genes among carbapenem-resistant Enterobacterales from community-and hospital- acquired urinary tract infections. BMC Infect Dis. 2025 Oct 09; 25(1):1260.
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Emergence of Escherichia coli sequence type 131 clone carrying blaCTX-M genes in Guilan Province, Northern Iran. Microbiol Spectr. 2025 Oct 07; 13(10):e0227024.
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Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline. Nat Commun. 2025 Jul 01; 16(1):5721.
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Carbapenem Resistant Serratia marcescens Harboring blaOXA-48, armA and aac(6')-Ib-cr Genes: The First Baseline Study from Pakistan. Curr Microbiol. 2025 Jun 03; 82(7):321.
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Bacteriophage treatment is effective against carbapenem-resistant Klebsiella pneumoniae (KPC) in a neutropenic murine model of gastrointestinal translocation and renal infection. Antimicrob Agents Chemother. 2025 02 13; 69(2):e0091924.
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Penicillin susceptibility among Staphylococcus aureus skin and soft tissue infections at a children's hospital. Microbiol Spectr. 2024 Oct 03; 12(10):e0086924.
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Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12):e2313513121.
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The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrob Agents Chemother. 2024 03 06; 68(3):e0110823.